Great opportunity! We’re looking to hire a Platform Manager to lead the decelopment and operations of the @ircm.bsky.social RNA Therapeutics core facility. If you have solid expertise in #RNA biology, particularly in methodologies to synthesize and purify oligonucleotides, mRNA and LNPs, apply now!

🎓 Congratulations to Vanda Gaonac’H-Lovejoy! The IRCM is very proud to highlight Vanda’s achievement in receiving the award for best thesis in bioinformatics from the University of Montreal. 👉Learn more: bit.ly/4oHQzW5

L'IRCM salue l'important soutien de la Fondation Brain Canada dans le cadre de son programme de subventions de soutien aux plateformes 2025 pour la mise sur pied PRIME-RNA, une plateforme novatrice dédiée à l’avancement des thérapies à base d’ARN pour les maladies du cerveau. 🔗 bit.ly/4uditKG

🧠 The IRCM welcomes the significant support of the Brain Canada Foundation through its 2025 Platform Support Grants program for the establishment of PRIME-RNA, an innovative platform dedicated to advancing RNA-based therapies for brain diseases. 🔗 Learn more: bit.ly/4o2apux

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

Excited to see this preprint out from the lab! Congrats to @heinarsson.bsky.social, Natsuda, @robertkrautz.bsky.social, and all co-authors involved in this major effort on developing nucCAGE and PRIME, and on evaluating transcription initiation-defined regulatory elements for variant interpretation!

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Sounds super interesting - hope we'll see more of these (lncRNAs linked by human genetics + mouse KOs to key phenotypes)! www.nature.com/articles/s41...

Looking for something fun to do on your free Thursday night of #RNA26 in Montreal @rnasociety.bsky.social? Join us for some Canadian Hospitality at an @rnacanada.ca BBQ! Tickets are only $10, purchase here: www.zeffy.com/en-CA/ticket.... Hope to see you there!

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Alternative splicing has been shown to drive stage IV breast cancer. By mapping the transcriptome of patient samples (RUO), Sophie Ehresmann is uncovering previously unseen isoforms — work that could pave the way for more effective treatments. Learn more: https://bit.ly/48HYT18

Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome. Grateful to the team & collaborators. www.nature.com/articles/s41...

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

www.cell.com/molecular-ce... check this beautiful paper

🆕 review with @jpunfried.bsky.social out in Nature SMB. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? www.nature.com/articles/s41...

Heads up all Junior RNA Scientists - March 31st is the deadline for poster abstract submission and early bird registration for the 2026 Annual RNA Society Meeting in Montreal! Don't miss out, we have an exciting panel and fun events planned!

Poster abstracts and early bird registrations for the 31st Annual Meeting of the RNA Society are due by March 31st! RNA 2026 website: rnasociety.org/conferences/ #RNA26

IRCM's Expertise in RNA The IRCM welcomes the significant funding from Médicament Québec to propel an integrated service offering in the development of RNA-based therapies and to address rare and complex diseases, neurological disorders, and cancers. bit.ly/47816lH

Expertise de l’IRCM en ARN L’IRCM salue l’octroi d’un important financement de Médicament Québec pour propulser une offre de service intégrée en développement de thérapies à base d’ARN et espérer déjouer les maladies rares et complexes, les désordres neurologiques et les cancers. bit.ly/4sRDv17

Excited to see this project get the underway. I am looking forward to working with Thomas Duchaine, @bcmagog.bsky.social & industry partners to develop new #RNA_Therapeutics targeting #splicing defects for neurological and tare diseases through our complementary biomanufacturing platforms.

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

Don’t forget today - MTL RNA salon. 4PM at IRCM www.mtlrna.org

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon. sites.google.com/view/codonus...

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior. These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy 🧵 by the amazing @christeldepienne.bsky.social 👇 1/3

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health. 🔗 bit.ly/3HGWhX3

Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/... This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick. Full thread 👇🏼

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening www.cell.com/cell/fulltex...

🚨 @healthsciences.mcgill.ca‬ is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry. ✍ Apply by July 4:

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 biorxiv.org/content/earl...

Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!

We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal. More details on the position and on how to apply here: www.ircm.qc.ca/en/position-...

A 🧵 to walk those interested through this paper...

For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

Next week! RNA Canada sponsored series: Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...

Beautiful paper

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇 www.cell.com/molecular-ce...

🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’ @acfas.ca ! 📅5 mai 2025 🕐12h45 💡 En savoir plus : mcgill.ca/dna-to-rna/f... #ACFAS8

🚨 Appel à proposition 🚨 D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN ! $350 000 pour 2 ans Date limite : 15 mai 2025 🔗https://buff.ly/Ub5D45x

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details. www.nature.com/naturecareer...

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years. Contact me if you are interested. www.nature.com/naturecareer...

The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....

At the #D2RSymposium2025, so far we’ve heard: ✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies ✔️ llumina's multi omics assays ✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies ✔️ UBC's research on a probe for optimizing RNA delivery

Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....