🧬 @benaroyaresearch.bsky.social scientists, led by Dr. John Ray, have unveiled how genetic variants associated with autoimmune diseases directly alter #Tcell gene regulation and function. Press release: https://bit.ly/4nQGT9S Abstract in @natgenet.nature.com#Tcell https://go.nature.com/4guL8FE

@uwcse.bsky.social researchers @suinlee.bsky.social, @chanwoo-kim.bsky.social & @sohamgadgil.bsky.social argue that a key standard for deploying medical #AI is transparency — that is, using various methods to clarify how a medical AI system arrives at its diagnoses and outputs.

🧫 A new study by @fredhutch.org's Dr. Taran Gujral compares the effectiveness of drugs tested on two different kinds of samples: the conventional cancer cells grown in a Petri dish and on “microtumors". The model predicts 3X as many drugs would be effective on #microtumors: https://bit.ly/3W8So0A

Synthesize Bio, a Seattle-based startup founded by Drs. Jeff Leek and Robert Bradley from @fredhutch.org, announced $10 million in funding. 💊 The biotech aims to make new drug discovery faster and cheaper by simulating the results from hypothetical lab experiments with AI: https://bit.ly/4nlp2s3

Explore this article to see the featured work from Dr. Jay Shendure at @uwgenome.bsky.social!

Dr. Lee Hood has been named one of the inaugural recipients of the Michael Sela Prize in Biomedical Sciences, awarded by the Weizmann Institute of Science. He shares the honor with Drs. Francis Collins and Eric Lander for pioneering work that has reshaped modern medicine. https://bit.ly/46sK1lf

Congrats to Dr. Joshua Hill on being the recipient of a 5-year K24 Midcareer Investigator Award from @niaidnews.bsky.social! 👏 The proposed studies will evaluate best approaches for the use of antibody infusions and vaccination to reduce infections after #CARTTherapy. https://bit.ly/46i9zmr

🧠 Scientists shot lasers into brain cells to uncover how illusions work. This study, published in @natneuro.nature.com, was supported by the @alleninstitute.org’s OpenScope program and could help us better understand neuropsychiatric disorders. Learn more: https://bit.ly/3Kb0Ute #Neuroscience

new pape from our lab, led by the indefatigable @chrisjdallmann.bsky.social. i am very proud of this one.

The Washington Research Foundation has awarded $1 million to @fredhutch.org to accelerate the development of technologies with significant potential to improve patient health. Congratulations to Drs. Sujatha Srinivasan, David Fredricks, Dan Raftery, and Kristin Lastwika! https://bit.ly/3Vn6xHk

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Dr. Elizabeth Swisher, who leads #GynecologicOncology at @fredhutch.bsky.social#GynecologicOncology was recently named the inaugural recipient of the Torkelson Family Endowed Chair. 🍻 Congratulations Dr. Swisher! https://bit.ly/42iHBoj

From epigenetics to optogenetics, scientists are uncovering how environment and brain chemistry shape addiction. In a new #LabNotes episode, @amityaddrisi.bsky.social and @lizdueweke.bsky.social blend neuroscience with lived experience to reframe the crisis. alleninstitute.org/news/lab-not...

In a new paper in @science.org, a @uwgenome.bsky.social research team led by Dr. Jen Davis shows that #fibroblasts, often thought of as helpers, may weaken the heart by causing a harmful cycle of stiffening and scarring. 📰 Press release: https://bit.ly/3ViR7Uo 📝 Abstract: https://bit.ly/4mbwvbv

An ISCRM research team of biologists, engineers, and physicians shows that fibroblasts, often thought of as helpers, may weaken the heart by causing a harmful cycle of stiffening and scarring, and pinpoint a potential fix.

Neuroscientists are working to understand the mechanisms of addictive drug use and how to alleviate the debilitating withdrawal symptoms. 🎧 Check out the Lab Notes Podcast from the @alleninstitute.org to hear from researchers and social workers in the field: https://bit.ly/4n9qtJR #Neuroscience

Dr. Elizabeth Swisher, a pioneer in gynecologic oncology, receives the Torkelson Family Endowed Chair. This gives her more flexibility to pursue lifesaving research. https://bit.ly/4mYFNJp The chair was established by Doris Torkelson, who was successfully treated for ovarian cancer at Fred Hutch.

