Ian Henderson
@hendersi.bsky.social
📤 1986
📥 1833
📝 119
Plant genetics and epigenetics @ University of Cambridge, Department of Plant Sciences
Repetitive seashore?
1 day ago
0
3
0
6 days ago
0
7
0
reposted by
Ian Henderson
Michael Brockhurst
7 days ago
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan. Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
loading . . .
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology
Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.
https://www.jobs.manchester.ac.uk/Job/JobDetail?JobId=33867&source=JobTrainRSSFeed
1
15
26
reposted by
Ian Henderson
School of Biological Sciences
18 days ago
Read more about the projects:
www.cam.ac.uk/research/new...
loading . . .
Eight Cambridge researchers awarded €17 million in ERC Consolidator Grants
Funding from the European Union’s Horizon Europe programme will support promising mid-career scientists to pursue creative research ideas across a broad range
https://www.cam.ac.uk/research/news/eight-cambridge-researchers-awarded-eu17-million-in-erc-consolidator-grants
0
3
1
Monday morning dot plot...
19 days ago
0
12
0
Interesting study suggesting that nucleus, cytoskeleton, and endomembranes preceded acquisition of mitochondria, during eukaryogenesis
www.nature.com/articles/s41...
loading . . .
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
https://www.nature.com/articles/s41586-025-09808-z
23 days ago
0
32
10
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
www.science.org/doi/10.1126/...
@levine-lab.bsky.social
very cool work
loading . . .
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
https://www.science.org/doi/10.1126/science.adv0657?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=SCIeToc&et_rid=35351378&et_cid=5804810
30 days ago
0
27
14
reposted by
Ian Henderson
Lars Jansen Lab
about 1 month ago
A new and fascinating story from
@bencarty.bsky.social
and the group, with crucial help from the teams of
@naltemose.bsky.social
, Simona Giunta, and
@dfachinetti.bsky.social
. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
10
66
33
reposted by
Ian Henderson
Vangeli Geshkovski
about 1 month ago
What a nice coincidence to have Kelly Dawe present his work on karyotype engineering for todays seminar
@thesainsburylab.bsky.social
@johninnescentre.bsky.social
add a skeleton here at some point
0
13
4
Genetics Society Anniversary Day 25-26th June, Edinburgh
genetics.org.uk/events/anniv...
Society Prize Winners: Hilary Martin, Joe Felsenstein, Richard Durbin, Zam Iqbal Honorary Members: Brian Charlesworth, Deborah Charlesworth, Kay Davies, Paul Nurse, David Sherratt, Veronica van Heyningen
loading . . .
Anniversary Day 2026 | Genetics Society
We will celebrate the Genetics Society Anniversary Day in Edinburgh, June 25th-26th, 2026. The event will celebrate with talks from our Honorary Members, 2026 Prize and Medal winners, and Summer Stud...
https://genetics.org.uk/events/anniversary-day-2026/
about 1 month ago
0
4
0
Chromosome Dynamics 2026 @ Awaji Japan
www.fbs.osaka-u.ac.jp/labs/fukagaw...
about 1 month ago
0
15
8
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science
www.science.org/doi/10.1126/...
Very nice work from Holger Puchta & colleagues
loading . . .
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
https://www.science.org/doi/10.1126/science.adz8505
about 1 month ago
1
47
18
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Nobel Prize winner Svante Pääbo giving the Genetics Society public lecture at
@crick.ac.uk
. Svante is recounting how Neandertals and Denisovans live on in many of us!
0
11
3
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Congratulations
@hilarycmartin.bsky.social
from
@sangerinstitute.bsky.social
on being awarded the 2026 Balfour Lecture!
5
37
17
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Congratulations to
@zaminiqbal.bsky.social
from
@milnerevolution.bsky.social
on being awarded the 2026 Mary Lyon Medal!
3
35
12
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Congratulations to
@vinuesalab.bsky.social
from
@crick.ac.uk
on winning the 2026 JBS Haldane Lecture. Carola will present her JBS Haldane Lecture next year at
@rigb.org
!
0
10
7
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal!
0
102
35
reposted by
Ian Henderson
Genetics Society UK
about 1 month ago
Congratulations to Richard Durbin on being awarded our Genetics Society Medal!
