@fra-florini.bsky.social
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reposted by
Akshay Vishwanatha
2 months ago
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research!
@oupprimary.bsky.social
@narjournal.bsky.social
Read more here.
tinyurl.com/794brb6h
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https://tinyurl.com/794brb6h
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reposted by
Shubha Bevkal
2 months ago
New paper out ! Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
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Stage-specific regulation of the Plasmodium falciparum proteasome activity reveals adaptive rewiring in artemisinin resistance
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum to maintain protein homeostasis, adapt to proteotoxic stress, and regulate parasite growth and stage transitions. The prote...
https://www.biorxiv.org/content/10.1101/2025.11.21.689772v1
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reposted by
Sebastian Shaw
4 months ago
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories. Genetics 101 😊
#Cryptosporidium
#Apicomplexa
#Clofazimine
#AntimicrobialResistance
#AMR
#ParasiteResearch
www.biorxiv.org/content/10.1...
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Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
https://www.biorxiv.org/content/10.1101/2025.10.07.680968v1
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reposted by
Sebastian Shaw
4 months ago
🚨 New paper out! 🚨 🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence! Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites
#Cryptosporidium
#Genetics
#InfectiousDiseases
#ForwardGenetics
www.sciencedirect.com/science/arti...
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Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
https://www.sciencedirect.com/science/article/pii/S2211124725010861
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reposted by
University of Glasgow School of Infection & Immunity
6 months ago
🎥 | WATCH | Dr Francesca Florini (
@fra-florini.bsky.social
|
@weillcornell.bsky.social
) discusses the immune evasion in malaria using insights from single-cell analysis of Plasmodium falciparum. The full GRiP-ing seminar is now available on our YouTube channel: 📺
youtu.be/bKU2Cfv79K8?...
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Had such a wholesome experience this past week, helping with the One Health Research workshop at WACCBIP. So much passion and engagement from the students!
6 months ago
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Preprint Alert 🚨 Check out the latest piece of work from the
@kirkdeitsch.bsky.social
lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
add a skeleton here at some point
7 months ago
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reposted by
Nature Microbiology
8 months ago
🚨Out now! scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by
@fra-florini.bsky.social
@kirkdeitsch.bsky.social
#MicroSky
#Plasmodium
🦠🧬
www.nature.com/articles/s41...
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scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
https://www.nature.com/articles/s41564-025-02008-5?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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So proud of this work finally out in
@natmicrobiol.nature.com
! We examined antigenic variation in malaria parasites at single-cell level and found a surprising level of diversity. Make sure to check it out and don’t miss my talk on Thursday to hear about this story!
#malaria
#scRNA-Seq
#EMBLMalaria
add a skeleton here at some point
8 months ago
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Something fun (very much needed these days): the
@kirkdeitsch.bsky.social
and Kirkman labs crushing the CUIMC Team Relay Marathon!
9 months ago
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There’s a new doctor in the
@kirkdeitsch.bsky.social
lab and we couldn’t be prouder!
10 months ago
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#standupforscience
11 months ago
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What an awesome opportunity it was to present my work today at
#EMBLInfectionBiology
and connect with so many amazing scientists studying
#infectionbiology
! Great thanks to the organizers for giving me this chance
about 1 year ago
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