For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Are you in years 3-8 of an independent faculty position? The Emerging Leader Award was built to give you the research runway you need. The award now offers $1M over 4 years and is open to investigators worldwide!🌎 Apply by April 30: themarkfoundation.org/emerging-lea... #ResearchFunding

There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

We are recruiting a computational scientist for a postdoc position to work on detecting RNA modifications using nanopore sequencing: tinyurl.com/RiboComp Deadline March 4th. Please share and repost! More on the group: www.bric.ku.dk/research-gro...

Happy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

eIF2B Selectively Anchors and Activates Mutant KRAS www.biorxiv.org/content/10.1...

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below! www.findaphd.com/phds/project...

We have an exciting PhD opportunity to study ribosome hibernation in archaea using cryo-electron microscopy, tomography, microfluidics, omics, and confocal imaging. @daumlab.bsky.social, @lsiexeter.bsky.social Apply via: www.exeter.ac.uk/study/fundin... Any questions, IM me.

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...

Here's the latest from the lab! In it we dive into the role of ribosomal proteins in antigen processing and presentation! academic.oup.com/narcancer/ar...

Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social: www.nature.com/articles/s41...

'Cancer Research UK told The Observer that several pieces of research had been affected by...immigration costs, which have risen by 126% since 2019 and are up to 17 times higher than the average of comparable countries including France, Australia, the US and South Korea.' Not only cancer research.

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

I'm reading the report behind these headlines about glyphosate and it may be the most scientifically illiterate thing I've come across (although it's a close thing with the recent MAHA report). 1/n

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data. academic.oup.com/nargab/artic...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates www.sciencedirect.com/science/arti...

Very interesting work from Samie Jaffrey's lab: m6A promotes ribosome collisions, with big effects on RNA stability. #RNASky www.cell.com/cell/fulltex...

Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky www.sciencedirect.com/science/arti...

Ever wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! www.biorxiv.org/content/10.1...

Will be taking a deep dive into this today. Congrats to Joe Lobel and Nick Ingolia! #RNAsky #RNAbiology www.nature.com/articles/s41...

We’ve loved having @liamfaller.bsky.social at the NKI! As he heads to the UK, we’re sharing this video about this outstanding and likable scientist, whose family inspired his dedication to cancer research. Best of luck Liam, you will be missed! 💙 www.youtube.com/watch?v=ra88...

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...

Message to my 11 followers in Bluesky: We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open! Details and registration: www.eventsforce.net/hg3/frontend... The Organizing Committee

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9

The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....

"these approaches estimate the number of ribosomes on a transcript, the translation initiation rate, and the overall number of translation events before its decay, all in a genome-wide manner" #rnasky #ribosome www.nature.com/articles/s41...

New preprint time!! This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way. www.biorxiv.org/content/10.1...

Incredible stuff (as always) from the Barna lab: A subcellular map of translational machinery composition and regulation at the single-molecule level | Science www.science.org/doi/10.1126/...

Excited to see issue on ribosome heterogeneity and specialisation out @royalsociety.org Philosophical Transactions B. Thanks to authors & co-editors @liamfaller.bsky.social @andershlund.bsky.social Maria Barna. Wonderful cover Bulat Fatkhullin! #ribosomes royalsocietypublishing.org/toc/rstb/202...

New review from the lab looking at high throughput methods of identifying ribosome heterogeneity. Great work from @ferhatalkan.bsky.social, Edwin Kyei-Baffour, and Qi Chang Lin! royalsocietypublishing.org/doi/10.1098/...

On this #InternationalDayofWomenandGirlsinScience we proudly present to you: our roving scientist! She supports women scientists during their maternity leave, which often happens during a crucial phase in their careers. Read more ➡️ www.nki.nl/news-events/...

I am a day late, but to celebrate International Women and Girls in Science Day, @nkinl.bsky.social has launched our Roving Scientist program! This initiative aims to ensure that experiments don't stop when someone takes parental leave. vimeo.com/1055578665/6... #WomeninSTEM

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

Amazing stuff from @marvintanenbaum.bsky.social! Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex... #RNAsky #RNABiology

Delight to share the latest from the lab, led by @sofiaramalho.bsky.social and @thejoanasilva.bsky.social! In it we highlight the importance of the nascent polypeptide associated complex (NAC) in intestinal stem cells! www.science.org/doi/10.1126/... #RNAsky

Beautiful stuff from Zachary Campbell's lab, showing the role of translation elongation in pain: www.cell.com/molecular-ce... #RNAsky