An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

OFERTA DE EMPLEO (por favor difundir): Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas 👇

NIH Director Jay Bhattacharya has struggled to convince observers he has the agency’s best interests in mind—and is truly in charge. https://scim.ag/3MMXDSh

Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:

🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....

Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division! www.nature.com/articles/s41...

ChatGPT no pasa la prueba: así pone en peligro la vida de menores.

Ponencia de Ángel Carracedo en las XIII Jornadas científicas de Genyo.

📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural 🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental. #díamundialdelaevolución

Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com www.nature.com/articles/s41...

There is one point of agreement among both enthusiasts and sceptics: the future has already arrived go.nature.com/48M5Xuu

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf

🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)

Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...

Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.

Thomas Mann describiendo con un asombroso realismo las redes sociales (como esta) en «La montaña mágica», escrito hace más de 100 años.

💬 “Science is the mother of industry” In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty. 🔗 europa.eu/!m3hK7c

From the archives: Transposable elements shape the evolution of mammalian development go.nature.com/4mfy7lI #Review by Anna D. Senft & Todd S. Macfarlan

A strain of bacterium that often causes infections in hospital can break down plastic https://go.nature.com/3SvsiTC

Beautiful work 🤩

📢 Register! us02web.zoom.us/webinar/regi... @akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social #GenomeArchitecture #Senescence

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

US President Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies that, if enacted, would deal a devastating blow to US science, policy specialists say. https://go.nature.com/4jYv3IP

Very interesting reflection. I would include in primary and secondary school curriculas a yearly dedicated class to teach ways to identify truth in the post-truth era.

We are excited to have Emmanuel Boakye (African Reproducibility Network), Henk Kummeling (Utrecht University, CoARA), and Andiswa Mfengu (PhD) (University of Cape Town) sharing perspectives for the Africa&Europe launch, hosted by DORA Vice-Chair @rnls.bsky.social. Register at bit.ly/Africa-Europ...

A new policy from the US National Institutes of Health (NIH) will end billions of dollars of funding to laboratories and hospitals outside the United States, imperiling thousands of projects on topics such as emerging infectious diseases and cancer. https://go.nature.com/4jEDppr

Nature research paper: Cold memories control whole-body thermoregulatory responses https://go.nature.com/4iAvCHU

NEW: Entire scientific fields have been wiped out by the nearly 800 grants cancelled at NIH, finds a @nature.com analysis of the unprecedented cuts. About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone. See the other topics and US states hardest hit here:

Congras sergi! That is a start!

Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today! Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes! With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs. See thread below:

"Why an overreliance on AI-driven [insert] is bad for science" I said what I said.

#TEsky #RNASky #RNAbiology

Our latest paper is out in NAR! 🥳 In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates. Read: academic.oup.com/nar/article-...

Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c... 1/3

Review @cellcellpress.bsky.social 20 years of histone lysine demethylases: From discovery to the clinic and beyond www.cell.com/cell/fulltex...

🚨New in @science.org🚨 With Simon Townsend (@nccrlanguage.bsky.social) and Martin Surbeck, we have investigated whether wild bonobos can combine calls in complex combinations, similar to how humans combine words into sentences 🧪 www.science.org/doi/10.1126/... #ScienceResearch #AnimalCommunication

A turning point in the antibiotics crisis? A new vaccine concept combines vaccination with targeted colonisation of the intestine by harmless microorganisms. Research supported by the ERC, via @mucosalimmunology.bsky.social at @ethzurich.bsky.social Read more buff.ly/YARSd3D

Absolute banger from my dear friends in the Boettiger lab. Worth a read for anyone interested in chromatin dynamics: www.biorxiv.org/content/bior...

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....

"This is my home - I really love my country. But a lot of my mentors have been telling me to get out, right now" 75% of US scientists who answered our poll are considering relocating. Read the full story: https://go.nature.com/3QS4TLC

An immigration crackdown in the United States is rattling the global research community, with high-profile detentions and deportations of academics stoking fears even for travellers with valid entry documents. https://go.nature.com/3FG63rf

Looking for a PhD in sunny Barcelona? ☀️🔬 Our team is hiring a PhD student for the @hologen.bsky.social project! 📅 Deadline: Apr 20 ⚠️ READ THE MOBILITY RULE FOR THIS POSITION 🔁 Please, spread the word All the info here 👉 www.cnag.eu/jobs/phd-stu... #PhDlife #Genomics #HoloGen #Barcelona

📢 Our work on the orchestration of pluripotent stem cell genome reactivation during mitotic exit is now out www.sciencedirect.com/science/arti... A short 🧵

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪 www.nature.com/articles/d41...

I think one way to go is paying a small fee to reviewers. This would result in careful selection by the editor of 2-3 experts max, increase the pool of people ready to review, reduce reviewing times as determined in the review agreement.

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵 www.nature.com/articles/s41...

Nature research paper: Gene-modified pig-to-human liver xenotransplantation https://go.nature.com/421xqmT