Ian Henderson
@hendersi.bsky.social
📤 1857
📥 1692
📝 100
Plant genetics and epigenetics @ University of Cambridge, Department of Plant Sciences
reposted by
Ian Henderson
Maddy Seale
about 14 hours ago
Out First Release in
@science.org
this week: A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
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Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
https://www.science.org/doi/10.1126/science.ady3475
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Excellent work from
@piotraz.bsky.social
group demonstrating juxtaposition of heterozygous & homozygous regions in maize attracts meiotic recombination to het regions
rdcu.be/eHmn9
@natplants.nature.com
builds from work we did together in Cambridge on Arabidopsis way back in 2015. Great stuff Piotr!
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Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions
Nature Plants - This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding...
https://rdcu.be/eHmn9
3 days ago
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Ian Henderson
Oxford Biology
8 days ago
Oxford Biology is growing 📢 We’re appointing 3 Associate Professors in: 🌱 Plant Sciences 🦉 Animal Behaviour 🔬 Molecular Cell Biology 3 fields. 3 opportunities. One new home for Oxford Biology. Learn more 👉
bit.ly/41S2Tc7
Apply now 👉
bit.ly/488CNW3
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Ian Henderson
19 days ago
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in
@natgenet.nature.com
in collaboration with
@naltemose.bsky.social
investigates the role of DNAme at human centromeres
www.nature.com/articles/s41...
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DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
https://www.nature.com/articles/s41588-025-02324-w
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Ian Henderson
EPIGENETIC HULK
26 days ago
IT BEST HEALTH! FOR SKIN! MAYBE ELAINE FUCHS INVOLVED! NEED CELLULAR EPIGENETICS FOR EVERYTHING PLEASE!
add a skeleton here at some point
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Some nice pyrite-ammonites we found on Charmouth beach
#fossilhunting
26 days ago
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Ian Henderson
Schnittger Lab
29 days ago
Six more years—plus a lot of blood, sweat, and tears—later, we are thrilled to finally share it: a cytological framework of female meiosis in Arabidopsis!
www.biorxiv.org/content/10.1...
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A cytological framework of female meiosis in Arabidopsis
Female and male meiosis often differ in many aspects, such as their duration and the frequency as well as the positioning of crossovers. However, studying female meiosis is often very challenging and ...
https://www.biorxiv.org/content/10.1101/2025.08.22.671760v1
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Ian Henderson
Kumud Saini
28 days ago
What beauty!
add a skeleton here at some point
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Ian Henderson
Justin Blumenstiel
about 1 month ago
The original circos plot? From the 1947-1948 Carnegie Yearbook, the page prior to McClintock's Mutable Loci in Maize paper.
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Ian Henderson
PlantEvolution 🌱🌾
about 1 month ago
Out after peer review now, follow up from our 2019 pna-NLRome paper (which was based on enrichment and long-read sequencing). It is remarkable how much more can be learned with complete genome sequences. Next. pan-NLRome from hundreds of A. thaliana long-read genomes! Big thanks to the entire team!
add a skeleton here at some point
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Ian Henderson
Nick Desnoyer
about 1 month ago
Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
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Oatk: a de novo assembly tool for complex plant organelle genomes
link.springer.com/article/10.1...
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Oatk: a de novo assembly tool for complex plant organelle genomes - Genome Biology
Plant organelle genomes, particularly large mitochondrial genomes with complex repeats, present significant challenges for assembly. The advent of long-read sequencing enables the assembly of complete...
https://link.springer.com/article/10.1186/s13059-025-03676-6
about 2 months ago
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Ian Henderson
Javier Santoyo
about 2 months ago
Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing.
#HiC
#RecombinationMaps
#GameteSequencing
#Genomics
#Genetics
academic.oup.com/genetics/adv...
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Ian Henderson
Genetics Society UK
about 2 months ago
Are you passionate about
#genetics
and
#communication
? We're looking for an Editor for our magazine. Training funds are available, you will be a trustee of the society and get free attendance to all of our conferences. Application deadline: 12 September!
genetics.org.uk/committee-va...
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5 August 2025 - Committee vacancy, Magazine Editor | Genetics Society
We are searching for a new Editor of the Genetics Society magazine! Check our vacancies page for details on the role and how to apply.
https://genetics.org.uk/committee-vacancy-magazine-editor/
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Ian Henderson
Robert Arkowitz
about 2 months ago
Escherichia coli with a 57-codon genetic code | Science
www.science.org/doi/10.1126/...
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Escherichia coli with a 57-codon genetic code
The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we re...
https://www.science.org/doi/10.1126/science.ady4368?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=1stRelease&et_rid=17154784&et_cid=5690638
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Spindle checkpoint can secure additional cheating time for selfish expanded centromeres
cell.com/current-biol...
