NucleiSky in a smart microscopy pipeline 🧠🔬 A query image is first acquired on Microscope A (widefield). As the video shows 📹 the same sample is then moved to Microscope B (spinning disk), where it is automatically scanned, NucleiSky recognises the same FoV and triggers high-resolution re-imaging.

This is how Steve met Brad...

Should I get over my revulsion and put the dead cockroach that appeared in my office on a scope?

A week-overdue 🧵on the newest paper from the Cimini lab- do you ever do spatial transcriptomics? If you do, and you want free extra phenotypic info, step in to learn more about "Evaluating integrative strategies for incorporating phenotypic features in spatial transcriptomics". 🧪 (1/x)

Lunch and learn returns!

Found an old flash drive from 2017 with a tif file just labeled "caterpillar", so I had to open it up. It's apparently an SEM image from an Amray 1810 (SEM), but I have no idea what part of the animal I took!

Welcome to the resistance (checks notes) Moody's Ratings fixedincome.fidelity.com/ftgw/fi/FINe...

Just because England had a draw last night, didn't stop her from wearing her full personalized England kit for sports day at school

The Scottish statue treatment has made it to Harvard's BioLabs 🤭

Explain your @: I wish it was a better story, but I'm really into microscopy education

Our summer series is back! Free pizza and cool new swag provided by Zeiss Check out the full schedule: hcbi.fas.harvard.edu/calendar

I'll be giving a presentation this summer on how to prepare for your microscopy experiment before you arrive at the facility. Is "The Art of Not Collecting Useless Data" too much?

🚨 Deadline Alert! Tomorrow is your final day to apply for the IHCIF Course at the Marine Biological Laboratory! 📅 Application deadline: June 16th 💸 Financial aid is available – request upon registration 🔗 hcs.memberclicks.net/ihcif-course

Answer: It's @voigtvision.bsky.social fault 😝

I work earlier than everyone else. No one will give me a real answer on why there is a scan head outside my office, and no systems and missing one 🤔

My eye is literally twitching like this. Might be time for a vacation...

📢On June 1st, we will be launching CenSpark650, the very first selective fluorescent probe for imaging centrioles and cilia in live cells.🔬 No transfection, zero genetic manipulation. Just Add & Image 1 hour later. Learn more: spirochrome.com/12-may-2026/ #Bioimaging

This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," www.npr.org/2026/05/21/n...

The Rejoin petition jumped from 70K to 75K yesterday. It needs to hit 100K by June 8th when the petition closes in order to get a debate in Parliament. The 10th anniversary of the Brexit vote is June 23rd.

3i Ltd is looking for a Technical Support Specialist to join its team in London, England. The ideal candidate has earned a bachelor's degree and has experience with optics. Familiarity with multiphoton, confocal, imaging analysis, advanced microscopy and fluorescent microscopy is preferred. 1/n

Check out my "rough draft" of my instrument status page for the HCBI. Any feedback before I set it up on an HCBI GitHub? hbrown227.github.io/lab-instrume...

🔬 Ever seen a mitochondrion “flicker”? We designed HBmito, a membrane voltage sensor, to catch nanoscale nanoscale electrical spikes in real time—the first optical glimpse of single mitochondrial channels in action. #Mitochondria #CellBiology #Biophysics link.springer.com/article/10.1...

My daughter was recently diagnosed with Alpha-Gal Syndrome from a tick bite. Why am I announcing this? Because, unlike Lyme Disease, where a tick needs to be attached for ~24 hours before transmission, AGS only needs a tick to attach (think 15 mins). Be safe out there. www.cdc.gov/mmwr/volumes...

TIL that some wood is fluorescent! I need to find some and put it on a macro scope for pretty pictures ;-) www.wood-database.com/wood-article...

I make up songs for important topics for my daughter such as "If it looks like poison ivy stay away...If it has 3 leaves and shiny, you don't want that on your heiney" (to If you're happy and you know it). What songs should I make for core users to get them to remember the important rules? 😜

🚨Faculty job search: University of Illinois Chicago Micro & Immuno department is hiring! Open rank and open area within host-pathogen interactions. Apply by May 31 to join us in UI College of Medicine in the heart of Chicago! uic.csod.com/ux/ats/caree...

