📅 Program of the NCCR RNA & Disease Seminar Series for the Autumn Semester 25/26:
For more information visit: nccr-rna-and-disease.ch/news/article...
 @unibe.ch @ethz.ch @snf-fns.ch

*️⃣ Step-by-step STAR protocol for Cell-free translation and mRNA decay *️⃣ What to do (and what not to do 😅) guide based on our work on Nsp1 published in @cp-cellreports.bsky.social. www.sciencedirect.com/science/arti... @unibe.ch @mcid-unibe.bsky.social @nccr-rna-disease.bsky.social @snf-fns.ch

🌙🔬 Our “RNA – Master of Versatility” booth at Nacht der Forschung 2025 was a hit! Big thanks to our Science Knights and amazing organizers. 💙🙌 Read more: nccr-rna-and-disease.ch/news/article... #ndfunibern @unibe.ch

Publication by the Polacek lab & collaborators w/ co-1st authors Stefano Gallo & Anastasiia Suspitsyna "Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2 Open Access" @narjournal.bsky.social Cancer academic.oup.com/narcancer/ar... @unibe.ch

Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data buff.ly/WYwzw5V @mihaelazavolan.bsky.social @biozentrum.unibas.ch

🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩‍🔬 Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR! www.nachtderforschung.unibe.ch #ndfunibern @unibe.ch

Finden wir Gold auf der Grossen Schanze? Finden Sie es heraus 👉 youtu.be/fNrbVeYL6Cs. Wollen auch Sie mehr über Ihren Boden erfahren? Dann lassen Sie ihn kostenlos an der Nacht der Forschung analysieren – einfach eine handvoll mitbringen! 📍 Am 06.09., ab 16 Uhr, Grosse Schanze Bern #ndfunibern

An der Nacht der Forschung zeigen wir, wie vielfältig Sprache sein kann! Kommen Sie vorbei – Eintritt frei! 📍 6. September 2025, ab 16 Uhr, Grosse Schanze Bern www.youtube.com/watch?v=gHFn... #ndfunibern

Wer hat das Zeug zum Profi? ⚽ Die #Sportwissenschaft zeigt’s an der Nacht der Forschung! 👉https://www.youtube.com/watch?v=AzNyYS4v2fo. 📍06.09.2025, 16–23 Uhr, Universität Bern #ndfunibern

Dolly (@dollymehta.bsky.social‬) developed a pipeline to screen for conserved #RNA structures across genomes. She then applied it ~14,000 #plastid genomes and identified nearly 60 conserved structures. doi.org/10.1101/2025...

Preprint by the Bukau, Kramer, Shan, Tans & Ban labs w/ co-1st authors J. Santos, M. Günnigmann, R.J. Gora "NAC promotes co-translational protein folding at the ribosomal tunnel exit" @biorxivpreprint.bsky.social buff.ly/fd2rL15 @thebanlab.bsky.social @ethz.ch

Preprint by the Thiel, Heller&Chao labs w/1st author Reto Lang "Stress granules formed during different RNA virus infections show remarkable plasticity &substantial virus-specific differences in their formation&composition" @biorxivpreprint.bsky.social buff.ly/vU7Tdg6 @profvolkerthiel.bsky.social

Preprint by the Mühlemann & Ruepp labs w/ 1st author Alexander Hofer "Analysing the effect of full-length & C-terminally truncated progranulin on proliferation, colony formation, & migration in HepG2 & U87 cells" @biorxivpreprint.bsky.social buff.ly/0BOLAJb @omuhlemann-lab.bsky.social @unibe.ch

Preprint by the Jinek and Martinez labs with 1st author Moritz Pfleiderer " Structural framework for the assembly of the human tRNA ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4 @martinjinek.bsky.social @maxperutzlabs.bsky.social

Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social buff.ly/mL3a71T @dadita.bsky.socia @mihaelazavolan.bsky.social

Paper by the Shan, Ban & Deuerling groups with co-1st authors Martin Gamerdinger & Blanca Echeverria "Mechanism of cotranslational protein N-myristoylation in human cells" in Molecular Cell buff.ly/ddV1RIn @cp-molcell.bsky.social @thebanlab.bsky.social @uni-konstanz.de @ethz.ch @caltech.edu

