“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...

“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics www.yahoo.com/news/article...

“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites www.yahoo.com/news/article...

“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...

“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics www.technologynetworks.com/neuroscience...

“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French news.yahoo.com/articles/dna...

“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...

“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...

“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...

"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group." www.sciencealert.com/restless-leg...

Registration ends 30 Sept 2025 for the virtual East Coast Genetic Genealogy Conference. You have until 31 Dec 2025 to watch all of the recordings. There’s an ISOGG presentation where we celebrated ISOGG’s 20th year, review the history and discuss future goals. #ISOGG #DNA #ECGGC ecggc.org

“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu www.the-independent.com/news/science...

“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...

New finding on #osteoporosis: “Researchers from the University of Leipzig in Germany and Shandong University in China, identified the cell receptor GPR133 (also known as ADGRD1) as being crucial to bone density, via bone-building cells called osteoblasts.” www.sciencealert.com/new-breakthr...

Nice blog post by Linda Yip on the East Coast Genetic Genealogy Conference which you can STILL sign up to watch the recordings through Dec 31, 2025. Registration ends Sept 30,2025 so don’t procrastinate on registering. #geneticgenealogy #ISOGG #DNA #ECGGC past-presence.com/2025/09/14/k...

“The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.” hms.harvard.edu/news/could-l...

"Moreover, G2a2* is represented by only one sub-lineage (G2a2b2a1a1b*, L497) except for the Iceman, which carries a different one (G2a2a1a2a1a1b, G-Z6208, or formerly G2a2a1a2 L-91" #DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman www.nature.com/articles/s41...

Ireland’s Genealogical Gazette FREE talk on 9 Sept 2025 at 20:00 “Isotopes and Ancestry: Exploring how Archaeochemistry can answer Genealogical Questions,” given by Dr Ashley McCall, an independent researcher based in Dublin. Join via Zoom ID 844 6097 4398 and passcode 66 18 37 #DNA #ISOGG #Ireland

“Scientists just found a sugar switch that protects your brain from Alzheimer's. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.” #isogg #DNA #epigenetics #glp1 www.sciencedaily.com/releases/202...

“Moreover, we demonstrated that a higher FI score of mtDNA variants was associated with both premature epigenetic aging in the early 20s and premature biological aging in the late 20s." #isogg #DNA #epigenetics #haplogroups www.nature.com/articles/s41...

“Results from a randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.” #isogg #telomeres #epigenetics news.harvard.edu/gazette/stor...

Well done study on the HAY surname! #ISOGG #DNA #FTDNA #FamilyTreeDNA #BigY #Ychromosome #Hay #geneticgenealogy www.biorxiv.org/content/10.1...

“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee www.qmul.ac.uk/media/news/2...

Have you had the Shingles vaccine? If you’ve had the Shingles vaccine (and/or RSV vax) then you may have given yourself a dementia preventative. #isogg #dna #shingles #shingrix #RSV #epigenetics www.sciencealert.com/huge-study-r...

“Intranasal insulin has been clinically tested in Alzheimer’s Disease patients, demonstrating positive effects on memory and a decrease in Aβ42 levels.” #DNA #epigenetics #isogg #Alzheimers #insulin pmc.ncbi.nlm.nih.gov/articles/PMC...

“Over an average follow-up of 6.7 years, 280 participants, or 27.3 percent, were diagnosed with Alzheimer’s. Researchers found that 39 percent of the “total effect of egg intake” was linked to choline, a nutrient in egg yolks known to support memory & brain function.” thehill.com/policy/healt...

“When IDO1 is blocked, however, macrophages regain their ability to absorb cholesterol.This suggests that reducing IDO1 activity could offer a new way to help prevent heart disease by keeping cholesterol levels in check.” #DNA #isogg #epigenetics #cholesterol www.news-medical.net/news/2025062...

“These findings identify a light-responsive cell-intrinsic timer that controls time-of-day variations in antibacterial activity.” #isogg #DNA #epigenetics #circadian www.science.org/doi/10.1126/...

Does Alzheimer’s even come close to being an Does Alzheimer’s even come close to being an Autoimmune Disease? #DNA #epigenetic #isogg www.j-alz.com/editors-blog...

“Addressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.” #isogg #epigenetics #dementia #alzheimers pubmed.ncbi.nlm.nih.gov/33570509/

“Their study, published in the journal Nature, describes the first whole ancient Egyptian genome, and the oldest DNA sample from Egypt to date.” #DNA #isogg #Egypt #Nature amp.dw.com/en/dna-shows...

