Ethan (Chee Kiang) Ewe
@ethanewe.bsky.social
📤 492
📥 592
📝 156
Postdoc, firstgen, scientist, worm breeder, cats dad 🏳️🌈
pinned post!
🔥my latest paper from
@odedrechavi.bsky.social
lab🔥 we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
5 months ago
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Another great paper!
@michaelphart1.bsky.social
, your lab is on 🔥 🔥 :)
add a skeleton here at some point
12 days ago
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Ethan (Chee Kiang) Ewe
bioRxivpreprint
14 days ago
Crosstalk between and developmental dynamics of C. elegans Argonaute proteins
https://www.biorxiv.org/content/10.64898/2025.12.17.694999v1
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Ethan (Chee Kiang) Ewe
Alliance of Genome Resources
15 days ago
New in Alliance v8.3.0: The Transgene Alleles section of gene pages has been updated to include alleles in which the gene serves only as a regulatory region driving another component (such as a fluorescent tag or a binary driver like GAL4); previously such alleles weren't displayed on gene pages.
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Ethan (Chee Kiang) Ewe
Ian Hutchins
16 days ago
Can scientists get a fair shake publishing solid work in specialty journals? Definitely if article metrics were used; many such papers are revealed to be as influential as papers from high tier journals 1/4
#AcademicTwitter
#AcademicChatter
#NIH
#NSF
#OpenScience
journals.plos.org/plosbiology/...
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Most researchers would receive more recognition if assessed by article-level metrics than by journal-level metrics
Are authors fairly judged by assessment of the prestige of the journals in which their work is published? This study compares article level metrics with journal level metrics, finding that the vast ma...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003532
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"In other words, basing our approach on journallevel metrics would generate enough noise to make the signal of a future breakthrough difficult or impossible to detect. " On a similar note:
journals.plos.org/plosbiology/...
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15 days ago
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Ethan (Chee Kiang) Ewe
The bumbling biochemist (Bri Bibel)
11 months ago
Hi all. I'm the bumbling biochemist, on a mission to make biochemistry and chemistry fun and accessible for all. I have a blog & YouTube with a lot of content that can hopefully help people, especially biochemists-in-training. Hope it helps!
thebumblingbiochemist.com
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Home
biochemistry (hopefully) made accessible! You can also find lots of videos on my YouTube channel here - as in life - feel free to explore! My site is constantly a work in progress, so...
https://thebumblingbiochemist.com
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Ethan (Chee Kiang) Ewe
Shihui Chen
17 days ago
New review out! 🧬🪱 How do Argonautes bind the right small RNAs? We synthesize how small RNA features, Argonaute properties, chaperones, and subcellular organization shape small RNA binding specificity.
rnajournal.cshlp.org/content/earl...
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Decoding Argonaute Specificity: Insights from C. elegans and Beyond
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
https://rnajournal.cshlp.org/content/early/2025/12/16/rna.080816.125
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Ethan (Chee Kiang) Ewe
Carl T. Bergstrom
18 days ago
@jbakcoleman.bsky.social
and I had some thoughts about this a while back.
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AI, peer review and the human activity of science
When researchers cede their scientific judgement to machines, we lose something important.
https://www.nature.com/articles/d41586-025-01839-w
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Ethan (Chee Kiang) Ewe
bioRxivpreprint
18 days ago
RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing
https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
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Ethan (Chee Kiang) Ewe
Patrick Steinmetz
18 days ago
Excited to share our story nutrition and cell quiescence in sea anemones, great postdoctoral work of
@eudaldpascual.bsky.social
Finally out in
@plosbiology.org
And thanks to
@msarscentre.bsky.social
for the nice news piece:
www.uib.no/en/michaelsa...
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Ethan (Chee Kiang) Ewe
Nick Stroustrup
18 days ago
What tools do we need to start engineering
#aging
and
#longevity
? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the
@crg.eu
: technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
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Ethan (Chee Kiang) Ewe
Carl T. Bergstrom
18 days ago
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
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Carl T. Bergstrom
18 days ago
In my case, this painstaking labor in the process through which the science gets done. Science isn't measuring stuff in a lab. It's thinking deeply, extracting the heart of idea from the soup of thoughts running through my mind, molding it, and finding a way to communicate that idea to others.
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Yamuna Krishnan
18 days ago
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Surojit Sural
19 days ago
Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy
www.nature.com/articles/s41...
