(@xuening-he.bsky.social)

Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations! Preprint: www.biorxiv.org/content/10.1... Github: github.com/anderssonlab...

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Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation Transcription factor (TF) cooperativity plays a critical role in gene regulation. However, the underlying genomic rules remain unclear, calling for scalable methods to characterize the TF binding site... https://www.biorxiv.org/content/10.1101/2025.06.19.660093v1