Another great paper! @michaelphart1.bsky.social, your lab is on 🔥 🔥 :)

Crosstalk between and developmental dynamics of C. elegans Argonaute proteins https://www.biorxiv.org/content/10.64898/2025.12.17.694999v1

New in Alliance v8.3.0: The Transgene Alleles section of gene pages has been updated to include alleles in which the gene serves only as a regulatory region driving another component (such as a fluorescent tag or a binary driver like GAL4); previously such alleles weren't displayed on gene pages.

Can scientists get a fair shake publishing solid work in specialty journals? Definitely if article metrics were used; many such papers are revealed to be as influential as papers from high tier journals 1/4 #AcademicTwitter #AcademicChatter #NIH #NSF #OpenScience journals.plos.org/plosbiology/...

"In other words, basing our approach on journallevel metrics would generate enough noise to make the signal of a future breakthrough difficult or impossible to detect. " On a similar note: journals.plos.org/plosbiology/...

Hi all. I'm the bumbling biochemist, on a mission to make biochemistry and chemistry fun and accessible for all. I have a blog & YouTube with a lot of content that can hopefully help people, especially biochemists-in-training. Hope it helps! thebumblingbiochemist.com

New review out! 🧬🪱 How do Argonautes bind the right small RNAs? We synthesize how small RNA features, Argonaute properties, chaperones, and subcellular organization shape small RNA binding specificity. rnajournal.cshlp.org/content/earl...

@jbakcoleman.bsky.social and I had some thoughts about this a while back.

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

Excited to share our story nutrition and cell quiescence in sea anemones, great postdoctoral work of @eudaldpascual.bsky.social Finally out in @plosbiology.org And thanks to @msarscentre.bsky.social for the nice news piece: www.uib.no/en/michaelsa...

What tools do we need to start engineering #aging and #longevity ? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10

I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.

In my case, this painstaking labor in the process through which the science gets done. Science isn't measuring stuff in a lab. It's thinking deeply, extracting the heart of idea from the soup of thoughts running through my mind, molding it, and finding a way to communicate that idea to others.

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy www.nature.com/articles/s41...

My colleagues from @i2sysbio.es led by Santiago Elena @sfelena.bsky.social published a paper in iScience on how Orsay #virus infection influences C. elegans development #microsky

New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish. www.biorxiv.org/content/10.6...

Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2. www.biorxiv.org/content/10.6...

Incredible resource!

Even the the damn twitter card for this Nature Scientific Reports is clearly AI Slop.

Such a clever design of a C. elegans genetic screen to unravel the underlying biology of Friedreich’s ataxia. Truly a 'screen from heaven'!

Transposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix @nature.com @harvardmed.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...

Oh I have a comment: “Loss of promising talent supported by these [DEI] programmes will substantially weaken our research capacity, limit innovation and substantially reduce discoveries important for driving scientific advancements.” pubmed.ncbi.nlm.nih.gov/41131402/

Now in print: tour de force mitonuclear epistasis study in C. elegans. Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social

Hot off the press at EMBO Journal. The culmination of several years of work and hopefully useful to people in the field! BIG Shout-out to Review Commons, who handled the submission. It's a sensible and efficient model and all the journals I like (Society and NFP) are already participating. 🙏

1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...

What an amazing group of gems!

“Remember that there are people on the other side of this who will be reading your review. Those people have feelings. Many will be junior trainees. Your review could be the thing that convinces them to stay in or leave science.”

such a fantastic gang <3

Great day with these certified knuckleheads that are absolutely the best (and future) of their fields 🧪 @ethanewe.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @amjeve.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social Martina and Toshi

😀 Nictation behavior in nematodes link.springer.com/article/10.1...

Our Lab @ NCBS, Bangalore is hiring PhD students! If you’re excited about cell & developmental biology, tissue mechanics, and imaging — come join us! We use C. elegans to uncover how forces shape organs 🧫🔬 CSIR/DBT/ICMR fellowship holders encouraged to apply!Apply 👉 lnkd.in/gr9EUHnp

PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans genesdev.cshlp.org/content/earl...

We’re tackling inequalities in research & publishing. See what we’ve achieved in the last 6 months & what’s next for 2025 👇 buff.ly/2GIgGPH

WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome https://www.biorxiv.org/content/10.64898/2025.12.02.691955v1

Nature research paper: Dated gene duplications elucidate the evolutionary assembly of eukaryotes go.nature.com/4azJDF8

I met the most wonderful peer group through this program!

Apply now for the PI programme: www.biologists.com/grants/devel... Deadline: Monday 2 February 2026

A path to success: Development's Pathway to Independence programme In this Perspective, @ingridtsang.bsky.social discusses how our Pathway to Independence (PI) programme helps postdocs establish their own labs and showcases the progress of our inaugural 2023 fellows. doi.org/10.1242/dev....

#Celegans adapts to starvation & other stressors by transiting through the quiescent #dauer stage, but how? This study shows that TOR activity is inhibited by AMPK & a novel RNA-binding helicase in the #GermLine during dauer, preserving developmental quiescence @plosbiology.org 🧪 plos.io/48NEHvc

We built this site to allow you to probe our single-nucleus RNA-seq data for adult #Celegans neurons (wt & daf-2 herms, and wt males v herms): cestaan.princeton.edu and a microPub about how to use it: www.micropublication.org/journals/bio... We hope the #Celegans community finds it useful! 🧪

Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans. www.biorxiv.org/content/10.1...

sept-1/zina-1 is an Ancient Toxin-Antidote System in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.11.28.691152v1

What happens to the germline under heat stress? New study in #G3journal shows how wild-type #Celegans increase their germline apoptosis levels from the physiological baseline in response to moderate temperature stress to maintain fertility. buff.ly/SXdoQFA

All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e

Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1

One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6 For more trending articles, visit https://ow.ly/q6Cl50XxHGN.

Interventions that promote healthy #aging differ in their effectiveness between individuals. This #Celegans study shows that the effect of a pro- #longevity intervention can be strongly influenced by early-life #splicing factor activity & metabolic landscape @plosbiology.org 🧪 plos.io/49AxSOv

Our results also uncover an even deeper principle. Nematode and plant F-box proteins are thought to engage in arms races with parasitic elements. In this conflict, accidental targeting of self-proteins is inevitable—making the birth of selfish genes a by-product of innate immunity.

🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.