The 18th Edition of the NCCR RNA & Disease Newsletter - The Messenger has been published: nccr-rna-and-disease.ch/news/article... @omuhlemann-lab.bsky.social @goldlab.bsky.social @martinpacesa.bsky.social @martinjinek.bsky.social @unibe.ch @ethz.ch @snsf.ch

Preprint by the lab of Marc Bühler with first author Josip Ahel "Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin" @biorxivpreprint.bsky.social buff.ly/mTYarjo @aheljo.bsky.social @marcbuhler.bsky.social @fmiscience.bsky.social

Paper by the Lingner lab with 1st author Suna In "TERRA R-loops trigger a switch in telomere maintenance towards break-induced replication and PRIMPOL-dependent repair" @embojournal.org buff.ly/4wG0reE

Publication by the Sander lab with first author Tizian Griesser "Selective inhibition of Mycobacterium tuberculosis GpsI unveils a novel strategy to target the RNA metabolism" @narjournal.bsky.social nccr-rna-and-disease.ch/news/article...

Preprint by the lab of Marc Bühler with first author Jakob Schnabl-Baumgartner "ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment" @biorxivpreprint.bsky.social buff.ly/hAXKoZ3 @jakobschnabl.bsky.social @marcbuhler.bsky.social @fmiscience.bsky.social

Congratulations to Magdalini Polymenidou on being elected a Member of the European Molecular Biology Organization (EMBO)! nccr-rna-and-disease.ch/news/article... @polylab.bsky.social

A recent study by Anne Spang @spanglab.bsky.social and Roche reveals that slowing down intracellular transport of RNA-based drugs can boost their effectiveness. These promising therapies are used to treat rare genetic [email protected] @natcomms.nature.com www.biozentrum.unibas.ch/news/detail/...

Welcome @mandymuller.bsky.social as new associate member of the NCCR RNA & Disease! Her lab recently moved from UMass 🇺🇸 to CHUV Lausanne🇨🇭. Now assoc. prof. at UNIL’s Institute of Microbiology, her research is on virology & RNA biology, focusing on RNA stability during infection. @unibe.ch @ethz.ch

Preprint by the Schneider Lab ( @schneian.bsky.social‬ ) with first author Philip Stettler "Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex" @biorxivpreprint.bsky.social‬ buff.ly/IS2V6ee ‪@unibe.ch‬

Paper by the @karousislab.bsky.social‬ & @omuhlemann-lab.bsky.social‬ with first author Jana Ziegelmüller "Efficient cell-free translation from diverse human cell types" in the Journal of Biological Chemistry buff.ly/TwKbgRp @unibe.ch‬

🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Rotem Karni! 📍 16.06.25 – 16:30 University of Bern, DCBP 📍 17.06.25 – 16:00 ETH Zürich, Hönggerberg More Infos 👉 lnkd.in/dnTtsBvD @unibe.ch @ethz.ch @snf-fns.ch

🎉 Excited to welcome Prof. Raphaëlle Luisier as Assistant Prof in #Omics Data Science for #Transcriptomics! Starting June 2, 2025, she leads research applying #AI & #bioinformatics to tackle neurodegenerative diseases & #cancer. 👉 tiny.cc/yjql001 @nccr-rna-disease.bsky.social @unibe.ch

Our method paper to produce efficient cell-free translation lysates from diverse human cell types is out 🎉 www.jbc.org/article/S002... @unibe.ch @mcid-unibe.bsky.social @muehlemann.bsky.social @nickkouvelas.bsky.social

Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social‬ "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control" @biorxivpreprint.bsky.social‬ buff.ly/hP9Iani ‪@anupamd.bsky.social‬

Preprint by the Gatfield, Ray and Bechtold labs with first author Noelia Martinez-Sanchez "The 18S rRNA methyltransferase, BUD23, is required for appropriate lipid and mitochondrial metabolism" @biorxivpreprint.bsky.social doi.org/10.1101/2025... @dabechtold.bsky.social @unil.bsky.social

The Allain developed a method for the quantification of key properties of macromolecular condensates w/o the need to label the involved molecules for the rapid NMR measurements at modest concentrations & field. #NMRchat nccr-rna-and-disease.ch/news/article... @ethz.ch @natcomms.nature.com

