CK2 inhibitor, CX-4945, enhances BH3 priming and promotes apoptosis of venetoclax-resistant AML by targeting antiapoptotic proteins https://www.biorxiv.org/content/10.64898/2025.12.24.696284v1

Comprehensive Genotoxicity and Subchronic Oral Toxicity Evaluation of Kumamolisin from Bacillus sp. MN-32 for Human Use https://www.biorxiv.org/content/10.64898/2025.12.25.696157v1

Epidemiological Survey of Snail Intermediate Hosts of Schistosomiasis in Zaria, Northwest Nigeria and Molluscicidal Screening of Ficus exasperata Extracts https://www.biorxiv.org/content/10.64898/2025.12.23.695224v1

Whole-Tissue Distribution Analysis for Visualization of Nanoplastics in the Mouse Brain https://www.biorxiv.org/content/10.64898/2025.12.23.696138v1

Rat and rabbit whole embryo culture as a new approach method for unlabeled therapeutic antisense oligonucleotide hazard identification with no requirement for microinjection or assisted transfection https://www.biorxiv.org/content/10.64898/2025.12.23.692174v1

Genome-wide CRISPR screens identified C18orf32 as a novel regulator of lipid metabolism that mediates PFOA-induced toxicity https://www.biorxiv.org/content/10.64898/2025.12.23.696201v1

Correlative evaluation of anticancer effects of a modified methioninase MGL-KPV using 2D and 3D cell models, human cancer xenografts in zebrafish embryos and Balb/c nude mice https://www.biorxiv.org/content/10.64898/2025.12.23.696173v1

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model https://www.biorxiv.org/content/10.64898/2025.12.22.696115v1

Effects of nonpharmacological manipulations and repeated xanomeline treatment on methamphetamine-vs-food choice in Sprague Dawley and Long Evans rats https://www.biorxiv.org/content/10.64898/2025.12.22.696048v1

A Data-Driven Approach for the Development of a Time-informed Adverse Outcome Pathway-network for Cardiotoxicity of Environmental Chemicals https://www.biorxiv.org/content/10.64898/2025.12.22.695928v1

Acriflavine delivery via Polyurethane nanocapsules to treat neovascular age-related macular degeneration https://www.biorxiv.org/content/10.64898/2025.12.22.695712v1

Concentration-dependent suppression of macrolide resistance in Mycobacterium avium by combination therapy: an improved in vitro time-kill assay and PK/PD modelling study https://www.biorxiv.org/content/10.64898/2025.12.21.695645v1

Physiologically Based Pharmacokinetic Modeling of mRNA-Encoded Therapeutics: A Multiscale Framework for LNP and Antibody Trafficking in Mice https://www.biorxiv.org/content/10.64898/2025.12.20.695667v1

Withania somnifera root extract reduces susceptibility of the model worm Caenorhabditis elegans to different types of stressors https://www.biorxiv.org/content/10.64898/2025.12.18.695325v1

In vitro evidence for bisphenol A as a human liver carcinogen: Environmentally relevant doses inhibit cancer protective ESR1 signaling in a human liver cell line https://www.biorxiv.org/content/10.64898/2025.12.18.695265v1

Extraction method dominates phytochemical profiles of aromatic medicinal herbs: a comparative HPTLC study https://www.biorxiv.org/content/10.64898/2025.12.18.694438v1

(S)-ketamine augments behavioral and physiological responses to Δ9-tetrahydrocannabinol https://www.biorxiv.org/content/10.64898/2025.12.18.695060v1

Divergent Side-Chain Networks of the Mineralocorticoid Receptor Control Mutation-Altered Drug Response https://www.biorxiv.org/content/10.64898/2025.12.18.695081v1

Elemental Composition and Degradation Rate Impact the Biocompatibility of Copper Chalcogenide Nanocrystals https://www.biorxiv.org/content/10.64898/2025.12.17.695045v1

Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease https://www.biorxiv.org/content/10.64898/2025.12.17.694919v1

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells https://www.biorxiv.org/content/10.64898/2025.12.16.694451v1

