Don’t forget today - MTL RNA salon. 4PM at IRCM www.mtlrna.org

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon. sites.google.com/view/codonus...

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior. These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy 🧵 by the amazing @christeldepienne.bsky.social 👇 1/3

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health. 🔗 bit.ly/3HGWhX3

Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/... This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick. Full thread 👇🏼

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening www.cell.com/cell/fulltex...

🚨 @healthsciences.mcgill.ca‬ is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry. ✍ Apply by July 4:

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 biorxiv.org/content/earl...

Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!

We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal. More details on the position and on how to apply here: www.ircm.qc.ca/en/position-...

A 🧵 to walk those interested through this paper...

For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

Next week! RNA Canada sponsored series: Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...

Beautiful paper

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇 www.cell.com/molecular-ce...

🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’ @acfas.ca ! 📅5 mai 2025 🕐12h45 💡 En savoir plus : mcgill.ca/dna-to-rna/f... #ACFAS8

🚨 Appel à proposition 🚨 D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN ! $350 000 pour 2 ans Date limite : 15 mai 2025 🔗https://buff.ly/Ub5D45x

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details. www.nature.com/naturecareer...

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years. Contact me if you are interested. www.nature.com/naturecareer...

The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....

At the #D2RSymposium2025, so far we’ve heard: ✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies ✔️ llumina's multi omics assays ✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies ✔️ UBC's research on a probe for optimizing RNA delivery

Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social

The department of biochemistry and molecular medicine at the Université de Montréal has a job opening for an assistant/ associate professor in the field of cryo-EM and its use to study fundamental questions in biology. Please email me for details or contact the department chair, Dr. Pascale Legault.

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

RNA Collaborative Seminar next Wed Dec 4 at 4 pm ET, hosted by Riboclub. Zoom link below. 1) “Proximity Labeling Identifies Putative Germ Granule and Small RNA Factors in C. elegans” @farmgirlphd.bsky.social 2) “From RNA Structure to Function” by Hosna Jabbari us02web.zoom.us/webinar/regi...

Done go.bsky.app/TzBHeud

🚨Job Alert Come work with us. The Quebec Network for RNA Therapy Development & Production (DePTAQ) is looking to hire a Network Director to coordinate activities at 3 platforms located at @ircm.bsky.social, @mcgillu.bsky.social , and Sherbrooke. Details 👇 mcgill.wd3.myworkdayjobs.com/en-US/McGill...

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Structural basis of tRNA-like small RNA generated from MALAT1 and NEAT1 www.nature.com/articles/s41... www.nature.com/articles/s41...

RNA Canada trainees, Give your feedback on Tech Workshops designed to equip you with skills & knowledge in RNA research, provide practical advice, troubleshoot, & tutorials for data processing. Help tailor them to your needs by filling out this survey: forms.gle/jQPyLW83EEy1...

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

We’re hiring!🚨 The IRCM is seeking a Core Manager to lead its new cutting-edge #RNA Therapeutics Core. If you’re passionate about RNA and ready to develop future therapeutics, this is your chance! Join our dynamic team in Montreal www.ircm.qc.ca/en/position-...

Ok so I love this new Cell paper on lncRNAs. and also it dovetails largely with the microproteins work on essential non-canonical ORFs that several groups have been studying including my own. #RNAsky #microproteins #cansky folks 🧪 💻+🧬 🔎 microproteins www.cell.com/cell/fulltex...

As a first post on this platform, here’s an editorial recapping highlights from the RNA Canada ARN 2024 conference last October. sciencepolicy.ca/posts/rna-ca...

Join us February 8th 4pm for the 1st Montreal RNA Salon of the year!!! This time at Mcgill University. Talks by David Langlais, Ivan Topisirovic and Eric Lecuyer labs. Details 👇🏼 www.mtlrna.org

Join us February 8th 4pm for the 1st Montreal RNA Salon of the year!!! This time at Mcgill University. Talks by David Langlais, Ivan Topisirovic and Eric Lecuyer labs. Details 👇🏼 www.mtlrna.org

Don’t miss the next What can #RNA do? Online Seminar series this January 29th 16h-18h EDT. This month’s topic: RNA in #condensates. See details below and register! www.rnacanada.ca/seminar-what...

A little something we’ve been working on. nouvelles.umontreal.ca/en/article/2...

Bel article sur les travaux de mon collègue Nabil Seidah sur une nouvelle cible prometteuse pour traiter la stéatose hépatique non-alcoolique @ircm_mtl. Heureux d’y avoir contribué pour développer un inhibiteur ciblant l’ARN (ASO). t.co/Hars1GG1U8

Excited to finally see this online and congrats to all involved. It was a privilege to work with Nabil Seidah’s team and help develop the ASOs against PCSK7, a novel regulator of apoB and target against NASH. www.metabolismjournal.com/article/S002...