“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Guess, I'll have a coffee then.

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/... From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

“Nurses should be at the very top of our social hierarchy but we live in a world where it’s just the opposite,” www.theguardian.com/film/2025/ju...

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health. Apply here: 👉 RA: www.jobs.cam.ac.uk/job/51988/ 👉 Postdoc: www.jobs.cam.ac.uk/job/51984/ Please share 🔬👩‍🔬

📢 We are recruiting! Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies. Please share and RT 🙏

Tomorrow at 19:30 a huge demonstration in Tel Aviv - The Israeli Academia demands to end the war NOW. These horrors are unbearable and must stop.

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback! github.com/vierstralab/...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:

Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations! Preprint: www.biorxiv.org/content/10.1... Github: github.com/anderssonlab...

Latest from the lab! Led by @xuening-he.bsky.social, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for transcription factor cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!

Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

Curious about epigenetics, gene regulation, and developmental biology? Apply for the PhD position in Mannervik lab at Stockholm University! We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social www.jobs.cam.ac.uk/job/51488/

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....

New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95

Join our lab to study transcriptional regulation in mouse germ cells and embryonic stem cells at @haskoliislands.bsky.social in beautiful Reykjavík! Apply here: tinyurl.com/34y6jcrd #epigenetics #TranscriptionFactors #transcriptomics #stemCells #pluripotency

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social. Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply! lsi.exeter.ac.uk/groups/hendr...

we've put a Review together 👇 Just came out at www.nature.com/articles/s41... hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos Enjoy :) - feedback welcome

12. Like art, music, philosophy, and literature, science is literally part of humanity's heritage. My colleagues and I have had the amazing opportunity to be part of something vastly larger than ourselves, with meaning that transcends any state, regime, or generation. They can't take that away.

Important reminder by @vivienm.bsky.social that actively shaping the context in laboratories makes a difference for how included, represented and balanced researchers feel. Apart from being the right way of treating others, respect directly improves productivity, too. www.nature.com/articles/s41...

New preprint on a cross-species atlas of the dorsal vagal complex and neural mediators of cagrilintide’s effects on energy balance @metabolcenter.bsky.social >580,000 cells mapping to 89 rat, mice and rhesus macaque cell populations! www.biorxiv.org/content/10.1... #Neuroscience #Obesity 1/3

Thanks to the reviewers 🙏 Also, we’re looking for a Postdoc to explore how obesity-associated genetic variants impact hypothalamic circuits using CRISPR-based Perturb-seq & in vivo metabolic phenotyping candidate.hr-manager.net/ApplicationI... #neuroscience #obesity 3/3

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD - lnkd.in/dtKz_gnA PostDoc - lnkd.in/dBgn6AcK

We have a new website. The Tissue Gene Regulation Lab can now be found at tgrlab.org. 🫀 🧬 More information and updates will be added continuously.

Join us for this exciting @embo.org workshop to explore recent advances in our understanding of enhancer mechanisms and the critical roles of enhancers in human health! 🧬 🧪 Submit an abstract by March 17 to be considered for short talk. Register by April 1 to participate! 😊 @sdu.dk @dg.dk

“Totalitarianism in power invariably replaces all first-rate talents, regardless of their sympathies, with those crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.” -Hannah Arendt, “The Origins of Totalitarianism,” 1951. It's happening now 😰

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

All European Academies (ALLEA) statement on threats to academia: "These new restrictions also threaten the careers of [..] professionals, and may cause lasting harm to the fundamental research [..], as well as efforts to secure a healthy, just, and safe world for all." allea.org/wp-content/u...

Join my new group in Helsinki 🇫🇮❄️ as postdoctoral fellow specializing in deep learning for the integration of cancer data. Apply 👇 jobs.helsinki.fi/job/Helsinki...

Great summary from Ayako Suzuki on the impact FANTOM and FLJ had on genome annotation and protein inference before reference genomes 🧬 even existed. Full length cDNAs, cap and oligo trapping 🪤 were leading the way! www.nature.com/articles/s41...

Interested in exploring epigenetic cell memory? Join us!! 6 PhD and postdoc positions available in our new center, EpiC.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...

Job alert.🚨 Come join us in beautiful Copenhagen 🇩🇰 to develop computational tools to decode gene regulatory mechanisms from single cell data.💻🔬🧫 @randersson.bsky.social will be hiring either a PhD or a PostDoc. There is no supervisor I could recommend more! tinyurl.com/3v4uvmz4 tinyurl.com/yc83enfa

Job alert! We are hiring a postdoc or PhD student focusing on * developing computational methods to resolve gene regulation in single cells * investigating the mechanisms and cell-type specific effects of genetic variants PhD student: bsky.app/profile/jobr... Postdoc: bsky.app/profile/jobr...

I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War. Same link, new title and some updates.

How can we build better predictive models? And what can AI tell us about complex ecosystem mechanisms? I’m hiring a PhD student to work with me on applying data-driven discovery methods on high-frequency lake data to begin September 2025. Application is due on May 4.

In 1933, the German Chancellor dismantled democracy in only 53 days. History does not repeat itself, but it rhymes. www.theatlantic.com/ideas/archiv...

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...

Auschwitz was at the end of a long process. It did not start from gas chambers. This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.

A one-way relationship or mutual influences? In our new review we discuss a few recent studies on the interplay between enhancer-promoter interactions and transcription. www.sciencedirect.com/science/arti...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

📣 Registration for the next Non-Coding Genome course at @institutcurie.bsky.social closes on February 15th! Don't miss this opportunity to explore the versatility of non-genic DNA elements and non-coding RNAs with internationally renowned experts. ▶️ training.institut-curie.org/courses/non-...

1/ Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits. www.biorxiv.org/content/10.1...