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Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy - Nature Communications
Cells rely on diversification and redundancy of protein chaperones to maintain proteostasis. Here, the authors show that two C. elegans orthologs of a chaperone have distinct roles in stress resistanc...
https://www.nature.com/articles/s41467-025-65998-0
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Ethan (Chee Kiang) Ewe
Maria Dzunkova
19 days ago
My colleagues from
@i2sysbio.es
led by Santiago Elena
@sfelena.bsky.social
published a paper in iScience on how Orsay
#virus
infection influences C. elegans development
#microsky
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Ethan (Chee Kiang) Ewe
Johan Jakobsson
20 days ago
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
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Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
https://www.biorxiv.org/content/10.64898/2025.12.12.693858v1
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Ethan (Chee Kiang) Ewe
Jogender Singh
21 days ago
Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2.
www.biorxiv.org/content/10.6...
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RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response
Organisms can activate innate immunity not only by detecting pathogens but also by sensing disturbances to essential cellular processes. Such damage-based surveillance provides a means to identify cel...
https://www.biorxiv.org/content/10.64898/2025.12.09.693339v1
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Incredible resource!
add a skeleton here at some point
20 days ago
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Ethan (Chee Kiang) Ewe
Carl T. Bergstrom
about 1 month ago
Even the the damn twitter card for this Nature Scientific Reports is clearly AI Slop.
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Ethan (Chee Kiang) Ewe
Surojit Sural
22 days ago
Such a clever design of a C. elegans genetic screen to unravel the underlying biology of Friedreich’s ataxia. Truly a 'screen from heaven'!
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Ethan (Chee Kiang) Ewe
Waggoner Lab
24 days ago
Transposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix
@nature.com
@harvardmed.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
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Ethan (Chee Kiang) Ewe
Needhi Bhalla 💅🏽
22 days ago
Oh I have a comment: “Loss of promising talent supported by these [DEI] programmes will substantially weaken our research capacity, limit innovation and substantially reduce discoveries important for driving scientific advancements.”
pubmed.ncbi.nlm.nih.gov/41131402/
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Ethan (Chee Kiang) Ewe
Matt Rockman
21 days ago
Now in print: tour de force mitonuclear epistasis study in C. elegans. Start to finish, vision and execution, 100% Tuc Nguyen
@tuchmnguyen.bsky.social
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Ethan (Chee Kiang) Ewe
Wyoming Wormboy
23 days ago
Hot off the press at EMBO Journal. The culmination of several years of work and hopefully useful to people in the field! BIG Shout-out to Review Commons, who handled the submission. It's a sensible and efficient model and all the journals I like (Society and NFP) are already participating. 🙏
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Integrating endogenous TurboID and data-independent acquisition mass spectrometry for in vivo proximity labeling - The EMBO Journal
Proximity labeling has emerged as a powerful approach for identifying protein–protein interaction networks within living systems, particularly those involving weak or transient associations. Here, we ...
https://link.springer.com/article/10.1038/s44318-025-00660-5?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20251211&utm_content=10.1038%2Fs44318-025-00660-5
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Ethan (Chee Kiang) Ewe
Alexei Maklakov
23 days ago
1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by
@eduxbury.bsky.social
with
@alicegodden.bsky.social
@immler.bsky.social
Johnny de Coriolis Hanne Carlsson
www.biorxiv.org/content/10.6...
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
https://www.biorxiv.org/content/10.64898/2025.12.05.692572v1
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What an amazing group of gems!
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23 days ago
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Ethan (Chee Kiang) Ewe
Denise Walker
24 days ago
“Remember that there are people on the other side of this who will be reading your review. Those people have feelings. Many will be junior trainees. Your review could be the thing that convinces them to stay in or leave science.”
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Ethan (Chee Kiang) Ewe
Max Farnworth
26 days ago
such a fantastic gang <3
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Ethan (Chee Kiang) Ewe
MadScientist
26 days ago
Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪
@ethanewe.bsky.social
@marliesoomen.bsky.social
@giuliapaci.bsky.social
@amjeve.bsky.social
@maxfarnworth.bsky.social
@anzymiller.bsky.social
Martina and Toshi
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Ethan (Chee Kiang) Ewe
Gavin Woodruff
26 days ago
😀 Nictation behavior in nematodes
link.springer.com/article/10.1...
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Nictation behavior in nematodes - BMC Biology
Nictation is a dispersal behavior in nematodes, aiding movement and host-finding under stress. This review explores its diversity, genetic and neuronal basis, regulation, and ecological relevance. Nic...
https://link.springer.com/article/10.1186/s12915-025-02443-0
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Ethan (Chee Kiang) Ewe
Priti Agarwal
26 days ago
Our Lab @ NCBS, Bangalore is hiring PhD students! If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬 CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉
lnkd.in/gr9EUHnp
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LinkedIn
This link will take you to a page that’s not on LinkedIn
https://lnkd.in/gr9EUHnp
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Ethan (Chee Kiang) Ewe
Surojit Sural
27 days ago
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
genesdev.cshlp.org/content/earl...
