Sebastian Shaw
@millseba.bsky.social
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Dad. Scientist. Interested in how Cryptosoridium tricks its host cells!
pinned post!
🚨 New paper out! 🚨 🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence! Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites
#Cryptosporidium
#Genetics
#InfectiousDiseases
#ForwardGenetics
www.sciencedirect.com/science/arti...
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Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
https://www.sciencedirect.com/science/article/pii/S2211124725010861
26 days ago
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Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories. Genetics 101 😊
#Cryptosporidium
#Apicomplexa
#Clofazimine
#AntimicrobialResistance
#AMR
#ParasiteResearch
www.biorxiv.org/content/10.1...
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Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
https://www.biorxiv.org/content/10.1101/2025.10.07.680968v1
6 days ago
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🚨 New paper out! 🚨 🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence! Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites
#Cryptosporidium
#Genetics
#InfectiousDiseases
#ForwardGenetics
www.sciencedirect.com/science/arti...
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Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
https://www.sciencedirect.com/science/article/pii/S2211124725010861
26 days ago
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How many red flags more will it take?
26 days ago
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Happy
#SwissNationalDay
🇨🇭 Meanwhile, Trump just slapped 39% tariffs on Swiss goods. How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
2 months ago
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No ERC Starting Grant this time 😔 7 great reviews — and 1 that… didn’t quite agree. Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
3 months ago
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“Coachella of molecular parasitologists” 😜
add a skeleton here at some point
4 months ago
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Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻
4 months ago
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Sebastian Shaw
Kristian G. Andersen
5 months ago
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion. The proposed 15% cap on indirect costs remains. Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
add a skeleton here at some point
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Sebastian Shaw
bioRxiv Genetics
5 months ago
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
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🚨 Preprint Alert 🚨 We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium
#Genomics
#Parasitology
#InfectiousDiseases
#Preprint
#BioRxiv
www.biorxiv.org/content/10.1...
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Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. An array of parasites with similar genomes produce...
https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
5 months ago
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Sebastian Shaw
Nature Microbiology
5 months ago
🚨Out now! scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by
@fra-florini.bsky.social
@kirkdeitsch.bsky.social
#MicroSky
#Plasmodium
🦠🧬
www.nature.com/articles/s41...
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scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
https://www.nature.com/articles/s41564-025-02008-5?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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Sebastian Shaw
Kirk Deitsch
5 months ago
Very happy to congratulate
@fra-florini.bsky.social
and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites:
rdcu.be/emjbn
and an earlier version here:
www.biorxiv.org/content/10.1...
. Francesca will present some of this work next week at BioMalPar 2025.
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scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
http://rdcu.be/emjbn
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Sebastian Shaw
Keith Matthews
5 months ago
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/12490
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Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.
6 months ago
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Had a wonderful time in New York attending Joe’s defense (he rocked it!) and seeing my PhD buddies Francesca and Shubha and many more 😍
7 months ago
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On my way back to Philadelphia after an amazing two-week trip! Spent time with family & friends in Switzerland, then headed to Würzburg for a joint parasitology meeting—caught up with old friends and made new ones. Great science, great people!
7 months ago
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I wouldn’t sprint like it’s the Olympics for free food after a seminar.
7 months ago
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Presented my work at the Joined Parasitology Spring Meeting in Wurzburg today! 😍
7 months ago
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Stupidest way to waste money and undermine science in one go 💵 🚮
www.reuters.com/business/hea...
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Exclusive: U.S. CDC plans study into vaccines and autism, sources say
The U.S. Centers for Disease Control and Prevention is planning a large study into potential connections between vaccines and autism, two sources familiar with the matter told Reuters, despite extensive scientific research that has disproven or failed to find evidence of such links.
https://www.reuters.com/business/healthcare-pharmaceuticals/us-cdc-plans-study-into-vaccines-autism-sources-say-2025-03-07/
7 months ago
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How many more red flags does it need?
7 months ago
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reposted by
Sebastian Shaw
Wallace Marshall
7 months ago
Today I decided that my car wasn’t getting the mileage I wanted, so I put on a blindfold, took my socket wrench, and started randomly removing parts from the engine and throwing them away. Just kidding, I didn’t do that, because it would have been stuoid and counter-productive
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Applying for a grant, pouring in hours of work, and then seeing that “You made it to the second round” email! 😍🥳🤞🏻🤞🏻🤞🏻
#StepByStep
8 months ago
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Sebastian Shaw
Katie Mack
8 months ago
The first measles death in the US in a decade -- the tragic, preventable death of a child whose parents chose not to protect them with vaccination -- should spark an immediate nation-wide campaign to ensure all children are protected against preventable diseases. Anything less is unconscionable.
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Sebastian Shaw
British Society for Parasitology
8 months ago
🚨 Three weeks until the big Joint
#Parasitology
Spring Meeting 2025 with the BSP, SSTMP, and DGP!! 🚨 - 𝟏𝟏-𝟏𝟒𝐭𝐡 𝐌𝐚𝐫𝐜𝐡 𝟐𝟎𝟐𝟓 - Würzburg, Germany - Website at
parasitology-meeting.de
- Registration at
tinyurl.com/3x32vycr
#parasitology
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Switzerland, I miss you more than ever right now…
www.bmj.com/content/388/...
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Anger, despair, and defiance from a voice within the US federal research system
People around the world are watching with disbelief as the new US government closes down its aid programme, withdraws from the World Health Organization (WHO) and the Paris agreement on climate change...
https://www.bmj.com/content/388/bmj.r294
8 months ago
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Sebastian Shaw
Dr. Sven-Eric Jordt #TobRegSky
8 months ago
#TobRegSky
#PedSky
#MedSky
#EpiSky
#addictionsci
#policysky
#polisky
#PCCM
🧪🛟 March 7, 2025, DC and state capitals !
standupforscience2025.org
#standupforscience2025
#scienceforall
#sciencenotsilence
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Super excited to go to Wurzburg in March to present my work on genetic crosses and virulence in Cryptosporidium! 😍
#parasitesrule
9 months ago
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Go Birds!!! 🦅
add a skeleton here at some point
9 months ago
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reposted by
Sebastian Shaw
Andy Richter
9 months ago
Tired of pooping in solitude? Have a kid.
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Sebastian Shaw
Faria Tryps Lab
9 months ago
Are you interested in
#trypanosomes
#biomolecularcondensates
and/or
#geneexpression
? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! Please share!
jobs.york.ac.uk/vacancy/post...
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Sebastian Shaw
LabEx ParaFrap
9 months ago
💼 Two funded PostDoc positions (3 years) on Trypanosoma brucei and its interactions with blood vessels | Lisbon, Portugal | Labs:
@luisamfigueiredo.bsky.social
#GIMM
and Cláudio Franco
#BCR
🔬
#Parasite
- vasculature interactions 🗓️ Start: by June 2025 🔗 Details:
labex-parafrap.fr/en/job-offers
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Grant proposal submitted! 🤞🏻🤞🏻🤞🏻#Cryptosporidium
#parasitesrule
9 months ago
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Ezra’s having a meltdown because he thinks we missed a page in the book. We did not miss a page and now he is frantically searching for the “missed page”!
#toddlerproblems
10 months ago
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Going to buy a Christmas tree! Hannah wants the biggest tree that still fits into our apartment. Didn’t tell Natalie yet…
10 months ago
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Hello? Anyone here? 😉
11 months ago
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