A @brotmanbaty.bsky.social-led paper shows that #VariantEffects span a multi-dimensional continuum, rather than a pathogenic-benign binary, or 1-D spectrum. Learn more about how Drs. Sriram Pendyala and Doug Fowler used VIS-seq to visualize molecular and cellular phenotypes: https://bit.ly/47yrhTI

Congrats to @xiangyiding.bsky.social et al. on their new study on the intense cellular dance happening in worm cells! 🕺 Dive into the #FrontierScience of organelle crowd control. 👇

Lila Biologics, a startup that spun out of Nobel Laureate Dr. David Baker’s lab at the University of Washington, announced a collaboration with Eli Lilly to develop therapies for treating solid tumors. Learn more from CEO Dr. Jake Kraft and Chief Scientist Dr. Anindya Roy: https://bit.ly/3Ib3tLk

Dr. Tim Dellit was among the "Academic Medical Center CEOs to Know" profiled in Becker's Hospital Review.

A recent study from the Gerner and Urdahl labs at UW and @seattlechildrens.org uncovers fundamental determinants of tuberculosis lung pathology. This has important implications for new strategies to prevent or treat tuberculosis. 🧐 See the abstract in @jem.org : https://bit.ly/41IdeHA

We know hormones impact the brain, but what if we could see it happening on a cellular level? 🧠👀 @neurrriot.bsky.social, Stephanie Correa, and Ed Van Veen are making a platform that directly observes relationship b/w hormones and brain state. #FrontierScience 🧠📈 alleninstitute.org/division/fro...

Wondering what’s happening in Seattle’s life sciences scene this September? Look no further than our events calendar! It's your one-stop hub for biotech talks, conferences, trivia nights, and more across academia and industry! 📆 Never miss a moment of discovery: https://bit.ly/41IoWlm

Recent PhD grad Dishuck unveiled NPIP structural variation & evolutionary dynamics across 169 human haplotypes—revealing brain-expressed paralogs & more: pubmed.ncbi.nlm.nih.gov/40848717 🎧 Base by Base Ep 129: Dives into NPIP’s role in our genome: basebybase.castos.com/episodes/str... @hhmi.org

🚗 Dr. Juliane Gust at @seattlechildrens.org is not only advancing #CARTTherapy, she's leading groundbreaking work to safeguard neurocognitive health. As one of the first to document CAR T neurotoxicity, Dr. Gust pioneers research aimed at reducing side effects: https://bit.ly/468DSuA

Together with @nautilus.bio, we're mapping the spread of tau proteins in Alzheimer's disease at a new level of detail. Molly Coddington for Technology Networks dives into why the focus on tau proteins versus amyloid plaques and how it could help #EndAlz. www.technologynetworks.com/proteomics/b...

Fentanyl is 100x stronger than morphine and it's reshaping the public health landscape. In a new #LabNotes episode, dive into the neuroscience of addiction and the human stories behind the crisis: alleninstitute.org/news/lab-not... Feat. researchers Christian Luscher and Seattle's Recovery Cafe.

Celebrate Open Science Week with us with science trivia at Flatstick Pub South Lake Union on Sept. 17! 🧬💡 Trivia rounds begin at 7pm and 8pm. Get there at 6pm to chat with scientists and even invite one to join your team! RSVP for a free drink ticket: alleninstitute.org/events/scien...

Researchers at @fredhutch.bsky.social and @uwbiology.bsky.social want to find the function of every protein-coding gene in the human genome by discovering what happens when that gene is turned off using cell culture models. Dr. Wei Sun co-leads this huge data analysis: https://bit.ly/4na9bMd

Dr. Sarah Holton (@drylungs.bsky.social from @@uwmedicine.bsky.socialis the recipient of a K23 award to support her efforts to define the immune cell populations that lead to progression of fibrosis in Interstitial Lung Disease. Congratulations Dr. Holton! https://bit.ly/4g0cHq4

Aging. It happens to all of us yet we don’t fully understand how it happens. Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...