Preprint by the Schimanski & Schneider ( @schneian.bsky.social ) labs & collaborators w/ 1st author Clirim Jetishi "Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53 " @biorxivpreprint.bsky.social buff.ly/ZxzIwnu @unibe.ch

Preprint by Roignant lab & collaborators, incl. the Gatfield & Leidel labs, with co-first authors Michael Stocker & Maria Guillen Angel "Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming" buff.ly/3zwKNQV

Researchers at #unibern, @stanford.edu, and @embl.org have discovered a new cellular mechanism that influences the stability of mRNA. 🧬 The findings could enable new approaches in #cancer therapy: mediarelations.unibe.ch/media_releas.... @nccr-rna-disease.bsky.social

Preprint by the Allain lab & collaborators w/ first author Esteban Finol "Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding" buff.ly/fyHsutu @ethzurich.bsky.social

I am very excited and grateful for the opportunity to present our work and exchange ideas with the research community at LMU Munich hosted by Jonathan Bohlen! @jonathanbohlen.bsky.social @jonathanbohlen.bsky.social @unibe.ch @mcid-unibe.bsky.social @nccr-rna-disease.bsky.social

🔬 NCCR RNA & Disease Seminar Series🔬 We are excited to welcome Dr. Joshua Mendell (HHMI & UT Southwestern Medical Center, Dallas, USA) as the next speaker. More information: lnkd.in/dnTtsBvD @unibe.ch @ethzurich.bsky.social @snf-fns-ch.bsky.social

Review by the lab of @mariusznowacki.bsky.social w/ 1st author Adrian Stefanov "Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination" Biochemical Society Transactions ( @biochemsoc.bsky.social ) buff.ly/6oZt3Qk @izb-unibern.bsky.social @unibe.ch

Publication by the Leidel & Steinmetz labs & collaborators w/ co-1st authors Bastian Linder, Puneet Sharma, Jie Wu "tRNA modifications tune m6A-dependent mRNA decay" in Cell. bit.ly/43bbreZ @mcm5s2u.bsky.social @unibe.ch @cellpress.bsky.social @snsf-ch.bsky.social

📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz! 🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch @snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social

tRNA modification and m6A functionally interact in tuning decoding and mRNA decay. Great collaboration with the Steinmetz lab! Now out in Cell. Submission date still 2023... www.sciencedirect.com/science/arti...

Preprint by the Schneider lab( @schneian.bsky.social ) & collaborators w/ co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @biorxivpreprint.bsky.social buff.ly/Ptdqzs9 @unibe.ch

Paper by the Lingner and Doksani ( @doksanilab.bsky.social ) labs w/ 1st author Trang Thu Nguyen "Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops" @narjournal.bsky.social buff.ly/ToocEA2 @ifomresearch.bsky.social

What happens when our #DNA breaks? ETH Zurich scientists mapped over 150,000 gene interactions to reveal how cells fix their DNA - and how #Cancer cells might be stopped in their tracks. A breakthrough in #CancerResearch could be closer than we think. Read more:

Publication by the Schratt lab with first author Darren Kelly "A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons" @naturecomms.bsky.social buff.ly/OeXxPDb @ethzurich.bsky.social

🔬 NCCR RNA & Disease Seminar Series – We are excited to welcome Dr. Kelly Nguyen from MRC Laboratory of Molecular Biology, Cambridge, UK 📅 Date: 07.04.2025: 16.30 DCBP EG16 08.04.2025: 16:00 ETH Zurich Hönggerberg HPM H33 More information: nccr-rna-and-disease.ch/education/nc...

🦠😷 Researchers at the #unibern have gained new insights into an early mechanism of #coronavirus infection. 👉 mediarelations.unibe.ch/media_releas... @karousislab.bsky.social @nccr-rna-disease.bsky.social @mcid-unibe.bsky.social Image: © Adrian Bothe

Paper by the Polymenidou Lab ( @polylab.bsky.social ) & collaborators w/ 1st author Carlo Scialò "Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures" @cp-neuron.bsky.social buff.ly/UZNif5A @frattalab.bsky.social

Our latest research on #Coronavirus Nsp1 found its home (and a new name) at @cp-cellreports.bsky.social www.cell.com/cell-reports... Thankful to the first (dream) team of my lab and funding for making this happen. @nccr-rna-disease.bsky.social @mcid-unibe.bsky.social @unibe.ch