Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment https://www.biorxiv.org/content/10.64898/2026.04.13.718206v1

Three nitrogen atoms turn old kinase inhibitors into new targetable remedy https://www.biorxiv.org/content/10.64898/2026.04.11.717649v1

Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy https://www.biorxiv.org/content/10.64898/2026.04.11.717944v1

Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders https://www.biorxiv.org/content/10.64898/2026.04.10.717852v1

Cannabidiol (CBD) Promotes Post-TBI Astrocyte Viability and Decreases Injury-Induced Glial Stress Responses Across Zebra Finch Song Control Nuclei https://www.biorxiv.org/content/10.64898/2026.04.13.717820v1

Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs https://www.biorxiv.org/content/10.64898/2026.04.09.717524v1

Reversible CD28 checkpoint modulation by cyclic peptides outperforms biologic blockade under exposure-limited conditions https://www.biorxiv.org/content/10.64898/2026.04.09.717469v1

Impact of Sex on Heroin Intravenous Self-Administration by Heterogeneous Stock Rats https://www.biorxiv.org/content/10.64898/2026.04.08.717349v1

Influence of different pharmaceuticals on the germination and early development of two leafy vegetable species https://www.biorxiv.org/content/10.64898/2026.04.08.717353v1

Stability of Oxycodone Solutions Containing S-Ketamine or Dexmedetomidine https://www.biorxiv.org/content/10.64898/2026.04.08.717252v1

Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase https://www.biorxiv.org/content/10.64898/2026.04.08.717320v1

PROTAC internalization and target degradation require clathrin-mediatedendocytosis https://www.biorxiv.org/content/10.64898/2026.04.06.716751v1

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato https://www.biorxiv.org/content/10.64898/2026.04.06.716494v1

Synergistic induction of a lethal Autosis-to-Apoptosis switch by phytocannabinoids and β-Caryophyllene in Triple-Negative Breast Cancer Cells https://www.biorxiv.org/content/10.64898/2026.04.05.716056v1

Exofection as a Therapeutic Modality: Restoring P-gp Activity via Trophoblast-Derived EV in Neuroinflammatory Disorders https://www.biorxiv.org/content/10.64898/2026.04.02.716001v1

Simian Immunodeficiency Virus and Antiretroviral Therapy Impact Rhesus Macaque Brain Lipid Distribution https://www.biorxiv.org/content/10.64898/2026.04.03.716347v1

Changes in dysbiosis and gene expression in the gut of wharf roach (Ligia Spp.) fed with expanded polystyrene https://www.biorxiv.org/content/10.64898/2026.03.31.715705v1

Low cadmium concentrations alter B and T cell responses in Jamaican fruit bats (Artibeus jamaicensis) https://www.biorxiv.org/content/10.64898/2026.03.31.715675v1

Nicotine self-administration increases impulsive action: differential effects of nAChR modulators in a Go/No-Go task https://www.biorxiv.org/content/10.64898/2026.03.31.715632v1

Decoding the Structural and Functional Impact of the Leukaemia-Associated A338V Mutation in GPR183 https://www.biorxiv.org/content/10.64898/2026.03.30.715362v1

Electroconvulsive seizures for alcohol use disorder: a preclinical study https://www.biorxiv.org/content/10.64898/2026.03.30.715248v1

Steroid-based Tide Quencher 1 probes enable real-time mapping of novel non-canonical cholesterol sites on the M1 muscarinic receptor https://www.biorxiv.org/content/10.64898/2026.03.26.714567v1

In vivo pharmacokinetics and tissue distribution profile of a Wnt/β-catenin pathway-targeting anticancer cassane diterpene isolated from Caesalpinia pulcherrima https://www.biorxiv.org/content/10.64898/2026.03.30.715187v1

Cirrina: LLM-driven pharmacological reasoning agent enables preclinical CNS drug evaluation https://www.biorxiv.org/content/10.64898/2026.03.29.713781v1

Study comparing characteristics of ademetionine-containing tablets from different countries https://www.biorxiv.org/content/10.64898/2026.03.27.714742v1

Targeting Protease-activated Receptor 4 (PAR4) Protects Against Acute Kidney Injury (AKI) in Ischemia Reperfusion Injury https://www.biorxiv.org/content/10.64898/2026.03.27.714572v1