🚀 Seattle science is out of this world—literally! Specially designed cells from the @alleninstitute.org blasted off to the International Space Station as part of a multi-year research project investigating if #StemCells can be turned into heart and brain organoids in space: bit.ly/4mEbVBH

Dr. Nasa Sinnott-Armstrong from @fredhutch.bsky.social has been awarded $300,000 for research to develop AI tools to treat #LymeDisease. Their work will efficiently evaluate potential treatments and drug candidates for Lyme disease. 🍾 Congratulations! bit.ly/4g8ruz9

We are looking for a new coordinator to join the Education & Engagement team at @alleninstitute.org! This person will support the full breadth of our efforts here in the program, including administrative support, participant communications, helping with field trips, and much more. 1/2

🗺️🔬 A first-of-its-kind map of lipid traffic is demystifying an important yet elusive aspect of how cells work. Read the study, out now in @nature.com, by Allen Distinguished Investigators Alf Honigmann, @nadlerlab.bsky.social, and collaborators: www.nature.com/articles/s41... #FrontierScience

🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools. 🔗 royalsociety.org/medals-and-p...

Dr. Madhav Dhodapkar, the Scientific Director of @fredhutch.bsky.social’s Multiple Myeloma Program, is the new Milton B. Rubin Family Endowed Chair. 🤩 The Dhodapkar lab has been investigating immune-based approaches for the treatment of multiple myeloma: bit.ly/41ponwE

Every gene has a job. Fred Hutch is helping figure out what they are—and how they impact our health. #Genomics #PrecisionMedicine #CRISPR #humangenome Read more: https://bit.ly/4oLe6ou

🧠 Bill Gates and the Alzheimer’s Disease Data Initiative has launched a new $1 million global competition that aims to accelerate #Alzheimer’s disease research using AI. Learn more: https://bit.ly/3JxNKWT

📣 NCI has officially renewed the Program Project Grant, “Immunobiology and Immune Therapy for Merkel Cell Carcinoma,” led by Dr. Paul Nghiem at @uwdeptmedicine.bsky.social & @fredhutch.bsky.social for $14.3 million. Congratulations to Dr. Nghiem and his collaborators! https://bit.ly/47H6QDV

We've got two #SeattleScience podcasts to keep you company on your upcoming summer road trip! 🎧 Check out EthnoMed Podcast from @uwmedicine.bsky.social researchers: https://bit.ly/4fNARnE Listen to insights from the @alleninstitute.org#SeattleScienceon the Lab Notes Podcast: https://bit.ly/4fT6qwD

RFdiffusion2 is now live! github.com/RosettaCommo... You can now design proteins, and in particular enzymes from just partially defined amino acid side chains, and without defining their sequence position or order!

In a new @uwbiology.bsky.social publication, the @jraslab.bsky.social describes the discovery of a transitional cell type, dendritic #MerkelCells, that connects keratinocyte progenitors to mature touch-sensitive Merkel cells. 📰Press release: https://bit.ly/4mj1xPE 🥼Abstract: https://bit.ly/43Zd3cn

Fred Hutch bone marrow transplant pioneer Dr. Rainer Storb marked two major milestones this year: turning 90 and retiring after nearly 60 years in a career that helped shape modern hematology. Read more: https://bit.ly/3Hi7ptq

@uofwa.bsky.social researchers are helping to restore tribal fishing stocks by harnessing satellite data to determine river temperatures. More: www.washington.edu/forwashingto...

🚨 Final call! The Science in Seattle giveaway ends tonight! Want the inside scoop on local life science news and a shot at winning some awesome science-themed prizes and a $50 Starbucks card? ☕ Sign up now: https://bit.ly/3UAUAgM

Tomorrow is the final day to enter the Science in Seattle giveaway. 🎉 Sign up for the newsletter to stay on top of Seattle's latest life science news — and you could win a $50 Starbucks card + science-themed socks. 🧦🧬 👉 Enter now: https://bit.ly/3UAUAgM

Cystic fibrosis' mucus buildup traps bacteria over time, leading to damaging infections. A new @uwmnewsroom.bsky.social study meticulously sampled different lung regions in people with cystic fibrosis to understand why infections persist after new treatments: bit.ly/4fMZCAA

Meet one of the winners of our MapMySections challenge! 🧠📈 Nikhil Karthik and Chaitali Khan’s GT2CT Bayesian Mapper brings advanced spatial probability modeling to the neuroscience community. Join us on Aug. 27 for a live demo of all the winning tools. RSVP: alleninstitute.org/events/mapmy...