Context: Gene expression noise has been observed to decrease with growth rate in E. coli. journals.plos.org/plosbiology/... Consequently, fast growing cells are more phenotypically stable, and this has major implications for phenotypic adaptation www.pnas.org/doi/10.1073/... 2/n

What are the main sources of gene expression noise in bacteria, and why do slower growing bacteria exhibit more expression noise? TLDR: we found growth-rate fluctuations are a key driver of gene expression noise that increase as average growth rate decreases. www.biorxiv.org/content/10.6... 1/n

Sad day... way too soon

Is this f*g real? The comedic tragedy we're living in.

Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate. Please repost and notify potential candidates!

What novel biological dynamics might be hiding under the measurement noise of your time-lapse fluorescence microscopy data? Try our new RealTrace tool to find out! Fantastic work by Bjoern Kscheschinski and others. Tweetorial follows. 1/n www.biorxiv.org/content/10.1...

Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data buff.ly/WYwzw5V @mihaelazavolan.bsky.social @biozentrum.unibas.ch

Hey there, #mRNAtranslation buffs! Our latest multi-faceted dataset from liver cancer cell lines is out in #ScientificData: RNA-seq, ribosome run-off/ribo-seq, polysome-seq, pSILAC. rdcu.be/eC86H. Great team effort spearheaded by Asier Gonzalez Sevine and Niels Schlusser. Happy data crunching!

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

🤔 Can migrating cells 'remember' their past trajectories? In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question: Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history! www.nature.com/articles/s41...

The key point here is rather "who would your rather trust"? Because what is offered is not for anyone to decide for themselves, but rather one is coerced to go along with decisions made by few. People are expected to follow the orders of someone who understands nothing.

OTD in 1949 Soviets forcibly deported 30,000 people from Moldova, after we had "liberated them from fascism". Imagine mass deportations happening today...

Right! Maybe these folks who like to push others into various spheres of influence should try living there.

Really nice to see some fresh initiatives on the Romanian science scene 1health.ro/biotech-boot... kudos to the biomentorhub.ro and all those who made this possible.

Back to reality www.brainonllm.com. Now imagine the cognitive debt on stuff that involves some abstraction...

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops bit.ly/3YTwlNq

'Data analysed by the BBC show that Ukraine's Western allies have paid Russia more for its hydrocarbons than they have given Ukraine in aid.' What a bleak set of statistics.

It's really happening: AI-enabled noise injection in scientific information, from which models are trained, for more automated noisy inferences... journals.plos.org/plosbiology/...

Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE

An alternative to tSNE & UMAP for more accurate data visualization: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data. The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.

Amazing tour-de-force through the representation and analysis of scRNA-data analysis from @dhdegroot.bsky.social @erikvannimwegen.bsky.social‬, with strikingly deep implications. Oranje boven! 😂

Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers led by @erikvannimwegen.bsky.social @biozentrum.unibas.ch shows: the slower cells grow, the more sensitively they respond to their environment.

This is how you do it!

📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz! 🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch @snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social

Surreal!

Yeah, missing metadata in SRA was a motivation for academic.oup.com/bioinformati...

tRNA modification and m6A functionally interact in tuning decoding and mRNA decay. Great collaboration with the Steinmetz lab! Now out in Cell. Submission date still 2023... www.sciencedirect.com/science/arti...

I agree with Minna…she’s smart and she’s right. Ukraine should not take a bad deal that doesnt meet their interests. They are actually winning on the battlefield, according to SACEUR Cavoli’s testimony in front of HASC and SASC…and the Russians will never live up to any agreement unless compelled.

The most profound insights are often also the most simple: growth-rate, by setting the dilution rate of intra-cellular molecules, controls the sensitivity of gene regulatory circuits. In retrospect it seems crazy that this effect seems to have been overlooked so far. www.science.org/doi/10.1126/...

“Zelensky survived a dozen Russian assassination attempts including a special forces assault on his presidential complex.He stood up to Trump. I’m sure he’ll be deeply impressed to learn our Congressional Republicans live as terrified hostages of their own party leader.” ~ @michaeldweiss.bsky.social

You don't believe our nuclear bluffs anymore. Yet you still let us kill with impunity.

How about having a counter for how many times we need to reach this conclusion before acting on it? Here's one tick: genomebiology.biomedcentral.com/articles/10....

What the is early stress response in exercised #muscle for? At least for Klf5, this seems important to shape lipid homeostasis in the acute (fatty acid metabolism) and chronic (lipid synthesis) settings. All this and more in our new paper: #myoblue www.sciencedirect.com/science/arti...

I have exhorted others to share positive news even in these uncertain times for US science. I am really excited that @tamanash.bsky.social’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online. Follow along here 🧪🧵

Look what's been hanging out in Basel University's library (Nietzsche's literary opus) www.unibas.ch/de/Aktuell/N...

The extent to which all these wannabe strong men bend over backwards to satisfy each other's delusions of grandeur has reached phantasmagorical proportions.

Creativity and innovation are precisely what gets us out of crisis situations. Blind hits to these capacities do not.

Issue is that it's not one man

Six children confirmed murdered by the russian ballistic strike on a residential neighbourhood in Kryvyi Rih. On a warm Friday evening. Six children murdered. More than 50 people are injured. The death toll will likely rise. This is beyond evil. This is unforgivable.

In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...

Preprint by the Mühlemann Lab ( @omuhlemann-lab.bsky.social ) with first author Sofia Nasif "UPF1 shuttles between nucleus and cytoplasm independently of its RNA binding and ATPase activities" @biorxivpreprint.bsky.social buff.ly/7McFICn @unibe.ch

If you're using AAVs to develop a gene therapy or to study gene function in skeletal muscle, then this may be of interest to you. In our latest work, we show that AAVs commonly used to deliver transgenes to muscle fibers also target mononuclear cells: www.cell.com/molecular-th...

James Bond spoiler alert! And yeah, madness reigns

Congratulations Anne!

Be sure to follow @eccb-europe.bsky.social for updates about the upcoming conference!

One week left to register and submit abstracts for being considered for talks at our upcoming #EMBO Meeting "RNA Meets Protein Degradation" in Vienna! Check out the program with a fantastic line-up of speakers, including keynotes by Rachel Green and Manu Hedge. meetings.embo.org/event/25-rna...

Dictatorship 101: Its not compulsive liars but compulsive believers that are important.

Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available. More information: www.biozentrum.unibas.ch/education/de... #Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland

OTD in 1939 Nazi Germany, using threat of armed force, annexed Klaipeda from Lithuania. Despite 4 countries signing a treaty assuring Lithuanian territory, they chose appeasement - causing more demands from Hitler & eventually a terrible war. Imagine that happening today...