The mind-bending power of placebo Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought. www.nature.com/articles/s41...

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health insight.jci.org/articles/vie...

Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts journals.plos.org/plosbiology/...

Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!

Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons www.pnas.org/doi/10.1073/...

Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...

We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF And meet our Editorial Board! 👋

HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1

Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance www.science.org/doi/full/10....

Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans www.embopress.org/doi/full/10....

The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇 www.nature.com/articles/s41...

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation www.science.org/doi/full/10....

Aversive Learning Induces Context-Gated Global Reorganization of Neural Dynamics in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685731v1

A positive feedback loop promotes the active internal state of the C. elegans egg-laying circuit www.cell.com/current-biol...

A default silencing mechanism restrains stress-induced genes in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.22.683740v1

Phenotypic plasticity as the foundation of lifelong development journals.biologists.com/dev/article/...

The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans www.embopress.org/doi/full/10....

The importance of basic research “no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world” 🧪 #Research #Scicomm www.nature.com/articles/d41...

Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1

DAF-16/FOXO maintains genome integrity following genotoxic stress https://www.biorxiv.org/content/10.1101/2025.10.27.684284v1

Metabolic regulation of behavior by the intestinal enzyme FMO-2 www.science.org/doi/10.1126/...

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

'Here we find that the sense of touch interacts with nutritional state to modulate lifespan in Caenorhabditis elegans. Worms subjected to dietary restriction are shorter-lived when they perceive tactile stimuli that mimic bacterial food and/or protective soil.' www.pnas.org/doi/10.1073/...

The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement www.cell.com/current-biol...

This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...

Guess what? COVID mRNA vaccines don't just protect against COVID. COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl Let's fund more mRNA research! #medsky #oncsky 🛟😷🧪

A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans onlinelibrary.wiley.com/doi/10.1111/...

People with some cancers live longer after COVID vaccination 😮 mRNA vaccines can augment immune checkpoint inhibition efficacy for patients with skin or lung cancers - by globally boosting immune responses 💉🧪⚕️ www.nature.com/articles/d41... Grippen et al study: www.nature.com/articles/s41...

ICYMI: New online! Towards a reference cell atlas of liver diversity over the human lifespan

The enteric nervous system: a primer www.cell.com/current-biol...

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state https://www.biorxiv.org/content/10.1101/2025.10.20.683577v1

Reduced reproduction does not always increase organismal lifespan. Three different strategies to block reproduction all result in increased fat storage, but only one of them induces robust extension of lifespan. www.nature.com/articles/s41...

Olfactory basis for essential amino acid perception during foraging in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2024.07.11.603021v1

Identity and functions of monoaminergic neurons in the predatory nematode Pristionchus pacificus reveal nervous system conservation and divergence https://www.biorxiv.org/content/10.1101/2025.10.16.682888v1

P. aeruginosa disrupts CDC-42/ARP-2/3 mediated F-actin organization to induce intestinal deformation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.08.681298v1

An acyltransferase protects Caenorhabditis elegans from thiol reductive stress through an autoinhibitory hypoxia response pathway https://www.biorxiv.org/content/10.1101/2025.10.09.681334v1

Transposon Regulation in the Caenorhabditis elegans Germline and Soma https://www.biorxiv.org/content/10.1101/2025.10.09.681459v1

Methionine restriction and mimetics to ameliorate human aging and disease www.cell.com/trends/endoc...

Translational regulation in stress biology www.nature.com/articles/s41...

Comprehensive evaluation of lifespan-extending molecules in C. elegans. Some of these compounds also extend lifespan in Drosophila melanogaster, demonstrating a conserved effect across species. onlinelibrary.wiley.com/doi/10.1111/...

We are excited to announce the second Western VGZT of Season 7! 🗓️Thursday, October 16th ⏰9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET Our speakers: 👉 Hidenobu Miyazawa (on X: @HidenobuAnzo) 👉 Girish Kale (@girishkalephd.bsky.social) See you next week! 👋

Alkalinization of glial cells increases lifespan and healthspan in C. Elegans www.science.org/doi/10.1126/...

Reaffirming the value of model organisms in training scientific minds @ishmailsaboor.bsky.social exactly what we were talking about re your #Celegans background setting you up for creative work in other systems! www.nature.com/articles/s41...

We were just having this conversation @meera-sundaram.bsky.social! Using C.elegans as a model in your lab as a PhD student, I learned to think about biological systems as integrated networks. This has shaped my approach to studying the nervous system, attempting to link the body and brain.

A bacterial food source for effective laboratory cultivation of the freshwater nematode Plectus sambesii www.micropublication.org/journals/bio...

A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat longevity @science.org science.org/doi/10.1126/... science.org/doi/10.1126/... www.nature.com/articles/d41...

🧪 Direct link to the study: www.sciencedirect.com/science/arti...

Deep Neural Networks to Register and Annotate Cells in Moving and Deforming Nervous Systems elifesciences.org/reviewed-pre...

Catch up on Development presents… webinar on gut development Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi... thenode.biologists.com/catch-up-on-...

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...