Hennig-Lab
@hennig-lab.bsky.social
📤 272
📥 350
📝 29
Research around the world of RNAs
reposted by
Hennig-Lab
Ewan Birney
17 days ago
I have been one of the many people across the world impacted by the sudden death of Peer Bork - a friend, colleague and remarkable scientist. I now have enough time this weekend to write some personal thoughts about Peer.
www.linkedin.com/posts/ewan-b...
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Peer Bork - personal thoughts | Ewan Birney
Personal thoughts on the passing of Peer Bork
https://www.linkedin.com/posts/ewan-birney-5a4378_personal-thoughts-on-the-passing-of-peer-ugcPost-7420847292859019264-c_Jt?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAAN1EwBk99GoecGmXKXGcMqGlX3Ga3wbcw
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Congratulations to Sutapa Chakrabarti on this exciting publication:
www.nature.com/articles/s41...
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Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay - Nature Communications
Replication-dependent histone mRNA decay involves the RNA helicase UPF1, the histone stem-loop binding protein SLBP and the exoribonuclease 3’hExo. Here, the authors present evidence for assembly of a...
https://www.nature.com/articles/s41467-025-67991-z
about 1 month ago
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Finally! Our work on TRIM2/TMEM106B is published:
link.springer.com/article/10.1...
It was a long journey and hopefully more to come. Who would have thought that the IDR of TMEM106B is responsible for its dimerization via Zn binding. With implications on lysosome assembly.
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TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway - EMBO Reports
TRIM2 is a mammalian E3 ligase with particularly high expression in Purkinje neurons, where it contributes to neuronal development and homeostasis. The understanding of ubiquitin E3 ligase function hi...
https://link.springer.com/article/10.1038/s44319-025-00667-3?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20260103&utm_content=10.1038/s44319-025-00667-3
about 1 month ago
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Hennig-Lab
Olivier Duss
3 months ago
The story of how multiple RBPs cooperate to repress translation is now out in
@cp-cellreports.bsky.social
by
@marcopayr.bsky.social
and in a great collaboration with
@hennig-lab.bsky.social
!
www.cell.com/cell-reports...
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Hennig-Lab
SPC Facility & Garcia-Alai Lab
5 months ago
Congrats to the Grünewald, Topf groups & et. al
@cssbhamburg.bsky.social
on their Nature paper! 📃 🍾 Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙 Glad that our SPC facility have contributed to this
[email protected]
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Anna Leder
6 months ago
Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum!
www.nature.com/articles/s41...
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Martin Pacesa
6 months ago
"Hey Bob, just dock the AF3 prediction into density and deposit"
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Instagram-ready group picture from our lab hike
7 months ago
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The most expensive bike stand in the world! 😢
7 months ago
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If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper:
www.cell.com/cell-reports...
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.
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A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex
Gaber et al. identify a direct protein-protein interaction between the oskar mRNA transport particle components Staufen and Tropomyosin1-I/C. They map the interaction surface at amino acid resolution ...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00677-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124725006771%3Fshowall%3Dtrue
8 months ago
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Hennig-Lab
Michael Jendrusch
8 months ago
Happy to see
@embl.org
highlight our work on protein design at Korbel group with
@typaslab.bsky.social
and
@hennig-lab.bsky.social
! Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
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Hennig-Lab
Michael Jendrusch
8 months ago
Happy to announce the first paper from my PhD at Korbel group at
@embl.org
has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with
@typaslab.bsky.social
,
@hennig-lab.bsky.social
and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
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New publication by the Korbel group
@embl.org
. Very cool new protein design pipeline. We just validated some of the designs for them by NMR . See below for more. AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology
www.embopress.org/doi/full/10....
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AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology
imageimageAlphaDesign combines hallucination and sequence generation to design various classes of proteins, from monomers to oligomers and site-specific binders. AlphaDesign was applied to design in v...
https://www.embopress.org/doi/full/10.1038/s44320-025-00119-z
8 months ago
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Last Saturday I rode the Vätternrundan with the charity organization "I move for cancer" to raise money for breast cancer research. The goal was to finish the ride of 315 km around beautiful lake Vättern faster than 9 h.
