Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”. www.biorxiv.org/content/10.6... We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.

Meet our Preprint Editors We are pleased to welcome our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles. #preprints journals.biologists.com/dev/pages/ed...

Published in @natmed.nature.com today, Stephen Mayhew, Dave Allan and David Roblin share ten lessons learned from a decade of translating science at the Crick towards health and societal impact. www.nature.com/articles/s41...

New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...

Online Now: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization Online now:

A biochemical curiosity: it is much more straightforward to go enzymatically from 5mC > T than it is to go from 5mC > C

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

Saddened to learn of the death of Greg Hannon, a former CSHL colleague and giant of modern molecular biology www.cruk.cam.ac.uk/news/in-memo...

Super excited that our two companion papers on saturation genome editing (SGE) of RNU4-2 and discovery of a novel recessive neurodevelopmental disorder (NDD) were published yesterday 🥳 SGE experiment: www.nature.com/articles/s41... Recessive NDD characterisation: www.nature.com/articles/s41... 🧵

An interesting read: Using synthetic enhancer combinations to switch on lethal payloads only when in the correct target cancer cells. Article: www.nature.com/articles/s41... News&Views: www.nature.com/articles/d41...

Scientists have identified a set of genetic variants that could help to explain why responses to obesity drugs vary markedly from person to person go.nature.com/4ccK07M

Happy to share our new review on X-chromosome reactivation in the germline, just published in @biochemsoc.bsky.social Transactions! We highlight the latest discoveries on how this epigenetic mechanism unfolds during mammalian germline reprogramming. Hope you enjoy the read 😊

🔥 How does CTCF shape enhancer–promoter communication? In our new preprint, we systematically test how the position and orientation of CTCF binding sites (CBSs) influence gene regulation at the mouse Sox2 locus. 🧪 full paper can be found here: www.biorxiv.org/content/10.6...

Some good, critical questions by Hannah Fry @fryrsquared.bsky.social here! www.youtube.com/watch?v=--CP...

Integrated small and long RNA sequencing reveals piRNA mediated transposon repression during human oogenesis www.nature.com/articles/s41...

Hot off the press from the Zamore & Gainetdinov labs: Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness 🏊️ buff.ly/O40kIi3 #piRNA #mRNA #fertility

Friends Davor Solter and Azim Surani receiving the wonderful Paul Ehrlich and Ludwig Darmstaedter Prize for Genomic Imprinting👏 👍 @Frankfurt Germany. With official talks from politicians using words like Education, Knowledge, Democracy 🙏 @maxplanck.de @gurdoninstitute.bsky.social

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

Considerations for the future of in vitro gametogenesis in fertility care - @hannahlandecker.bsky.social @uclacrshe.bsky.social @uclamcdb.bsky.social @uclastemcell.bsky.social go.nature.com/4l2e9en

Holy macaroni!!!

Happy to share our latest paper. Our findings uncover a unique chromatin architecture and spatial chromosome arrangement in gonadal germ cells and document that alongside global DNA demethylation, the germline epigenetic reprogramming involves reorganisation of the 3D genome.

Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹 Full info below, and please share! 🫶🏻 bit.ly/467TO0M

📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social

Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling https://www.biorxiv.org/content/10.64898/2026.01.18.696654v1

Issue 12 is complete! Cover: Members of BiO's community, including a founding Editor, past & present Editors-in-Chief, our academic Editors and some of the reviewers from BiO's Fast & Fair peer review initiative. We would like to thank them all. bit.ly/4piig6y

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner. #piRNA #histone #mRNA #maternal #RNAbiology #RNASky www.biorxiv.org/content/10.6...

Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬 Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort! A "meme-torial" of the science is coming soon 👀

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

Helping the next generation of scientists find their voice. 📣 Discover how @seahsamantha.bsky.social empowers students through her path from preLights to Executive Editor of the Journal of Emerging Investigators. Interview: prelights.biologists.com/news/from-pr...

I don't think scientists should work for anyone else. They should work for discovery and for their own curiosity. –Maria Leptin, ERC President @marialep.bsky.social on 'The Night Science Podcast'

Another envelope protein in the human genome. Expressed in the placenta, of course.

High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome

Research Highlight: Mouse In vitro oogenesis breaks free of the ovary www.cell.com/developmenta... @cp-devcell.bsky.social

🚀 Looking for talented PhD students! Join us in 🇸🇬 Singapore for 1-2 years to push the frontiers of AI for Genomics. Work on: 🧬 Cancer genome reconstruction 🧫 Cancer genome & cell foundation models 💊 RNA drug & mRNA therapeutic design #AI #Genomics #PhD 1/5

Learn more in the open access Nature Genetics paper: www.nature.com/articles/s41...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

A TE insertion controls throat colour in wheatears. The gene involved (ASIP) is the same one that is epigenetically affected by an IAP insertion the famous Avy mice. As if we needed more reasons to love TEs.

The quest to make babies with lab-grown eggs and sperm. An excellent news feature by Nature: tempered optimism, with critical caveats underscored. And great to see commentary from so many names in the field! www.nature.com/articles/d41...

The 'Handler genome' of OSCs, a rare and stably growing cell line that runs a piRNA pathway to silence transposons. Dominik (@86dominik.bsky.social) assembled the genome of this Drosophila cell line. Besides making some cool findings, the goal was to turn this into useful resource for the field.

Read ‘Sperm sequencing reveals extensive positive selection in the male germline’ from @sangerinstitute.bsky.social and collaborators in @nature.com below: nature.com/articles/s41...

It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists. 🔗 www.gurdon.cam.ac.uk/nobel-laurea...

Sad to hear this. John was a brilliant scientist and also someone who engaged with everyone personally & as equals, especially young scientists and students. www.cam.ac.uk/research/new...

So sad to hear the news - John truly was an inspiration to so many, and one of a kind. www.cam.ac.uk/research/new...

Very candid responses from Azim Surani here on his initially turbulent scientific journey, & accounts of genomic imprinting and the pioneering of mammalian scRNA-seq. Great to see this put together by Ashley Moffett & @geraldinejowett.bsky.social journals.biologists.com/dev/article/...

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Excited to share our latest News & Views published in Nature! @nature.com rdcu.be/eI2NJ Sherif Khodeer and I discuss how stem cell-based embryo models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.

I do think this human egg story is being massively overhyped. To be clear, no eggs have been "generated", "created" or "made" from human skin cells - rather, existing human eggs have been given the DNA from skin cells using a kind of cloning 1/

Embryonic signatures of intergenerational epigenetic inheritance across paternal environment & genetic background @jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet www.embopress.org/doi/full/10....

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...