@fra-florini.bsky.social
📤 124
📥 131
📝 9
reposted by
Sebastian Shaw
6 days ago
Excited to share our new paper, co-led by Gracyn Buenconsejo and me. Why did a promising anti-#Cryptosporidium drug fail? We asked whether the parasite itself might already be genetically prepared to escape treatment.
doi.org/10.1038/s415...
#Clofazimine
#forwardgenetics
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Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance - Nature Microbiology
Forward and reverse genetics identifies the mode of action of clofazimine in the parasite Cryptosporidium. The genomic locus encoding the target is heterogeneous, and a resistance-conferring allele is...
https://doi.org/10.1038/s41564-026-02331-5
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reposted by
The EMBO Journal
2 months ago
Mechanistic insights into coordinated var transcriptional switching in malaria parasites
@kirkdeitsch.bsky.social
and coworkers
link.springer.com/article/10.1...
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Mechanistic insights into coordinated var transcriptional switching in malaria parasites - The EMBO Journal
The exceptional virulence of the human malaria parasite, Plasmodium falciparum, is attributed to the adhesive properties of infected red blood cells and the parasite’s ability to avoid antibody recogn...
https://link.springer.com/article/10.1038/s44318-026-00751-x
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🚨New paper out 🚨 Excited to see this work from Joe Visone and me published! We dissect the molecular mechanisms behind var2csa transcription and translation. Take a look👇
link.springer.com/article/10.1...
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Mechanistic insights into coordinated var transcriptional switching in malaria parasites - The EMBO Journal
The exceptional virulence of the human malaria parasite, Plasmodium falciparum, is attributed to the adhesive properties of infected red blood cells and the parasite’s ability to avoid antibody recogn...
https://link.springer.com/article/10.1038/s44318-026-00751-x
2 months ago
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If you are searching for a postdoc position or know someone who does, cannot recommend this position enough!
add a skeleton here at some point
3 months ago
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reposted by
Sebastian Shaw
3 months ago
Happy International Day of Women and Girls in Science! Let’s continue to support and celebrate them, and fight for equal opportunities for women in STEM! Shout-out to
@shubhabevkal.bsky.social
and
@fra-florini.bsky.social
! You’re the best!
#WomenInScience
#WomenInSTEM
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reposted by
Akshay Vishwanatha
6 months ago
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research!
@oupprimary.bsky.social
@narjournal.bsky.social
Read more here.
tinyurl.com/794brb6h
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Validate User
https://tinyurl.com/794brb6h
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reposted by
Shubha Bevkal
6 months ago
New paper out ! Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
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Stage-specific regulation of the Plasmodium falciparum proteasome activity reveals adaptive rewiring in artemisinin resistance
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum to maintain protein homeostasis, adapt to proteotoxic stress, and regulate parasite growth and stage transitions. The prote...
https://www.biorxiv.org/content/10.1101/2025.11.21.689772v1
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reposted by
Sebastian Shaw
7 months ago
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories. Genetics 101 😊
#Cryptosporidium
#Apicomplexa
#Clofazimine
#AntimicrobialResistance
#AMR
#ParasiteResearch
www.biorxiv.org/content/10.1...
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Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
https://www.biorxiv.org/content/10.1101/2025.10.07.680968v1
1
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reposted by
Sebastian Shaw
8 months ago
🚨 New paper out! 🚨 🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence! Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites
#Cryptosporidium
#Genetics
#InfectiousDiseases
#ForwardGenetics
www.sciencedirect.com/science/arti...
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Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
https://www.sciencedirect.com/science/article/pii/S2211124725010861
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reposted by
University of Glasgow School of Infection & Immunity
10 months ago
🎥 | WATCH | Dr Francesca Florini (
@fra-florini.bsky.social
|
@weillcornell.bsky.social
) discusses the immune evasion in malaria using insights from single-cell analysis of Plasmodium falciparum. The full GRiP-ing seminar is now available on our YouTube channel: 📺
youtu.be/bKU2Cfv79K8?...
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Had such a wholesome experience this past week, helping with the One Health Research workshop at WACCBIP. So much passion and engagement from the students!
10 months ago
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Preprint Alert 🚨 Check out the latest piece of work from the
@kirkdeitsch.bsky.social
lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
add a skeleton here at some point
10 months ago
0
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reposted by
Nature Microbiology
12 months ago
🚨Out now! scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by
@fra-florini.bsky.social
@kirkdeitsch.bsky.social
#MicroSky
#Plasmodium
🦠🧬
www.nature.com/articles/s41...
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scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
https://www.nature.com/articles/s41564-025-02008-5?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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So proud of this work finally out in
@natmicrobiol.nature.com
! We examined antigenic variation in malaria parasites at single-cell level and found a surprising level of diversity. Make sure to check it out and don’t miss my talk on Thursday to hear about this story!
#malaria
#scRNA-Seq
#EMBLMalaria
add a skeleton here at some point
about 1 year ago
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Something fun (very much needed these days): the
@kirkdeitsch.bsky.social
and Kirkman labs crushing the CUIMC Team Relay Marathon!
about 1 year ago
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There’s a new doctor in the
@kirkdeitsch.bsky.social
lab and we couldn’t be prouder!
about 1 year ago
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#standupforscience
about 1 year ago
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What an awesome opportunity it was to present my work today at
#EMBLInfectionBiology
and connect with so many amazing scientists studying
#infectionbiology
! Great thanks to the organizers for giving me this chance
over 1 year ago
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