8 months ago
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Billionaires are attacking our rights, our media, and our freedom. It’s time to resist. I just signed this petition—add your name and be part of the movement:
act.gp/3Rqfnlz
#TimeToResist
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Think corporate elites should not control our rights and freedom? Sign - Greenpeace International
Billionaires and corporations are tightening their grip on our democracies — and silencing dissent. They weaken protections for people and the planet, bankroll politicians who serve their interests, c...
https://act.gp/3Rqfnlz
8 months ago
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If you are inclined to support cancer research, check this out and donate. You also keep me motivated 😁:
egeninsamling.brostcancerforbundet.se/fundraisers/...
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Vätternrundan 315 km under 9:00 h with IMFC: 14th of June 2025
The goal is to finish one of the biggest bike events of the world in under 9:00 h (315 km, average riding speed 37 km/h, on the 14th of June 2025), while supporting cancer research (specifically breas...
https://egeninsamling.brostcancerforbundet.se/fundraisers/janosch-hennig?tab=donations
9 months ago
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Hennig-Lab
Olivier Duss
10 months ago
The timeline of co-transcriptional
#mRNA
processing and
#modification
may have to be revised: cleavage, termination, and
#m6A
deposition may occur earlier than most
#splicing
! Potential textbook changing study in bioRxiv by
edueyras.bsky.social
& Rippei Hayashi labs!
www.biorxiv.org/content/10.1...
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Single-molecule multimodal timing of in vivo mRNA synthesis
mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...
https://www.biorxiv.org/content/10.1101/2025.04.27.650906v1
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Hennig-Lab
Saganism
10 months ago
“We've arranged a society based on science and technology, in which nobody understands anything about science and technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces.” ~ Carl Sagan
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Hennig-Lab
10 months ago
What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from
@lindsayabecker.bsky.social
@sofiquinodoz.bsky.social
@davidaknowles.bsky.social
www.biorxiv.org/content/10.1...
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Genome-wide mapping of mesoscale neuronal RNA organization and condensation
Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...
https://www.biorxiv.org/content/10.1101/2025.04.19.649570v1
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Hennig-Lab
Carl Zimmer
10 months ago
120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link:
nyti.ms/3GbrEaZ
🧪
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Astronomers Detect a Signature of Life on a Distant Planet (Gift Article)
Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.
https://nyti.ms/3GbrEaZ
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Hennig-Lab
Katie Mack
10 months ago
Looks like the evidence for this weird chemical abundance in an exoplanet atmosphere has gotten stronger with new JWST data:
www.nytimes.com/2025/04/16/s...
Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭
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Hennig-Lab
Olivier Duss
10 months ago
Ever wondered how several individual RBPs cooperate to repress translation? Lead by
@marcopayr.bsky.social
and in great collaboration with
@hennig-lab.bsky.social
, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
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Hennig-Lab
Sergio Cruz-León
10 months ago
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/
@jpkreysing.bsky.social
,
@johannesbetz.bsky.social
,
@marinalusic.bsky.social
, Turoňová lab,
@hummerlab.bsky.social
@becklab.bsky.social
@mpibp.bsky.social
🔗 Preprint here
tinyurl.com/3a74uanv
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Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (
www.biorxiv.org/content/10.1...
). Great collaboration with Olivier Duss (
@olivierduss.bsky.social
). Great Work Marco Payr (
@marcopayr.bsky.social
) and thanks for the video, explaining our paper.
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10 months ago
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Hennig-Lab
Kresten Lindorff-Larsen
11 months ago
Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
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Hennig-Lab
Basil Greber
11 months ago
On Fox News claiming this is no biggie. 🤷♂️🫣
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Hennig-Lab
birtehoecker.bsky.social
11 months ago
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme
@kortemmelab.bsky.social
and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends.
@gbmev.bsky.social
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An impressive talk by Dorothee Kern at the GBM Mosbacher Kolloquium last Friday and I was honoured to make the laudatory introduction to her Eduard Buchner Prize.
11 months ago
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Hennig-Lab
Martin Pacesa
11 months ago
What an amazing experience to be at the 76th Mosbacher kolloquim! Awesome talks on protein design and structural biology and a lot of conceptual discussions on where the field is going. Glad to also have been able to present our poster on binder design using BindCraft!
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Hennig-Lab
Khmelinskaia Lab
11 months ago
Had a great time at the Mosbacher Colloquium 2025—fantastic science, engaging discussions, and lots of inspiration. Shoutout to Anna and Hubert for taking the stage and board with their work!!!
