Lymph nodes (LNs) can limit pathogen spread while driving adaptive immunity, but how are LN responses regulated? A @uwmedicine.bsky.social study shows that after infection, LN architecture is rapidly altered, with large-scale, polarized recruitment of immune cells: https://bit.ly/45zMJWD

📖 A new review co-authored by Institute for Systems Biology scientists outlines how advances in #SystemsBiology and AI could help detect the earliest transitions from wellness to disease. This work could enable interventions long before symptoms appear: https://bit.ly/49PmTAx

The first cohort of postdocs has been selected for the SeaBridge Fellowship, a translational research training program affiliated with the Seattle Hub for Synthetic Biology focused on cell and genome programming technologies. 🤩 Congratulations to all eight fellows! https://bit.ly/4rlwWTL

#RheumatoidArthritis is often thought to begin when joints become stiff and painful. But new research from @alleninstitute.org & @benaroyaresearch.bsky.social#RheumatoidArthritissuggests that the autoimmune disease may start quietly, years before symptoms appear, deep within the immune system: https://bit.ly/4r9KCkG

Dr. Nancy Davidson at @uwmedicine.bsky.social is the 2026 recipient of the David Karnofsky Science of Oncology Award from @ascocancer.bsky.social. Dr. Davidson is being recognized for decades of groundbreaking work on epigenetic changes in #BreastCancer. 🥳 Congratulations! https://bit.ly/4pZj1BK

Are you hiring in academia, healthcare, biotech, or industry? Share your open role on the Science in Seattle Job Board! 🧪 Free to post 🥼 Built for the Seattle life science community We help great science find great people. Submit your job today: https://bit.ly/4qCZRm8

Two obstacles in #CancerImmunotherapy are tumor-infiltrating T cell exhaustion & mitochondrial dysfunction. Drs. @yapeng-su.bsky.social & Philip Greenberg at @fredhutch.org & @uwdeptmedicine.bsky.social#CancerImmunotherapyidentified KLHL6 as a dual-negative regulator of both. Abstract: https://go.nature.com/4qqLAsK

Researchers have identified two #biomarkers that could distinguish between people with and without #schizophrenia, according to a study published by Drs. Robert Chen and Debby Tsuang at @uwmedicine.bsky.social.#biomarkers#schizophreniaLearn more: https://bit.ly/45lTxXI

🎊 Congratulations to the 2025 William J. Bremner Endowed Mentorship Award recipients, Drs. William Altemeier and Ellen Schur at @uwmedicine.bsky.social! These awards honor their contributions to the scientific, educational, and patient care missions through their mentorship: https://bit.ly/4r0kskf

.@fredhutch.org is seeking applications for the 8th Annual Dr. Eddie Méndez Scholar Award which recognizes outstanding and diverse postdocs who are conducting cancer, infectious disease or basic science research. Apply by Feb. 1, 2026: https://apply.interfolio.com/176955 #MendezSymposium

Coming up! with Yuriy Baglaenko @baglaenkolab.bsky.social and Stephan Riesenberg @mpi-eva-leipzig.bsky.social Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...

Dr. @aimeedudley.bsky.social 's lab at @pnrigenetics.bsky.social has overturned a long-held belief in genetics: that inheriting two harmful variants in the same gene always worsens disease. They found that two harmful variants can actually restore normal protein function: https://bit.ly/4qx3RVw

🫀 Dr. Dabin Yeum at @uwmedicine.bsky.social has been awarded an @americanheart.bsky.social Postdoctoral Fellowship for early career scientists! Her work examines whether inflammation in the hypothalamus can explain why people develop #HeartDisease or diabetes later: https://bit.ly/3NhboZT

"Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications," presented by Nicole Vo, PhD @uwmedicine.bsky.social #organoids #genome #renal #podocyte #cells #nephsky #research Watch: youtu.be/YeAmH_kN2o8

The UW Medicine Diabetes Institute (UWMDI) has established a research partnership with Steno Diabetes Center Copenhagen, one of the world’s leading diabetes research institutions. “I’m thrilled to see this partnership come to life,” said UWMDI Director Dr. Petter Bjornstad: https://bit.ly/4qW4kQP

Teach neuroscience to undergraduates? Learn how to incorporate our connectomics data into your courses! 🧠 "Incorporating open connectomics data into teaching neuroscience" 🗓️ July 23-24 🛫 Travel funds available ⏳ Apply by Feb. 2: https://bit.ly/3LAfOdy #neuroskyence

