vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki) www.jobs.gla.ac.uk/job/research...

Our 2025 Sep issue bit.ly/2N9R8Es reviews species sanitation & structural resilience in malaria control, animal trypanosomosis control, parasite genome organization, Leishmania attachment in sandflies, nonchemotherapeutic nematode control, tick & host microbiotas, parasitic neural manipulation &more

A study in Nature Medicine uses a supervised deep neural network to explain the network of concurrent molecular and macroscopic patterns related to insurgence and course of myalgic encephalomyelitis/chronic fatigue syndrome. go.nature.com/4mhoLpp #medsky 🧪

Drs @singh-parul.bsky.social @trypsleon.bsky.social‬ Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization. #Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment www.cell.com/trends/paras...

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

#NewResearch A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity #MicroSky 🦠 www.nature.com/articles/s41...

#NewResearch Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social #BacteriaCellWall #MicroSky 🦠 www.nature.com/articles/s41...

#NewResearch Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity. #MicroSky 🦠 www.nature.com/articles/s41...

New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries www.sciencedirect.com/science/arti...

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...

And what a pleasure it was!!!

We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity: www.cell.com/trends/paras...

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1

Predicting the translation efficiency of messenger RNA in mammalian cells go.nature.com/4mgXR0C

Generalizable direct protein sequencing with InstaNexus https://www.biorxiv.org/content/10.1101/2025.07.25.666861v1

Over a week since Graduation already! Débora shares her experience: "Through all challenges I have had to overcome, very notably moving from the other side of the globe alone, I know I would not be here if it were not for my degree and the Department of Biology..." Read more here - bit.ly/4fznGXD

Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning pubmed.ncbi.nlm.nih.gov/40735494/

🚨 2-year post-doc position available in my lab. More details below. Please repost! acrobat.adobe.com/id/urn:aaid:...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection go.nature.com/481iCHt rdcu.be/exfh8

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions https://www.biorxiv.org/content/10.1101/2025.07.22.666098v1

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo https://www.biorxiv.org/content/10.1101/2025.07.22.666069v1

Out now: Structure of an archaeal ribosome reveals a divergent active site and hibernation factor @jhdcate.bsky.social @banfieldlab.bsky.social @diptinayak.bsky.social & co #microsky www.nature.com/articles/s41...

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism! rdcu.be/ewPA2

Don’t miss this opportunity!! ⬇️⬇️ excellent lab and very exciting projects!

5' untranslated regions tune Toxoplasma translation https://www.biorxiv.org/content/10.1101/2025.07.14.664749v1

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids www.biorxiv.org/content/10.1101/2025.07.08.663533v1

www.biorxiv.org/content/10.1... Check this 💥💥💥

Finally out! Mass spec analysis of #trypanosome flagellar tubulins reveals some surprises including a new #glutamylation site on beta-tubulin! Many thanks to the teams of Julia Chamot-Rooke and Mariette Matondo! pubs.acs.org/doi/10.1021/...

Mass Spectrometry Reveals Novel Features of Tubulin Polyglutamylation in the Flagellum of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40634267/

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase - @uchichemistry.bsky.social bit.ly/46yTSaT

Liquid-like transcription condensates locally constrain chromatin in living human cells https://www.biorxiv.org/content/10.1101/2025.07.05.663270v1

A nucleation distance sets the cell size-dependent P-body assembly https://www.biorxiv.org/content/10.1101/2025.07.08.663506v1

Postdoc position open to investigate chronic Toxoplasma infection! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

(1/n) New preprint from @claricehongky.bsky.social Fan Fang Varshini Ramanathan in collab w Jie Liu. Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

Excellent opportunity for a postdoc to join @sjorsscheres.bsky.social in the LMB’s Structural Studies Division to work on #cryoEM structure determination of amyloid filaments in a lively, multi-disciplinary group. Read more: www.nature.com/naturecareer... Closes 03 AUG #PostdocJobs #ScienceJobs

I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor. doi.org/10.1038/s414...

www.nature.com/articles/s41... Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!

Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉 Many thanks to Céleste Gangolphe for the exceptional work!

#ResearchBriefing A newly identified human cytomegalovirus cell entry complex couples the canonical envelope glycoprotein H with a mimic of glycoprotein L to incorporate the immune-evasion molecule UL141 into virions. This complex is a promising target for vaccines. www.nature.com/articles/s41...

Straight from Antarctica: our new July issue has arrived! Sample it here: www.nature.com/nmicrobiol/v...

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social

🥳♥️

Next generation genetic screens in kinetoplastids pubmed.ncbi.nlm.nih.gov/40530689/

Histo-LCM-Hi-C reveals the 3D chromatin conformation of spatially localized rare cells in tissues at high resolution https://www.biorxiv.org/content/10.1101/2025.06.10.658807v1

Fantastic news! 👏👏👏 How the #malaria #parasite evades the immune system… and how the human body fights back: @sam-chamberlain.bsky.social and @parasitematt.bsky.social @ox.ac.uk make ground-breaking discovery, just published in @nature.com. Read more ⬇️

This is very clever www.nature.com/articles/s41...

🧬 Sticky situation in the nucleolus? A new study shows that the ‘Treacle’ protein forms liquid-like condensates that organise nucleolar structure and keep ribosome production flowing. #Genetics #CellBio buff.ly/eyOFzvR