Preclinical Safety Evaluation of Human Lactoferrin Alpha (Effera(R)) https://www.biorxiv.org/content/10.64898/2026.05.28.728516v1

Stochastic Differential Equations (SDEs) in NONMEM for Probing Population Pharmacokinetic Model Misspecification: Diagnostic Utility, Practical Considerations, and Future Directions https://www.biorxiv.org/content/10.64898/2026.05.28.728340v1

A field method to optimize dried blood spot sampling for mercury biomonitoring https://www.biorxiv.org/content/10.64898/2026.05.27.727713v1

Controlled delivery of iNOS antagonist, 1400W, for synergistic breast cancer therapy https://www.biorxiv.org/content/10.64898/2026.05.28.728138v1

Computational Design of Two New 5-HT1B Serotonin Receptor Agonists Derived from Naratriptan https://www.biorxiv.org/content/10.64898/2026.05.27.728311v1

PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners https://www.biorxiv.org/content/10.64898/2026.05.27.728112v1

Oral exposure to Perfluorooctanoic acid disrupts the microbiota-gut-liver axis and enhances the severity of chemically induced colitis in mice. https://www.biorxiv.org/content/10.64898/2026.05.26.727994v1

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3 https://www.biorxiv.org/content/10.64898/2026.05.26.727856v1

Accelerating drug development in infectious diseases using zebrafish disease models supported by pharmacokinetic pharmacodynamic modeling as new approach methodology (NAM) https://www.biorxiv.org/content/10.64898/2026.05.29.728504v1

Pharmacological profiling of brain activity in zebrafish https://www.biorxiv.org/content/10.64898/2026.05.27.728255v1

Translational Quantitative Proteomic Assay for Bacteriophages: A New Frontier in Phage Pharmaceutical Development https://www.biorxiv.org/content/10.64898/2026.05.27.728049v1

A Novel Hydrogen Polysulfide Donor Alleviates Neuropathic Pain by Enhancing A-Type Potassium Currents via LIMK1-Cofilin Mediated Interaction between Filamin A and Kv4.2 https://www.biorxiv.org/content/10.64898/2026.05.25.727751v1

Nicotine cessation in female, but not in male mice, mitigates the metabolism-disrupting offspring effect of nicotine exposure https://www.biorxiv.org/content/10.64898/2026.05.24.727521v1

An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidates https://www.biorxiv.org/content/10.64898/2026.05.23.727430v1

Interconnecting ADC Structure with Tumor Cell Biology with Multimodal Learning https://www.biorxiv.org/content/10.64898/2026.05.22.727320v1

Daikenchuto modulates gut microbial metabolism to mitigate irinotecan-induced enterotoxicity https://www.biorxiv.org/content/10.64898/2026.05.22.727323v1

An AI-agent-orchestrated grey-box Transformer framework for sparse pharmacokinetic curve reconstruction and pharmacometric model initialization https://www.biorxiv.org/content/10.64898/2026.05.23.727373v1

Polystyrene Nanoplastics Disrupt Mouse Placenta Development in a Sex-Dependent Manner https://www.biorxiv.org/content/10.64898/2026.05.22.727211v1

(+)-trans-Cannabidiol is a CB2 receptor agonist https://www.biorxiv.org/content/10.64898/2026.05.25.727077v1

Human CNS-3D organoids predict clinical seizure liability from calcium network activity https://www.biorxiv.org/content/10.64898/2026.05.20.726675v1

Harnessing TfR1 for Cross-Species Systemic Delivery of siRNAs to Deep Brain Regions Using Single-Domain Antibodies https://www.biorxiv.org/content/10.64898/2026.05.20.726486v1

High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimers Disease https://www.biorxiv.org/content/10.64898/2026.05.19.726383v1

Reappraisal of GPR40/FFAR1 as a Therapeutic Target for Type 2 Diabetes Mellitus: Systematic Cheminformatic Analysis of 2,637 Compounds in ChEMBL 36 Identifies Superior Candidates to Fasiglifam https://www.biorxiv.org/content/10.64898/2026.05.19.726272v1

Glucagon-like peptide-1 receptor agonist, semaglutide, attenuates intravenous self-administration of fentanyl in female rats https://www.biorxiv.org/content/10.64898/2026.05.19.726324v1

