Discussed @mrsantos.bsky.social lit review: Analog epigenetic memory revealed by targeted chromatin editing. www.sciencedirect.com/science/arti...

Trick or Treat! 👻🎃

Discussed @mrsantos.bsky.social lit review: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. www.biorxiv.org/content/10.1...

Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...

(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.

The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more 👉 https://www.isscr.org/nominations

John Gurdon was a true giant: - founder of cell reprogramming; - founder of molecular embryology; - unabashed advocate for basic research; - advisor to numerous successful trainees/PIs; - gentle human that touched so many. In dark times with science under attack, let his vision be a guiding light.

🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost!

Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.

(1/4) New preprint from the lab! The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...

‪Discussed @mrsantos.bsky.social lit review: A single-cell time-lapse of mouse prenatal development from gastrula to birth. www.nature.com/articles/s41...

🌞 Let's enjoy the summer time in Toronto! 🏖️

Discussed @mrsantos.bsky.social lit review: Recovering undersampled single-cell transcriptomes with HyperCell. www.researchsquare.com/article/rs-6...

(1/3) Latest preprint from the lab! 📝 This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells. doi.org/10.1101/2025...

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

‪Discussed @mrsantos.bsky.social lit review: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos www.nature.com/articles/s41...

Congrats to Dr. Cho on the successful PhD defense!

Discussed @mrsantos.bsky.social lit review: Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. pubmed.ncbi.nlm.nih.gov/27454292/

Discussed @mrsantos.bsky.social lit review: Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator. www.nature.com/articles/s41...

Discussed @mrsantos.bsky.social lit review: Genome-coverage single-cell histone modifications for embryo lineage tracing. www.nature.com/articles/s41...

Discussed @mrsantos.bsky.social lit review: How epigenetic inheritance fails to explain the Black-White health gap. www.sciencedirect.com/science/arti...

Discussed @mrsantos.bsky.social lit review: RNA polymerase II at histone genes predicts outcome in human cancer. www.science.org/doi/10.1126/...

Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption: (1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.

Read the recent review by @mrsantos.bsky.social that marks two decades of stem cell breakthroughs 🔬 🙌 🎉 Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease. www.cell.com/stem-cell-re...

Two more weeks to apply to join us in Paris ! research.pasteur.fr/en/call/call...

Out now at Stem Cell Reports @isscr.org: a Perspective on the history of stem cell transcriptomics. We show that a stemness signature from the early 2000’s (Miguel's PhD work) foreshadowed stem cell hypertranscription. Thanks @pairedbox.bsky.social for this adventure! www.cell.com/stem-cell-re...

🗞️Breaking News: our team was just awarded a new, 5-year CIHR Project Grant for our studies of the regulation of hypertranscription! We are very grateful to the Canadian Institutes of Health Research for their continued support of our research in developmental epigenetics. @sinaihealth.bsky.social

We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements. www.genesdev.org/cgi/doi/10.1...