The Gersch Group developed a well characterized matched chemical pair of inhibitor and degrader for the investigation of the DUB USP7 in #solidcancers together with the Cancer Center at the University Hospital Essen. Congrats to @nikolasklink.bsky.social et al. www.nature.com/articles/s41...

We are proud of Arianna Esposito Verza who successfully completed her #doctoralthesis in @andrea-musacchio.bsky.social lab! Her research into the regulation of cell division was recently published in @embojournal.org ➡️ link.springer.com/article/10.1... We wish you all the best for your future!

Millions in funding @wellcometrust.bsky.social for a new study by the groups of @adesaurin.bsky.social & Tony Ly from @dundee.ac.uk and @andrea-musacchio.bsky.social @maxplanck.de on phosphorylation-dephosphorylation dynamics during #celldivision www.mpi-dortmund.mpg.de/news/million...

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

Ihr blieb der Ruhm versagt, den sie verdient gehabt hätte. Ein Hörspiel über die Wissenschaftlerin und starke Persönlichkeit #LiseMeitner 🎧 www.ardaudiothek.de/episode/urn:... #MaxPlanckHistory #Wissenschaftsgeschichte

It’s out! 🥳 Excited to share our new paper (with Kai Walstein, @andrea-musacchio.bsky.social and all others) on the role of M18BP1 in CENP-A loading! “M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans” link.springer.com/article/10.1...

Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1

We warmly welcome our new #LiseMeitner Group Leader Katerina Naydenova. Her group will investigate cellular defence mechanisms and develop novel methods in the field of cryogenic electron microscopy. Learn more about Katerina and click on the link 🔗 www.mpi-dortmund.mpg.de/news/katerin...

We warmly welcome our new independent @maxplanck.de Group Leader Andrija Sente. His group will investigate the molecular mechanisms of neuronal communication. Learn more about Andrija and his work and click on the link🔗 www.mpi-dortmund.mpg.de/news/new-max...

paper alert🚨 Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry www.nature.com/articles/s41...

paper alert 🚨 CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases - published by the groups of Tanja Bange @lmumuenchen.bsky.social & @andrea-musacchio.bsky.social in @nature.com Communications www.nature.com/articles/s41...

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders - Published by the Waldmann Group in @angewandtechemie.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

Researchers from @raunser-lab.bsky.social have redefined the function & role of key factors in actin filament disassembly. "We uncovered a dance between proteins - a molecular choreography.” Congrats @woutoosterheert.bsky.social et al. @cellpress.bsky.social www.mpi-dortmund.mpg.de/news/dancing...

"My time at the MPI Dortmund has been amazing! Not only have I made many friends, but I've also gained the required skills that laid the foundation for the next step in my career. " Congrats to @woutoosterheert.bsky.social on his new group leader position at the the Netherlands Cancer Institute

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

We are happy to announce that we will have two new scientific groups led by Andrija Sente and Katerina Naydenova soon! If you are interested to join their lab as a PhD Student apply at our @imprs-lm.bsky.social www.imprs-lm.mpg.de/index.php/jo...

Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.

New paper alert! ⏰ Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing Published by the lab of Peng Wu in @nature.com Communications www.nature.com/articles/s41...

📃 New paper alert! The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com: www.nature.com/articles/s41...

@vcmentowski.bsky.social & @andrea-musacchio.bsky.social have solved the mystery surrounding the ‘crown’ of #celldivision . They showed how the #kinetochore #corona is constructed and how this guarantees the error-free distribution of #chromosomes www.mpi-dortmund.mpg.de/news/crown-o...

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

Pushing calcium against the flow: high-speed pumps in the cell - The first comprehensive transport model of a plasma membrane calcium pump explains its high speed and opens up new avenues for drug development www.mpi-dortmund.mpg.de/news/pushing...

paper alert🚨 Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - published by @raunser-lab.bsky.social @maxplanck.de & Fakler lab @uni-freiburg.de in @nature.com www.nature.com/articles/s41...

"My time at the MPI has laid a very strong foundation for this next step in my career and I couldn't have done it without the excellent support of the institute." The MPI congratulates Peter 't Hart on his appointment to the University of Münster! www.mpi-dortmund.mpg.de/news/thart-m...

Are you curious about what PLK1 kinase is up to these days? Have a look at our latest review on @cp-trendscellbio.bsky.social. Arianna Esposito Verza, @andrea-musacchio.bsky.social and I discuss the latest findings on a very important enzyme that is still full of surprises, 35+ years from discovery!

Packing 🧬DNA on time for cell division Trans-European research team discovers how a molecular switch controls DNA packing on time for cell division Read the story ▶️ www.mpi-dortmund.mpg.de/news/packing...

