Excited to share this highlight of a beautiful study into how myeloperoxidase acts as a chromatin transformer

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps go.nature.com/4pxKgV6

📃 New paper alert! The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com: www.nature.com/articles/s41...

We just published this paper of which I am immensely proud: www.nature.com/articles/s41... In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of. Let's dive in... 🧵

I have an open postdoc position in my group at @mpi-dortmund.bsky.social @maxplanck.de! If you are passionate about structural biology and/or membrane proteins, apply today! The position is initially funded for two years, starting from this October. Deadline for application is on July 15th.

1/3 Today I can proudly present the first preprint from my project group! biorxiv.org/content/10.1... We determined the CryoEM structure of the Slo1 potassium channel in complex with the regulatory subunit γ1 and propose a mechanism of how γ1 can activate Slo1.

Together with Stefan Raunser, I wrote a little review on neurotoxic insecticides acting on ion channels. We focus on structures and mechanisms and try to reveal similarities in modes of action between chemically diverse compounds. In the end, many act surprisingly similar! rdcu.be/doHyK