@wellerchen.bsky.social
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reposted by
Chris McGinnis
10 months ago
Thrilled to see our paper out today in
@cp-cancercell.bsky.social
— in collaboration with
@yardenasamuels.bsky.social
@wellerchen.bsky.social
and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here
add a skeleton here at some point
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reposted by
Parker Institute for Cancer Immunotherapy (PICI)
10 months ago
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer. 🔗
www.cell.com/cancer-cell/...
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Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...
https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00082-0
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Thanks a lot
@acir-org.bsky.social
for highlighting our work and generating this great illustration!!
add a skeleton here at some point
10 months ago
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Brilliant meeting at the
#MICC2025
in Athens! I was fortunate to get a picture with my mentor
@yardenasamuels.bsky.social
next to my poster.
10 months ago
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