A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪

#Jobalert 🚨: Please RT ! Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ? #epigenomics, #epigenetics, #metabolism www.helmholtz-munich.de/en/ife/job-o...

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Lab-grown organoids reproduce some of a kidney’s internal structure and function. https://scim.ag/4n0YH26

Surprising?

"We are so very late that many students will not be able to apply this year." My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org www.science.org/content/arti...

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Unmasked: transposable elements as drivers and targets in cancer. #TransposableElements #TEs #CancerDrivers @cp-trendsgenetics.bsky.social www.cell.com/trends/genet...

Survey the landscape of healthy human immune cells from childhood to adulthood with the Human Immune Health Atlas! This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc... #OpenScienceWeek

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...

🚀 WE'RE BACK! "The Many Faces of Cancer Evolution" is coming back to Rimini on May 27-29, 2026! meetings.embo.org/event/26-can... Join me, Luca @magnanilab.bsky.social , Celine Vallot, and Samra @turajliclab.bsky.social for 3 days of amazing science on the beach! @embo.org meeting #cancer 👇👇

Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth go.nature.com/4lZtawb

(1/4) New preprint from the lab! The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Pretty amazing observation in nature rdcu.be/eEebw

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars! stanfordsciencefellows.stanford.edu

🧬 The 2025 Emma Whitelaw ECR publication award is now open! Full T&Cs and application form are on the AEpiA website www.aepia.org.au/emma-whitela... We can't wait to see the exciting research that has been published over the last year! #epigenetics #ECR #research #AEpiA

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Epigenetics Update - Thymic epithelial cells amplify epigenetic noise to promote immune tolerance go.nature.com/45srCWG Andrew S. Koh (University of Chicago) reporting in Nature #Epigenetics #Noise #Chromatin #Immunity --- High-resolution insights without cell sorting; epigenometech.com

Very proud of these two! Anna Pascual Reguant | Kellie Wise A beautiful collaboration with Jasmine Plummer & Holger Heyn CNAG | St Jude Children’s Research Hospital #STAMP Imaging-based multimodal profiling of single cells with STAMP | Nature Reviews Genetics www.nature.com/articles/s41...

A new study, led by VAI’s Dr. Russell Jones and published in @cp-cellmetabolism.bsky.social, reveals that glucose, long known as a vital fuel for immune cells, also plays a key role in helping cancer-fighting T cells communicate and function effectively. www.vai.org/article/swee...

The American Chemical Society announced that the ACS Board of Directors has approved $2.5 million to be granted to graduate students who have been impacted by the termination or cancellation of their adviser’s research grant(s) cen.acs.org/acs-news/acs... #chemsky

NIH Institutes seem to be working to keep existing grants whole (mostly) (Type 5). But are severely behind in issuing new grants (Type 1). Blue/grey lines represent data from years 2015-2024. Red lines are 2025 data.

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

In mice, maternal antibodies ingested in breast milk in the first week after birth help to regulate immune responses in the newborn gut, according to a new study in Science. Learn more: scim.ag/45yW4Nq

What’s next in metabolism research? VAI’s Metabolism and Nutrition (MeNu) Program recently asked top experts to forecast their bold ideas. Read about six areas they said are primed for discovery: www.vai.org/article/what...

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...

Congratulations to @nickburton.bsky.social, who was named today as a Pew Scholar in the Biomedical Sciences! This four-year award supports exceptional early-career scientists who seek answers to pressing questions about health and disease.

Congratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Nature research paper: Parent-of-origin effects on complex traits in up to 236,781 individuals go.nature.com/4ox9fr5

Excited to share that my first-author publication from my PhD on the interplay of p53 with cofactors on chromatin is now online in Molecular Cell @cp-molcell.bsky.social : www.cell.com/molecular-ce... Nucleosomes filter cofactor access to p53 - USP7 can bind whereas E6AP-E6 fails to form a complex.

Researchers have registered more than 120 clinical trials to date evaluating the potential of mRNA-based approaches for treating many types of cancer, including lung, breast, and prostate, pancreatic, and brain tumors.

Around the world, the student visa landscape is undergoing a tectonic shift. My latest for @nature.com looks at the impacts on early career researchers—& country economies. One PhD student from China now plans to leave the US: “I want to work somewhere where I feel seen, valued and appreciated”

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures www.cell.com/cancer-cell...

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...

Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2

Want to gain a deeper understanding of the analyses and considerations that guide decisions about which articles to publish in NEJM? And how this knowledge will impact your career? If so, consider applying for the 2026–2027 NEJM editorial fellowship. Applications due August 1. nej.md/3cCQajB

Moving to a four-day work week without losing pay leaves employees happier, healthier and higher-performing go.nature.com/4lIJ9zf

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

New preprint from the lab - using variance QTLs to identify GxE interactions in genetically-identical twins @kingslsm.bsky.social @kingscollegelondon.bsky.social

Epigenetics Update – The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate go.nature.com/4lK2uQS Abigail Buchwalter (UCSF) reporting in Nat Cell Biol #Epigenetics #H3K9me2 #StemCells --- High-resolution insights without cell sorting; epigenometech.com

A landmark study published in @nature.com by @aaronmring.bsky.social et al. has revealed that autoantibodies — immune proteins traditionally associated with autoimmune disease — may profoundly influence how cancer patients respond to immunotherapy. Read more: www.fredhutch.org/en/news/rele...

new out in Nature www.nature.com/articles/s41...

🚨 New paper alert 🚨 I am excited to share our new work on epigenetic enhancer priming in early mammalian development genomebiology.biomedcentral.com/articles/10.... Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd. Short 🧵