ToxMCP: Guardrailed, Auditable Agentic Workflows for Computational Toxicology via the Model Context Protocol https://www.biorxiv.org/content/10.64898/2026.02.06.703989v1

Predicting Sex-Specific Antiarrhythmic Strategies for Atrial Fibrillation through a Regression-Guided Computational Modeling Pipeline https://www.biorxiv.org/content/10.64898/2026.02.06.704432v1

Disulfiram Protects Against Diet-Induced Obesity by Reprogramming Systemic Lipid Partitioning Independent of GSDMD https://www.biorxiv.org/content/10.64898/2026.02.06.704424v1

Cellular thermal shift assay of subcellular isolates for evaluating drug-membrane target interactions https://www.biorxiv.org/content/10.64898/2026.02.03.703651v1

Ribociclib as a Potential Multi-Target Inhibitor of Pro-Inflammatory Cytokines: An In Silico Investigation https://www.biorxiv.org/content/10.64898/2026.02.04.703909v1

A Human Next Generation PBK Model for PFOA https://www.biorxiv.org/content/10.64898/2026.02.04.703497v1

Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug Development https://www.biorxiv.org/content/10.64898/2026.02.03.703154v1

Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces https://www.biorxiv.org/content/10.64898/2026.02.04.703700v1

Tracing PFAS Transfer from Mother to the Fetoplacental Unit: Insights from Trimester-Specific Maternal Serum Profiles https://www.biorxiv.org/content/10.64898/2026.02.02.703409v1

Model Ensembling and Machine Learning Approaches to Predict the First Dose of Amoxicillin in Intensive Care https://www.biorxiv.org/content/10.64898/2026.02.03.703266v1

Visual - Acoustic Thigmotaxis in Zebrafish Larvae: A High throughput NAM for Neurotoxicity Assessment https://www.biorxiv.org/content/10.64898/2026.02.03.703464v1

Predicting early bactericidal activity of tuberculosis drug combinations using a translational pharmacokinetic-pharmacodynamic modeling approach https://www.biorxiv.org/content/10.64898/2026.01.29.702705v1

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice https://www.biorxiv.org/content/10.64898/2026.01.28.702297v1

Structural Optimization of CHI3L1 Inhibitors with Improved Pharmacokinetics and Functional Activity in 3D Glioblastoma Models https://www.biorxiv.org/content/10.64898/2026.01.28.702243v1

Intracellular targeting of a light-activated GPCR elicits spatially selective signalling https://www.biorxiv.org/content/10.64898/2026.01.29.702683v1

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission https://www.biorxiv.org/content/10.64898/2026.01.29.702703v1

A Robust Chemical-free Platform for Age-Synchronized Caenorhabditis elegans Populations Maintenance for High-Throughput Screening in Aging Studies https://www.biorxiv.org/content/10.64898/2026.01.27.702075v1

Pharmacokinetics and Physiologically Based Pharmacokinetic Modeling of Mycobacteriophages: Insights into Pulmonary Distribution and Clearance https://www.biorxiv.org/content/10.64898/2026.01.27.702067v1

Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern https://www.biorxiv.org/content/10.64898/2026.01.27.702058v1

Identification of clofibric acid as a SYVN1 ligand for PROTAC development https://www.biorxiv.org/content/10.64898/2026.01.26.701774v1

A comprehensive resource on chemicals used in aquaculture and their ecotoxicity https://www.biorxiv.org/content/10.64898/2026.01.26.701529v1

Radiosynthesis and Evaluation of Novel Cholesterol 24-Hydroxylase Positron Emission Tomography Tracers https://www.biorxiv.org/content/10.64898/2026.01.25.701607v1

Development of a NanoBiT based high throughput screening assay for discovery of NOS1-CAPON interaction inhibitors https://www.biorxiv.org/content/10.64898/2026.01.25.701608v1

Potential nematicides identified through targeted in vivo screening of a 5-HT-gated chloride channel, MOD-1 https://www.biorxiv.org/content/10.64898/2026.01.25.701312v1

Gut microbiota-derived indole-3 acetic acid mitigates key hallmarks of metabolic dysfunction-associated steatotic liver disease (MASLD) in an NLRP3-dependent manner in in vitro and diet-induced mouse models https://www.biorxiv.org/content/10.64898/2026.01.25.701562v1