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Very cool to witness the award procedure of the Otto Warburg Medal, which is awarded to Matthias Hentze just now by the German Society for Biochemistry and Molecular Biology!
11 months ago
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Hennig-Lab
GBM (Gesellschaft für Biochemie und Molekularbiologie)
11 months ago
Feodor-Lynen-Lecture delivered by Tanja Kortemme (UCSF) at the Mosbacher Kolloquium. Congratulations!
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Hennig-Lab
GBM (Gesellschaft für Biochemie und Molekularbiologie)
11 months ago
Mosbach at Night.Done with science for today, let the party begin!
@jgbm.bsky.social
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Hennig-Lab
Ben Engel
11 months ago
We're on the cover of
@science.org
this week. Awesome work by
@florentwaltz.bsky.social
.
#CryoET
is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by
@verenaresch.bsky.social
. Always a pleasure making
#SciArt
with you!🧪🧶🧬🌾
add a skeleton here at some point
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Christie Wilcox
11 months ago
Tardigrades are all the rage for studying how critters survive extreme conditions. But they could be great neuroscience models, too. That and more of the best in
@science.org
and science in this edition of
#ScienceAdviser
:
www.science.org/content/arti...
🧪
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Hennig-Lab
Morgan J Freeman
11 months ago
Trump walks to Marine One to head to Mar-a-Lago to play golf on the taxpayers dime. This trip will cost us $3.1 million, which could be used by USAID to feed 710 starving children for a full year.
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Hennig-Lab
Alfredo Castello
11 months ago
Excellent talk of Louisa Iselin on the remodelling of the RBPome by interferon at the "Expanding Universe of RBPs" in
@embl.org
, Heidelberg. The
@castello-lab.bsky.social
is very proud 🍾🥂🎊🎊
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Please RT: If you are interested in doing your PhD at the ILL, Grenoble in collaboration with the Hennig-Lab at University of Bayreuth, Germany, look here:
esrf.gestmax.eu/1874/1/phd-s...
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ESRF - PhD student at ILL: Structural biology of an RNA helicase by NMR, SANS and segmental labelling
Consultez toutes les offres d'emploi ESRF et postulez en ligne a nos annonces emploi sur le site recrutement ESRF
https://esrf.gestmax.eu/1874/1/phd-student-at-ill-structural-biology-of-an-rna-helicase-by-nmr-sans-and-segmental-labelling-f-m/en_US
11 months ago
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Hennig-Lab
GBM (Gesellschaft für Biochemie und Molekularbiologie)
11 months ago
Who would have ever thought of such a thing happening?
add a skeleton here at some point
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Hennig-Lab
Randall Munroe
12 months ago
RNA
xkcd.com/3056
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Hennig-Lab
ArdennenBob 🇪🇺
11 months ago
Banksy did it again.
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Hennig-Lab
John Skiles Skinner
12 months ago
I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story:
18f.org
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We're not done yet | 18F
https://18f.org/
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Hennig-Lab
SJ Weiss
11 months ago
For my birthday my wife got me the new Carl Zimmer book, Air-borne, The Hidden History of The Life We Breathe. This is a great book as I've come to expect from Zimmer given his previous works. Timely, as science has come under fire recently, we need this now.
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Hennig-Lab
Bluesky Wins
12 months ago
We have a massive academic base on Bluesky, we can lobby unis to quit X. The French are leading on this, others can do it too. 3 more French unis quit Twitter: Université Paris-Saclay
@univparissaclay.bsky.social
Université PSL
@psl-univ.bsky.social
Sorbonne Université
@sorbonne-universite.fr
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Hennig-Lab
Oregon 🕎🎲
12 months ago
Holy shit this is amazing They treated spinal muscular atrophy with no signs of the condition so far 2 years in.
www.nature.com/articles/d41...
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Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
https://www.nature.com/articles/d41586-025-00534-0
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Hennig-Lab
Torben Heick Jensen
12 months ago
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here:
www.mRNP.au.dk
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Hennig-Lab
Laura Helmuth
12 months ago
Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.
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Hennig-Lab
Katie Sandlin
12 months ago
Today, along with 2,000 other NIH employees, I had to clear out my office 😭 It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
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