And now it's time without further ado for my 12th Annual Top 10 Muscle Papers of the Year countdown. This year, we had over 70 votes for the top muscle papers of 2025. Thank you to all participants and authors for an exciting year of muscle biology. #Myoblue

#10. Peng et al., Nat. Comms., Stage-specific and cell-autonomous functions of Delta-like 1 in skeletal muscle stem cells and myogenesis. #Myoblue tinyurl.com/mkxmrjw5

#9. Sica et al., Cell Reports., The central clock drives metabolic rhythms in muscle stem cells. #Myoblue tinyurl.com/3v6dyc43

The GDF3–SMAD2/3 axis as a critical driver of age-associated chromatin remodeling adipose tissue macrophage-mediated inflammation and a promising therapeutic target for mitigating macrophage-related inflammation in #aging www.nature.com/articles/s43...

New athero paper! We only played a minor part but very happy for our @ipekresearch.bsky.social collaborators that this is out now: www.atherosclerosis-journal.com/article/S002...

Previously shared: A study to take to heart This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....

Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan... #incretins #MedSky #EndoSky

good new this morning: manuscript accepted! Final form of this pubmed.ncbi.nlm.nih.gov/40894762/ coming soon to @dev-journal.bsky.social. Congratulations to everyone from @ucsanfrancisco.bsky.social @ucsfanesthesia.bsky.social @gladstoneinst.bsky.social, and Alex Clark in @jsauce7.bsky.social's lab.

PPARα-dependent mitochondrial programming promotes the differentiation of SC-β cells and may be a promising target to improve β cell replacement efforts for #T1D #stemcells #islets www.nature.com/articles/s41... 🧪

It is that time again, time to vote for the 12th Annual Matt's Totally Biased (but less so) Top 10 Muscle Papers of the Year. Due to prohibitive shipping costs, this year’s winner will receive an e-gift card in lieu of a plaque. Voting will end Dec. 20. uab.co1.qualtrics.com/jfe/form/SV_...

After disappointments in neurodegenerative disorders #Parkinsons #AlzheimersDisease will GLP-1 medicines prove useful with an effective safety and efficacy profile in substance use disorders? www.nature.com/articles/d41... 🧪

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis: Cell www.cell.com/cell/fulltex...

I wanted to highlight our lab's recent #CommsBiology manuscript: Conditional Dmd ablation in muscle and brain causes profound effects on muscle function and neurobehavior. Credit to Muthukumar Karuppasamy & all collaborators, and team. #Myoblue tinyurl.com/2f4s2ar7

Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten. Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪 physoc.onlinelibrary.wiley.com/doi/10.1113/...

On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Based on extensive mouse studies demonstrating miR-432 exacerbates #obesity induced dysregulation of glucose and lipid metabolism, the authors propose miR-342 antagonist to treat cardiometabolic disorders diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...

I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏 full text access here rdcu.be/ePcEK

Need a big toolkit for your next cloning project, a whole palette of biosensors or fluorescent proteins, or expression constructs spanning your favorite pathway? Addgene kits may be just what you need!

In case you missed the ILCOR release, highlights of the new resuscitation guidelines can be found here: cpr.heartandstroke.ca/s/article/20...

The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect thelancet.com/journals/lan...

I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...