⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...

We can learn a lot about our own biology just by figuring out how viruses hack our systems! Avoid mRNA circularization to scape the codon usage trap set by the host. www.nature.com/articles/s41...

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

@qmbci.bsky.social @cruk-cityoflondon.bsky.social @cancerresearchuk.org @bartscharity.bsky.social

RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions academic.oup.com/nar/article/...

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Programmable initiation of mRNA translation by trans-RNA - @cornelluniversity.bsky.social @iecb.bsky.social go.nature.com/3K7SEdO

We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky

🚨 New paper alert!! RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells. A new mechanism showing how post-transcriptional control keeps our immune cells in check! #RNA #Bcells #GenomeStability www.science.org/doi/10.1126/...

Come and join us at Queen’s University Belfast via these tenure-track independent fellowships. www.qub.ac.uk/Research/fel...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky www.gla.ac.uk/postgraduate...

www.biorxiv.org/content/10.1... Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

Amazing paper & very cool mechanism!

Looking forward to a few days of exciting discussions at the #EMBLProtein synthesis and translational control meeting www.embl.org/about/info/c...

We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky

The Svedberg unit!

FMRP represses translation by competing with eIF4G1 for binding to cap-bound eIF4E www.sciencedirect.com/science/arti...

Few places can compete with the drama of Scottish landscape. Now imagine that along with some great science!

Looking forward to a great lineup of speakers and posters. And the icing on the cake is that the venue is literally a stone’s throw from Arthur’s Seat. #TLUK2025, #RNASky #RNA

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

A challenging observation about the GRB10-interacting GYF protein 2 (GIGYF2), linked to autism and the antiviral innate immune response. Unlike its mouse homologue, the human GIGYF2 does not interact with GRB10! www.life-science-alliance.org/content/8/9/...

🚨 We’re looking for a curious mind to join our lab at the NIH! Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging? Interested in a postdoc or a PhD research visit at NIH? Let’s connect. 📩 DM or email for details! #Bioinformatics #AI #ComputationalBiology

Opportunities if you're interested in immunity: we have projects on RNA binding proteins in B & T cell memory and effector responses. marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-p...

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates www.sciencedirect.com/science/arti...

We have a competitive PhD studentship in my lab to study the role of mRNA translation and quality control mechanisms in cellular response to anti-cancer treatments in AML. Please share with your network and if interested apply through the link below. #PhD www.findaphd.com/phds/project...

Translation UK abstract deadline is tomorrow!

Checkout our review article at PLOS. Happy to see the thoughts of Stefano and myself on influenza virus RNA trafficking published in PLOS Pathogens a few days ago. A topic we are both greatly interested in. dx.plos.org/10.1371/jour...

We have a new preprint, led by @pharrissnell.bsky.social & (former) postdoc Parisa Naeli. We report a chordate-specific mechanism, mediated by 2 prologue RBPs ZC3H7A/B, that links codon usage to mRNA translation/stability. Huge thanks to our amazing collaborators! www.biorxiv.org/content/10.1...

Translation meeting in Edinburgh (that I'm co-organising). Invited speakers include Allen Buskirk on his deep mechanistic work on prokarotic translation, Karen Merchante on plant ribosomal proteins and their effect, and the UK Translation community bringing their best science! #RNAbiology #ribosome

Are you registered for the 30th Translation UK meeting? This year, our ever-popular conference is taking place at the incredible University of Edinburgh! Be quick - abstract submission and earlybird discount ends 30 April. 🧪 Register today: www.eventsforce.net/biochemsoc/2...

We really need to pay more attention to IDRs in RBPs and this is a great example of how much we are missing by not doing so!

Brilliant!

Yet another study showing how changes in RNA modifications & metabolism contribute to mechanisms-of-action of a widely used chemotherapeutic drug. Something that is, unfortunately, still being discounted by the wider cancer research community as a mere afterthought! academic.oup.com/nar/article/...

Cellular responses to RNA damage: Cell Such a great and timely review for a topic that remained under-explored for such a long time but has attracted a lot of attention in the last few years. The field is now moving in leaps and bounds. #RNAsky www.cell.com/cell/fulltex...

Attention Attention Attention If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri

This is as perfect a place & project combination for postdoc training as it could get.

Sharing this from last year, just to test & celebrate the addition of @bsky.app share button to @science.org, hopefully followed by other journals! Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction | Science Advances www.science.org/doi/10.1126/...

Neoepitopes arising from W>F substitution present shared and highly expressed immunogenic targets with the potential to overcome current limitations in adoptive T cell therapy. www.cell.com/immunity/ful...

Here is a clever way to stop the next coronavirus in its tracks… www.nature.com/articles/s41...

We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these! And, please help me spread this. Thanks! www.imb.de/jobs/jobdeta... www.imb.de/jobs/jobdeta...

⚡️Now online⚡️: Our review on how ZAKa and #ribosomes regulate cell death when things go bad ☠️ 🧪 @cellpress.bsky.social @annaconstancevind.bsky.social 👏 ⬇️

Oh snap. Those are fighting words. Trying to clean out the swamp of bad data. 🧹🧹🧹 www.biorxiv.org/content/10.1...

Nuclear RBPs moonlighting in the cytoplasm as part of the host response to Sindbis virus. Another beautiful work by Alfredo Castelo’s group. I’m struggling to keep up with reading all the amazing papers they’ve published in the last few months. www.cell.com/molecular-ce...

It’s a great pleasure to see our work published in @pnas.org. It has been a fantastic collaboration with Virginie Marcel from the #CRCL. Let me to highlight the most important points of the work. (1/2) www.pnas.org/doi/10.1073/...

RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development. #crispr #iclip #omics Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas www.findaphd.com/phds/project...

Another cool paper from Agami group. Chemotherapy induces ribosome collision, followed by presentation of the aberrant peptide on MHCs and triggering T-cell response.

Time for our first post here 🥳 Our latest paper is online 🙌 We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

Please check out our paper in collaboration with Nahum Sonenberg's group. We show how some DNA viruses co-opt the host cell translation machinery to repress the cGAS/STING response. TLDR; the cap-binding protein 4EHP represses the cGAS mRNA translation. #RNA, #RNASky www.pnas.org/doi/10.1073/...