André Schneider, University of Bern
@schneian.bsky.social
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📥 173
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Biochemist interested in mitochondria, trypanosomes and science in general
pinned post!
🎨🔬 Interested in the interface between Art & Science?🎨🔬 Check out my assay "Drawing conclusions" about how doodling and drawing catalyzed my scientific creativity
link.springer.com/article/10.1...
18 days ago
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André Schneider, University of Bern
Yamuna Krishnan
4 days ago
What he said.
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André Schneider, University of Bern
ianVisits
13 days ago
Commiserations to Sir David Attenborough on his 100th birthday, as he is now too old to be allowed to play with LEGO.
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GxxxG motifs of the T. brucei mito OM insertase pATOM36 are essential. Similar motifs also occur in its functional analogues: yeast MIM and human MTCH1/2. - Great collaboration between cvb-lab.bsky.social and
@schneian.bsky.social
. Congratulations to Stephan and Siri.
www.jbc.org/article/S002...
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Disruption of GxxxG motifs in pATOM36 impairs biogenesis of the mitochondrial protein translocase of the outer membrane in Trypanosoma brucei
Mitochondrial biogenesis requires efficient import of cytosolically produced proteins and correct segregation of the mitochondrial genome during cytokinesis. In T. brucei, a parasitic protozoan with a...
https://www.jbc.org/article/S0021-9258(26)01998-8/fulltext
13 days ago
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André Schneider, University of Bern
Will Ratcliff
14 days ago
Really reading the literature has always given scientists in training a huge advantage. But these days, it seems like a superpower. So many people skim/AI summarize papers, but then you miss out on so much! It's like reading a description of a Van Gogh painting vs. staring at it for 2h.
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🎨🔬 Interested in the interface between Art & Science?🎨🔬 Check out my assay "Drawing conclusions" about how doodling and drawing catalyzed my scientific creativity
link.springer.com/article/10.1...
18 days ago
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Absolutely fantastic!
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23 days ago
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André Schneider, University of Bern
c0nc0rdance
27 days ago
A COLOSSAL 62 ft long (20 m) hyper-predatory octopus in the Late Cretaceous that could comfortably eat a Mosasaur. I have never wanted a time machine MORE.
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André Schneider, University of Bern
NCCR RNA & Disease
29 days ago
Imagine curing diseases by rewriting the code of life!🧬Discover how CRISPR/Cas9, guided by RNA, acts as molecular scissors to precisely edit genomes, for which the 2020 Nobel Prize in Chemistry was awarded
www.youtube.com/watch?v=0rz-...
@snsf.ch
@unibe.ch
@ethz.ch
@nobelprize.org
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RNA Explained: Rewriting the Code of Life - CRISPR/Cas9 and the Genome Editing Revolution
YouTube video by NCCR RNA & Disease
https://www.youtube.com/watch?v=0rz-ZZYvz3g
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André Schneider, University of Bern
Nigel Moss 🌻
about 1 month ago
Listening to In Our Time on
#BBCRadio4
discussing Escher, and I'm reminded of this classic from the New Yorker
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André Schneider, University of Bern
Harmit Singh Malik
about 1 month ago
They should have called it Straight of Schrödinger: it is both open and closed depending on whom you talk to and when.
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🆕T. brucei Kozak sequences are unusual, hard to detect, but important for translation regulation - Check out the work conceived💡, carried out🔬and written up ✍️ by Philip Stettler, with only a minor contributions from me and the Polacek group - CONGRATULATIONS🎉👏
academic.oup.com/nar/article-...
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Kozak sequences regulate gene expression in Trypanosoma brucei
Abstract. The Kozak consensus sequence around the AUG start codon of mRNAs allows efficient cytosolic translation initiation in eukaryotes. It has not yet
https://academic.oup.com/nar/article-abstract/doi/10.1093/nar/gkag310/8644109?utm_source=authortollfreelink&utm_campaign=nar&utm_medium=email
about 1 month ago
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André Schneider, University of Bern
John Bistline
about 2 months ago
This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.
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André Schneider, University of Bern
Ian Sudbery
about 2 months ago
This is of course hard on the junior and untenured, but not as hard as some seem to think. Is it better for your metees to burn through 5 postdocs so that one lucky one gets a CNS paper, or is it better for all 5 to get respectable, but less glam publications?
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André Schneider, University of Bern
Ian Sudbery
about 2 months ago
Deciding not to submit to CNS is, in part, deciding to be happier doing good science and having a "sucessful" career, as measured by traditional measures. Will chasing glam journals hurt my chances of making full Prof? Who knows? Do I care that much about making full Prof? Not really.
