Great opportunity! We’re looking to hire a Platform Manager to lead the decelopment and operations of the @ircm.bsky.social RNA Therapeutics core facility. If you have solid expertise in #RNA biology, particularly in methodologies to synthesize and purify oligonucleotides, mRNA and LNPs, apply now!

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

We have a new preprint!!! Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation. #RNASky, #RNA, www.biorxiv.org/content/10.6...

We're no longer asking whether mRNA works. We're refining it. New in Nature: ac4C, an mRNA modification that boosts protein yield AND accuracy, reducing translational errors. This is what a maturing platform looks like—precision, molecule by molecule. 🔗 www.nature.com/articles/s41...

Very glad to have our latest study, led by the former stellar PhD student @pharrissnell.bsky.social and postdoc Parisa Naeli, out in @cp-cellreports.bsky.social. Translation-dependent regulation of stability of non-optimal mRNAs by 2 vertebrate-specific RBPs, ZC3H7A/B. www.cell.com/cell-reports...

RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions: Molecular Cell www.cell.com/molecular-ce...

Looking for a truly unique PhD programme on RNA drugs and therapeutics? We have just opened the call for the second cohort of RNAmed-Future leaders in RNA-based medicine. More details under www.rnamed.de Please spread the word.

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

Answer to a key and longstanding question; How does the integrated stress response terminate? | Science www.science.org/doi/10.1126/...

There ain’t much that eIF3 doesn’t do! Very nice (and rather comprehensive) review on all things eIF3. link.springer.com/article/10.1...

This is brilliant!

eIF5B-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology. From the talented PhD student Pavan Narasimha in Nehal Takhor lab. Great to see this work out in preprint and looking forward to more cool stuff from Pavan's recent works! www.biorxiv.org/content/10.6...

⭐NAR Breakthrough! ⭐ #RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪. Read the full article here: doi.org/10.1093/nar/...

Join us; We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system. #Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs hrwebapp.qub.ac.uk/tlive_webrec...

Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

This is pretty cool!

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

Wow; Derepression of a single microRNA target causes female infertility in mice!

Very much looking forward to hosting @alf-castello.bsky.social for this talk as part of the @irishrna.bsky.social online lecture series. Don’t miss it if either host-virus interactions, RNA-binding proteins, or both are interesting to you!

⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...

We can learn a lot about our own biology just by figuring out how viruses hack our systems! Avoid mRNA circularization to scape the codon usage trap set by the host. www.nature.com/articles/s41...

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

@qmbci.bsky.social @cruk-cityoflondon.bsky.social @cancerresearchuk.org @bartscharity.bsky.social

RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions academic.oup.com/nar/article/...

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Programmable initiation of mRNA translation by trans-RNA - @cornelluniversity.bsky.social @iecb.bsky.social go.nature.com/3K7SEdO

We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky

🚨 New paper alert!! RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells. A new mechanism showing how post-transcriptional control keeps our immune cells in check! #RNA #Bcells #GenomeStability www.science.org/doi/10.1126/...

Come and join us at Queen’s University Belfast via these tenure-track independent fellowships. www.qub.ac.uk/Research/fel...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky www.gla.ac.uk/postgraduate...

www.biorxiv.org/content/10.1... Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

Amazing paper & very cool mechanism!

Looking forward to a few days of exciting discussions at the #EMBLProtein synthesis and translational control meeting www.embl.org/about/info/c...

We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky

The Svedberg unit!

FMRP represses translation by competing with eIF4G1 for binding to cap-bound eIF4E www.sciencedirect.com/science/arti...

Few places can compete with the drama of Scottish landscape. Now imagine that along with some great science!

Looking forward to a great lineup of speakers and posters. And the icing on the cake is that the venue is literally a stone’s throw from Arthur’s Seat. #TLUK2025, #RNASky #RNA

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

A challenging observation about the GRB10-interacting GYF protein 2 (GIGYF2), linked to autism and the antiviral innate immune response. Unlike its mouse homologue, the human GIGYF2 does not interact with GRB10! www.life-science-alliance.org/content/8/9/...

🚨 We’re looking for a curious mind to join our lab at the NIH! Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging? Interested in a postdoc or a PhD research visit at NIH? Let’s connect. 📩 DM or email for details! #Bioinformatics #AI #ComputationalBiology

Opportunities if you're interested in immunity: we have projects on RNA binding proteins in B & T cell memory and effector responses. marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-p...

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates www.sciencedirect.com/science/arti...

We have a competitive PhD studentship in my lab to study the role of mRNA translation and quality control mechanisms in cellular response to anti-cancer treatments in AML. Please share with your network and if interested apply through the link below. #PhD www.findaphd.com/phds/project...

Translation UK abstract deadline is tomorrow!

Checkout our review article at PLOS. Happy to see the thoughts of Stefano and myself on influenza virus RNA trafficking published in PLOS Pathogens a few days ago. A topic we are both greatly interested in. dx.plos.org/10.1371/jour...

We have a new preprint, led by @pharrissnell.bsky.social & (former) postdoc Parisa Naeli. We report a chordate-specific mechanism, mediated by 2 prologue RBPs ZC3H7A/B, that links codon usage to mRNA translation/stability. Huge thanks to our amazing collaborators! www.biorxiv.org/content/10.1...

Translation meeting in Edinburgh (that I'm co-organising). Invited speakers include Allen Buskirk on his deep mechanistic work on prokarotic translation, Karen Merchante on plant ribosomal proteins and their effect, and the UK Translation community bringing their best science! #RNAbiology #ribosome