Specialization of ubiquitin ligases to distinct nucleic acid sensors https://www.biorxiv.org/content/10.1101/2025.10.01.678329v1

Great opportunity and submissions are a little down so nominate your outstanding recent graduate, worm peeps!

Microbes suppress genetic disorders of hyper-activated Ras by inhibiting iron-mediated growth factor modulation in C. elegans https://www.biorxiv.org/content/10.1101/2025.09.30.679430v1

Hi fellow C. elegans scientists, I've made a few videos that may be of use for new trainees working in worm labs. Hoping to add more in the future, but figured I'd share this resource as is in case it's helpful :) www.youtube.com/@Workingwith...

A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author! @unibas.ch @natcomms.nature.com @snsf.ch #Longevity #healthspan rdcu.be/eI1vZ

How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @plosbiology.org 🧪 plos.io/4nU79QF

Worm peeps: nominate a newly minted PhD for the Sydney Brenner Thesis Award! #celegans

This is an embarrassing way to cover a paper that is basically negative results (spoiler alert: this did not go as the investigators might have hoped). bbc.com/news/article...

So glad to be among these good eggs, as @mads100tist.bsky.social once called us!

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

With perspectives from my esteemed colleagues @ethanewe.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @sonyawiden.bsky.social and Toshimichi Yamada 🧪RNAs of all kinds, junk, jumping, and fluctuating genes, cells&tissues with opinions!

New cures feel sudden, but the seeds were planted decades ago by basic scientists. Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵

C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]

I loved this! Read it if you have time. Read it even if you don’t….

This is not just maths. It's a design choice, supported by benchmarks that reward false certainty. Good to see OpenAI do some of the research, but it's also a reminder that OpenAI shouldn't be relied upon to do all the research.

This preprint title for the win! "The First of Us: Ophiocordyceps use a novel scramblase-binding peptide to manipulate zombie ants" doi.org/10.1101/2025... Science is cool too! Authors use #celegans to identify the targets... #cilia and scramblases

I am ready for the apocalypse, got my sequence of pPD95.75 and others right here #celegans

The Braendle Lab in Nice, France is hiring two postdocs to study nematode genetics, evolution, and ecology. Start Jan–Jul 2026. Deadline Nov 30, 2025. Apply: [email protected]

The Ubiquitin-Proteasome Pathway Mediates Selective Degradation of Unloaded Argonautes in C. elegans https://www.biorxiv.org/content/10.1101/2025.09.10.675458v1

Exciting new #speciation + #phylogenetics dating work now out @plos.org by PhD students Daniel Fusca & Maia Dall'Acqua! #celegans doi.org/10.1371/jour...

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Labeling of Nascent RNA in C. elegans Intestine https://www.biorxiv.org/content/10.1101/2025.09.08.675001v1

The impact of rearing environment on C. elegans: Phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats https://www.biorxiv.org/content/10.1101/2025.09.07.674770v1

Extreme climate events can catalyze rapid evolutionary change! in our new Current Biology (@currentbiology.bsky.social) piece, Colin and I argue it’s time to study their evolutionary consequences systematically — beyond opportunistic observations. www.cell.com/current-biol...

Planning on watching the ERC's webinar this Thursday 11 September? It's for grant applicants with in-depth questions on the ERC process. But, before you tune in: Make sure you know the basics 📹 bit.ly/463AbYl Get answers to some extra questions 📑 europa.eu/!y49yxF

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...

🚨 New call for preLighters!🚨 Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍 Interested? Apply today & help shape the future of science publishing! 📢 More info: prelights.biologists.com/news/join-th...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1

🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance

New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

Inspired by the all the amazing science at the Argonaute meeting, I painted an argonaut!

Epigenetic inheritance of complex learning abilities in the mammalian brain https://www.biorxiv.org/content/10.1101/2025.08.31.673327v1

Haven’t got enough of Argonaute in the past few days. Found more in the National Museum in Prague. It was such a great meeting!

best conference swag ever from the Prague Argonautes meeting from @svobodalab.bsky.social. Ago playing cards with helpful data on each one, bottle of Argonaut gin. special thing for poster winners, cards signed by the speakers, including @vambros.bsky.social! (+ian macrae @astridhaase.bsky.social).

Kicking off our third day of #argonautes2025 with a talk by Nobel Prize winner and all around amazing person, scientist, and mentor, Victor Ambros! 🐙

So excited for all the fun science in the next 4 days!

Excited for the start of #argonautes2025 tomorrow! This year we're in Prague, @imgprague.bsky.social. Looking forward to sharing science and community with Argonaute aficionados and Argonaute Syndromes Alliance families! 🐙

A hierarchy of causes of death in senescent C. elegans https://www.biorxiv.org/content/10.1101/2025.08.21.671442v1

1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research. This is wrong. And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.

New from the lab led by @natrigg.bsky.social. We started by characterizing mRNA in sperm, EVs, and the epithelium across epididymal transit. This revealed evidence that sperm acquire specific mRNAs through fusion with epididymal EVs, which we further established with in vitro co-incubation assays

Sciece is my profession but also my hobby. Another hobby of mine is watercolor and I’ve been thinking I should share more that here. Painting has big influence on how I do science and vice versa. More on this later 🎨🧬🔬🥼

Hey everybody! @drjuliawester.bsky.social and I have a new paper! We surveyed over 800 scientists, science communicators, and science educators who use social media. Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑 doi.org/10.1093/icb/...

LET'S FUCKING GO

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Toshi Yamada, one of @dev-journal.bsky.social's 2025 PI fellows, presented his research at our #DevPres webinar on stem cells and organoids. You can view his presentation here: thenode.biologists.com/catch-up-on-...

Two of Development’s PI fellows, Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, will be giving talks in our upcoming #DevPres webinar on gene regulation. 🗓️Wednesday 27 August, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...

"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0

@ethanewe.bsky.social is one of our preLights ambassadors for 2024-25. He is also the initiator of spotLights, an interview series that shines a spotlight on cutting-edge biological research and the minds behind it. You can hear him speaking in episode #5 here: prelights.biologists.com/spotlights/