1
83
29
FastGA -> ALNview; step into the centromeric matrix!
github.com/thegenemyers
Probably the best dot plot software on the planet...
about 2 months ago
7
199
19
reposted by
Ian Henderson
Tanmay Bharat
about 2 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
10
386
192
reposted by
Ian Henderson
Julius Brennecke
about 2 months ago
Some impressions from the rather fabulous
#EMBOmobilegenome
Mobile Genome meeting in Heidelberg Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org
The transposon community is going very strong. see you all again in 2027!!
2
55
11
reposted by
Ian Henderson
Patrick Pausch
about 2 months ago
After 5 years of waiting, the new
#CRISPR
classification by Makarova et al. is out
@natmicrobiol.nature.com
www.nature.com/articles/s41...
loading . . .
An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology
An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.
https://www.nature.com/articles/s41564-025-02180-8
0
49
25
reposted by
Ian Henderson
Jolyon Troscianko
about 2 months ago
BehaveAI is live! Our biologically inspired video analysis tool sees motion as colour. Track animals or objects, classify their behaviour, and handle complex natural scenes with ease. Semi-supervised annotation, no GPUs required, user-friendly, free & open source. Pre-print
tinyurl.com/BehaveAI
loading . . .
2
68
26
reposted by
Ian Henderson
Gregor Mendel Institute of Molecular Plant Biology
about 2 months ago
Magnus Nordborg of the GMI from the
@oeaw.bsky.social
has received a Synergy Grant from the
@erc.europa.eu
. With Richard Durbin and
@felipekteixeira.bsky.social
, they will investigate how transposable elements shape genome evolution in eukaryotes. Read more:
www.oeaw.ac.at/gmi/news-eve...
0
49
8
reposted by
Ian Henderson
Jake Harris
about 2 months ago
Very excited to share our work published in Nature Comms last week! Here we describe a range of cool things that can be done once you have the power to control deposition of H3K4me3…
rdcu.be/eNEf4
A short thread:
loading . . .
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis
Nature Communications - Binenbaum et al. demonstrate that precise CRISPR-based targeting of a key chromatin mark (H3K4me3) can switch on genes, boost disease resistance, and unlock meiotic...
https://rdcu.be/eNEf4
2
50
19
reposted by
Ian Henderson
James Davies
about 2 months ago
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
6
208
89
reposted by
Ian Henderson
Julius Brennecke
about 2 months ago
great to be at the
#EMBOMobileGenome
meeting in Heidelberg with a wonderful bunch of colleagues, speakers and attendees. this meeting is a good reflection of the excitement and collegiality in the transposon field. kindly sponsored by
@embo.org
add a skeleton here at some point
1
51
9
‘Epigenetic serum’ makes you wonder !
about 2 months ago
9
38
7
reposted by
Ian Henderson
Svetlana Dodonova
2 months ago
Lab’s first paper is out!! We show the first structures of
#Asgard
#chromatin
by
#cryo-EM
🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across
#Archaea
, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here:
www.cell.com/molecular-ce...
6
329
123
reposted by
Ian Henderson
Yasin Dagdas
2 months ago
Really cool work by the
@dodonova-sveta.bsky.social
lab
@embl.org
www.cell.com/molecular-ce...
#archea
#evochromo
loading . . .
Cryo-EM reveals open and closed Asgard chromatin assemblies
Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed co...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00818-4?rss=yes
0
37
13
reposted by
Ian Henderson
Rob Klose
2 months ago
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost!
tinyurl.com/mr3m7bd3
0
77
99
reposted by
Ian Henderson
Stephen Tang
2 months ago
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
1
84
36
reposted by
Ian Henderson
Sternberg Lab
2 months ago
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
loading . . .
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
https://www.biorxiv.org/content/10.1101/2025.10.16.682844v1
5
220
119
Crazy red flesh apple - tastes good too! 🍎
3 months ago
1
11
0
reposted by
Ian Henderson
Maddy Seale
3 months ago
Out in
@science.org
this week: A new FRET sensor for salicylic acid gives insight into spatial dynamics of pathogen infection
www.science.org/doi/10.1126/...
(1/2)
#PlantScience
loading . . .
SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance
Salicylic acid (SA) is a key phytohormone that orchestrates immune responses against pathogens, including Pseudomonas syringae bacteria. The timing and extent of SA accumulation are tightly controlled...
https://www.science.org/doi/10.1126/science.adw7650
1
57
14
reposted by
Ian Henderson
PlantEvolution 🌱🌾
3 months ago
Congrats, Joe Ecker
@salkinstitute.bsky.social
, to receiving the McClintock Prize! Joe has been a visionary leader of the field of genetics and genomics – not only for plants – for decades
www.salk.edu/news-release...
