New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion. @tiengwe-tryplab.bsky.social @zephyris-science.bsky.social @fariatrypslab.bsky.social www.imperial.ac.uk/news/article...

New preprint from @tiengwe-tryplab.bsky.social _How do trypanosomes diversify their surface antigens? We found ESAG3 - a new glucosyltransferase - novel primary and quaternary structure that's essential for generating diversity in antibody epitopes. www.biorxiv.org/content/10.6...

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes https://www.biorxiv.org/content/10.64898/2026.01.27.701950v1

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes www.biorxiv.org/content/10.64898/2026.01.27.701950v1

Here it is... an amazing team effort from 3 Masters students and collaborators! Thanks to reviewers for constructive comments. Plasmids available here: www.addgene.org/search/catal... royalsocietypublishing.org/doi/10.1098/...

"Enter BioEmu-1—a deep learning model that can generate thousands of protein structures per hour on a single graphics processing unit. Today, we are making BioEmu-1 open-source" #science #ai #microsoft www.microsoft.com/en-us/resear...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

If you're a non-UK scientist who wants to come to the UK for a postdoc, this year's Newton Fellowships are now open. You'll need a lab to host you (which could be me, but truly, could be any PI, so get in touch with someone you'd like to work with!) royalsociety.org/grants/newto...

Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! Please share! jobs.york.ac.uk/vacancy/post...

Excited to share our gene tagging toolkit! It's a protein tagging system that maintains regulatory elements. Originally built for Kinetoplastids but adaptable to any system - no parasite-specific sequences in vectors. Prefect for studying post-transcriptional control! www.biorxiv.org/content/10.1...