After a hiatus, the discoba lineage-optimised Alphafold2 structure predictions are back up! Get your improved Trypanosoma and Leishmania structure predictions here. Try out the Google Colab iPython notebook (and let me know if you have any problems) colab.research.google.com/github/zephy...

Watch the related Science Sketch video: youtu.be/uBpPMyVTj5c?..., created by @marionamec.bsky.social

A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...

Very cool new study about how multiple cilia self-coordinate for swimming by @micromotility.bsky.social www.biorxiv.org/content/10.1...

Thank you @dereklowe.bsky.social for featuring our work in In the Pipeline (www.science.org/content/blog...). It's been 6 year journey, but we finally have a target, a mechanism and a paper! www.nature.com/articles/s41...

Having spent an afternoon developing some models with Google AI Studio, Ted Chiang seems more prescient than ever. It's only about a page, worth reading right now! www.nature.com/articles/350...

Hiro's paper is out! @hiro-cg5445.bsky.social Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors. Big congratulations and thank you to anyone involved! www.nature.com/articles/s41...

Small molecule targeting intrinsically disordered protein domains to help neurodegeneration, really great to finally have this collab with @hymanlab.bsky.social out! www.nature.com/articles/s41...