Your PhD journey starts NOW! Join our #webinar on Sept 4 (1-3 PM CEST) to explore #PhD opportunities at Max Planck's #PhDprograms in NRW, Germany! 🇩🇪 Gain insights into groundbreaking research & register here: events.gwdg.de/e/PhDatMaxPl... #IMPRS #MaxPlanck #Research #Germany #Science

SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...

Condensin II activation by M18BP1 - published by @andrea-musacchio.bsky.social Lab & @alessandrovannini.bsky.social @humantechnopole.bsky.social & Rowland Lab @nkinl.bsky.social in molecular @cellpress.bsky.social congrats to @duccioconti.bsky.social et al. www.sciencedirect.com/science/arti...

Arp2/3-complex regulation – Novel insights and open questions - published by Peter Bieling, Micaela Boiero Sanders and Theresia Stradal in Curr Opin Cell Biol. www.sciencedirect.com/science/arti...

I have an open postdoc position in my group at @mpi-dortmund.bsky.social @maxplanck.de! If you are passionate about structural biology and/or membrane proteins, apply today! The position is initially funded for two years, starting from this October. Deadline for application is on July 15th.

The MtL Lecture Series continues with talks by Marcus Müller from @uni-goettingen.de‬, Andrea Musacchio from @mpi-dortmund.bsky.social & @unidue.bsky.social‬, and David Zwicker from the Max Planck Institute for Dynamics and Self-Organization. Register now on our website!

🚨Paper alert🚨 Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex - published by the @andrea-musacchio.bsky.social Group in @natcomms.nature.com www.nature.com/articles/s41...

With great sadness and deep regret, we have to inform you that our department director and highly esteemed colleague Philippe Bastiaens @maxplanck.de passed away suddenly and unexpectedly on 15th of May.

There are currently high hopes for the development of novel Parkinson's drugs. Malte Gersch & his team have now deciphered the mode of action of these drugs. The findings can help to develop innovative therapeutics for Prakinson's disease & other disorders. www.mpi-dortmund.mpg.de/news/promisi...

New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by Malte Gersch group in Nature Struct. & Mol. Biol. www.nature.com/articles/s41...

Congrats to our @crc1430.bsky.social member @vcmentowski.bsky.social on defending her PhD in the @andrea-musacchio.bsky.social Lab! 🎓👏 A remarkable achievement that showcases her dedication and hard work. We’re excited for her future successes! 🎉 #PhDDefense #ResearchExcellence #AcademicAchievement"

New Publication by the @waldido.bsky.social Group: An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products - Published in ChemBioChem chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Congrats for a fantastic defense and your even more fantastic achievements @vcmentowski.bsky.social

We congratulate Max Haase, #Postdoc in the @andrea-musacchio.bsky.social group , on receiving the highly-coveted Marie Sklodowska-Curie (MSCA) Postdoctoral Fellowship funded by the @ec.europa.eu Commission

🚨Paper alert🚨 The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning - Published in @embojournal.org by the Peter Bieling Group & William Bement Group & Scott Hansen Group www.embopress.org/doi/full/10....

Paper Alert🚨 Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT - published by the @andrea-musacchio.bsky.social Group in Journal of Cell Biology rupress.org/jcb/article/...

Huge congrats to Heng Zhou & Jagannath Maharana from the @raunser-lab.bsky.social on being awarded the prestigious Humboldt Fellowship! Jagannath will investigate the causes of inherited cardiomyophaties & Heng how certain bacterial Tc toxins target and enter host cells #cryoEM #cryoET

Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #molecularbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply to join us at the IMPRS-LM. Application deadline: 3 April, 2025.

Using a genome-wide CRISPR screen, Schröter and colleagues @mpi-dortmund.bsky.social highlight role of Med12 in mESCs during early cell differentiation. Fernkorn et al 2024. bioRxiv doi.org/10.1101/2024.01.22.576603, peer reviewed by Review Commons eeb.embo.org/doi/10.1101/2024.01.22.576603

A molecular syringe paves the way to new therapeutic approaches - read how a team of researchers @raunser-lab.bsky.social @maxplanck.de & University of Geneva & @hhu.de found important insights into how pathogenic bacteria inject deadly enzymes ▶️ www.mpi-dortmund.mpg.de/news/molecul...

Today is the #InternationalDayofWomenandGirlsinScience We are celebrating all our female scientists! Check the interview with our postdoc and mother Louisa Hill, who recently got the prestigious EMBO fellowship! www.mpi-dortmund.mpg.de/news/interna...

High-level teamwork for a better molecular understanding of muscle wasting Structural biologist and Humboldt Fellow @amunts.bsky.social Amunts will be researching age-related bioenergetics together with MPI Director Stefan Raunser @raunser-lab.bsky.social www.mpi-dortmund.mpg.de/news/2025/hi...

This @raunser-lab.bsky.social review summarizes recent insights into the molecular mechanisms of #actin polymerization and disassembly obtained through high-resolution structures of actin filament assemblies. #cryoEM www.sciencedirect.com/science/arti...