Our findings suggest that Rmd9 plays a critical role in yeast mitochondrial gene expression by regulating ribosomal biogenesis and mRNA stability bit.ly/3E3bLCu

The application of UNA and LNA modifications allows for the manipulation of oligonucleotide hybridization preference, which in turn enhances the regulatory properties of SSOs and helps to verify the regulatory function of intron 9 bit.ly/40CEwPj

Highly recurrent somatic mutations in the gene encoding the core splicing factor SF3B1 are drivers of multiple cancer types. We discuss how specific transcripts affected by aberrant splicing in SF3B1-mutant cells contribute to the initiation and progression of cancer bit.ly/4bqmRy2

Discoveries of the SMN complex and its unanticipated function in RNP assembly, essential for spliceosomal snRNP biogenesis, advanced understanding of RNA biology and pathogenesis bit.ly/3Xv2hGX

Activated protein synthesis is a hallmark of cancer. Targeting eukaryotic translation initiation factor 4F (eIF4F) complex has been identified as a promising strategy for cancer treatment bit.ly/3F4Sv8g

In this review, we describe the current state of knowledge on adenosine deamination type RNA editing, its involvement in disease development, and its potential as a therapeutic. Lastly, we highlight open challenges and questions that need to be addressed. bit.ly/3F3Vqy1

TRAP1 moonlights as an RNA-binding protein, enhancing translation of the splicing factor LUC7L3 to drive proliferation in high-grade serous ovarian cancer cells. #TRAP1 #RBP #ovariancancer bit.ly/47t3apu

Here, we discuss promising approaches employed to regulate NMD for therapeutic purposes and highlight potential challenges in future clinical development bit.ly/3F86Ron

This review discusses the distribution, regulation, and mechanisms of cytoplasmic polyadenylation element-binding proteins (CPEBs), highlighting their dual roles in either promoting or repressing gene expression depending on cellular context. bit.ly/41pFqhp

A better understanding of how genetic variants contribute to the pathogenesis of cardiac diseases will necessitate exploration of how functions beyond splicing are impacted bit.ly/3DkHM9d

OMA-1 is a zinc finger RNA-binding protein required for oocyte maturation. This work identifies an arginine-rich peptide upstream of the zinc finger required for both RNA binding and embryogenesis bit.ly/3JBkwXg

The absence of an inductive effect confers pseudouridine residues with resistance to enzyme-catalyzed and spontaneous strand cleavage bit.ly/4lF0dFP

We present a method to profile RNA within membrane-less organelles, utilizing in situ transcription and linear amplification. We substantiate the accumulation of immature pre-mRNAs in stress granules bit.ly/4mALAEk

PACT suppresses PKR activation, thus preventing activation of the integrated stress response, NF-κB, and cell death. Dimerization and double-stranded #RNA binding by PACT is required for this function. @kylecottrell.bsky.social @cancer-inst-purdue.bsky.social bit.ly/4oC3Vm7

Spatiotemporal NAIL-MS analysis shows that ALKBH5 does not affect global m6A turnover in human mRNA across subcellular compartments under standard growth conditions bit.ly/4lvVtC6

An internal 8U tract in a recoded influenza A virus segment causes viral polymerase slippage. This in turn leads to truncated protein production, interferon stimulation and reduced virus production bit.ly/4lr9hxX

Two-step VEGF HDB recognition by an aptamer, t44.27, was unveiled. Transient interaction was followed by a tight-complex formation and latter of which is essential to antagonize heparin binding bit.ly/4lb8Uap

FBF-1 RNA binding is not regulated by its C-terminal tail (CT), whereas highly similar FBF-2 is inhibited by its essential CT. Partner protein competes with CT binding to regulate FBF-2 but not FBF-1 bit.ly/3UjicGr

Coevolution of protein-only RNase P and tRNA genes in Aquifex aeolicus: most precursor tRNAs have an A residue upstream of the 5’-cleavage site and generally lack stable acceptor stem extensions bit.ly/4m4oKF0

In silico λ-dynamics accurately predicts interactions of modified RNA to a model RNA-binding protein. The work opens opportunities to study modified RNA-protein interactions without in vitro reagents bit.ly/45v1nO3

Translational helicases eIF4A, Ded1 and Slh1 are found to be dispensable for mRNA scanning in search of the start codon by 40S ribosomes. Instead, mRNA scanning is driven by one-dimensional diffusion bit.ly/4mxiYeY

Visualization of full-length 7SK and 7SL RNAs tertiary atomistic models derived using small-angle x-ray scattering, coarse-grained modelling, and molecular dynamics simulations bit.ly/45pKe8e

Stress granules elevate p21 RNA levels and reduce Rb phosphorylation, promoting cell cycle exit bit.ly/46IvJ1P

Rampant A-to-I RNA editing in Drosophila lncRNA roX1 is non-adaptive and does not provide a selective advantage to the organism bit.ly/45a2C6p