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening https://www.biorxiv.org/content/10.64898/2025.12.16.694776v1

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility https://www.biorxiv.org/content/10.64898/2025.12.16.694775v1

Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system https://www.biorxiv.org/content/10.64898/2025.12.16.694641v1

MOPRs in mouse islets of Langerhans modulate cell signaling and secretion https://www.biorxiv.org/content/10.64898/2025.12.15.694418v1

The Immunogenicity Database Collaborative (IDC): A Standardized, Publicly Available Database for Clinical Immunogenicity Observations and Insights https://www.biorxiv.org/content/10.64898/2025.12.08.692993v1

Licoisoflavone A improves adipose tissue dysfunction in response to diet induced obesity by promoting METTL3 expression https://www.biorxiv.org/content/10.64898/2025.12.14.694234v1

Cholinergic regulation of prolonged alcohol withdrawal differs by sex https://www.biorxiv.org/content/10.64898/2025.12.12.693968v1

Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD https://www.biorxiv.org/content/10.64898/2025.12.12.693988v1

Dissecting GPCR Selectivity: A complex interplay of various intracellular motifs determines G-protein binding and activation https://www.biorxiv.org/content/10.64898/2025.12.12.693856v1

Assessing PDMS Biocompatibility in Microfluidic Applications: Toxicity and Survival Outcomes in C. elegans https://www.biorxiv.org/content/10.64898/2025.12.11.693574v1

Ehrlich occupancy time: Beyond koff to a complete residence time framework https://www.biorxiv.org/content/10.64898/2025.12.10.693538v1

Exploring the Application of the MoCMC System for Determining In Vitro Product Comparability https://www.biorxiv.org/content/10.64898/2025.12.10.693525v1

Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial https://www.biorxiv.org/content/10.64898/2025.12.09.693172v1

Epoxyazadiradione ameliorates Parkinson's disease by upregulating heat shock factor 1 and protein degradation pathways in mice. https://www.biorxiv.org/content/10.64898/2025.12.08.692835v1

Lysosomal accumulation of Masitinib alters autophagy via pH-dependent trapping. https://www.biorxiv.org/content/10.64898/2025.12.07.692822v1

Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicity https://www.biorxiv.org/content/10.64898/2025.12.04.691500v1

AlphaFold3 for Structure-guided Ligand Discovery https://www.biorxiv.org/content/10.64898/2025.12.04.692352v1

A broad set of synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG https://www.biorxiv.org/content/10.64898/2025.12.03.692044v1

μ-Opioid Receptor Superagonists Engage a Sodium-Bound Active State https://www.biorxiv.org/content/10.64898/2025.12.01.691612v1

N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation https://www.biorxiv.org/content/10.64898/2025.11.30.691375v1

Deposition of microplastics associated with bioaccumulation of heavy metals in human lungs of smokers: Implications of adsorption and mobilization of metals via microplastics https://www.biorxiv.org/content/10.64898/2025.11.30.691449v1

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery. https://www.biorxiv.org/content/10.1101/2025.11.27.690949v1

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants https://www.biorxiv.org/content/10.1101/2025.11.30.691394v1

SARS-CoV-2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways https://www.biorxiv.org/content/10.1101/2025.12.01.691535v1

Mechanistic analysis of compounds that modulate VEGF-A splicing in podocytes with therapeutic potential for diabetic nephropathy https://www.biorxiv.org/content/10.1101/2025.11.27.690981v1

Selective induction by statins of FAM134B-mediated sarcoplasmic reticulum (SR)-phagy degrades the SR calcium pump SERCA1 and contributes to myopathy https://www.biorxiv.org/content/10.1101/2025.11.26.690680v1

MicroRNAs are differentially altered by ethanol and caffeine consumption in the rat prostate https://www.biorxiv.org/content/10.1101/2025.11.26.690806v1

Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling study https://www.biorxiv.org/content/10.1101/2025.11.26.690715v1

Peptide nanoparticles for systemic mRNA delivery in rodents and non-human primates https://www.biorxiv.org/content/10.1101/2025.11.26.690657v1