UT-018 Accelerates Wound Repair and Hair Follicle Regeneration in Murine Models https://www.biorxiv.org/content/10.64898/2026.05.18.726121v1

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension https://www.biorxiv.org/content/10.64898/2026.05.14.725284v1

Occupationally Relevant Wildfire Smoke Inhalation Impairs Nitric Oxide Signaling and Promotes Progressive Aortic Stiffening in Hypercholesterolemic Mice https://www.biorxiv.org/content/10.64898/2026.05.18.725908v1

Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent https://www.biorxiv.org/content/10.64898/2026.05.17.725760v1

Multiscale Free-Energy Methods for Protonation-Coupled Light-Responsive Binding of Ionizable Photoswitchable eDHFR Inhibitors https://www.biorxiv.org/content/10.64898/2026.05.16.725670v1

Multiple Pesticides and their Mixtures Tested for Genotoxicity in the Micronucleus Assays on Intestinal Caco-2 Cells https://www.biorxiv.org/content/10.64898/2026.05.16.725095v1

Bidirectional interactions between gut microbiota and fluorochemical biotransformation and bioactivity https://www.biorxiv.org/content/10.64898/2026.05.15.725488v1

Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead https://www.biorxiv.org/content/10.64898/2026.05.15.725542v1

Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats https://www.biorxiv.org/content/10.64898/2026.05.14.725258v1

Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity https://www.biorxiv.org/content/10.64898/2026.05.14.725303v1

Validation and testing of an in vitro model to study medical treatments for anterior urethral stricture disease: assessing the potential efficacy of phosphodiesterase-4 (PDE4) inhibition and testosterone https://www.biorxiv.org/content/10.64898/2026.05.13.724950v1

Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction-Associated Steatohepatitis in Mice https://www.biorxiv.org/content/10.64898/2026.05.12.724693v1

Report on pre-validation of an animal-free alternative method (NAM) for regulatory safety testing: InfiniteLungDT, an in-vitro-learned digital twin for the prediction of material-triggered chronic neutrophilic lung inflammation https://www.biorxiv.org/content/10.64898/2026.05.12.723437v1

Pharmaceutical assessment of low global warming potential alternatives to HFA-134a in a budesonide, glycopyrrolate, and formoterol fumarate pressurized metered dose inhaler https://www.biorxiv.org/content/10.64898/2026.05.12.724523v1

An N, S-acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken Pseudomonas aeruginosa biofilm and dampens LPS-driven acute pulmonary inflammation https://www.biorxiv.org/content/10.64898/2026.05.13.724891v1

Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of the class B1 GPCRs, calcitonin gene-related peptide and parathyroid hormone 1 receptors, in native-like nanodiscs https://www.biorxiv.org/content/10.64898/2026.05.13.724797v1

Effects of NMDA antagonists on social behaviour: a systematic review and meta-analysis of preclinical studies https://www.biorxiv.org/content/10.64898/2026.05.13.724847v1

Topological Pharmacokinetics: Reading the Shape of Drug Disposition from Data https://www.biorxiv.org/content/10.64898/2026.05.13.724751v1

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload https://www.biorxiv.org/content/10.64898/2026.05.12.724311v1

A Cherry-Flavoured E-Cigarette Adduct, BPGA, Reprograms Alveolar Epithelial Cell Fate Through Epithelial-to-Mesenchymal Transition and Evasion of Apoptosis https://www.biorxiv.org/content/10.64898/2026.05.12.724520v1

ERRγ deletion in podocytes accelerates aging related kidney disease https://www.biorxiv.org/content/10.64898/2026.05.11.724391v1

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling https://www.biorxiv.org/content/10.64898/2026.05.11.724263v1

Comparative metabolism of the Alternaria toxins altenuene and tentoxin in rat and human primary hepatocytes https://www.biorxiv.org/content/10.64898/2026.05.11.724251v1

Drug Proarrhythmic Evaluation in a High Throughput Cardiac New Approach Methodology https://www.biorxiv.org/content/10.64898/2026.05.11.722965v1

Toward a Random Background for Ligand Optimization https://www.biorxiv.org/content/10.64898/2026.05.10.724162v1

Adequate coating and change in morphology increase the performances of silver nanoparticular biocides https://www.biorxiv.org/content/10.64898/2026.05.11.724204v1