Network Toxicology, Molecular Docking, and Molecular Dynamics Simulations Reveal the Mechanism of Tetrabromobisphenol A in Bullous Pemphigoid. https://www.biorxiv.org/content/10.64898/2026.03.27.714718v1

Comparative chemical characterisation of chitosans and their impact on growth, faecal consistency and microbiota composition in weaned piglets https://www.biorxiv.org/content/10.64898/2026.03.26.714014v1

Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease https://www.biorxiv.org/content/10.64898/2026.03.26.714294v1

A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafish https://www.biorxiv.org/content/10.64898/2026.03.26.714438v1

Enhancing Transcriptional Data Reliability in Fish Oogenesis Using cDNA-Based Normalization https://www.biorxiv.org/content/10.64898/2026.03.26.714387v1

AI-Enforced Ultra-Large Virtual Screening Discovers Potent CD28 Binders https://www.biorxiv.org/content/10.64898/2026.03.26.714621v1

The metalloproteinase inhibitor Marimastat improves skeletal muscle regeneration when administered intravenously after myonecrosis induced by the venom of Bothrops asper https://www.biorxiv.org/content/10.64898/2026.03.25.714270v1

INVESTIGATION OF ETHYLENE OXIDE GENOTOXICITY DOSE-RESPONSE TO INFORM CANCER RISK ASSESSMENT https://www.biorxiv.org/content/10.64898/2026.03.25.714257v1

Molecular Dosimetry of DNA Adducts in Mice Exposed to Ethylene Oxide https://www.biorxiv.org/content/10.64898/2026.03.25.714191v1

Nonlinear Mixed-Effects and Full Bayesian Population Pharmacokinetic Analysis of Ceftolozane-Tazobactam in Critically Ill Patients https://www.biorxiv.org/content/10.64898/2026.03.24.713879v1

Polystyrene Nanoplastics Accumulate in Murine Cortex and Induce Transient Microglial Activation via Endolysosomal Retention https://www.biorxiv.org/content/10.64898/2026.03.24.712727v1

An optimized protocol for single-brain isolation of sex-defined pure mouse astrocyte cultures https://www.biorxiv.org/content/10.64898/2026.03.23.713747v1

Integrated evaluation of immune system perturbation using structural, functional and cellular immunotoxicity endpoints in rats https://www.biorxiv.org/content/10.64898/2026.03.22.713556v1

In vitro investigation and evaluation of the antidiabetic potential of the ethanolic extract of Asparagus racemosus using starch digestion, glucose diffusion, glucose uptake, and DPPH assays https://www.biorxiv.org/content/10.64898/2026.03.22.713478v1

Transporter-Mediated Uptake of Microcystin-LR in Human Trophoblasts: Regulation By Oxygen Concentration and Cell Fusion https://www.biorxiv.org/content/10.64898/2026.03.22.713491v1

Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine https://www.biorxiv.org/content/10.64898/2026.03.22.713446v1

Benchmarking Artificial Intelligence Models for Predicting Nuclear Receptor Activity from Tox21 Assays https://www.biorxiv.org/content/10.64898/2026.03.20.713297v1

Microencapsulated Vaccinium floribundum Kunth extract promotes angiogenesis and attenuates inflammation in in vitro and in vivo models. https://www.biorxiv.org/content/10.64898/2026.03.20.713210v1

Investigating the nicotinic receptor EAT-2 as a novel target to mitigate plant parasitic nematode infections https://www.biorxiv.org/content/10.64898/2026.03.20.711559v1

Effects of polystyrene and polylactide nanoparticles on macrophages under a repeated exposure mode https://www.biorxiv.org/content/10.64898/2026.03.20.713103v1

Anti-oxidant and anti-inflammatory Effects of Aerosolised microalgal-derived extracellular vesicles in Bronchial Epithelial-Macrophage Co-cultures at the Air-Liquid Interface https://www.biorxiv.org/content/10.64898/2026.03.19.712886v1

Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation https://www.biorxiv.org/content/10.64898/2026.03.19.712761v1

Molecular Determinants Governing the Antitubercular Activity of Griselimycin https://www.biorxiv.org/content/10.64898/2026.03.19.712639v1

BODIPY-Tagged β-Lactams as Selective Quenched Activity-Based Probes to Target Human Neutrophil Elastase https://www.biorxiv.org/content/10.64898/2026.03.19.712884v1