our latest work summary: cohesin is preferentially loaded at/near active enhancers and loop extrudes in both directions, forming loops that create the dna contacts that appear as the newly defined "fountains" in hic maps pubmed.ncbi.nlm.nih.gov/40210441/

Ha. Idiots!

Kickass worm-friend @rnareylab.bsky.social wrote a piece for @sciencehomecoming.bsky.social and you should read it and send it to your red-state friends and fam. Hurting research hurts all of us. #invertsolidarity 🧪 www.heraldbanner.com/opinion/colu...

The Postbaccalaureate Research Education Program at UMass Chan prepares students with a bachelor’s or master’s degree for doctoral study in the biomedical sciences through a yearlong, mentored research project. Apply by Feb. 28: direc.to/mqhT #MolecularGenetics #CellBiology #PublicHealth

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

www.embopress.org/doi/epdf/10..... Please check out Xuhang's exciting article in MSB!

👇🏻👇🏻

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

NY Times: www.nytimes.com/2025/02/07/u...

FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States

Very cool paper!!!

Indeed! Cool paper!

Itziar Pinilla-Macua, Sachin Surve and Alexander Sorkin find that that signalling through the EGFR-VAV2-Rac1 pathway persists in endosomes and is required for EGFR-driven cell migration. #OpenAccess Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

All of these podcasts are fantastic. Try them out!

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...

“Dr Phil joins Chicago immigration raid…” ….headline says it all.

Great meeting! Register now!

Spotlight: Edward Courvan and Roy Parker @colorado.edu discuss new work from Escayola, Zhang, @karlaneugebauer.bsky.social and colleagues (https://buff.ly/4fPlwBt) that carefully profiles Cajal Body components and finds an unexpected role for 60S ribosomal proteins. https://buff.ly/40rjnaD

It's still true that no philosopher has had a bigger impact on science than Popper, who argued that we should make risky and bold predictions to test our ideas. Do the killer experiment, he would say; the one that has a chance to kill your hypothesis.

ALAS1 acts as an inhibitor of the miRNA pathway in the cytoplasm. Normally ALAS1 acts in mitos in heme synthesis. Great work from @lucksmith.bsky.social www.science.org/doi/10.1126/...

LIN-67 functionally interacts with heterochronic miRNAs and regulates developmental timing in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2024.12.31.630947v1

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

Good papers lead to more questions than they answer. That's because (as Blaise Pascal wrote) knowledge is like a sphere: the larger it gets the larger also its surface, which is its interface with the unknown.

Jan 1, and my first day as an Asst. Professor at Berkeley. The lab opens in just a few weeks and I am currently staffing at all levels- www.lotuslofgren.com/new-page-1

If you want to learn about how a tiny worm led to major insights in developmental biology and human disease check out the Nobel lectures from Victor Ambros and Gary Ruvkun. www.youtube.com/watch?v=VQ9N...

www.cell.com/molecular-ce... #RNASky #RNAbiology

Oh man, oh man! Can't wait: www.kraftwerktour25.com

Excited for the #DevelopmentalBiology GRC and GRS! Abstract deadline: 20th of January! With talks from @denisduboule.bsky.social @adameykolab.bsky.social @jacob-hanna.bsky.social @chrmosimann.bsky.social @cmhammell.bsky.social and @sarawickstrom.bsky.social amongst others, see full programme below!

Another cool paper from Agami group. Chemotherapy induces ribosome collision, followed by presentation of the aberrant peptide on MHCs and triggering T-cell response.

I'm just happy when the NA of the objective is actually included.

Great science!

It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.

Yes! Already trying this in worms! Can’t wait.

1000%

I was going to look up reviews for this restaurant but then remembered that they don’t matter…

Works for me. I requested the Bluesky addition and it’s coming!

Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...

Wild!

Just saw this and hopefully its the gamechanger for our system www.biorxiv.org/content/10.1...

This @salkinstitute.bsky.social scientist followed her innate curiosity to make startling discoveries about how plants absorb carbon, and perhaps how they might help battle climate change: www.wsj.com/science/envi...

New work from the Keil lab. www.biorxiv.org/content/10.1...

In September the world lost one of the great biologists of our time: Joe Gall. He bridged the transition from the histology era of cell biology to our molecular present, contributing a remarkable set of insights in his 9 decades 1/n 🧪 rupress.org/jcb/article-...