Genomics continues to revolutionise science. But there’s untapped potential for new discoveries through collaboration between genomics and the humanities, social sciences, bioethics and wider stakeholders.

Can you find therapeutic targets for cardiomyopathies using simple, clean genetics in a human cell line? www.nature.com/articles/s41...

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

"Pat, why do you carry that ridiculous 600mm lens on long hikes?" Buddy, I can see mountains reflected in the eyes of a trailside pika.

Extremely proud to see this work led by @mihkeljesse.bsky.social now out on biorxiv!

I've reached 100 British springtail species! This was helped by a recent glasshouse sampling trip, where I added these 4 species. 3 are now in the pipeline to have reference-quality genomes sequenced for the first time, by the @sangerinstitute.bsky.social. More info in the thread below! 🧵1/7

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

Recruitment is now open for the EMBL-EBI–Sanger Postdoctoral Programme. ESPOD builds on the collaborative relationship between EMBL-EBI and the @sangerinstitute.bsky.social, offering projects that combine experimental and computational approaches. www.ebi.ac.uk/research/pos... 🧬🖥️🔬#postdocjob

We are hiring a scientist to lead our 'Build' team at the Seattle Hub for Synthetic Biology. @alleninstitute.org Job posting below: alleninstitute.org/careers/jobs... Please reach out if you have any questions!

New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.

New preprint: Allostery is a widespread cause of loss-of-function variant pathogenicity by the great @xt117.bsky.social biorxiv.org/content/10.1...

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

New preprint - collab with the groups of @mehurles.bsky.social and @dr-appie.bsky.social. We imputed missing fluid intelligence test scores into ~170k @ukbiobank.bsky.social indivs & showed how this reduces bias and increases power for rare+common variant analyses. www.medrxiv.org/content/10.1...

The evolution of allostery in a protein family. Aina's new preprint containing seven complete comparative allosteric maps biorxiv.org/content/10.1...

Our manuscript on how single-cell imaging of protein dynamics of paralogs reveals sources of gene retention is out in iScience with a great team of collaborators @leopoldparts.bsky.social @guilbourque.bsky.social www.cell.com/iscience/ful...

Which RNAs are functional? Been a long time goal of @deboramarks.bsky.social to start an RNA sequence —> function and structure mapping. Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!

Delighted that the 'flagship' manuscript on our @genesandhealth.bsky.social 44k exomes (British Pakistanis & Bangladeshis) is now preprinted. Great academic-industry collaboration. Lots of new associations (mostly additive, a few recessive) and new insights into homoz knockouts & drug discovery.

tree of life core lab has put together such a manuscript, detailing a lot of information on the lab work needed for reference genomes for biodiversity which you can find here: www.biorxiv.org/content/10.1...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

In a medical breakthrough, a team including IGI’s @urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months. Read more: ow.ly/G0Bg50VTonC #RareDisease 🧬

Our BAT paper is accepted in Nature Ecology & Evolution! Single cell, gene regulation, TADs and key TFs that shape the bat wing. Genomics goes Evodevo 😍

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!

We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @bennibolo.bsky.social www.science.org/doi/10.1126/...

Happy to share the first preprint from my lab. Great work by Lewis Fisher and collaboration with Jukka Corander www.biorxiv.org/content/10.1...

Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions https://www.biorxiv.org/content/10.1101/2025.04.21.649048v1

MPRAbase (mprabase.ucsf.edu) , a customized database for massively parallel reporter assays (MPRAs) to easily find and download MPRA data. Amazing work by Jingjing Zhao, Fotis Baltoumas, Georgios Pavlopoulos, @vagar.bsky.social, ilias Georgakopoulos-Soares & others. genome.cshlp.org/content/earl...

Excited to announce our preprint today @biorxivpreprint.bsky.social Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells: www.biorxiv.org/content/10.1...

I am elated to share that our manuscript describing Variant-EFFECTS, a high-throughput technology we developed to precisely and quantitatively measure the effects of CRISPR-mediated edits on gene expression, is now published at @cellpress.bsky.social: authors.elsevier.com/c/1kxgiL7PXu...

Delighted to announce that @matteason.me has made a fully navigible online form for those who would like to make use of my Department of Teeth Reimbursement Form TF-230, but digitally. Come for the uncannily accurate .gov assets. Stay for the clickable teeth map. Enjoy. tf230.matteason.co.uk

Congratulations to Rory Maizels delivering the @bsdb.bsky.social Beddington Medal lecture at #Biologists100

Many congratulations to Rory Maizels. Well deserved winner of the 2025 BSDB Beddington Medal for his PhD thesis.

@aylwyn-scally.bsky.social is on a roll, new preprint on North Sea IBD, looking at DNA segment sharing across present-day populations of Northern Europe (although mainly focussed on Denmark and Britain) to show legacies of historical interactions. www.biorxiv.org/content/10.1...

Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation

If you have experience in sc/spatial transcriptomics with an interest in microbes....come and join our team as a computational postdoc: sanger.wd103.myworkdayjobs.com/WellcomeSang... Incredibly exciting datasets on host-microbe interactions in the lung. Pls RT and reach out if you are interested.

How does a young person who loves both science and art decide on a career? Seattle Hub's Dr. Jonas Koeppel has a theory. @alleninstitute.bsky.social @jonaskoeppel.bsky.social @chanzuckerberg.bsky.social @sudpinglay.bsky.social brotmanbaty.org/news/promisi...

The queen of modifiers, @jsvanleeuwen.bsky.social, continues to illuminate how a gene can be crucial in one genetic context, but completely dispensable in another. Each modifier is cool biology, but also inroad to suppressing a disease mutation, or finding a synthetic lethal small molecule!

We’ve put together an exciting lineup of short talks for #CRISPR25! Check out the full programme here: bit.ly/4bnAcqT 📅Don't miss out—register by 4 March to join our incredible speakers! bit.ly/3Amz34N @leopoldparts.bsky.social @durocher1.bsky.social @uweohler.bsky.social @erika-alden.bsky.social

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

Poster submission is open now!👋 We are organizing the 54th Naito Conference on Genome Editing. Gorgeous speakers, including Feng Zhang, Patrick Hsu, @leopoldparts.bsky.social, Silvana Konermann, Mike Bassik, Ailong Ke, Wenning Qin, Henry Kim, Caixia Gao, Pietro Genovese, and Virginijus Siksnys.

We're hiring to expand on the work to understand the human genome by engineering it! lnkd.in/da-gitNc

We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

My favorite part of this work isn’t just in the papers—it’s the collaboration behind them. The coordination of these two studies showcases the best of doing your science out in the open. Deeply grateful to @leopoldparts.bsky.social and @jonaskoeppel.bsky.social for their trust and friendship.

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church. www.science.org/doi/10.1126/...

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...

Way to go @marisepp.bsky.social!! More power for Estonian genomics 💪 🧬

The Week in Bio #34. Research highlights from the week including randomisation of a super-enhancer, catalytic LYTACs from Lycia Therapeutics and de novo design of binders for snake venom. Link below.