Small molecule modulators targeting the interactions of small GTPase ARF1 with C9orf72:SMCR8:WDR41 complexes implicated in ALS/FTD https://www.biorxiv.org/content/10.64898/2026.01.24.701325v1

DEDuCT 3.0: An enhanced and expanded FAIR-compliant resource and toxicology knowledge graph for endocrine disrupting chemicals https://www.biorxiv.org/content/10.64898/2026.01.23.701267v1

Pharmacological Restoration of Mitochondrial Permeability Transition Pore Flickering by High-Content Drug Repurposing https://www.biorxiv.org/content/10.64898/2026.01.23.701330v1

Cyanine dye conjugates of a 2'-deoxycytidine-based auto- and mitophagy activator extend Caenorhabditis elegans lifespan https://www.biorxiv.org/content/10.64898/2026.01.23.701232v1

Biodistribution of mRNA vaccines in rats: Enrichment in injection site and lymph tissues and rapid clearance without tissue persistence https://www.biorxiv.org/content/10.64898/2026.01.23.701408v1

Cannabidiol Inhibits PIEZO Channels to Mitigate Red Blood Disorders https://www.biorxiv.org/content/10.64898/2026.01.22.700543v1

Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease https://www.biorxiv.org/content/10.64898/2026.01.22.701013v1

Perinatal Exposure to Organophosphate Flame Retardants Induces Sex- and Hormone-Dependent Alterations in Anxiety, Memory, Neurotransmitter Content, and Hippocampal Gene Expression https://www.biorxiv.org/content/10.64898/2026.01.21.700648v1

Asarinin Inhibits RANKL-Induced Osteoclast Differentiation by Targeting the p38/ERK-c-Fos-NFATc1 Axis https://www.biorxiv.org/content/10.64898/2026.01.21.700569v1

Real world data based evaluation of a novel target-mediated drug disposition approximation model https://www.biorxiv.org/content/10.64898/2026.01.20.700502v1

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models https://www.biorxiv.org/content/10.64898/2026.01.19.700278v1

Effects of chronic intraperitoneal administration of the GABA-B receptor agonist 3-aminopropyl (methyl) phosphinic acid on food intake and body weight in rats https://www.biorxiv.org/content/10.64898/2026.01.18.700182v1

Isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential https://www.biorxiv.org/content/10.64898/2026.01.17.700097v1

CTLA-4 inhibitors drive colitis through metabolic reprogramming-mediated Treg/Th17 imbalance https://www.biorxiv.org/content/10.64898/2026.01.20.700699v1

Development of Physiologically Based Liver Distribution Model that Incorporates Intracellular Lipid Partitioning and Binding to Fatty Acid Binding Protein 1 (FABP1) https://www.biorxiv.org/content/10.64898/2026.01.17.700130v1

Late gestational exposure to flutamide alters stromal composition and immune landscape in the rat mammary gland during pre-puberty, peri-puberty, and adulthood https://www.biorxiv.org/content/10.64898/2026.01.16.699958v1

Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses https://www.biorxiv.org/content/10.64898/2026.01.15.699745v1

Prioritizing Neuroactive Ligands Using Motif-Guided Virtual Discovery and Zebrafish Profiling https://www.biorxiv.org/content/10.64898/2026.01.15.699747v1

Negative allosteric modulation of α5-GABAA receptors engages dynamic cortical glutamatergic and GABAergic mechanisms underlying adaptive behavior in mice https://www.biorxiv.org/content/10.64898/2026.01.15.699507v1

Dualsteric and dual-acting modulation of muscarinic receptors by antagonist KH-5 https://www.biorxiv.org/content/10.64898/2026.01.15.699667v1

Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity https://www.biorxiv.org/content/10.64898/2026.01.15.699687v1

Updating ACC preclinical models: characterization of two new patient-derived cell lines https://www.biorxiv.org/content/10.64898/2026.01.15.699554v1

NexaSweet Attenuates DSS-Induced Colitis and Preserves Colon Architecture in BALB/c Mice https://www.biorxiv.org/content/10.64898/2026.01.15.699670v1

Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations https://www.biorxiv.org/content/10.64898/2026.01.14.699504v1

Transient silencing of spinal nociceptive neurons leads to a long-term reduction in joint pain mediated by recruitment of opioid activity. https://www.biorxiv.org/content/10.64898/2026.01.14.699276v1