Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

What determines cell-cycle-dependent loading of human CENP-A? Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows @andrea-musacchio.bsky.social and coworkers to identify determinants, including structure of the M18BP1 SANTA domain link.springer.com/article/10.1...

Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1

It’s out! 🥳 Excited to share our new paper (with Kai Walstein, @andrea-musacchio.bsky.social and all others) on the role of M18BP1 in CENP-A loading! “M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans” link.springer.com/article/10.1...

Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!

Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry Another #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...

Plasma cells are the immune system’s antibody factories, and they originate from B-cells. Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

Finally out! Check out our new work on how M18BP1, known so far to be important for the epigenetic maintenance of centromeres, supports chromosome condensation when the cell enters mitosis. We also uncover a regulatory ménage á trois between condensin II, M18BP1 and MCPH1.

📢Open call: the International Birnstiel Award for Doctoral Research in Molecular Life Sciences is now accepting nominations! Do you know an outstanding PhD student who deserves recognition? Nominate them by 30 June 👉 www.imp.ac.at/achievements... 🎥 www.youtube.com/watch?v=ghfQ...

It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Schweighofer, Mulay, @andrea-musacchio.bsky.social et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal #kinetochore rupress.org/jcb/article/... #mitosis

🌟🚨 Don't miss the opportunity to register! 🚨🌟

Congratulations on this well-deserved prize, Meinrad! An outstanding scientist and mentor! 👏 🥳

We are diving into 2025 with how we finished 2024: with great research. The lab of Jan-Michael Peters discovered how #cohesin not only drives #chromatin architecture, but also links it to #epigenetics. Now in @embojournal.bsky.social: www.embopress.org/doi/full/10.... www.imp.ac.at/news/article...

The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences. training.vbc.ac.at/summer-school/ @impvienna.bsky.social @imbavienna.bsky.social @gmivienna.bsky.social @maxperutzlabs.bsky.social

Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!