Do you use or analyse trypanosomes, leishmania, etc. genomes? You might find this useful - we've got loads of genomes, but an annotation gap for mRNAs, this tool aims to fix that.

Want to computationally analyse a genome's-worth of protein localisations? Have data for 4.5 million cells at your fingertips using this Python tool to access TrypTag.org data www.biorxiv.org/content/10.6... (we're out of beta and releasing on time 🎂)

A brief communiqué on the temporary funding pause recently announced by UKRI detailing a summary of the main changes can now be found on the network website. www.cilianetwork.org.uk/news/4687/uk...

The AlphaFold Database, jointly developed with Google DeepMind, now contains datasets from specialist communities. This includes rich datasets for microbes, viruses & parasites associated with tropical diseases. Explore the new datasets in the AlphaFold Database. www.ebi.ac.uk/about/news/u...

Better parasite protein structure predictions, now on the official @EMBL-EBI Alphafold database. www.ebi.ac.uk/about/news/u...

Welcome, piles of slop filling up the journals with clouds of useless wordy garbage. Case in point:

New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion. @tiengwe-tryplab.bsky.social @zephyris-science.bsky.social @fariatrypslab.bsky.social www.imperial.ac.uk/news/article...

It was very interesting contributing to this, fascinating to go head to head with cutting edge AI models. www.nature.com/articles/s41...

Hot take. Stop AI-generated peer reviews by encouraging journals run the paper through a few LLMs to check for basic factual and statistical errors.

Check out this thread for a nice breakdown (with videos!) of some of our questions about how dyneins generate a beat, all from our new preprint:

Very excited to share this one! Our comprehensive structure, genetics and biophysics dissection of which flagellar dyneins and other proteins are needed for flagella to beat and drive cells swimming behaviours: www.biorxiv.org/content/10.1...

tryptag.org update now done... Now with gene annotations from the latest genome, better links to source data (on BioImage Archive www.ebi.ac.uk/biostudies/B...), fixed missing images, and better cell cycle stage examples (selected using github.com/zephyris/try...). Any problems, let me know.

I'm working on some server changes for tryptag.org, you might see missing data (particularly missing images)... But don't worry, it will all be up again soon!

After a hiatus, the discoba lineage-optimised Alphafold2 structure predictions are back up! Get your improved Trypanosoma and Leishmania structure predictions here. Try out the Google Colab iPython notebook (and let me know if you have any problems) colab.research.google.com/github/zephy...

Watch the related Science Sketch video: youtu.be/uBpPMyVTj5c?..., created by @marionamec.bsky.social

A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...

Very cool new study about how multiple cilia self-coordinate for swimming by @micromotility.bsky.social www.biorxiv.org/content/10.1...

Thank you @dereklowe.bsky.social for featuring our work in In the Pipeline (www.science.org/content/blog...). It's been 6 year journey, but we finally have a target, a mechanism and a paper! www.nature.com/articles/s41...

Having spent an afternoon developing some models with Google AI Studio, Ted Chiang seems more prescient than ever. It's only about a page, worth reading right now! www.nature.com/articles/350...

Hiro's paper is out! @hiro-cg5445.bsky.social Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors. Big congratulations and thank you to anyone involved! www.nature.com/articles/s41...

Small molecule targeting intrinsically disordered protein domains to help neurodegeneration, really great to finally have this collab with @hymanlab.bsky.social out! www.nature.com/articles/s41...