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PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
https://genesdev.cshlp.org/content/early/2025/12/04/gad.353265.125.abstract
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Ethan (Chee Kiang) Ewe
eLife
28 days ago
We’re tackling inequalities in research & publishing. See what we’ve achieved in the last 6 months & what’s next for 2025 👇
buff.ly/2GIgGPH
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Ethan (Chee Kiang) Ewe
bioRxiv Genetics
29 days ago
WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome
https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1
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Ethan (Chee Kiang) Ewe
Nature
29 days ago
Nature research paper: Dated gene duplications elucidate the evolutionary assembly of eukaryotes
go.nature.com/4azJDF8
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Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex archaea that already possessed an elaborated cytoskeleton, membrane trafficking, endomembrane, phagocytotic machinery and a nucleus.
https://go.nature.com/4azJDF8
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I met the most wonderful peer group through this program!
add a skeleton here at some point
about 1 month ago
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Ethan (Chee Kiang) Ewe
Development
about 1 month ago
Apply now for the PI programme:
www.biologists.com/grants/devel...
Deadline: Monday 2 February 2026
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Ethan (Chee Kiang) Ewe
Development
about 1 month ago
A path to success: Development's Pathway to Independence programme In this Perspective,
@ingridtsang.bsky.social
discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows.
doi.org/10.1242/dev....
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Ethan (Chee Kiang) Ewe
PLOS Biology
about 1 month ago
#Celegans
adapts to starvation & other stressors by transiting through the quiescent
#dauer
stage, but how? This study shows that TOR activity is inhibited by AMPK & a novel RNA-binding helicase in the
#GermLine
during dauer, preserving developmental quiescence
@plosbiology.org
🧪
plos.io/48NEHvc
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Ethan (Chee Kiang) Ewe
Coleen Murphy
about 1 month ago
We built this site to allow you to probe our single-nucleus RNA-seq data for adult
#Celegans
neurons (wt & daf-2 herms, and wt males v herms):
cestaan.princeton.edu
and a microPub about how to use it:
www.micropublication.org/journals/bio...
We hope the
#Celegans
community finds it useful! 🧪
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CeSTAAN: An atlas of C. elegans adult neurons for fast queries of single-nucleus RNA sequencing data | microPublication
https://www.micropublication.org/journals/biology/micropub-biology-001785
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Ethan (Chee Kiang) Ewe
Jogender Singh
about 1 month ago
Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans.
www.biorxiv.org/content/10.1...
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Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling
Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and initiate appropriate immune responses. In Caenorhabditis ...
https://www.biorxiv.org/content/10.1101/2025.11.25.690479v1
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Ethan (Chee Kiang) Ewe
phy_papers
about 1 month ago
sept-1/zina-1 is an Ancient Toxin-Antidote System in Caenorhabditis elegans
https://www.biorxiv.org/content/10.1101/2025.11.28.691152v1
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Ethan (Chee Kiang) Ewe
Genetics Society of America
about 1 month ago
What happens to the germline under heat stress? New study in
#G3journal
shows how wild-type
#Celegans
increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility.
buff.ly/SXdoQFA
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Ethan (Chee Kiang) Ewe
Proceedings of the National Academy of Sciences
about 1 month ago
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS:
https://ow.ly/uNqU50Xyj4e
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Ethan (Chee Kiang) Ewe
bioRxiv Evolutionary Biology
about 1 month ago
Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila
https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1
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Ethan (Chee Kiang) Ewe
Proceedings of the National Academy of Sciences
about 1 month ago
One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6 For more trending articles, visit
https://ow.ly/q6Cl50XxHGN
.
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Ethan (Chee Kiang) Ewe
PLOS Biology
about 1 month ago
Interventions that promote healthy
#aging
differ in their effectiveness between individuals. This
#Celegans
study shows that the effect of a pro-
#longevity
intervention can be strongly influenced by early-life
#splicing
factor activity & metabolic landscape
@plosbiology.org
🧪
plos.io/49AxSOv
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Ethan (Chee Kiang) Ewe
Alejandro Burga
about 1 month ago
Our results also uncover an even deeper principle. Nematode and plant F-box proteins are thought to engage in arms races with parasitic elements. In this conflict, accidental targeting of self-proteins is inevitable—making the birth of selfish genes a by-product of innate immunity.
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Ethan (Chee Kiang) Ewe
Alejandro Burga
about 1 month ago
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
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