@currentbiology.bsky.social
@takashiakeralab.bsky.social
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Spindle checkpoint can secure additional cheating time for selfish expanded centromeres
Expanded centromere DNA repeats violate Mendel’s law of segregation by preferentially segregating to the egg in animals and plants. Using oocytes collected from hybrid mice, Walton et al. show that th...
https://cell.com/current-biology/abstract/S0960-9822(25)00813-9?dgcid=raven_jbs_etoc_email
about 2 months ago
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reposted by
Ian Henderson
katja heuer
about 2 months ago
1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with
@r3rt0.bsky.social
,
doi.org/10.1101/2025...
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New studious lab pic just dropped ! A few others to be digitally added in due course!
about 2 months ago
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Ian Henderson
Julius Brennecke
about 2 months ago
last call! submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
add a skeleton here at some point
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Annual 307 laboratory day on the river!
about 2 months ago
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Ian Henderson
André Marques
about 2 months ago
Happy to share our new work with exciting findings, incl. different centromere organisations and all kinds of weird polyploids giving rise to the mysterious carnivorous sundews! Great word led by my postdoc Laura in collaboration with
@plantgenomes.bsky.social
www.biorxiv.org/content/10.1...
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Contrasting centromere structures in carnivorous sundews uncover a dynamic evolutionary trajectory shaped by polyploidy and chromosomal remodeling
Sundews (Drosera) are carnivorous plants that capture prey using mucilage-producing glands with both secretory and absorptive functions. Within a remarkably diverse clade that includes the Venus flytr...
https://www.biorxiv.org/content/10.1101/2025.07.27.666937v1
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Ian Henderson
Josje Romeijn
3 months ago
The first paper of my PhD is now available as a preprint! 🎉 Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
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https://www.biorxiv.org/content/10.1101/2025.06.16.659975v1
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Ian Henderson
Saioa Manzano-Morales
about 2 months ago
Today is Asgard Friday! So happy that the project that has taken a big chunk of my PhD journey is out as a preprint (for now!) “Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication”
www.biorxiv.org/content/10.1...
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Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication.
Asgard archaea hold a pivotal position in the tree of life as the closest known relatives to eukaryotes and are therefore crucial for understanding eukaryogenesis. Earlier genomic analyses revealed th...
https://www.biorxiv.org/content/10.1101/2025.07.24.666526v1
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Ian Henderson
Simon Fisher
2 months ago
Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in
@nature.com
by
@glennislogsdon.bsky.social
& colleagues. 👇🧬🧪
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Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
https://www.nature.com/articles/s41586-025-09140-6
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Ian Henderson
Alexis Verger 🧬🧫🧪
2 months ago
How it started / How it's going 😱 (
www.biorxiv.org/content/10.1...
/
www.nature.com/articles/s41...
)
#preprint
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Ian Henderson
Dan Sloan
2 months ago
Please share! Our lab is recruiting a PhD student to join us starting fall 2026. Our group is broadly interested in plant molecular evolution and comparative genomics. More info about our lab and grad programs at Colorado St. is available on our lab website.
sites.google.com/site/danielb...
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Sloan Lab
Welcome! Our research focuses on the evolutionary process at the molecular level. In particular, we investigate how a mixture of natural selection and non-adaptive forces create and maintain the amazi...
https://sites.google.com/site/danielbsloan
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Ian Henderson
Juliane Glaser
3 months ago
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published
@natgenet.nature.com
🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details:
www.nature.com/articles/s41588-025-02248-5
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Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
https://www.nature.com/articles/s41588-025-02248-5
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REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes
www.nature.com/articles/s41...
Lovely work from Jacobsen lab on genetics of epigenetics
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REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes - Nature Cell Biology
Wu et al. demonstrate that REM transcription factors and GDE1 guide RNA polymerase IV to specific genomic loci, establishing a DNA sequence-dependent mechanism for siRNA biogenesis and DNA methylation...
https://www.nature.com/articles/s41556-025-01691-0
2 months ago
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Seeing this Nature cover art for first time from the Crick selfish dna article. Reminds me of this joke: Why do crustacean genomes contain a lot of transposons ? It’s shellfish DNA
3 months ago
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Ian Henderson
STCmicrobeblog
3 months ago
RIP Franklin W. Stahl (1929–2025) here is Frank explaining semiconservative replication of DNA in the marvelous interview from 2020 together with Matt Meselson (
youtu.be/7-tnuAqEp9g
)
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Ian Henderson
Genetics Society UK
3 months ago
We need your nominations! Do you know an outstanding researcher whose work has made a significant impact in genetics? Now is the perfect time to recognise their contributions. Our awards celebrate excellence across all areas of
#genetics
research!
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Magnificently primal looking Gunnera @ Cambridge botanics
3 months ago
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A sea of wheat!
3 months ago
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Amazing study of kelptoplastic sea slugs!
www.cell.com/cell/abstrac...
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A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
https://www.cell.com/cell/abstract/S0092-8674(25)00637-3
3 months ago
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deepmind.google/discover/blo...
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AlphaGenome: AI for better understanding the genome
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome/
3 months ago
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Midsummer Delphinium looking so vivid!