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André Schneider, University of Bern
Faria Tryps Lab
about 2 months ago
(1/7) How does T. brucei achieve a 140-fold stoichiometric excess of VSG mRNA over upstream ESAGs from a single polycistronic unit? Our latest research in
@natmicrobiol.nature.com
reveals a mechanism of spatially regulated RNA decay to fine-tune expression of virulence genes
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André Schneider, University of Bern
Jonathan Eisen
about 2 months ago
Nice article about cave microbes and the work of people like Hazel Barton from BBC News
www.bbc.com/future/artic...
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'Predators that just run in and grab, stab and kill': The deep cave bacteria resistant to modern medicine
In the brutal world of deep caves, bacteria live in a miniature world of terror. The weapons they have evolved can defeat antibiotics – but now they are inspiring powerful new drugs.
https://www.bbc.com/future/article/20260318-the-deep-cave-bacteria-resistant-to-modern-medicine
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André Schneider, University of Bern
Writing our Destiny aka Andrew
2 months ago
OMG, the passenger riding along!
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André Schneider, University of Bern
OMühlemann lab
2 months ago
Congratulations Sebastian!
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André Schneider, University of Bern
Marie Ruiz-Vidal
3 months ago
Hergé
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André Schneider, University of Bern
Sebastian Shaw
3 months ago
🚨 Postdoc position 🚨 I’m moving back to Switzerland this summer to launch my lab at the University of Zurich and am recruiting a Postdoctoral Fellow (start: late 2026). Details & application:
jobs.uzh.ch/job-vacancie...
. Please share! 😊
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UZH: Postdoc
The newly founded Cryptosporidium lab at the Institute of Parasitology focuses on the genetic and transcriptomic basis of parasite virulence and persistence in Cryptosporidium and is committed to incl...
https://jobs.uzh.ch/job-vacancies/postdoc/e639e72a-6302-42f7-9a1e-cbcb2f2c4a57
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How many mechanistically different protein insertases are there? Maybe fewer than you think! Check out our tale of pATOM36, MIM, MTCH1/2 and YidC in the preprint by Stephan Berger of the Schneider and the Ballmoos Labs.
www.biorxiv.org/cgi/content/...
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https://www.biorxiv.org/cgi/content/short/2026.02.13.705746v1
3 months ago
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André Schneider, University of Bern
Sophien Kamoun
3 months ago
Vorholt Lab re-created endosymbiosis in the lab: injected bacteria into a fungus and evolved a heritable partnership. Evolution, fast-forwarded.
doi.org/10.1038/s415...
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Inducing novel endosymbioses by implanting bacteria in fungi - Nature
A study presents an approach to establish and track a new endosymbiotic partnership by implanting bacteria in a non-host fungus and shows that stable inheritance of the implanted bacteria is possible ...
https://doi.org/10.1038/s41586-024-08010-x
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Yasin Dagdas
3 months ago
This is a beautiful case of how real science happens & serious scientists work. Kudos to both set of authors: “This has been a humbling experience, but one that speaks to the self-correcting nature of the scientific endeavor.”
www.science.org/doi/10.1126/...
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RETRACTED: Integrative phylogenomics positions sponges at the root of the animal tree
Determining whether sponges or ctenophores root the animal tree has important implications for understanding early animal evolution. Here, we examined support for these competing hypotheses by constru...
https://www.science.org/doi/10.1126/science.adw9456#elettersSection
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André Schneider, University of Bern
3 months ago
With new book 'The Dawn Fisherman' out soon, delighted to have explained with co-author Ralf Dahm to
@meganwollerton.bsky.social
at National Geographic how pus, old bandages (& later, salmon gonads!) led to discovery of DNA in freezing cold castle kitchen!
www.nationalgeographic.com/history/arti...
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The discovery of DNA started with this overlooked scientist
In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would later reshape biology and our understanding of life itself.
https://www.nationalgeographic.com/history/article/friedrich-miescher-nucleic-acid-nuclein-dna-helix
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André Schneider, University of Bern
Dewar Lab
4 months ago
🧬Fully Funded PhD Mitochondria|Protein Homeostasis|Antibody Technologies 🤝In collaboration with
@menzieslab.bsky.social
and Nick Robinson
@blslancasteruni.bsky.social
🎓UK students only ⏰6th March 2026 📩Enquiries:
[email protected]
www.findaphd.com/phds/project...
#phdopportunity
#mitochondria
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Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University on FindAPhD.com
PhD Project - Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University, listed on FindAPhD.com
https://www.findaphd.com/phds/project/safeguarding-the-powerhouse-antibody-based-characterisation-of-trypanosome-mitochondrial-quality-control-proteins/?p193962
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I find this kind of ironic, this is what happens if AI generated content is not checked.
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4 months ago
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This could be big! - Got it in January
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4 months ago
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André Schneider, University of Bern
Christophe 🔬 Leterrier
4 months ago
Tracking the details of an experiment in successively cited Methods sections
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André Schneider, University of Bern
John Shirley
4 months ago
Nature can be wickedly cunning.
