First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering www.biorxiv.org/content/10.1101/2025.09.26.678825v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin. www.biorxiv.org/content/10.1101/2025.09.24.678203v1

Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei www.biorxiv.org/content/10.1101/2025.09.25.678491v1

The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures https://www.biorxiv.org/content/10.1101/2025.09.22.677690v1

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana www.biorxiv.org/content/10.1101/2025.09.19.677349v1

New pre-print from Guy @goldrieve.bsky.social on vsgseq2 - a much improved, robust tool to analyse VSG expression in tryps

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression www.biorxiv.org/content/10.1101/2025.09.08.674917v1

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟

A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania www.biorxiv.org/content/10.1101/2025.09.10.675331v1

Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating Trypanosoma cruzi persistence. www.biorxiv.org/content/10.1101/2025.09.09.675056v1

Genome-wide overexpression screen reveals a novel transcription termination factor in Trypanosoma brucei www.biorxiv.org/content/10.1101/2025.09.02.673782v1

A Trypanosome Trifecta: an independently tunable triple inducer system for genetic studies in Trypanosoma brucei. www.biorxiv.org/content/10.1101/2025.08.31.673413v1

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...

Single-molecule landscape of DNA replication pausing https://www.biorxiv.org/content/10.1101/2025.08.14.670160v1

The absence of the Leishmania major telomerase TERT component links telomeres and cell homeostasis with infectivity pubmed.ncbi.nlm.nih.gov/40848782/

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social www.sciencedirect.com/science/arti...

Integrating tRNA gene epigenomics and expression with codon usage unravels an intricate connection with translatome dynamics in Trypanosoma cruzi pubmed.ncbi.nlm.nih.gov/40788054/

Trypanosoma cruzi surface components: Why so many? Why so polymorphic? pubmed.ncbi.nlm.nih.gov/40774760/

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events pubmed.ncbi.nlm.nih.gov/40768333/

Discovery of unique mitotic mechanisms in <em>Paradiplonema papillatum</em> pubmed.ncbi.nlm.nih.gov/40763799/

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning pubmed.ncbi.nlm.nih.gov/40735494/

Using the DNA language model, GROVER, to parse sequence and epigenetic effects on genome stability https://www.biorxiv.org/content/10.1101/2025.07.23.666402v1

The microtubule-severing enzyme spastin regulates spindle dynamics to promote chromosome segregation in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40702310/

G4s mapped in T. brucei using ChIPseq - finally!

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions https://www.biorxiv.org/content/10.1101/2025.07.22.666098v1

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids https://www.biorxiv.org/content/10.1101/2025.07.08.663533v1

Telomere replication stress-induced DNA damage response triggers inflammatory signaling via canonical and non-canonical STING pathways https://www.biorxiv.org/content/10.1101/2025.07.11.664434v1

Single-molecule sequencing maps replication dynamics across the fission yeast genome, including centromeres https://www.biorxiv.org/content/10.1101/2025.07.16.665067v1

Comparative mitochondrial genome and transcriptome analyses reveal strain-specific features of RNA editing in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40671526/

Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of Trypanosoma brucei through the involvement of G-quadruplexes pubmed.ncbi.nlm.nih.gov/40677914/

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids www.biorxiv.org/content/10.1101/2025.07.08.663533v1

Role of the nucleotide excision repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40603543/

Structure and activity of the essential UCH family deubiquitinase DUB16 from Leishmania donovani pubmed.ncbi.nlm.nih.gov/40570172/

Stage-specific MCM protein expression in <em>Trypanosoma cruzi</em>: insights into metacyclogenesis and G1 arrested epimastigotes pubmed.ncbi.nlm.nih.gov/40491435/

Clinical <em>Trypanosoma cruzi</em> isolates share a common antigen repertoire that is absent from culture adapted strains pubmed.ncbi.nlm.nih.gov/40501824/

Stumpy forms are the predominant transmissible forms of <em>Trypanosoma brucei</em> pubmed.ncbi.nlm.nih.gov/40522086/

Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis pubmed.ncbi.nlm.nih.gov/40492681/

when worlds collide - german ravens appear to have trypanosomes

Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.05.26.656218v1

So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk

Innovation through instability? Genome (dis)organisation in Trypanosoma cruzi pubmed.ncbi.nlm.nih.gov/40399166/

Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei www.biorxiv.org/content/10.1101/2025.05.02.651885v1

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

New PhD position to study paper mills - Research Information buff.ly/Z6IHRiG

Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid <em>Vickermania</em> pubmed.ncbi.nlm.nih.gov/40203041/

Stochastic variation in surface protein expression diversifies Trypanosoma cruzi infection www.biorxiv.org/content/10.1101/2025.04.07.647584v1

Trypanosoma cruzi Has 32 Chromosomes: A Telomere-to-Telomere Assembly Defines Its Karyotype. https://www.biorxiv.org/content/10.1101/2025.03.27.645724v1

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes www.biorxiv.org/content/10.1101/2025.03.21.644654v1