Louisa Hill
@louisa-hill.bsky.social
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Chromosome biology and centromeres. PostDoc with Andrea Musacchio @MPI Dortmund, PhD @IMPvienna.
reposted by
Louisa Hill
Max Haase
3 months ago
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
https://www.nature.com/articles/s41586-025-10092-0
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reposted by
Louisa Hill
The EMBO Journal
4 months ago
What determines cell-cycle-dependent loading of human CENP-A? Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows
@andrea-musacchio.bsky.social
and coworkers to identify determinants, including structure of the M18BP1 SANTA domain
link.springer.com/article/10.1...
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M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans - The EMBO Journal
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
https://link.springer.com/article/10.1038/s44318-026-00698-z
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reposted by
Louisa Hill
Andrea Musacchio
4 months ago
Two new papers from the lab published in The EMBO Journal!
link.springer.com/article/10.1...
By Kai Walstein,
@louisa-hill.bsky.social
and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
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It’s out! 🥳 Excited to share our new paper (with Kai Walstein,
@andrea-musacchio.bsky.social
and all others) on the role of M18BP1 in CENP-A loading! “M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans”
link.springer.com/article/10.1...
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M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans - The EMBO Journal
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
https://link.springer.com/article/10.1038/s44318-026-00698-z
4 months ago
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reposted by
Louisa Hill
Lesly Calderón
4 months ago
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the
@jem.org
,
@rupress.org
!!!
add a skeleton here at some point
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reposted by
Louisa Hill
The EMBO Journal
4 months ago
Arianna Esposito Verza,
@andrea-musacchio.bsky.social
et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry Another
#RefereedPreprint
℅
@reviewcommons.org
link.springer.com/article/10.1...
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Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
https://link.springer.com/article/10.1038/s44318-025-00681-0
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reposted by
Louisa Hill
IMP
4 months ago
Plasma cells are the immune system’s antibody factories, and they originate from B-cells. Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
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reposted by
Louisa Hill
IMP
7 months ago
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP:
www.imp.ac.at/career/open-...
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reposted by
Louisa Hill
Andrea Musacchio
10 months ago
www.biorxiv.org/content/10.1...
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Molecular requirements for PLK1 activation by T-loop phosphorylation
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
https://www.biorxiv.org/content/10.1101/2025.07.25.666769v1
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reposted by
Louisa Hill
Duccio Conti
11 months ago
Finally out! Check out our new work on how M18BP1, known so far to be important for the epigenetic maintenance of centromeres, supports chromosome condensation when the cell enters mitosis. We also uncover a regulatory ménage á trois between condensin II, M18BP1 and MCPH1.
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Condensin II activation by M18BP1
Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this proc…
https://www.sciencedirect.com/science/article/pii/S109727652500543X?via%3Dihub
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reposted by
Louisa Hill
Andrea Musacchio
11 months ago
www.sciencedirect.com/science/arti...
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Condensin II activation by M18BP1
Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this proc…
https://www.sciencedirect.com/science/article/pii/S109727652500543X
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reposted by
Louisa Hill
Andrea Musacchio
11 months ago
www.biorxiv.org/content/10.1...
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M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans
Deposition of CENP-A, the histone H3 variant considered an epigenetic landmark of centromeres, reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The lo...
https://www.biorxiv.org/content/10.1101/2025.06.27.661933v1
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reposted by
Louisa Hill
IMP
about 1 year ago
📢Open call: the International Birnstiel Award for Doctoral Research in Molecular Life Sciences is now accepting nominations! Do you know an outstanding PhD student who deserves recognition? Nominate them by 30 June 👉
www.imp.ac.at/achievements...
🎥
www.youtube.com/watch?v=ghfQ...
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International Birnstiel Award for Doctoral Research in Molecular Life Sciences
YouTube video by Research Institute of Molecular Pathology
https://www.youtube.com/watch?v=ghfQVZA_MJE
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reposted by
Louisa Hill
Max Haase
about 1 year ago
It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
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Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
https://www.biorxiv.org/content/10.1101/2025.04.25.647736v1
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reposted by
Louisa Hill
Anton Goloborodko
about 1 year ago
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
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Rules of Engagement
YouTube video by Johan Gibcus
https://www.youtube.com/watch?v=pmvOrmErhhc
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reposted by
Louisa Hill
Journal of Cell Biology
about 1 year ago
Schweighofer, Mulay,
@andrea-musacchio.bsky.social
et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal
#kinetochore
rupress.org/jcb/article/...
#mitosis
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reposted by
Louisa Hill
Francesca Maci
over 1 year ago
🌟🚨 Don't miss the opportunity to register! 🚨🌟
add a skeleton here at some point
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Congratulations on this well-deserved prize, Meinrad! An outstanding scientist and mentor! 👏 🥳
add a skeleton here at some point
over 1 year ago
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reposted by
Louisa Hill
IMP
over 1 year ago
We are diving into 2025 with how we finished 2024: with great research. The lab of Jan-Michael Peters discovered how
#cohesin
not only drives
#chromatin
architecture, but also links it to
#epigenetics
. Now in
@embojournal.bsky.social
:
www.embopress.org/doi/full/10....
www.imp.ac.at/news/article...
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reposted by
Louisa Hill
Vienna BioCenter Scientific Training
over 1 year ago
The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences.
training.vbc.ac.at/summer-school/
@impvienna.bsky.social
@imbavienna.bsky.social
@gmivienna.bsky.social
@maxperutzlabs.bsky.social
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reposted by
Louisa Hill
IMP
over 1 year ago
Are you a
#postdoc
with an innovative vision for starting your own lab in
#Syntheticbiology
,
#Genomics
,
#GeneRegulation
,
#Development
,
#Cancer
,
#Immunology
or
#InfectionBiology
? @IMPvienna is inviting applications for group leader positions:
www.imp.ac.at/career/open-...
Pls share!
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