0
128
41
reposted by
Ian Henderson
Guillaume Bourque
3 months ago
🚨 New paper alert on telomeres! 🚨 Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
3
32
14
reposted by
Ian Henderson
Carolyn Bertozzi
3 months ago
My HPLC was definitely overlooked
www.nature.com/articles/d41...
loading . . .
Prizes must recognize machine contributions to discovery
The future of science will be written by humans and machines together. Awards should reflect that reality.
https://www.nature.com/articles/d41586-025-03217-y
20
301
68
reposted by
Ian Henderson
Jstheater
3 months ago
Heading in the correct direction: After success of pilot, Ireland expands basic support payments for artists, making them permanent:
www.irishtimes.com/politics/202...
loading . . .
Basic income support scheme for artists to be made permanent and opened to new entrants in budget
Negotiations down to the wire, with five big-spending departments yet to agree their budget allocations
https://www.irishtimes.com/politics/2025/10/06/budget-2026-states-basic-income-scheme-for-artists-made-permanent/
0
14
7
reposted by
Ian Henderson
bioRxiv Evolutionary Biology
3 months ago
Genomic Islands in Wolbachia Prophages Drive Amplification andDiversification of Cytoplasmic Incompatibility Genes in Culex pipiens
https://www.biorxiv.org/content/10.1101/2025.10.03.680192v1
0
4
1
reposted by
Ian Henderson
Ana Ignatieva
3 months ago
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE
academic.oup.com/mbe/article/...
(1/n)
loading . . .
The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla
https://academic.oup.com/mbe/article/42/9/msaf190/8223473
4
65
39
Russell R. Geiger Professorship of Crop Science
www.cam.ac.uk/jobs/russell...
@cam.ac.uk
@camplantsci.bsky.social
loading . . .
Russell R. Geiger Professorship of Crop Science
The Board of Electors to the Russell R. Geiger Professorship of Crop Science invite applications for this Professorship from persons whose work falls within the general field of the Professorship to
https://www.cam.ac.uk/jobs/russell-r-geiger-professorship-of-crop-science-pd47445
3 months ago
0
3
6
CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1
www.biorxiv.org/content/10.1...
loading . . .
https://www.biorxiv.org/content/10.1101/2025.09.22.677529v1.full.pdf
3 months ago
0
12
5
reposted by
Ian Henderson
Adam Phillippy
3 months ago
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺
youtu.be/JmlY5omxQVc
📄
www.nature.com/articles/s41...
loading . . .
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
https://youtu.be/JmlY5omxQVc
4
44
30
reposted by
Ian Henderson
Maddy Seale
3 months ago
Out First Release in
@science.org
this week: A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
loading . . .
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
https://www.science.org/doi/10.1126/science.ady3475
0
50
20
Excellent work from
@piotraz.bsky.social
group demonstrating juxtaposition of heterozygous & homozygous regions in maize attracts meiotic recombination to het regions
rdcu.be/eHmn9
@natplants.nature.com
builds from work we did together in Cambridge on Arabidopsis way back in 2015. Great stuff Piotr!
loading . . .
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions
Nature Plants - This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding...
https://rdcu.be/eHmn9
3 months ago
1
28
8
reposted by
Ian Henderson
Oxford Biology
3 months ago
Oxford Biology is growing 📢 We’re appointing 3 Associate Professors in: 🌱 Plant Sciences 🦉 Animal Behaviour 🔬 Molecular Cell Biology 3 fields. 3 opportunities. One new home for Oxford Biology. Learn more 👉
bit.ly/41S2Tc7
Apply now 👉
bit.ly/488CNW3
0
72
94
reposted by
Ian Henderson
4 months ago
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in
@natgenet.nature.com
in collaboration with
@naltemose.bsky.social
investigates the role of DNAme at human centromeres
www.nature.com/articles/s41...
loading . . .
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
https://www.nature.com/articles/s41588-025-02324-w
9
85
37
reposted by
Ian Henderson
EPIGENETIC HULK
4 months ago
IT BEST HEALTH! FOR SKIN! MAYBE ELAINE FUCHS INVOLVED! NEED CELLULAR EPIGENETICS FOR EVERYTHING PLEASE!
add a skeleton here at some point
2
31
13
Some nice pyrite-ammonites we found on Charmouth beach
#fossilhunting
4 months ago
1
39
4
Load more
feeds!
log in