🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1.bsky.social with many others! www.cell.com/cell/fulltex...

Excited to see this collaborative work with @oligopain.bsky.social and @keribackus.bsky.social out as a preprint now! Took a ton of work from a great team of scientists @uwgenome.bsky.social and #UCLA The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!

Our new article in Trends in Genetics with Sonia Forcales discusses SST1/NBL2, a primate-specific macrosatellite repeat family that remains poorly understood despite its relevance to acrocentric chromosomes, epigenetic instability, and repeat-derived ncRNA. shorturl.at/SXdF4

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

A new paper out in @natmethods.nature.com introduces NimbusImage, a cloud-computing platform for image analysis ft. William Niu (SAS), Jingxin Li (@cambupenn.bsky.social), @aofarrell.bsky.social (Bioengineering) & @arjunraj.bsky.social (@penngenetics.bsky.social) www.nature.com/articles/s41...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025 Our last RNA event before the holidays. Also:Glühwein&snacks Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa... Please share @mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @pku1898.bsky.social go.nature.com/47yENVJ

This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word! academicjobsonline.org/ajo/jobs/30607

Excited to share some new work from our group - www.biorxiv.org/content/10.1... A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

One week left to register at www.rna-biochemistry.de !

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

If you are attending #EBSA2025 in Rome and are interested in how single-molecule super-resolution microscopy🔬can help to 'crack the spatial code' of ligand-induced receptor-adaptor oligomerization, pls consider to visit Alexandra presenting her work at poster #48 on Thursday (session 3.48)👇🏻

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis https://go.nature.com/46c474I

@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/... @jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu #ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster! A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de #ClustersOfExcellence #SCALEcluster 🧵

🎉 In the final round of the ExStra Program of the DFG, the CPI has been selected & is honored with funding for another 7 years! 🏆 With the vision that “precision biology drives precision medicine”, funds will be used for high-risk, innovative research for cardiopulmonary health ❤️🫁!

🚀 Two Future Clusters of Excellence for #GoetheUni! With @scale-cluster-ffm.bsky.social & @cpi-exstra.bsky.social, Frankfurt will become a hotspot for cell & health #research from 2026. Next step: Network of excellence @rheinmainunis.bsky.social with @unimainz.bsky.social & @tuda.bsky.social.

How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications! 🔗 rdcu.be/em7aM #lncRNA #macrophage #immunology

Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization! Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/... Congrats to all the authors and thanks to reviewers and editor!

Join us for an in-person mini-symposium at @qmbci.bsky.social on July 16th to discuss several topics at the intersection of RNA biology and cancer. Free to come. Pizza and drinks to network @diunguyenvnuk.bsky.social @kevinrouault.bsky.social @rnasociety.bsky.social 👇👇

🧫🔬 Are you a PhD student or a postdoc interested in RNA visualisation techniques? Last chance to apply for our 'FISHing for RNAs: classical to single molecule approaches' course – you have until 25 May! ✍🏼 #EMBOFISHingRNAs 👉🏻 https://s.embl.org/fis25-01-bl#EMBOFISHingRNAs 📅 31 Aug – 5 Sep 📍 EMBL Heidelberg

Very interesting work from Samie Jaffrey's lab: m6A promotes ribosome collisions, with big effects on RNA stability. #RNASky www.cell.com/cell/fulltex...

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓

Our lab is expanding! We are looking for an experimental or computational PhD student and a Technical Assistant for a project on RNA localization regulation. Details 👉 shorturl.at/fWH3u ⏳ +1 more PhD spot still open—10 days left to apply! shorturl.at/Udw0Q #PhD

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

Review | The regulation and function of post-transcriptional RNA splicing www.nature.com/articles/s41...

www.nature.com/articles/s41... #spatialbiology #RNAbiology

An interesting perspective and framework: #RNA condensates-not individual RNAs-may have acted as replicative units in early life. RNAs in condensate recruit similar RNAs, then the condensate divides once it reaches a critical size. #RNAsky

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇 www.cell.com/molecular-ce...

Our first Generative AI paper featuring ArrowDiff is now in out in TMLR! It enables efficient graph generation via Random Walk Diffusion, with therapeutic applications in small molecule and RNA design. Congratulions Tobias and Ghalia for leading this study! openreview.net/forum?id=tSF...

Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social! With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social www.cell.com/molecular-ce...

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...

Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to ⁦@DuyguKuzuoglu⁩ an amazing postdoc and all the authors and collaborators! cell.com/cancer-cell/fu…