And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.

On this BREAKFAST CLUB detention day anniversary, I want you to know I am still mad about this makeover after decades :) John Hughes, what did you have against cool goth girls?!

Missed the #Glycogen Symposium – Honouring the Legacy of #JoanGuinovart? You can now watch the full session and revisit the insights and tributes to an exceptional scientist. ▶️ www.youtube.com/live/CQBl90m... #Tribute #FEBS #IUBMB @iubmb.bsky.social

This is utterly jaw-dropping. A school that bans Atwood, Zadie Smith, Terry effing Pratchett and *literal George Orwell* is actively harming its pupils. www.indexoncensorship.org/2026/03/scho...

This is kinda bonkers. In addition, 20 amino acids were found on Ryugu, along with uracil and vitamin B3. These have been found in other instances, but since the samples from Ryugu were collected directly from the asteroid and delivered in sealed capsules, contamination on Earth could be ruled out.

Registration for the 2026 EMBO Ubiquitin Meeting is open! This meeting brings together leading scientists, emerging researchers, and innovators in the field for an inspiring programme of talks, discussions, and networking. Many selected short talk slots available. meetings.embo.org/event/26-ubi...

Registration now open for #EMBOUbiquitin. meetings.embo.org/event/26-ubi... Childcare, accessibility, and travel grants available. #ubiquitin #TargetedProteinDegradation #Proteostasis #UBL

The results are finally in! 🏆💻🧬 I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵

FAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators https://www.biorxiv.org/content/10.64898/2026.02.24.707758v1

FAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators https://www.biorxiv.org/content/10.64898/2026.02.24.707758v1

Trawling Facebook for legendary 80s icons stranded in Dubai must be quite the assignment.

🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.

Imagine being like this. Maybe we actually were all once like this. Be more like this guy!

I just did the dumbest thing of my entire career to prove a much more serious point. I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it

Among my first political memories was my immigrant parents being inspired by Jackson's 1984 campaign for President His rendition of 'I am somebody' and the childrens responses on Sesame Street is still inspiring youtu.be/iTB1h18bHlY?...

So he does believe in leaving one country and relocating to another for your safety after all?

The #Glycogen Symposium – Honouring the Legacy of #JoanGuinovart takes place on 20 March 2026 in a hybrid format. 🔹 Same scientific programme in both formats 🔹 Free registration Organised by FEBS, @iubmb.bsky.social & #IRBBarcelona. Register here: https://shorturl.at/XLVxd 🧪

Macbeth: SHIT

The rain will continue until morale improves.

What would you think to be thus used? This is the strangers case; And this your mountainish inhumanity.

Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...

NASA say that the crew member who was ill and returned to earth is doing well and now having a meal with colleagues.

I presume once you've reviewed and edited sufficient numbers of manuscripts, you max out your XP, level up, then start getting paid for it. Right?

A poem by Amanda Gorman For Renee Nicole Good Killed by ICE on January 7th, 2026

It’s a dark night when you look at the news and are forced to admit that you no longer believe in the power of the FIFA peace prize

This is one of the most beautiful things I have witnessed, the craft here is impeccable.

Pssst! I have a PhD position available. Please pass it on www.findaphd.com/phds/project...

So 2025 turned out to be a big year for de novo antibody design! Here are thoughts and predictions on the state of de novo antibody design heading into 2026 🧵

This entire weekend

The run that Rob Reiner went on between 1984 and 1992 is one of the most amazing hot streaks any director has ever had. Legendary stuff

SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.

Happy Fenton Day to all who celebrate. Jesus Christ, fourteen years. youtu.be/3GRSbr0EYYU

"I DON'T NEED YOU TO FUCKING REWRITE WHAT I'VE JUST WRITTEN!"

This morning my ChatGPT quota was inexplicably exhausted. It took a while but I pieced it together. Voice mode somehow got activated when I went to bed. The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.

A good day to remember John Gurdon’s school report from his biology master at Eton

Get in loser, we’re going to the rapture.

RAPTCHA

Look at the size of that pointer! That thing looks like a lightsabre.

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic: rdcu.be/eETIT

Art class From the latest Private Eye, out now.

FACT OF THE DAY. 2 September 1752. Britain replaced the Julian calendar with the Gregorian one which was used in most of Europe. The following day was 14 September 1752, meaning 11 days were cut from the 1752 British calendar. These days simply never existed.

Your mam shouts at hotels and your dad paints roundabouts

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...

Showing the endangered leader of an invaded country my hats

An incomparable legend.

Installing microwave ovens is hardly a tough gig is it? Put it on the worktop, plug it in- bosh. Money for nothing #liveaid