Matt Simon
@mattdsimon.bsky.social
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📥 577
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Chemical biologist studying chromatin & RNA biology at Yale University.
reposted by
Matt Simon
Lisa Racki
7 months ago
There is still time to submit an abstract - join us in Nashville!
add a skeleton here at some point
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reposted by
Matt Simon
Leo Schärfen
8 months ago
Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in
@cp-molcell.bsky.social
! With
@karlaneugebauer.bsky.social
,
@isaac-vock.bsky.social
,
@mattdsimon.bsky.social
www.cell.com/molecular-ce...
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Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
Schärfen et al. develop a method to measure the structure of nascent RNAs during their synthesis by RNA polymerases. Base pairing occurs rapidly in cells, revealing the strong regulatory potential of ...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00187-X
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reposted by
Matt Simon
Science Friday
8 months ago
Are you a scientist or student heading to a
@standupforscience.bsky.social
‬rally this Friday? We want to hear from you. Tell us about yourself and why you’re going, how far you’re traveling, why you’re fired up, and whether there will be car snacks. Call or text us at (646) 767-6532.
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reposted by
Matt Simon
Karla Neugebauer
12 months ago
We are happy to share the development of Co-transcriptional Structure Tracking by
@leoschaerfen.bsky.social
, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
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Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
https://www.biorxiv.org/content/10.1101/2024.11.26.625435v1
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