“This innovative strategy could potentially revolutionize our ability to address genetic hearing impairments, offering hope for more effective and durable treatments for individuals across a wider age range and at various stages of hearing loss progression.” #DNA www.frontiersin.org/journals/neu...

“Using population genetics, kinship analyses and the study of networks of identity-by-descent haplotype segment sharing, we elucidate the social and genetic dynamics of these communities between 4800−3900 calibrated years BCE.” #isogg #ancientdna #DNA #CarpathianBasin www.nature.com/articles/s41...

New to epigenetics? University College London has produced Epigenetics for the Lay Person. #DNA #isogg #epigenetics www.ucl.ac.uk/population-h...

“Mitochondrial DNA extracted from these cemeteries showed that although the female line was linked to Early Neolithic farming communities, the male line was similar to that of Jutlandic populations.” #isogg #ancientdna #DNA #Scotland archaeologymag.com/2025/06/pola...

“The authors explained that carnosic acid works by activating enzymes in the body's "natural defense system." They created a stable form known as diAcCA, which once consumed, converts to carnosic acid in the gut and is then absorbed into the bloodstream.”#isogg www.foodandwine.com/rosemary-car...

ChatGPT 4.5 summary: Human cells with mutations in 3 of the 6 proteins making up the Origin Recognition Complex (ORC) a group typically known for starting DNA replication. It breaks the long-held view that ORC’s job ends at replication. #isogg #DNA #epigenetics www.sciencedirect.com/science/arti...

“For example, APOE ε2 is known to offer protection against cardiovascular disease and Alzheimer’s. FOXO3A helps cells handle oxidative stress and repair DNA, both key processes in aging.” #DNA #epigenetics #isogg #aging scitechdaily.com/unlocking-th...

“Why Aging Comes in Dramatic Waves in Our 40s and 60s A new study suggests that waves of aging-related changes occur at two distinct points in our life” #DNA #isogg #aging #epigenetics www.scientificamerican.com/article/dras...

“In summary, this research presents a novel case for rilmenidine to be considered a potential calorie restriction mimetic through its prolongevity and health preserving effects, increased stress resistance, and increased autophagy.” #isogg #DNA #epigenetics onlinelibrary.wiley.com/doi/10.1111/...

“The presence of these cells, known as microchimerism, is thought to affect every person who has carried an embryo, even if briefly, and anyone who has ever inhabited a womb.” #DNA #isogg #microchimerism #pregnancy www.theatlantic.com/science/arch...

Interesting study that may help combat super-bugs. “Mutants deficient in these enzymes exhibit varying degrees of antifungal drug sensitivity.” #DNA #isogg #epigenetics #C.auris www.nature.com/articles/s41...

Looks like another new hominid! Here’s the telling sentence: “Maba 1 currently cannot be definitely classified in any known hominin taxon.” #AncientDNA #isogg #hominid #Maba1 onlinelibrary.wiley.com/doi/abs/10.1...

“Where site-by-site analyses are strongly underpowered for small effect differences, other methods incorporating statistics, machine learning, or averaging across many genes in the genome can still extract useful information on the factors shaping epigenetic variation” www.nature.com/articles/s41...

New @nataging.nature.com Our body-wide pace of aging predicts healthspan and lifespan: outcomes of mortality, morbidity, cognitive impairment, and disability in US and UK cohorts www.nature.com/articles/s43...

p-tau217 has been available in the US for the past ~2 years (Quest and LabCorp) the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems gift link www.nytimes.com/2025/05/21/h...

“Genetic studies have identified single nucleotide polymorphisms associated with ancestry as key contributors to lung cancer risk and outcomes, emphasizing the importance of genomic insights for early detection and personalized treatments.” #ISOGG #epigenetics www.sciencedirect.com/science/arti...

“We infer that the inhibitory activity of CD33, and other Siglecs on human microglia, may limit phagocytosis of misfolded proteins, contribute to disease progression. Inhibitory Siglec ligands in the brain, are potential AD-modifying agents and therapeutic targets.” #DNA www.jbc.org/article/S002...

“In the study, the researchers found that levels of a protein called MTBR-tau243 in the blood accurately reflect the amount of toxic accumulation of tau aggregates in the brain and correlate with the severity of Alzheimer’s disease.” #DNA #isogg #epigenetics medicine.washu.edu/news/highly-...

“Future studies should investigate levels of taurine in people with leukemia, Bajaj said. But most importantly: “Our current data suggest that it would be helpful to develop stable and effective ways to block taurine from entering leukemia cells,” she said. www.urmc.rochester.edu/news/story/a...