🎇 The @alleninstitute.org has announced the winners of its first-ever Innovation Awards, an internal grant mechanism designed to fund ambitious, high-impact projects that push the boundaries of science. Congratulations to all four winning teams, including the PEARLS project! https://bit.ly/3LN0P03

"Inflammaging" is unavoidable, but does nature have a way to slow it down? In Dr. Lev Silberstein’s lab at @fredhutch.org, Dorsa Toghani and Sanika Gupte discovered what can protect #HSCs from the deleterious effects of #inflammaging. Abstract in Nature Aging: https://go.nature.com/3YDag5a

Once #EColi bacteria get a strong grip, they can be difficult to flush out. 🦠 The Sokurenko lab at @uwmedicine.bsky.social#EColiuncovered several new mechanisms by which antibodies block E. coli bacteria that cause urinary tract infections from attaching to bladder cells: https://bit.ly/4btkNr0

Before we stop crossing out 2025 and remembering to write 2026 at the top of our lab notebooks, check out all that our Seattle institutes accomplished in 2025! 🎉 @isbscience.org: https://bit.ly/4su411j BBI: https://bit.ly/49fJZ30 @fredhutch.org: https://bit.ly/4qJf5Wi KPWHRI: https://bit.ly/4su5Fjv

Today is the last day to apply for our cell type summer workshop! 🗓️ April 6-8 in Seattle, WA ❌ No application fee. ✈️ Travel support available to accepted applicants. 🔗 https://alleninstitute.org/events/2026-cell-types-workshop/ #neuroskyence

Dr. Julie Gralow (@jrgralow.bsky.social) from @uwmedicine.bsky.social has been named on the 100 Most Influential People in #Oncology in 2025 by @@oncodaily.bsky.social#Oncology 🎉 Congratulations Dr. Gralow! https://bit.ly/4pxDnSu

🧠 Scientists have engineered a protein able to record the incoming chemical signals of brain cells as opposed to just their outgoing signals. Check out the molecular “glutamate indicator" created by researchers at the @alleninstitute.org and @hhmi-science.bsky.social : https://bit.ly/49bX4dF

The WRF has awarded three-year postdoctoral fellowships to a new cohort of 12 early-career researchers who will pursue innovative, high-impact projects. 📝 See the full list including Drs. Winston Dredge, Nastacia Goodwin, Stefany Cruz, and Nathaniel Ritz: https://bit.ly/3L0DhEM

In this interview with @ascopost.bsky.social, Dr. Filippo Milano talked about the progress being made in #cordbloodtransplantation, the advantages and disadvantages of this procedure, and the personal reward of seeing patients live a long, high-quality life in survivorship: https://bit.ly/49HCaDd

There's new work from the lab of Dr. Patrick Stayton at @uwbioe.bsky.social! 👇 It shows that an alveolar macrophage-targeted polymeric #prodrug serves as a reservoir for releasing #antibiotics to treat infections caused by a primarily extracellular bacterium. 🗒️: https://bit.ly/49lJWS1

New year, new experiments… and maybe some new habits too! Kick off 2026 with Lab Coats and Life, the podcast that helps scientists navigate the human side of research. If your resolutions include more balance, purpose, and curiosity, this is the perfect place to start. 🎧 https://bit.ly/4pTHNnx

Happy New Year! 🎉 May your 2026 be statistically significant, your experiments run smoothly, and your p-values forever low. Here’s to better data, brighter ideas, and brilliant minds working together across Seattle!

The #1 spot in our Top 5 Countdown is... 🥁 Dr. Meghan Koch at @fredhutch.org, who uncovered a biological mechanism behind the gut's immune system! Congratulations and we cannot wait to see what discoveries await in 2026. https://bsky.app/profile/scienceinseattle.com/post/3m25u57xxk62x

At #2, we honor two leaders in biomedical research. Dr. Karel Svoboda and Dr. Jay Shendure (@jshendure.bsky.social) were elected to the National Academy of Medicine this year! A well-deserved recognition of visionary work. https://bsky.app/profile/scienceinseattle.com/post/3m3xapuxncp2y

🥉 Taking the #3 spot in our 2025 Post Countdown is the @isbscience.org Virtual Microbiome Symposium! Don't worry if you missed out, the full recap is online: https://bit.ly/4qeNDQ4 https://bsky.app/profile/scienceinseattle.com/post/3m5wob373ce2k

Our #4 story of the year maps the developing brain across species. This year, @alleninstitute.org researchers helped create the BRAIN Initiative Cell Atlas Network, a remarkable series of publications in Nature. 🤯 https://bsky.app/profile/scienceinseattle.com/post/3m5cxgqdfse2f

We're starting off our Top 5 Post Countdown with a new path for treating schizophrenia. WRF awarded a $275,000 commercialization grant to Dr. Nino Ramirez at @seattlechildrens.org to develop a therapy that could halt the disease. https://bsky.app/profile/scienceinseattle.com/post/3lwhlmuakyc23

Ready for the science highlight reel of the year? 🤓 🧪 Welcome to the Science in Seattle Top 5 Post Countdown, showcasing the most community-loved posts of 2025. Get ready for jaw-dropping discoveries and the people who made it all possible! Check back tomorrow for #5...