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Tropical spiders craft giant doppelgängers as decoys
The extraordinary anti-predator strategy of two tiny, orb-weaving spider species has been uncovered by scientists from The Australian National University (ANU) and the University of Florida.
https://phys.org/news/2025-11-tropical-spiders-craft-giant-doppelgngers.html
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André Schneider, University of Bern
5 months ago
💊 Resistance against antibiotics is a severe threat - also in 🇨🇭 The Forum Phagentherapie discusses with experts and the public about solutions. 👉 Register for our phage forum on Jan 31 in Basel:
lnkd.in/e-im3e-g
‼️ Voices from society and patients are vital to develop viable approaches.
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André Schneider, University of Bern
Dr. Raphael Marschall
5 months ago
The winner of ✨
#planetaryScience
image of 2025 ✨ is ✨Uranus as seen by JWST✨ Taken on: October 6, 2025 Credit: NASA/
@esa.int
/CSA/
@stsci.edu
/
@andrealuck.bsky.social
Full resolution:
www.flickr.com/photos/19227...
🧪⚛️
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David got company!
5 months ago
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André Schneider, University of Bern
Mark Histed
5 months ago
Well, this is an utter disaster for science. This gutting of peer review is very likely driven by Project 2025/OMB/Vought, very likely is about funding junk science, and very likely is coming for
#NIH
and biomedical research next. 🧪
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André Schneider, University of Bern
Carl T. Bergstrom
5 months ago
This is actually the trippiest thing I've ever seen that was not deliberately created by M C Fucking Escher. It straight up took me over a minute to make sense of and now I can't go back. This is the white-and-gold dress on a gram a week of trenbolone.
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In the early 1980ies the labs of Cordingley, Boothroyd and Borst discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events.
academic.oup.com/nar/article/...
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A trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA
Abstract. Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these
https://academic.oup.com/nar/article/53/22/gkaf1327/8378191
5 months ago
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André Schneider, University of Bern
Andrew Straw
6 months ago
Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too! preprint (with videos!) + thread 🧵 Precise, individualized foraging flights in honey
#bees
🐝 revealed by multicopter drone-based tracking
www.biorxiv.org/content/10.6...
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André Schneider, University of Bern
Alex Klotz
5 months ago
I wanted to take the bus but it was stationary
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André Schneider, University of Bern
Itai Yanai
6 months ago
How does a caterpillar completely dissolve inside its chrysalis, before reconstructing itself in the shape of a butterfly? “Metamorphosis is wild,” marvels historian Oren Harman in his beautiful new book, which I reviewed for this week's
@nature.com
www.nature.com/articles/d41...
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André Schneider, University of Bern
Eva Nowack
6 months ago
📢Postdoc position available!🧪🧫🧬 Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions. Full details & application:
karriere.hhu.de//index.php?a...
. Please help us get the word out!
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Postdoc (m/f/d) in Endosymbiosis Research
https://karriere.hhu.de//index.php?ac=jobad&id=535
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André Schneider, University of Bern
Paolo Crosetto
6 months ago
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma. It's *scientific publishing*. We call this the Drain of Scientific Publishing. Paper:
arxiv.org/abs/2511.04820
Background:
doi.org/10.1162/qss_...
Thread
@markhanson.fediscience.org.ap.brid.gy
👇
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André Schneider, University of Bern
Barba Papa 🏳️🌈 The Bear Did Lady
6 months ago
Schrödinger: Excuse me, miss, can I borrow that box for a science experiment? Pandora: Sure, be my guest.
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- Picture by Raymond Gosling and Rosalind Franklin, King's College - DNA by Rudolf Signer, University of Bern
add a skeleton here at some point
about 1 year ago
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André Schneider, University of Bern
Dacks Lab (Evolutionary Cell Biology)
6 months ago
Holy smokes!!!!
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André Schneider, University of Bern
Philippe Bastin's Lab
over 1 year ago
Here we are! To celebrate our arrival, here is a
#trypanosome
expanded ~13 times & stained for tubulin, individual cortical
#microtubules
can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to
@centriolelab.bsky.social
for training
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André Schneider, University of Bern
NCCR RNA & Disease
7 months ago
Paper by the Schneider lab(
@schneian.bsky.social
) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome"
@febsj.bsky.social
nccr-rna-and-disease.ch/news/article...
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Multiple so called "quality control checks" by the journal almost killed us. - But now it is out! A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out. Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
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FEBS Press
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we ...
http://doi.org/10.1111/febs.70297
7 months ago
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André Schneider, University of Bern
PLOS Biology
7 months ago
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in
#Trypanosome
.
@mbonhivers.bsky.social
&co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures
@plosbiology.org
🧪
plos.io/4n3bWi6
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André Schneider, University of Bern
Jeffrey J. Hall
8 months ago
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
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...and now something for RNA enthusiasts @nccr-rna-disease.bsky.social The function of the vault complex has finally been solved: it is a lampshade.
8 months ago
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Another case of convergent evolution?
8 months ago
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