3 months ago
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Ian Henderson
Neil Renic
3 months ago
I am once again pitching my romantic comedy: - two academics start dating - discover they are each other's terrible reviewer - hijinks ensue Working title: Love is Double-Blind
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Ian Henderson
Royal Society Publishing
3 months ago
Michael Ashburner FRS was an influential figure in the fields of Drosophila genomics and early sequencing database initiatives such as
@ebi.embl.org
. Read about their contributions across genetics and bioinformatics in the new biographical memoir:
buff.ly/f01zNat
@geneticscam.bsky.social
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Spoils of Belgium ! Love these cuberdons !!!
3 months ago
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Ian Henderson
André Marques
3 months ago
1/7 I am very excited to announce our🌹NEW PAPER OUT IN 𝑁𝐴𝑇𝑈𝑅𝐸!🌹 𝐃𝐑𝐈𝐕𝐄 𝐓𝐎 𝐒𝐔𝐑𝐕𝐈𝐕𝐄: Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis With the Ritz and Kovařík labs we show a potential role for centromeres on 𝘙𝘰𝘴𝘢 𝘤𝘢𝘯𝘪𝘯𝘢 bizarre reproduction!
www.nature.com/articles/s41...
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Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature
Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.
https://www.nature.com/articles/s41586-025-09171-z
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Ian Henderson
Institut de Biologia Evolutiva (IBE)
3 months ago
🧬 The study led by Rosa Fernández, #IBE principal researcher🔬, and published in
@natecoevo.nature.com
, shows that marine worms shattered their genome and rebuilt it in a radically different form when they first emerged from the sea 200 million years ago.
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Ian Henderson
Genetics Society UK
3 months ago
Join us next week for our anniversary day in Cambridge. Help us celebrate our prize winners and former summer students! Event is free but registration is required.
genetics.org.uk/events/genet...
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Genetics Society Anniversary Day 2025 | Genetics Society
We are pleased to announce the Genetics Society Anniversary Day, which will be held on 25th June 2025. This event will celebrate several of our prize winners and the summer students we have supported....
https://genetics.org.uk/events/genetics-society-anniversary-day-2025/
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Ian Henderson
Molly Gale (Gale-Hammell Lab)
3 months ago
🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences
#TransposonDay2025
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Ian Henderson
University of Cambridge
3 months ago
How did nature’s incredible diversity come to be? These cichlid fish may offer a clue 🐠 Cambridge researchers have found that chunks of ‘flipped’
#DNA
can help fish quickly adapt to new habitats and evolve into new species, acting as evolutionary ‘superchargers’ 👇
bit.ly/3HGqEN6
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Ian Henderson
Oded Rechavi
3 months ago
Don’t ask
#theconferencetoendallconferences
#TCTeAC
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Ian Henderson
PlantEvolution 🌱🌾
3 months ago
Please consider signing this petition, which emphasizes the importance of ring-fencing EU funds for ERC, Marie-Curie fellowships and other collaborative basic research.
www.petitions.com/open_letter_...
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Open Letter of scientists and entrepreneurs regarding MFF and FP10
June 10, 2025 After the presentation of the European Competitiveness Fund, there has been much uncertainty regarding the positioning and funding for Research and Innovation in the next European Multia...
https://www.petitions.com/open_letter_of_scientists_and_entrepreneurs_regarding_mff_and_fp10?utm_source=web_share
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Ian Henderson
Oli Clarke
3 months ago
1/x New story - the structure of the Vault cap, at 2.3Å! Matching a beautiful preprint from
@sjorsscheres.bsky.social
, we show that the cap of the vault particle has C13 symmetry, in contrast to the 39-fold symmetry of the body. Study lead by talented postdoc
@huanli00.bsky.social
from my group! ⬇️
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Ian Henderson
The EMBO Journal
4 months ago
REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!”
#TransparentPeerReview
Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
@juliusbrennecke.bsky.social
et al
www.embopress.org/doi/full/10....
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Ian Henderson
Nature Plants
4 months ago
New Article: "Leaf venation network evolution across clades and scales"
rdcu.be/epLNP
Evolution of leaf venation networks, from fewer, corrugated veins to high vein density and smoother loops. Herbivory as a potential driver of venation architectural changes.
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The mutational dynamics of the Arabidopsis centromeres
www.biorxiv.org/content/10.1...
Absolutely stunning new preprint on centromere mutation from @labschneeberger.bsky.social
@plantevolution.bsky.social
@jurriaanton.bsky.social @lisasmith
@plantylisasmith.bsky.social
& colleagues
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The mutational dynamics of the Arabidopsis centromeres
Centromeres are specialized chromosome regions essential for sister chromatid cohesion and spindle attachment during mitosis. Many centromeres comprise highly variable, megabase-scale satellite DNA ar...
https://www.biorxiv.org/content/10.1101/2025.06.02.657473v1
4 months ago
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