Integrative network-based construction of ecologically relevant computational adverse outcome pathways for organic mercury-induced toxicity https://www.biorxiv.org/content/10.1101/2025.10.25.684520v1

Metabolic effects and biotransformation of perfluorohexyloctane (F6H8) in human hepatocytes https://www.biorxiv.org/content/10.1101/2025.10.24.684326v1

In vitro multi-assay cytotoxicity assessment of iron oxide nanoparticles on neural cells and addressing spectrophotometric interference https://www.biorxiv.org/content/10.1101/2025.10.24.684369v1

Development of a Time-based Drug Screening Platform for Improved Clinical Translation https://www.biorxiv.org/content/10.1101/2025.10.24.684432v1

A portable 3D-printed near-infrared spectrometer to screen maize for deoxynivalenol and zearalenone contamination https://www.biorxiv.org/content/10.1101/2025.10.23.684207v1

Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response https://www.biorxiv.org/content/10.1101/2025.10.22.684045v1

Hot cue: Physiologically controlled release from an in situ forming liposomal depot https://www.biorxiv.org/content/10.1101/2025.10.22.683980v1

Terpenes as Modulators of Nociceptive Signaling: Behavioral and Molecular Insights from Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.22.683951v1

Inhibition of Mitochondrial Complex III Causes Dopaminergic Neurodegeneration by Redox Stress in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.21.683798v1

Dicloxacillin and flucloxacillin inhibit hepatic uptake transporters - in vitro investigations and physiological based pharmacokinetic modelling https://www.biorxiv.org/content/10.1101/2025.10.21.683780v1

Neutrophil extracellular traps-mediated thrombosis drive pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome https://www.biorxiv.org/content/10.1101/2025.10.21.683617v1

Isoflurane and Surgical Stress Disrupt Fatty Acid and Carbon Metabolism Leading to Cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.10.20.683563v1

A newly designed GABA-AT inactivator, (S)-MeCPP-115, suppresses paclitaxel-induced neuropathic pain in mice https://www.biorxiv.org/content/10.1101/2025.10.20.683456v1

Preclinical evaluation of Targeted IL-1β Knockdown via CD44-Immunoliposomes: A Nano-therapy against the Inflammatory Microenvironment https://www.biorxiv.org/content/10.1101/2025.10.17.683015v1

Structure-guided allosteric modulation of the delta opioid receptor https://www.biorxiv.org/content/10.1101/2025.10.16.682975v1

Gastroprotective Effects of Aleurites moluccanus (Candlenut) Oil Against Aspirin-Induced Gastric Injury in Rats: A Dose-Dependent Histopathological Evaluation https://www.biorxiv.org/content/10.1101/2025.10.16.682748v1

Pre-clinical evaluation of a gene therapy candidate for SOD1-ALS shows improved survival and signs of inflammation in the CNS of treated mice. https://www.biorxiv.org/content/10.1101/2025.10.16.682744v1

Acute oral toxicity and angiotensin-converting enzyme (ACE) inhibitory activity of the aqueous fractions of the methanol leaf extract of Psychotria luzoniensis https://www.biorxiv.org/content/10.1101/2025.10.14.681951v1

Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor https://www.biorxiv.org/content/10.1101/2025.10.14.682454v1

Ivermectin Reduces Withdrawal-Induced Alcohol Intake via CeA GABAergic Enhancement https://www.biorxiv.org/content/10.1101/2025.10.14.682432v1

Digital Twin Approaches for Interpretable Side Effect Prediction in Drug Discovery https://www.biorxiv.org/content/10.1101/2025.10.14.682276v1

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function https://www.biorxiv.org/content/10.1101/2025.10.14.682336v1

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation. https://www.biorxiv.org/content/10.1101/2025.10.13.682036v1

Targeting multidrug-resistant bacteria with genetic-information-free protein-only phages https://www.biorxiv.org/content/10.1101/2025.10.13.682247v1

