Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/42153621/

RNA decay sharpens antigenic variation in trypanosomes pubmed.ncbi.nlm.nih.gov/42156246/

Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/42138349/

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression pubmed.ncbi.nlm.nih.gov/42127156/

Comparative lipidomic profiling of the livestock pathogens Trypanosoma congolense and Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.04.21.719795v1

(1/7) How does T. brucei achieve a 140-fold stoichiometric excess of VSG mRNA over upstream ESAGs from a single polycistronic unit? Our latest research in @natmicrobiol.nature.com reveals a mechanism of spatially regulated RNA decay to fine-tune expression of virulence genes

Cell motility influences microfluidics capturing in scRNA-seq pubmed.ncbi.nlm.nih.gov/41971304/

Kozak sequences regulate gene expression in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41954982/

The trypanosome mRNA decapping enzyme ALPH1 prefers caps without m7G methylation and produces diphosphate RNA pubmed.ncbi.nlm.nih.gov/41954986/

Very happy to have contributed some confirmatory experiments to Jaclyn Smith and Monica Mugnier's excellent paper - out now @nature.com www.nature.com/articles/s41... @johnshopkinssph.bsky.social @rmc9z.bsky.social

DNA damage drives antigen diversification in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41951731/

Specialized RNA decay fine-tunes monogenic antigen expression in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41912648/

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes www.biorxiv.org/content/10.64898/2026.01.27.701950v1

Pathways of mRNA decay in trypanosomes pubmed.ncbi.nlm.nih.gov/41812468/

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins pubmed.ncbi.nlm.nih.gov/41805585/

Distinct nanoscale membrane organizations of mucins and trans-sialidases in Trypanosoma cruzi www.biorxiv.org/content/10.64898/2026.02.23.707421v1

Roz Laing and I are looking for a combined lab manager/(PD)RA to contribute to ongoing projects in the lab: initially for 18 months but hopefully a longer-term post, subject to funding. Closing date is 23 March. Please get in touch if you have any questions about the role. tinyurl.com/246m632j

Newest collaborative paper out now on biorxiv - new genome and VSG arrangements in T. congolense, excellent work by Marija! In the words of @scotomorph.bsky.social T. congolense ≠ T. brucei www.biorxiv.org/content/10.6... @rmc9z.bsky.social @keithrmatthews.bsky.social

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei https://www.biorxiv.org/content/10.64898/2026.02.19.706783v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin pubmed.ncbi.nlm.nih.gov/41709455/

T. congolense ≠ T. brucei

We are pleased to share a pre-print of collaborative work @scotomorph.bsky.social @janemunday.bsky.social @keithrmatthews.bsky.social @goldrieve.bsky.social describing the genome of Trypanosoma congolense and the organisation of VSG genes for immune evasion www.biorxiv.org/content/10.6...

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.02.19.706783v1

A Python module for programmatic access to TrypTag genome-wide subcellular protein localisation data in Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.02.17.706163v1

Histone H3 Ser10 phosphorylation occurs exclusively in replicative stages and peaks during mitosis in Trypanosoma cruzi www.biorxiv.org/content/10.64898/2026.02.16.706091v1

Comprehensive genomic analysis of Trypanosoma rangeli reveals key insights into the biology and evolution of this non-virulent American mammalian trypanosome www.biorxiv.org/content/10.64898/2026.02.11.700901v1

Euglenozoa are paraphyletic if the eukaryotic root lies between glycomonads and the rest of eukaryotes. Response to 'The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature' pubmed.ncbi.nlm.nih.gov/41685547/

The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature - a critical evaluation of Akiyoshi, 2025 pubmed.ncbi.nlm.nih.gov/41685546/

Differential regulatory role of AU-rich and GU-rich elements in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41657982/

High-Throughput Cell Cycle and Morphological Analysis of Leishmania mexicana and Other Kinetoplastids pubmed.ncbi.nlm.nih.gov/41627758/

A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/

Distinct Repeat Architecture Landscapes in the Proteomes of Protozoan Parasites www.biorxiv.org/content/10.64898/2026.01.20.700692v1

We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR! It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting. academic.oup.com/nar/article/...

If you assume GPI insertion signals = surface destination, trypanosomes disagree. Tom’s work shows GPI-anchored protein sorting occurs independently of GPI insertion signals, hinting at alternative sorting logic at the parasite surface. tinyurl.com/gpi-anchor #MembraneBiology #CellSurface

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in Leishmania mexicana www.biorxiv.org/content/10.64898/2026.01.15.699675v1

mimicDetector: a pipeline for protein motif mimicry detection in host-pathogen interactions pubmed.ncbi.nlm.nih.gov/41525347/

The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomes www.biorxiv.org/content/10.64898/2026.01.12.698981v1

The Nucleoporin MLP1 of the nuclear basket is essential for nuclear integrity and ploidy maintenance in Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.01.09.698594v1

An intimate view of Leishmania infantum chromosome ends reveals less conserved subtelomeric regions and variations in the telomeric repeat pubmed.ncbi.nlm.nih.gov/41500311/

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression pubmed.ncbi.nlm.nih.gov/41488253/

A Genome-Wide Genetic Screen Identifies a Novel kDNA Replication Protein in Trypanosomes www.biorxiv.org/content/10.64898/2026.01.05.697628v1

Origins and consequences of kinetoplast loss in trypanosomes www.biorxiv.org/content/10.64898/2025.12.24.696353v1

I am trilled to share my latest publication where we contribute to the knowledge of how ATR kinase, a DNA damage response factor, modulates DNA replication timing during stress in Leishmania major. Huge thanks to @rmc9z.bsky.social, @LuizTosi and the collaborators for the support and guidance!

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins https://www.biorxiv.org/content/10.1101/2025.04.22.649942v1

Leishmania mexicana telomeres at high resolution: Ku80, TERT, and alternative lengthening mechanisms pubmed.ncbi.nlm.nih.gov/41345908/

Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees pubmed.ncbi.nlm.nih.gov/41327030/

Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes pubmed.ncbi.nlm.nih.gov/41290700/

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ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major pubmed.ncbi.nlm.nih.gov/41284724/

The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41247779/