Thanks Johanna

EACR President @yardenasamuels.bsky.social‬ delivers the #EACR2025 Opening Address!

@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!

Targeting the Cancer Ecosystem: Presenters addressed microenvironmental and host-level changes that accompany tumor progression during an #AACR25 Plenary Session. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/fourth-... @yardenasamuels.bsky.social

Thanks #AACR25 for the huge honor!

Thanks AACR25 this has been an amazing honor

Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky www.sciencedirect.com/science/arti...

Thank you #AACR for this huge honor!

Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!

Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social  @yardenasamuels.bsky.social

With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!

What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer. 🔗 www.cell.com/cancer-cell/...

Thanks Chris! @cmcginnis.bsky.social‬ great working with you-looking forward to many more collaborations!

thanks Panos!

and all our amazing collaborators H. Palashati, D. Malko, M.D. Shmueli, P. Poulis, M.J. Zemanek, M.M. Nielsen, A. Khatib, Y. Levin, Y. Pilpel, M. Rodnina, J. Cox, Y. Merbl, F. Erhard, T. Suzuki, A.R. Buskirk and whole team!

✨ We are thankful to the @CancerCell editorial team and the reviewers for their constructive comments, and I am grateful to have such a wonderful team. (7/7)

🏥 Patient data completed the picture: Primary melanoma tumors with low TYW2 showed enhanced responses to ICB, even in patients with low TMB (@Tiangen). Translation fidelity defects may help predict immunotherapy responders, opening new paths for precision cancer treatment. (6/7)

Together with Yaron Carmi, we identified FS peptides that triggered robust T cell responses. Moreover, these peptides elicited de novo T cell responses specifically in TYW2-KO tumor-bearing mice! (5/7)

🐭 In mice, TYW2 loss increased tumor immunogenicity, specifically in immunocompetent mice. scRNA-seq revealed that TYW2-KO tumors were enriched for exhausted T cells. Indeed, TYW2-KO tumor-bearing mice were sensitive to immune checkpoint blockade (ICB) therapy.

Furthermore, in vitro T cell stimulation assays (@Johannaolweus & team) demonstrated that these aberrant peptides are potent immune triggers! Could translation errors fuel anti-tumor immunity? (3/7)

🧬 Loss of TYW2, a tRNA modifier, disrupts translation fidelity—causing ribosomes to pause at Phe codons and increasing frameshift (FS) events. This generates out-of-frame peptides, which are presented by MHC class I molecules. (2/7)

Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)

Fabulous group photos from our recent conference in Athens !🎉 #MICC2025 Please feel free to share and tag :) @peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social

Proud of my PhD student Nofar Gumpert giving an excellent talk at the #MICC conference un Athens!!!

@yardenasamuels.bsky.social opening #MICC2025 in Athens - the birthplace of Democracy. Looking forward to an amazing conference!

Liran Shlush from the Weizmann Institute - excellent first talk!

Excited to open the MICC conference in Athens! Excellent speakers ahead!