New paper out! Left-handed DNA cannot bind to natural, right-handed DNA. This leads to lower background if it is used as a probe in DNA-PAINT. Using Fluorigenic DNA-PAINT with left-handed DNA allows for low background, fast 3D DNA-PAINT! Congrats, Bas! skeetorial: 1/x pubs.acs.org/doi/full/10....

Antigen-stabilizable fluorescent nanobodies that become fluorescent upon binding intracellular targets enable background-free multicolor imaging and biosensing in living systems. @sdeoliveira.bsky.social www.nature.com/articles/s41...

New paper just dropped: “Practical Strategies for Marketing a Core Facility” We dug into what actually works for getting core facilities seen and used—based on real-world testing and community input. If that’s your world, check it out 👇 onlinelibrary.wiley.com/share/author...

Yesterday my daughter told me "we have beautiful salad eyes." I was confused. She went on "they're green with a bunch of other colors in them." And well, she is right. We have "salad eyes" 😂

This is the stat you want to highlight Yokogawa?

I think it would be cool to link up all the Imaging/Analysis YouTube Channels in the "Featured Channels" section of HCBI's YouTube homepage. What are some of the best we could highlight?

Story time! Last fall, I pulled 5 ticks off the dog, threw them in a bag in the freezer. I brought them to work, and when I opened the bag, I only found 4 ticks. Decided I must have remembered wrong. Mounted them on the slide only to discover that two of them were "attached." 🤭

Decided today at QI was for making dumb microscopy memes. Make sure to do your pilots before you do your final experiment!

@joachimgoedhart.bsky.social & #microscopy friends, we're using ymScarlet-i3. It's the best general purpose red FP we've tried in budding yeast. But in our hands it photobleaches really fast when exposed relatively low-intensity *488 nm* laser light (~20 W/cm^2). Have you seen this? Thoughts?

We have been having interviews for a Cryo-EM specialist and my co-workers have been letting me pick lunch places. Excited to have Harvard pay for a delicious Thai place today 😃

The poster that Nikon sent us to put on our bulletin board is a bit oversized 😂

TIL I'm supposed to put notes on slides not for my use, but for others to read if they are not there. I haven't used notes in years because as an academic my slides are just there to keep me on track 😝

It's like they don't trust me to read labels 😂

I'm moving to Purdue University as a tenured professor this summer! Excited to hire postdocs there and get a lab up and running with @runxishen.bsky.social as co-lead. More details: www.linkedin.com/posts/anneca...

I have to admit, I needed a good laugh today. Apparently a hawk has been attacking people outside Northwest building at Harvard this week. 😂

We are hiring a Software Engineer who can help us turn our methods into easily usable tools for: * Explainable AI * Cell Tracking * Interactive Learning ...and some more: careers.humantechnopole.it/job/Research... Feel free to reach out directly if you are interested and/or have questions!

🚨🚨🚨JOB ALERT🚨🚨🚨 The Image Analysis Unit at Human Technopole in Milan is recruiting for two positions to join our growing team: 1) Bioimage Analyst 2) Research Software Engineer (RSE) Read on to learn why one of these two people should be you!

What are you doing Boston?

Pablo Villar et al discover male octopus mating arms are sensory organs used to find females, navigate internally to the oviduct & deliver sperm. From behavior to structure, these findings offer a framework for how sensory systems shape reproduction & species barriers www.science.org/doi/10.1126/...

My co-worker and I are brainstorming ways to diversify the facility's revenue. His idea-- streaming microscope sessions like gamers do 😆

I'm thinking about doing High Content Imaging/ Analysis for my summer lunch and learn. What is something that you wish someone had told you when you first started out?

Lots of stickers left from the poster session. So if you see me ask me for a BINA sticker! I'll be handing some off to @michelleitano.bsky.social, so she can be your sticker dealer as well 😉

At #ABRF2026? Come visit me at poster 45 to talk about @bioimagingna.bsky.social or microscopy in general so I'm not lonely. I got stickers!

Penn State Huck core facilities has the office of research published acknowledgement guidelines so individuals core directors don't have to be the "bad guy" in requesting it. #ABRF2026