Since they don't expect anyone to be working today, they have made our hallway look like a scene out of Dexter...

✨ Blinking #nanobodies that work for single-molecule localization 🔬 Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!

Finally a year that week before Christmas, I only have one training. And it's someone that has used the 880 weekly for the last year and wants to use the 980 over break when he doesn't have to compete with anyone to use it

Trying not to screw over 2026 Heather, but 2025 Heather wants to do the bare minimum until break 😂

Thrilled to share our work on DISCO-seq, which combines RNA-preserving tissue clearing with whole-organ 3D imaging to enable anatomically unbiased single-cell transcriptomics, with applications in cancer and infection biology. #SpatialBiology #DISCOseq Preprint link www.biorxiv.org/content/10.6...

Everyone else go home — this is the year we secure ABOLISH ICE on a Chicago Snowplow chicagoshovels.org

who has favorite ways to measure hypoxia in tissues using immunofluorescence/microscopy? i guess maybe the gold standard is pimonidazole/hypoxyprobe- is there any reliable way that doesn't involve injecting anything in vivo? (like what do people do for human tissues?)

Well, it's official, you can catch me at #ABRF2026 where I will be presenting on Facility Marketing at the Monday "mini-workshop."

If you don't believe this can happen, women didn't have the legal right to have their own credit cards without needing a male co-signer until 1974, when the Equal Credit Opportunity Act (ECOA) was passed, a landmark law that made it illegal to discriminate in lending based on sex or marital status.

Help me come up with a story to tell today's users that's cooler than I fell on black ice 😝

I highly suggest putting random things on the microscope. I think I just took an image for the Nikon Small World image contest... if invertebrate sex doesn't disqualify it 😆 And no, I didn't realize it until after I finished an hour-long acquisition

Check out our poster #ASCB2025

It is 9F/-13C out, so time for dino santas knit sweater.

We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow. More about this work here: biorxiv.org/content/10.1...

Looking for another 25-35 responses from PCOS patients to give this student at least 50 to analyze in their honors research. We've had no luck with physician/provider responses, it may be too tough out there in 2025, but the patient responses are interesting. #MedSky

Rafiki voice: It is time! [to begin wearing obnoxious sweaters]

Interested in Zebrafish brain imaging? We released a 3D printed mold that's is super helpful for us. Check it out Customizable FDM-based zebrafish embryo mold for live imaging www.biorxiv.org/content/10.1... Work by Marcela and Jaakko in the lab

A specialized appendage responds to female sex hormones, allowing male octopuses to find their sex organs in the dark. https://scim.ag/4roFry3

I might finish my Power App in the next few weeks, so HCBI users can report problems. It sends an email to our joint email, and then they can check the status of any problems without getting constant emails. Wish me luck! (Because every time I fix one thing, a new thing breaks 😆)

I had a new coworker who had worked with us for 2 weeks. We were at a holiday party, and they asked, "Do they have anything other than beer and wine?" My response was, "they don't do liquor at work parties." She stared at me until I realized the question. "Oh, soda and seltzer." 😬

A holiday demonstration of the different penetration depths of red and blue light into tissue. #optics

It's a bit squished from being on a slide for yesterday's confocal images, but I hope you enjoy my uncleared tick imaged on the Zeiss Lightsheet 7, with multiview fusion.

Good.

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

Check out this tick I collected ;-) And by collected, I mean pulled off my pant leg after a walk in the woods

TIL there is such a thing as "super lice" 😬

Looking into possible networking apps for a future meeting. Why does every single one of them think we need "AI matchmaking?" If you want to narrow it down, it seems like filters for specific tags would be sufficient

"In 2025, 40% of women aged 15 to 44 say they would move abroad permanently if they had the opportunity. The current figure is four times higher than the 10% who shared this desire in 2014, when it was generally in line with other age and gender groups."

Northern lights report: too many clouds in Boston

Who else's core suddenly took a huge hit in September? 😬 Yes, it's 9:30, but there should be someone on a few of the systems...

Obligatory Northern lights report. Visible outside of Boston

It is always great to see the dissertation of a super user. We often don't see the whole picture of a project in the core.

What's some random autofluorescent stuff that I can find outside that would look cool on a microscope? Looking for weird samples to highlight some of the instruments in the faciliity

I had to turn down the position last Friday, but that means the HCBI gets stuck with me indefinitely!

A response to a new story saying Watson didn't credit Franklin. Tells you a lot about how the public sees scientists in general and women scientists in general 😡

I suppose it's fortunate that the explosion was caused by idiots rather than a dangerous mastermind abcnews.go.com/US/2-men-arr...

Got to check out the MBF "SLICE" this morning. It's so little, I wish I had a banana for scale 😂

🔬 THREAD: UK Bioimaging User Access Fund is OPEN! Up to £5k for imaging experiments, £2k for image analysis Access world-class facilities at Crick, ESRIC, KCL, Liverpool, Oxford Brookes & York First deadline: 9 Dec 2025 📅 🧵👇

Putting good vibes out there and singing "Let it go" while throwing out or putting things in a donate box

With SNAP benefits suspended for now, I just donated to my local food bank. If you can, you should consider donating to your local food bank. No one should be going hungry in this day and age

Registration for Halfway to I2K is now OPEN! And workshop submission is still too (for a bit)! Join 20+ presenters and counting, and hundreds of attendees in learning about image analysis, whether you're a complete beginner or a total pro.

So good news, I got a job offer in London! 🎉 Bad news, my husband has applied for 30 positions with no interviews. If anyone has any connections in London in the information security space, I would be eternally grateful

It's Halloween 🎃 #FlourescenceFriday! Here is a microscopic pumpkin generated by showing a cell nucleus in 🟠 with the primary cilium "stem" in 🟢! I hope everyone has a spooky 👻 day! 🔬 by @stjuderesearch.bsky.social grad student Christina Wang. 🧪

Hippocampus masquerading as a 🦇 for Halloween 🎃 #FluorescenceFriday Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪

Tomorrow! Come join us for MicRoN’s Open House Symposium. Learn about the research we get to support, meet our staff and instruments. micron.hms.harvard.edu/micron-open-...

I am "take an ibuprofen before a transatlantic flight" years old

💥 🍃 🏛️ 🧪 Paul Maddox for Congress Paul is a scientist running for Congress to cure the sickness in Washington - become a donor to Paul Maddox’s campaign!

When I was at UTMB, I had raw sewage leak on my confocal. It became known as the poop scope.

5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1... We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!