Distinct nanoscale membrane organizations of mucins and trans-sialidases in Trypanosoma cruzi www.biorxiv.org/content/10.64898/2026.02.23.707421v1

Roz Laing and I are looking for a combined lab manager/(PD)RA to contribute to ongoing projects in the lab: initially for 18 months but hopefully a longer-term post, subject to funding. Closing date is 23 March. Please get in touch if you have any questions about the role. tinyurl.com/246m632j

Newest collaborative paper out now on biorxiv - new genome and VSG arrangements in T. congolense, excellent work by Marija! In the words of @scotomorph.bsky.social T. congolense ≠ T. brucei www.biorxiv.org/content/10.6... @rmc9z.bsky.social @keithrmatthews.bsky.social

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei https://www.biorxiv.org/content/10.64898/2026.02.19.706783v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin pubmed.ncbi.nlm.nih.gov/41709455/

T. congolense ≠ T. brucei

We are pleased to share a pre-print of collaborative work @scotomorph.bsky.social @janemunday.bsky.social @keithrmatthews.bsky.social @goldrieve.bsky.social describing the genome of Trypanosoma congolense and the organisation of VSG genes for immune evasion www.biorxiv.org/content/10.6...

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.02.19.706783v1

A Python module for programmatic access to TrypTag genome-wide subcellular protein localisation data in Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.02.17.706163v1

Histone H3 Ser10 phosphorylation occurs exclusively in replicative stages and peaks during mitosis in Trypanosoma cruzi www.biorxiv.org/content/10.64898/2026.02.16.706091v1

Comprehensive genomic analysis of Trypanosoma rangeli reveals key insights into the biology and evolution of this non-virulent American mammalian trypanosome www.biorxiv.org/content/10.64898/2026.02.11.700901v1

Euglenozoa are paraphyletic if the eukaryotic root lies between glycomonads and the rest of eukaryotes. Response to 'The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature' pubmed.ncbi.nlm.nih.gov/41685547/

The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature - a critical evaluation of Akiyoshi, 2025 pubmed.ncbi.nlm.nih.gov/41685546/

Differential regulatory role of AU-rich and GU-rich elements in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41657982/

High-Throughput Cell Cycle and Morphological Analysis of Leishmania mexicana and Other Kinetoplastids pubmed.ncbi.nlm.nih.gov/41627758/

A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/

Distinct Repeat Architecture Landscapes in the Proteomes of Protozoan Parasites www.biorxiv.org/content/10.64898/2026.01.20.700692v1

We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR! It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting. academic.oup.com/nar/article/...

If you assume GPI insertion signals = surface destination, trypanosomes disagree. Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface. tinyurl.com/gpi-anchor #MembraneBiology #CellSurface

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in Leishmania mexicana www.biorxiv.org/content/10.64898/2026.01.15.699675v1

mimicDetector: a pipeline for protein motif mimicry detection in host-pathogen interactions pubmed.ncbi.nlm.nih.gov/41525347/

The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomes www.biorxiv.org/content/10.64898/2026.01.12.698981v1

The Nucleoporin MLP1 of the nuclear basket is essential for nuclear integrity and ploidy maintenance in Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.01.09.698594v1

An intimate view of Leishmania infantum chromosome ends reveals less conserved subtelomeric regions and variations in the telomeric repeat pubmed.ncbi.nlm.nih.gov/41500311/

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression pubmed.ncbi.nlm.nih.gov/41488253/

A Genome-Wide Genetic Screen Identifies a Novel kDNA Replication Protein in Trypanosomes www.biorxiv.org/content/10.64898/2026.01.05.697628v1

Origins and consequences of kinetoplast loss in trypanosomes www.biorxiv.org/content/10.64898/2025.12.24.696353v1

I am trilled to share my latest publication where we contribute to the knowledge of how ATR kinase, a DNA damage response factor, modulates DNA replication timing during stress in Leishmania major. Huge thanks to @rmc9z.bsky.social, @LuizTosi and the collaborators for the support and guidance!

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins https://www.biorxiv.org/content/10.1101/2025.04.22.649942v1

Leishmania mexicana telomeres at high resolution: Ku80, TERT, and alternative lengthening mechanisms pubmed.ncbi.nlm.nih.gov/41345908/

Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees pubmed.ncbi.nlm.nih.gov/41327030/

Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes pubmed.ncbi.nlm.nih.gov/41290700/

💥CONTAM CALENDAR GIVEAWAY💥 Here's your chance to win a ContamCalendar 2026! 🗓️🍄🦠 Just follow @contamclub.bsky.social and repost this post to enter the competition Winner will be randomly selected from Bluesky or Twitter on Wednesday @ 6pm UTC

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major pubmed.ncbi.nlm.nih.gov/41284724/

The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41247779/

Variation in surface protein expression leads to heterogeneous Trypanosoma cruzi populations during host cell infection pubmed.ncbi.nlm.nih.gov/41224774/

Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia pubmed.ncbi.nlm.nih.gov/41193429/

The evolutionary origin of host association and polycistronic transcription in trypanosomatids www.biorxiv.org/content/10.1101/2025.10.27.684775v1

academic.oup.com/nar/article/... Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab! @dundee.ac.uk @ybri-uoy.bsky.social @york.ac.uk

Our lab has two funded PhDs to start in 2026 via the NorthWestBio programme Project details here www.gla.ac.uk/postgraduate... ...and here www.gla.ac.uk/postgraduate... Application deadline is Nov 21st 2025; apply here: www.gla.ac.uk/postgraduate...

Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/

The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures pubmed.ncbi.nlm.nih.gov/41040140/

Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended www.biorxiv.org/content/10.1101/2025.10.03.680260v1

Splice site diversity and abundance of non-canonical introns in diplonemids (Diplonemea, Euglenozoa) pubmed.ncbi.nlm.nih.gov/41027712/

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering www.biorxiv.org/content/10.1101/2025.09.26.678825v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin. www.biorxiv.org/content/10.1101/2025.09.24.678203v1

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana www.biorxiv.org/content/10.1101/2025.09.19.677349v1

New pre-print from Guy @goldrieve.bsky.social on vsgseq2 - a much improved, robust tool to analyse VSG expression in tryps

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression www.biorxiv.org/content/10.1101/2025.09.08.674917v1