Petasol Exhibits Rapid and Efficient Epithelial Transport in Epithelial Barrier Models https://www.biorxiv.org/content/10.1101/2025.10.13.682130v1

Isomer-specific distribution of perfluorooctane sulfonate (PFOS) in hepatic zonation in mouse https://www.biorxiv.org/content/10.1101/2025.10.13.682167v1

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo https://www.biorxiv.org/content/10.1101/2025.10.11.681833v1

The Molecular Signature of Umami Palatability in Dogs Based on Amino Acid Interactions with Canine Taste Receptors. https://www.biorxiv.org/content/10.1101/2025.10.13.681969v1

Preclinical trial of avocado pulp supplementation in an L-NAME model of cardiovascular injury https://www.biorxiv.org/content/10.1101/2025.10.10.681762v1

CSF1R inhibitors pexidartinib and sotuletinib induce rapid glial ablation despite their limited brain penetrability https://www.biorxiv.org/content/10.1101/2025.10.11.681780v1

Hepatoprotective Effects of Vernonia amygdalina Leaf Extract: In Vivo and In Silico Evidence Against Ethanol-Induced Liver Injury https://www.biorxiv.org/content/10.1101/2025.10.08.678638v1

Assessment of the pharmacological and safety profile of the small molecule MP-004 after topical eye drops administration https://www.biorxiv.org/content/10.1101/2025.10.09.681374v1

Punarnavayolepa Choornam in Iron Deficiency Anaemia management: Pharmaceutic insights and biological activity. https://www.biorxiv.org/content/10.1101/2025.10.08.681069v1

Effects of oral cannabidiol (CBD) on spontaneous opioid withdrawal in male and female rats https://www.biorxiv.org/content/10.1101/2025.10.08.680984v1

Brief report on differential toxicity of legacy and second-generation PFAS on dopaminergic neurons and mitochondria https://www.biorxiv.org/content/10.1101/2025.10.08.681169v1

Structural hormesis in protein aggregation: A minimal mechanistic model https://www.biorxiv.org/content/10.1101/2025.10.07.681066v1

Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals https://www.biorxiv.org/content/10.1101/2025.10.07.680963v1

Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation https://www.biorxiv.org/content/10.1101/2025.10.06.680836v1

Glycan Profiling Identifies Chondroitin-4-sulfate as a Biomarker for Platinum Response and Therapeutic Target in Ovarian Cancer https://www.biorxiv.org/content/10.1101/2025.10.06.675352v1

Enhanced splicing modulation by NMA-modified antisense oligonucleotides https://www.biorxiv.org/content/10.1101/2025.10.06.680653v1

Exposure of male mice to nicotine leads to metabolic dysfunction in their male and female offspring https://www.biorxiv.org/content/10.1101/2025.10.04.680466v1

Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings https://www.biorxiv.org/content/10.1101/2025.10.03.680220v1

Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism https://www.biorxiv.org/content/10.1101/2025.10.03.680206v1

The Critical and Unexpected Role of a Methyl Group in Interleukin-17A Inhibitors https://www.biorxiv.org/content/10.1101/2025.10.02.680113v1

UGT35B1 is the principal enzyme mediating nicotine glycosylation in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.10.03.680272v1

Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1 https://www.biorxiv.org/content/10.1101/2025.10.02.679991v1

Large-Scale Structure-Based Virtual Screening Identifies Diverse KNa1.1 (KCNT1) Potassium Channel Inhibitors https://www.biorxiv.org/content/10.1101/2025.09.30.679465v1

Application-dependent assessment of the human exposure potential to microplastics https://www.biorxiv.org/content/10.1101/2025.09.29.679164v1

Overcoming rapaprotin resistance through inhibition of P-glycoprotein https://www.biorxiv.org/content/10.1101/2025.09.28.679086v1

Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss https://www.biorxiv.org/content/10.1101/2025.09.26.678829v1