EnzFinder: a sustainable alternative to chemical synthesis https://www.biorxiv.org/content/10.64898/2026.02.12.705490v1

Outpacing E. coli: Development of Vibrio natriegens as a Next-Generation Cloning Host https://www.biorxiv.org/content/10.64898/2026.02.11.705132v1

A toolkit for programmable transcriptional engineering across eukaryotic kingdoms https://www.biorxiv.org/content/10.64898/2026.02.10.705154v1

Artificial Recombination of Nonribosomal Peptide Synthetases Rapidly Evolves Natural Products https://www.biorxiv.org/content/10.64898/2026.02.09.704528v1

AI-driven discovery and engineering of human endogenous nanocage proteins for mRNA delivery https://www.biorxiv.org/content/10.64898/2026.02.07.704552v1

Engineering auronidin production in Marchantia polymorpha enables a new class of plant-derived textile pigments https://www.biorxiv.org/content/10.64898/2026.02.07.704544v1

Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis https://www.biorxiv.org/content/10.64898/2026.02.05.703998v1

Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping https://www.biorxiv.org/content/10.64898/2026.02.04.703058v1

A Multiscale Model of Collective Decision-Making in Hybrid Aspen Tree Tissues Describes Bud-Dormancy Break https://www.biorxiv.org/content/10.64898/2026.02.04.703817v1

Topological Environment in Genetic and Metabolic Networks https://www.biorxiv.org/content/10.64898/2026.02.02.703368v1

Quantitative measurement of synthetic repression curves reveals design challenges for genetic circuit engineering under growth arrest https://www.biorxiv.org/content/10.64898/2026.02.01.703179v1

Fine-tuned synthetic transcription factors for production of 3' phosphoadenosine-5'-phosphosulfate in yeast https://www.biorxiv.org/content/10.64898/2026.02.02.703094v1

Topological reprogramming transforms an integral membrane oligosaccharyltransferase into a water-soluble glycosylation catalyst https://www.biorxiv.org/content/10.64898/2026.01.30.702934v1

Development of a Fluorescent RNA Biosensor for Dual Detection of cGAMP and c-di-GMP Signals in Live Bacteria https://www.biorxiv.org/content/10.64898/2026.01.30.702909v1

Genome Position Does Not Impact Transgene Expression Efficiency in the Ancient Red Alga Cyanidioschyzon merolae https://www.biorxiv.org/content/10.64898/2026.01.31.703004v1

Quantitative modeling reveals sources of variability in transcriptional activation assays https://www.biorxiv.org/content/10.64898/2026.01.30.702786v1

A Yeast Surface Display Platform for Screening Dimeric Mammalian Receptors https://www.biorxiv.org/content/10.64898/2026.01.29.702702v1

Engineered Allosteric RNA Editors Enable Compact, Stimulus-Responsive Post-Transcriptional Circuits https://www.biorxiv.org/content/10.64898/2026.01.29.702378v1

Cross-strain transferability of CRISPRi systems and design rules from laboratory to clinical Escherichia coli strains https://www.biorxiv.org/content/10.64898/2026.01.28.702340v1

Encapsulation in a bacterial microcompartment shell improves thermal stability of a glycolytic enzyme https://www.biorxiv.org/content/10.64898/2026.01.28.702358v1

Protein-only centromeric chromatin assembly streamlines human artificial chromosome formation https://www.biorxiv.org/content/10.64898/2026.01.28.702397v1

Programmable artificial RNA condensates in mammalian cells https://www.biorxiv.org/content/10.64898/2026.01.28.702393v1

A computational framework for designing micron-scale crisscross DNA megastructures https://www.biorxiv.org/content/10.64898/2026.01.23.701435v1

ro-crate-rs: Development of a Lightweight RO-Crate Rust Library for Automated Synthetic Biology https://www.biorxiv.org/content/10.64898/2026.01.22.701040v1

Machine-learning-driven prediction and design of intrinsic transcription terminators https://www.biorxiv.org/content/10.64898/2026.01.22.701115v1

Evaluating valid parameter regimes for biocircuits https://www.biorxiv.org/content/10.64898/2026.01.19.700491v1

