We got a new preprint just published. Here, we redesigned double-stranded RNA binding domains to inhibit the RNA helicase DHX9 through a highly specific interface. A proof of principle for inhibitor design based on autoregulatory domains. www.biorxiv.org/content/10.6...

I have been one of the many people across the world impacted by the sudden death of Peer Bork - a friend, colleague and remarkable scientist. I now have enough time this weekend to write some personal thoughts about Peer. www.linkedin.com/posts/ewan-b...

Congratulations to Sutapa Chakrabarti on this exciting publication: www.nature.com/articles/s41...

Finally! Our work on TRIM2/TMEM106B is published: link.springer.com/article/10.1... It was a long journey and hopefully more to come. Who would have thought that the IDR of TMEM106B is responsible for its dimerization via Zn binding. With implications on lysosome assembly.

The story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social! www.cell.com/cell-reports...

Congrats to the Grünewald, Topf groups & et. al @cssbhamburg.bsky.social on their Nature paper! 📃 🍾 Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙 Glad that our SPC facility have contributed to this [email protected]

Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum! www.nature.com/articles/s41...

"Hey Bob, just dock the AF3 prediction into density and deposit"

Instagram-ready group picture from our lab hike

The most expensive bike stand in the world! 😢

If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper: www.cell.com/cell-reports... Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.

Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social ! Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.

Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published: embopress.org/doi/full/10.1038… Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵

New publication by the Korbel group @embl.org. Very cool new protein design pipeline. We just validated some of the designs for them by NMR . See below for more. AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....

Last Saturday I rode the Vätternrundan with the charity organization "I move for cancer" to raise money for breast cancer research. The goal was to finish the ride of 315 km around beautiful lake Vättern faster than 9 h.

Billionaires are attacking our rights, our media, and our freedom. It’s time to resist. I just signed this petition—add your name and be part of the movement: act.gp/3Rqfnlz #TimeToResist

If you are inclined to support cancer research, check this out and donate. You also keep me motivated 😁: egeninsamling.brostcancerforbundet.se/fundraisers/...

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs! www.biorxiv.org/content/10.1...

“We've arranged a society based on science and technology, in which nobody understands anything about science and technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces.” ~ Carl Sagan

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link: nyti.ms/3GbrEaZ 🧪

Looks like the evidence for this weird chemical abundance in an exoplanet atmosphere has gotten stronger with new JWST data: www.nytimes.com/2025/04/16/s... Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭

Ever wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! www.biorxiv.org/content/10.1...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.

Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published: www.pnas.org/doi/10.1073/... The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n

On Fox News claiming this is no biggie. 🤷‍♂️🫣

Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social

An impressive talk by Dorothee Kern at the GBM Mosbacher Kolloquium last Friday and I was honoured to make the laudatory introduction to her Eduard Buchner Prize.

What an amazing experience to be at the 76th Mosbacher kolloquim! Awesome talks on protein design and structural biology and a lot of conceptual discussions on where the field is going. Glad to also have been able to present our poster on binder design using BindCraft!

Had a great time at the Mosbacher Colloquium 2025—fantastic science, engaging discussions, and lots of inspiration. Shoutout to Anna and Hubert for taking the stage and board with their work!!!

Very cool to witness the award procedure of the Otto Warburg Medal, which is awarded to Matthias Hentze just now by the German Society for Biochemistry and Molecular Biology!

Feodor-Lynen-Lecture delivered by Tanja Kortemme (UCSF) at the Mosbacher Kolloquium. Congratulations!

Mosbach at Night.Done with science for today, let the party begin! @jgbm.bsky.social

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Tardigrades are all the rage for studying how critters survive extreme conditions. But they could be great neuroscience models, too. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Trump walks to Marine One to head to Mar-a-Lago to play golf on the taxpayers dime. This trip will cost us $3.1 million, which could be used by USAID to feed 710 starving children for a full year.

Excellent talk of Louisa Iselin on the remodelling of the RBPome by interferon at the "Expanding Universe of RBPs" in @embl.org, Heidelberg. The @castello-lab.bsky.social is very proud 🍾🥂🎊🎊

Please RT: If you are interested in doing your PhD at the ILL, Grenoble in collaboration with the Hennig-Lab at University of Bayreuth, Germany, look here: esrf.gestmax.eu/1874/1/phd-s...

Who would have ever thought of such a thing happening?

RNA xkcd.com/3056

Banksy did it again.

I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org

For my birthday my wife got me the new Carl Zimmer book, Air-borne, The Hidden History of The Life We Breathe. This is a great book as I've come to expect from Zimmer given his previous works. Timely, as science has come under fire recently, we need this now.

We have a massive academic base on Bluesky, we can lobby unis to quit X. The French are leading on this, others can do it too. 3 more French unis quit Twitter: Université Paris-Saclay @univparissaclay.bsky.social Université PSL @psl-univ.bsky.social Sorbonne Université @sorbonne-universite.fr

Holy shit this is amazing They treated spinal muscular atrophy with no signs of the condition so far 2 years in. www.nature.com/articles/d41...

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.