Had a wonderful time in Strasbourg presenting our latest HDX-MS research at the 5th International Conference for HDX! Excellent cheese, beer, wine, macarons and outstanding science to boot! Excellent work from the conference organisers Sarah, Julien and Cherine!

🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Fellowship rejected (after interview), root canal, and a -80 freezer failure all within 24h. Yay!

Another day another birthday party. The brief for this one was rainbow marshmallow sprinkles and I think I achieved that. Now for the ensuing hyperglycemic coma...

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee.. A few points and new information that bioscientists may find interesting... A 🧵

! 🧐 chemrxiv.org/doi/full/10....

Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry. Read more: www.nature.com/naturecareer... Apply by 11 FEB #PostdocJobs #ScienceJobs

Nothing will make Universities flee from embracing and embedding AI faster than sharing IP % points lol

Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵

Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop https://www.biorxiv.org/content/10.64898/2026.01.08.698367v1

Pssst! I have a PhD position available. Please pass it on www.findaphd.com/phds/project...

PXD053875 🚨 Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD. 🚨 New dataset alert! 🚨

Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social

Wait wut

This is great! www.bbc.co.uk/sounds/play/...

Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.

A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence

I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications. www.nature.com/articles/s41...

📢New preprint has landed! 📢 We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs. Comments and criticisms welcome! Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS. www.biorxiv.org/content/10.1...

Wait, what?

This is so illuminating. For all its potential faults, pubpeer manages to justify its existence very regularly. Just imagine if the Wakefield/MMR paper had been published in the era of pubpeer and had been so rosolutely picked apart - we would be living in a different world.

HRG is critical to immunity and coagulation, but a beast to work with due to disordered sections and PTMs. We gained some structural insights by working with human HRG, which is made in humans! Great collaboration with chums @ St Andrews Dr Alan Stewart & Steve. portlandpress.com/biochemj/art...

Our mission is to determine the molecular mechanisms of disease in order to advance human health. Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025. More information here: www.cimr.cam.ac.uk/postgraduate...

Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...

Wonderful that this is out, with data from PhD student Vanesa, now at GSK. Excellent nose-to-tail examination of how WEE1 inhibitors activate GCN2, paradoxically, of course. Congrats to Steve Jackson, Aldo Bader, + Stefan Marciniak and all the other groups and authors. www.nature.com/articles/s41...

At a party, John asked us students if we knew who Max Perutz was. I said "yes, he was a man who named himself after a lecture theatre." With supreme magnanimity he laughed. Met months later and he clocked me and we talked research for ages. Meant so much to a student! www.cam.ac.uk/research/new...

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

Wonderful to be part of this study with Stefan et al.!

Bumper year...

Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement. Great work by fantastic postdocs Lindsey and Reece (& student Maria) #PostdocAppreciationWeek www.biorxiv.org/content/10.1...

It's August

How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine? Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells www.embopress.org/doi/full/10....

Check out our latest work on cell cycle inhibitors, which has implications for how cancer cells could become resistant to these drugs #senescence #cellcycle #cancer 🧪 www.biorxiv.org/content/10.1...

That wonderful feeling of coming home to Scotland after a week's holiday in Ireland only to realise you left your suitcase back in Ireland. Along with your washbag. And your laptop. Outside. In the rain.

We've just posted a new preprint: "A GCN1-independent activator of the kinase GCN2"

Congratulations to Graham Neill who passed his PhD Viva today! 👏🎉👏🎉First PhD from the lab! Many thanks to Tony Ly from Dundee SLS and @antoncalabrese.bsky.social from Leeds for grilling Graham on all things kinases + hdx-ms. Read about Graham's Research on GCN2 here: www.biorxiv.org/content/10.1...

Main focus of the job will be Cryo-EM of membrane protein comolexes as well as protein/nucleic acid complexes involved in innate immunity. For more information, check this: www.mpi-dortmund.mpg.de/news/jobs/po...

Very happy to present some of our research on HDX-MS at the Royal Society/ Japanese Society Promotion of Science joint meeting in London today. Incredibly interesting meeting on a very broad array of topics.

A birthday treat for me and the wee one. Caught a bucket full of trout and cod, the seas were very choppy but glad to report my son has an iron stomach (which couldn't be said for some of our fellow fishers). Son delighted and ate his own cod for supper.

Delighted to share research on ISR kinase & Parkinson's target HRI, with help from @mrcppu.bsky.social's Miratual Muqit, spearheaded by MSc student Shivani. Recently, I presented this (far too quickly) at @ukproteostasis.bsky.social- if you wanted more details, here they are! tinyurl.com/5n7ptvju

Congrats Melissa!

Excited to share our recent paper on the Wnt signalosome www.nature.com/articles/s41...

The swifts have returned and are ruling the skies of Leuchars once more

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

Congratulations to Miratul and the team, wonderful project to be privy to. www.science.org/doi/10.1126/...