Engineering a PD-L1-sensing synthetic receptor for programmable macrophage-mediated phagocytosis https://www.biorxiv.org/content/10.64898/2026.01.21.700810v1

Integration-coupled activation of promoterless combinatorial pathway libraries in Clostridium avoids burden during DNA assembly https://www.biorxiv.org/content/10.64898/2026.01.20.700586v1

Host-aware Identification of Intrinsic Gene Expression Biopart Parameters from Combinatorial Libraries https://www.biorxiv.org/content/10.64898/2026.01.21.700808v1

An integrated synthetic biology and robotics approach for neutralising landmines in post-war communities https://www.biorxiv.org/content/10.64898/2026.01.20.700574v1

Expanding the Genetic Code of an Animal with Two Non-Canonical Amino Acids https://www.biorxiv.org/content/10.64898/2026.01.20.700547v1

Refactored genetic parts for modular assembly of the E. coli MccV type I secretion system used to screen class II microcin candidates from plant-associated bacteria https://www.biorxiv.org/content/10.64898/2026.01.19.700402v1

Multimolecular proofreading overcomes the activity-fidelity trade-off https://www.biorxiv.org/content/10.64898/2026.01.19.700236v1

Synthetic RNA-protein decoy granules to prevent SARS-CoV-2 infection https://www.biorxiv.org/content/10.64898/2026.01.16.699918v1

Genetic biosensor for optimizing double-stranded RNA production by bacterial symbionts https://www.biorxiv.org/content/10.64898/2026.01.18.700149v1

A reconfigurable DNA memory architecture for hierarchical data management via programmable phase transitions https://www.biorxiv.org/content/10.64898/2026.01.17.700124v1

Fundamental limitations of genomic language models for realistic sequence generation https://www.biorxiv.org/content/10.64898/2026.01.17.700093v1

Engineered probiotics that sequester arsensite in a mouse gastrointestinal system https://www.biorxiv.org/content/10.64898/2026.01.16.699961v1

Deep learning-guided design of cell type-specific AAV promoters https://www.biorxiv.org/content/10.64898/2026.01.13.699371v1

Unlocking Bacterial Cellulose Functionalisation: Comparative Genetic and Co-Culture Strategies in Komagataeibacter https://www.biorxiv.org/content/10.64898/2026.01.12.699149v1

uSort-M: Scalable isolation of user-defined sequences from diverse pooled libraries https://www.biorxiv.org/content/10.64898/2026.01.12.699065v1

Optimizing photoautotrophic production of soluble 3-hydroxybutyrate in Synechocystis sp. PCC 6803 through combinatorial translational tuning https://www.biorxiv.org/content/10.64898/2026.01.09.698553v1

Architecting cis-regulation to quantitatively tune gene expression in cereals https://www.biorxiv.org/content/10.64898/2026.01.08.698005v1

Intracellular Bismuth Coordination of Peptides and Miniproteins https://www.biorxiv.org/content/10.64898/2026.01.08.698318v1

Efficient in vitro refactoring and biosynthetic gene cluster amplification for the overproduction and accelerated discovery of anticancer thioamitides https://www.biorxiv.org/content/10.64898/2026.01.07.698260v1

Creating bacterial genomic diversity through large-scale reconfigurations reveals phenotype robustness to organizational genome change https://www.biorxiv.org/content/10.64898/2026.01.06.698047v1

De novo design of metalloproteases for targeted amyloid-β cleavage https://www.biorxiv.org/content/10.64898/2026.01.06.697903v1

Enhanced tRNA array method version 2 for simultaneous in vitro synthesis of 21 tRNAs https://www.biorxiv.org/content/10.64898/2026.01.06.697847v1

An Insoluble De Novo Protein Enables Survival of E. coli by Co-precipitating with a Gene Repressor https://www.biorxiv.org/content/10.64898/2026.01.02.697383v1

Generative AI-based design of hybrid transcriptional activator proteins with new DNA-binding specificity https://www.biorxiv.org/content/10.64898/2025.12.31.697150v1