Excellent new preprint by @sroig.bsky.social @djabaudon.bsky.social & collaborators on the prenatal assembly of functional cortical circuits. Great discussion of maturation www.biorxiv.org/content/10.6... 🧪🧠

New work from @estherkli.bsky.social and @djabaudon.bsky.social in @nature.com. Machine vision + cross-species comparison of developing mouse, human neocortex & organoids reveal how temporal gene regulation drives species-specific cortical features. www.nature.com/articles/s41...

Important work in @nature.com from @gordfishell.bsky.social lab reveals pyramidal neurons can actively shape both the diversity and circuit integration of interneurons in the cortex.

Fascinating work in @nature.com from Alex Pollen lab using CRISPRi screening to identify key transcription factors driving human radial glial neural stem cell fate—with causal validation. www.nature.com/articles/s41...

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n www.nature.com/articles/s41...

Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision! www.science.org/doi/10.1126/...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes @zhoujoeyyi.bsky.social www.nature.com/articles/s41...

Excited to share our study published in @natneuro.nature.com today! We conducted cross-species analyses of immature neurons arising from adult hippocampal neurogenesis, revealing distinct human-specific gene expression patterns but convergent biological processes. www.nature.com/articles/s41...

Great work in @nature.com by @qianxuyu.bsky.social from Dr. Chris Walsh lab revealing early specification of the human cortex using spatial omics. Congratulations Xuyu!🎊🎉

A new study in preprint from @amarsahay.bsky.social lab shows that prolonged maturation of adult-born hippocampal neurons affects hippocampal network by strengthening inhibitory brain circuitry. doi.org/10.21203/rs....

New preprint out from the lab, check out thread below!

Thank you, Dr. Boeckx, for highlighting our work ! It’s exciting to see the convergence of our findings, which suggest that lysosome function in neuronal development evolves across species in a spatiotemporal- and cell type-dependent manner, with human lysosomes playing unique roles.

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...