Our first PhD generation is flying out of the nest. Thank you Merve and Clara for shaping our lab from day one on. Wishing you all the best in your next chapters, we’re excited to see what comes next for you!

🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩‍🔬 Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR! www.nachtderforschung.unibe.ch #ndfunibern @unibe.ch

If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens! A big thank you to all co-authors that made this paper possible!

The authors report that all seven tested deep learning models failed to outperform simple baselines in predicting transcriptome changes after single or double perturbations. I will duck for cover.

Genome-wide chromatin recording resolves dynamic cell state changes https://www.biorxiv.org/content/10.1101/2025.08.05.668773v1

The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan. www.biorxiv.org/content/10.1...

Third defense this summer officially in the books. Huge congrats to Fabiola for a brilliant presentation and defense! #Summerofdefenses

….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...

Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social buff.ly/mL3a71T @dadita.bsky.socia @mihaelazavolan.bsky.social

How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!

PhDone 🥳🎓 The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A

The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!

new out in Nature today www.nature.com/articles/s41...

The very first PhD graduate of our lab! Great science, fantastic presentation and expertly defended. Huge congratulations on this well-earned milestone Dr. Duré!

Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social‬ "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control" @biorxivpreprint.bsky.social‬ buff.ly/hP9Iani ‪@anupamd.bsky.social‬

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

The former GRC Stem Cells & Cancer has found its new home in beautiful Malta, fantastic meeting ahead!

New Night Science Podcast episode! David Baker was awarded the 2024 Nobel Prize in Chemistry. He explains how he socially engineers his lab’s "communal brain", where all individuals function like neurons, densely interconnected to maximize idea generation. nightscience.buzzsprout.com/1744020/epis...

Preprint by the Sendoel lab ( @sendoellab.bsky.social ) with first author Fabiola Valdivia-Francia ( @fabiolavaldiviaf.bsky.social ) "In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component" @biorxivpreprint.bsky.social buff.ly/Ch7I3Gj

There is a new must-read paper for the weekend. 👀 Looking for the next future vision of #microprotein research? Check out this from @fabiolavaldiviaf.bsky.social @sendoellab.bsky.social. Really, what can't microproteins do? #RNAsky #genomics #bioinformatics 🧬 💻 www.biorxiv.org/content/10.1...

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9

A small appeal to young scientists looking for internship and PhD positions - websites are hard to maintain, papers can take years to publish & often end up behind a paywall. Read the preprints if you really want to know what a lab is up to. If they don’t preprint… this tells you something too ;)

📅 Program of the NCCR RNA & Disease Seminar Series for the Spring Semester 24/25: News entry NCCR website, incl. titles: lnkd.in/dMZAmeHg @unibern.bsky.social @ethzurich.bsky.social @snsf-ch.bsky.social

Remarkable paper on personalized mRNA vaccines in pancreatic cancer. www.nature.com/articles/s41...

Crick researchers have found that certain aggressive lung cancer cells can develop their own electric network, similar to the body’s nervous system. This can allow tumour cells to go ‘off grid,’ making them harder to treat. www.crick.ac.uk/news/2025-02...

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

Another fantastic NCCR RNA & Disease retreat! Great talks, engaging discussions and plenty of new ideas shared within the vibrant Swiss RNA community. A big thanks to all the organizers!

Explaining the Nobel Prizes in plain language! Don’t miss the Lindau matinee, where our postdoc Ramona Weber will explain this year’s Nobel Prize in Medicine to the public. #ScienceCommunication #Outreach www.schwaebische.de/regional/lin...

If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!

Very interesting study suggesting that the ribotoxic stress response mediates epidermal sunburn reactions. #Inribosomeswetrust www.sciencedirect.com/science/arti...

Microproteins are taking the center stage.

(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why

Are you a scientist working or interested in RNA Translation? Join our starter pack and share ideas, methodologies and tips to advance our knowledge in how life came to be! #RNA #ribosome go.bsky.app/VN78eTo

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.

We ask students to write a research proposal, but we should also teach them about how the project will likely actually unfold.

I'm thrilled to share the latest pre-print from our lab. An in vivo single-cell ribosome profiling study investigating the translational landscape of aging skin. #aging #single-cell #Ribo-sea

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6 www.biorxiv.org/content/10.1...

Hello from the Sendoel Lab, let's give this Elon-free space a shot.

One of the most ancient sequences in biology, the peptidyl transferase center of the ribosome, is not as conserved as we might have thought. #RNA #Ribosomes www.biorxiv.org/content/10.1...

15-year anniversary of discovering PIEZO1 today! Bertrand Coste, then a postdoc in my lab, was knocking down potential mechanosensory ion channels in Neuro2a cells. Candidate 72 yielded a result. Bertrand came into my office and said: ‘I got it!’ — November 13, 2009. A great memory!🧪🧠

It's not often that I wake up and read a paper about corn. Unless it is a #Microproteins paper!!! right up your alley, @cpatiou.bsky.social @microproteins.bsky.social 💻🧬 🧪 🔎 microproteins #GENEsky #RNAsky www.cell.com/cell/fulltex...

For a PhD student, choosing a good lab is 10 times more important than choosing a particular topic to study