Eukaryotic translation initiation factors (elFs) 5 and 2B compete for eIF2. The three binding sites on eIF2ß (K1, K2, and K3) allow simultaneous binding and faster mutual displacement from elF2y bit.ly/4lgdcgE

Comparison of convergent and divergent T7 RNA polymerase promoters for the production of dsRNA. Analysis was performed to quantify the dsRNA produced and measure dsRNA product quality #dsRNA #T7Polyermase bit.ly/4lZpBXl

RNA modifications in T cells are more stable than expected—primary and immortalized cells share most sites, suggesting common regulatory features can be studied across systems bit.ly/3GP97C8

M6A methylation of the Dand5 3’UTR blocks Bicc1 binding, suggesting it may limit the silencing and/or decay of this and potentially other mRNAs that is induced by flow-sensing cilia bit.ly/44MlRkR

U7 snRNA binds a ring of seven proteins, including Lsm10 and Lsm11, forming U7 snRNP core. This report identifies 3 proteins (blue) that interact with U7 snRNA and may participate in the assembly of this unusual and functionally critical ring bit.ly/46ApBZg

Free tRNALeu shows flexible variable arm and CCA end, reshaped by LeuRS and ribosome binding #tRNA #StructuralBiology bit.ly/45PxJF5

This review provides an overview of RNA aptamer-based ribonucleoprotein purifications for both novice and expert researchers to empower ribonucleoprotein research bit.ly/45Cyj94

Only 3 out of 9 tools for detecting protein-coding sequences beat a naive baseline — popular methods often fail on real data. #genomics #bioinformatics #lncRNA bit.ly/3GgrDD2

This work developed a structure model for the lncRNA SChLAP1, identified protein binding regions, and uncovered an unexpected role for retroviral insertions in forming an RNA conformational landscape bit.ly/440bLhb

Genetic changes in an RNA-editing enzyme reduce editing of a brain receptor gene, leading to abnormal receptor function, neuronal overactivity, seizures, and developmental delay. #RNAediting #Neurodevelopment bit.ly/3TGUN1i

New paper by Kwok Lab, RNA G-quadruplex structure targeting and imaging: recent advances and future directions bit.ly/45C3AJf

This review outlines how the ring-shaped RNA helicase Rho regulates bacterial gene expression, both genome-wide and at specific loci, using constitutive or alternative condition-dependent mechanisms bit.ly/4l22ICy

Human CCR4 deadenylase homolog Angel1 along with endonuclease N4BP2 and the SKI-exosome complex promotes degradation of aberrant mRNAs that lack stop codons causing ribosome stalling at the poly(A)-tail bit.ly/4lsYWC6

Mature sperm contain small RNAs, which are implicated in transmitting extra-chromosomal information from fathers to offspring. How many specific small RNAs are required for impact remains unclear bit.ly/44zI1I4

A bioinformatics approach and wet lab validations identify tissue-specific SEC31A alternative splicing mediated by RBM47 that facilitates lipid transport bit.ly/4nr2YN5

Kraus et al. report absolute miRNA concentrations required for productive cleavage of highly expressed transcripts and identify mouse miRNAs that reach this threshold in vivo bit.ly/44cYNvj

Community science presents an alternative discovery framework for precision ASO drugs. A community voting system facilitates the testing of top designs, followed by experimentation to evaluate and score how well player-designed drugs ameliorated molecular disease phenotypes bit.ly/44u5oTv

RBP Footprint Bioinformatics Grand Challenge: evaluation of novel computational methods to identify RNA-binding protein footprints from structural data bit.ly/4ekdgKL

OLE RNA dimers are depicted as integral membrane noncoding RNAs. This bacterial complex appears to penetrate membranes and mitigate cellular stresses. #ncRNA #RNAWorld @ronbreaker.bsky.social @yalembb.bsky.social bit.ly/3FVn5Cd

The C-terminal domain of EDC4 scaffolds P-body assembly, and its disruption by the NBDY 22–41 peptide activates the p53 pathway and limits tumor proliferation, linking P-body dynamics to gene control bit.ly/448qaGM

Discovery of a novel RNA polymerase III transcribed Alu RNA reveals a canonical and non-canonical tertiary structure and significant differences in association with the Alu RNA protein binding partner bit.ly/3TFUrbf

Zika virus negative-strand synthesis requires interaction between SLA and the viral polymerase, NS5, but the complementary negative-strand structure, SLA´, is not needed for positive-strand synthesis bit.ly/3GhvAHJ

Tpt1 removes an internal RNA 2'-PO4 by transferring it to NAD. This paper reports a crystal structure of Tpt1 bound to a 2'-PO4 RNA that illuminates principles of substrate recognition and catalysis bit.ly/44hsYBv

Mutations in genes encoding RNA exosome subunits cause exosomopathies. A comparative analysis of yeast models reveals shared and unique transcriptomic changes, highlighting distinct consequences bit.ly/44cWA2Z

Mice with cardiomyocyte-specific knockout of #YTHDF3 subjected to #cardiac stress had no increase in protein synthesis or cardiac hypertrophy bit.ly/4ekbfOH