Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry an extended set of proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. www.biorxiv.org/content/10.1...

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

🚀 New preprint! We used a human cell-free translation screen (~28 000 compounds) to discover NT-2, a #Fusarium -derived #mycotoxin that blocks human ribosomes. #Cryo-EM at 1.72 Å reveals a link between chemical inhibition and ribosome dormancy. www.biorxiv.org/content/10.1...

It was a joy hosting @mandymuller.bsky.social in Bern!

Nature Reviews Methods Primers (2025): "Flow biocatalysis" https://paradisiresearch.com/research-highlights/nature-reviews-methods-primers-2025-flow-biocatalysis/

Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm

*️⃣ Step-by-step STAR protocol for Cell-free translation and mRNA decay *️⃣ What to do (and what not to do 😅) guide based on our work on Nsp1 published in @cp-cellreports.bsky.social. www.sciencedirect.com/science/arti... @unibe.ch @mcid-unibe.bsky.social @nccr-rna-disease.bsky.social @snf-fns.ch

Excellent science, impeccable organisation and breathtaking views in and out the #RNA turnover #BiochemEvent in Brighton, UK 🌊🧬 @biochemsoc.bsky.social

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies: Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l

Translation efficiency covariation identifies conserved coordination patterns across cell types go.nature.com/3TXvmZy

🌊 Potential lab logo 🌊

New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome! Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu @snsf.ch @ethz.ch www.cell.com/molecular-ce...

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

What if I told you, there is a way to pause the time?

Great read from Akis and colleagues! @akispapantonis.bsky.social

A protein produced by the pathogenic bacteria Helicobacter pylori can block amyloid proteins from clustering, new #ScienceAdvances research finds.

Our method paper to produce efficient cell-free translation lysates from diverse human cell types is out 🎉 www.jbc.org/article/S002... @unibe.ch @mcid-unibe.bsky.social @muehlemann.bsky.social @nickkouvelas.bsky.social

Winning the lecturer of the year award from the #Biology department of @unibe.ch definitely made my day 🤩🎉 (after a tough week, otherwise 😅). UniBern has been very supportive and generous in providing excellent teaching courses so KUDOS to them!

I am very excited and grateful for the opportunity to present our work and exchange ideas with the research community at LMU Munich hosted by Jonathan Bohlen! @jonathanbohlen.bsky.social @jonathanbohlen.bsky.social @unibe.ch @mcid-unibe.bsky.social @nccr-rna-disease.bsky.social

Lessons on how to breathe 🌳🇨🇭 #Biochemistry #academicteaching @unibe.ch

🦠😷 Researchers at the #unibern have gained new insights into an early mechanism of #coronavirus infection. 👉 mediarelations.unibe.ch/media_releas... @karousislab.bsky.social @nccr-rna-disease.bsky.social @mcid-unibe.bsky.social Image: © Adrian Bothe

I think I study more #Biochemistry on semester weekends than my students 😅 Gluconeogenesis feat. Greek language lessons 🍭

The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition

A Perspective in Nature Reviews Neuroscience focuses on neural resonance theory in music, which summarizes how the dynamics of fundamental neural mechanisms can explain various aspects of music perception and performance. https://go.nature.com/3DXLLJ2 🔒

Our latest research on #Coronavirus Nsp1 found its home (and a new name) at @cp-cellreports.bsky.social www.cell.com/cell-reports... Thankful to the first (dream) team of my lab and funding for making this happen. @nccr-rna-disease.bsky.social @mcid-unibe.bsky.social @unibe.ch

Cellular responses to RNA damage: Cell www.cell.com/cell/fulltex...

Nature’s guide to the best AI tools for research - some excel at coding, whereas others are better for synthesizing information; a tool for every occasion? 🧪 @nature.com @natureportfolio.nature.com www.nature.com/articles/d41...

Aren't any protective constitutional mechanisms to stop this dangerous person and his friends from acting up?

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions: Cell Reports www.cell.com/cell-reports...

Impressive as always 🙌 @marvintanenbaum.bsky.social

Read my review!

Kandersteg has been the hub for the swiss @nccr-rna-disease.bsky.social RNA for most of the last 9 years of workshops. Collaborations and friendships were made, posters were drugged on ice streets, and plans and dreams were made on frozen slopes. Those #RNA days in Kandersteg have left their mark.

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...

Devastating news from the US

A -fantastic- essay about controls: and a great surprise from André @schneian.bsky.social: a scientist who can make many forms of art out of his science. We need more of this!

The very informative 2023-2024 #RNA review series in @embojournal.bsky.social has been completed. Throwback to our contribution, reviewing how #coronaviruses modulate host cell translation 🔬🦠 www.embopress.org/page/journal... www.embopress.org/doi/full/10....

It's great to see direct RNAseq thriving, largely thanks to @evamarianovoa.bsky.social efforts 🙌

Dear all, it was overdue to leave ex-Twitter and move to Bluesky. Happy to see that many of our old friends are here, too. We are attempting to connect to scientists interested in RNA biology and beyond. #translation #RNA #NMD

Something you don't see every day! Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins www.cell.com/cell/fulltex... open-access

New preprint shows that T7 protein kinase massively and promiscuously phosphorylates the E.coli proteome within 5 minutes of infection to defeat host defense mechanisms. Congrats to first-author @tarabartolec.bsky.social! www.biorxiv.org/content/10.1...

A very nicely written pre-holiday read by the @luciani-lab.bsky.social. Everything you wanted to know about #liposomes in delivery, and you were too shy to ask! There's even dual centrifugation in it (❤️)

RNase-resistant tricks by @lenasteckelberg.bsky.social

New pre-print 📢:Cell-free translation from diverse human cell types: Fast, reproducible and scalable t.co/IAld0ocjDf @nickkouvelas.bsky.social @unibern.bsky.social #biorxiv #mRNA #Ribosome