Dear gene regulation aficionados in the wider Copenhagen 🇩🇰area: Please feel cordially invited to our 3rd Copenhagen Gene Regulation Seminar 👨‍🏫 next week on Thursday, the 5th of March. 📆 Hope to see you in Panum for 2 exciting talks! 👇

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

Join us for a day of talks, posters, and discussions, featuring a morning joint lecture with Nobel Laureates Eric F. Wieschaus and Christiane Nüsslein-Volhard! Date: Monday, May 4th, 2026 Location: University of Copenhagen, Mærsk Tower sites.google.com/view/emergin... Free to participate

Healthcare in Greenland is publicly funded, free at the point of use, and despite geographical challenges considered very good. Healthcare costs in the USA are extortionate and responsible for 60% of all US bankruptcies. So maybe Denmark should be sending hospital ships the other way.

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers? Check our latest work, from @ybellaichelab.bsky.social Congratulations to all authors. Artwork from the artist @lale-alpar.bsky.social (lalealpar.com) www.cell.com/developmenta...

In 1927, Vera Menchik became the first Women's World Chess Champion at age 21 & is the longest-reigning women's champion in #chess history. She defended the title 7 times, held it undisputed until her tragic death in 1944 at age 38 in a V-1 rocket bombing during #WWII. She was born #OTD in 1906.

Interested in transcriptional regulation, enhancers and 3D genome folding? In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control www.biorxiv.org/content/10.6... detailed 🧵👇

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that 🧪

We need to teach PhD students how to write a great cover letter - one that links their research to a future lab’s goals, shows genuine enthusiasm, and clearly explains fit. It’s not a CV summary or a formality; it’s their first real conversation with future colleagues.

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

Every American needs to watch this:

Auschwitz was at the end of a process. We must remember that it did not start from gas chambers. This hatred gradually developed: from ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Our work on improving human egg quality was featured in @theguardian.com. We hope this will help to make #IVF more successful and allow more couples to conceive. 💜

I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...

Jeg står her omkring i morgen fra ca. kl 10 og frem til 11:30 eller der omkring. Så går turen videre til Panum. Håber vi ses!

Bizarre that our 2020 #Drosophila #AMP review already feels out of date. Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides. www.annualreviews.org/content/jour...

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...

Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41... Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon Brief thread 👇

“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Guess, I'll have a coffee then.

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/... From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

“Nurses should be at the very top of our social hierarchy but we live in a world where it’s just the opposite,” www.theguardian.com/film/2025/ju...

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health. Apply here: 👉 RA: www.jobs.cam.ac.uk/job/51988/ 👉 Postdoc: www.jobs.cam.ac.uk/job/51984/ Please share 🔬👩‍🔬

📢 We are recruiting! Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies. Please share and RT 🙏

Tomorrow at 19:30 a huge demonstration in Tel Aviv - The Israeli Academia demands to end the war NOW. These horrors are unbearable and must stop.

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback! github.com/vierstralab/...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:

Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations! Preprint: www.biorxiv.org/content/10.1... Github: github.com/anderssonlab...

Latest from the lab! Led by @xuening-he.bsky.social, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for transcription factor cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!

Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

Curious about epigenetics, gene regulation, and developmental biology? Apply for the PhD position in Mannervik lab at Stockholm University! We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social www.jobs.cam.ac.uk/job/51488/

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. www.embopress.org/doi/full/10....

New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95

Join our lab to study transcriptional regulation in mouse germ cells and embryonic stem cells at @haskoliislands.bsky.social in beautiful Reykjavík! Apply here: tinyurl.com/34y6jcrd #epigenetics #TranscriptionFactors #transcriptomics #stemCells #pluripotency

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social. Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply! lsi.exeter.ac.uk/groups/hendr...

we've put a Review together 👇 Just came out at www.nature.com/articles/s41... hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos Enjoy :) - feedback welcome

12. Like art, music, philosophy, and literature, science is literally part of humanity's heritage. My colleagues and I have had the amazing opportunity to be part of something vastly larger than ourselves, with meaning that transcends any state, regime, or generation. They can't take that away.

Important reminder by @vivienm.bsky.social that actively shaping the context in laboratories makes a difference for how included, represented and balanced researchers feel. Apart from being the right way of treating others, respect directly improves productivity, too. www.nature.com/articles/s41...

New preprint on a cross-species atlas of the dorsal vagal complex and neural mediators of cagrilintide’s effects on energy balance @metabolcenter.bsky.social >580,000 cells mapping to 89 rat, mice and rhesus macaque cell populations! www.biorxiv.org/content/10.1... #Neuroscience #Obesity 1/3

Thanks to the reviewers 🙏 Also, we’re looking for a Postdoc to explore how obesity-associated genetic variants impact hypothalamic circuits using CRISPR-based Perturb-seq & in vivo metabolic phenotyping candidate.hr-manager.net/ApplicationI... #neuroscience #obesity 3/3