❄️☃️ Looking for something insightful to listen to over the holidays? Explore the @immunologypodcast.com! Whether you're traveling or unwinding at home, it’s the ideal companion for curious minds. 🎧 https://bit.ly/47nGZAG

🎧 As the year winds down, it’s the perfect time to recharge your curiosity. Explore the @stemcellpodcast.com, where experts share insights on stem cell biology, new technologies, and the future of regenerative medicine. 🎄 Add it to your holiday playlist: https://bit.ly/4pJa6VA

Our website is taking a short holiday break while we recharge for 2026. But don’t worry, the science doesn’t stop! Keep an eye on our socials over the holidays for community highlights, Top 5 countdowns, and plenty of good science stories to carry you into the new year. See you in January! ❄️🔬

The Nobel Assembly at Karolinska Institutet has awarded the 2025 Nobel Prize in Physiology or Medicine to Drs. Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi in a ceremony on December 11! 👏 Let's give another round of applause for our Seattle researchers: https://bit.ly/48MHHYY

Dr. Peter Linsley from the @benaroyaresearch.bsky.social has been honored with the Puget Sound Business Journal’s 2025 Lifetime Achievement Award. 🏅 Dr. Linsley has spent nearly three decades advancing biotechnology and pharmaceutical research. Congratulations! https://bit.ly/4p4hTfD

If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here: youtube.com/playlist?lis... Thanks to all who helped make it happen!

💡Dr. Elizabeth Wayne is using the enzyme that gives fireflies their glow to study the white blood cells that attack cancer in the human body. With her team at @uwbioe.bsky.social, she has invented a new way of using bioluminescence to track the development of #macrophages: https://bit.ly/3L5R2Sm

A recent study from Drs. Alexandra Willcox and Julie Overbaugh at @fredhutch.org reveals when the #Zika virus invades, interferon musters the usual militia, but the alarm is regulated by a gene with a previously unknown antiviral function! 📰 https://bit.ly/48UjJJY 🧪 https://bit.ly/4gEa65P

Dr. Nora Disis from @uwbiology.bsky.social was honored with the Seahawks’ Delta Community Captain award for her groundbreaking work developing cancer vaccines that harness the body's immune system to fight disease. 🪶 Congratulations Dr. Disis! https://bit.ly/3MzX9ip

Dr. Min (Mia) Yang at @uwiscrm.bsky.social has received an NIH Director’s ­New Innovator Award that will enable her lab to recreate key aspects of early embryonic development. 🎇 Congratulations! https://bit.ly/44Jvzpd

🏅 Elana Thieme and Mark Mendoza from @fredhutch.org were the recipients of the @ash.hematology.org Graduate Awards! The two-year, $40,000 annual awards support emerging researchers studying myelodysplastic syndromes and pediatric #leukemia: https://bit.ly/3MwN2uM

Dr. Paul Yager at @uwmnewsroom.bsky.social developed inexpensive, paper-based tests that will allow individuals to frequently monitor multiple #biomarkers in blood or other biofluids in their homes. Dr. Yager is now pushing his innovation forward into a new startup, UbiDX: https://bit.ly/4oIu6q3

#StemCell and #DevBio communities, mark your calendars for Sept. 23-25! Together with @isscr.org and @socdevbio.bsky.social#StemCell#DevBiowe're presenting a scientific symposium led by the next generation. Researchers at all stages are invited to be a part of this collaborative event 🔗 https://bit.ly/4rO7xTy

Two new studies published in Nature bring the world closer to potential long-term treatments for #HIV. The studies bring together formidable teams of more than 40 scientists, including Dr. Lillian Cohn at @fredhutch.org#HIV: https://bit.ly/4q2mu2U

📢 Check out this new study from the lab of Dr. Alison Paquette (@alisonpaquette.bsky.social) at Seattle Children’s Research Institute! It shows that the placental transcriptome serves as a mechanistic link between prenatal #phthalate exposure and #placental efficiency. 🔗 https://bit.ly/4rFwgcV

📣 @uwproteindesign.bsky.social is releasing RFdiffusion3 as #OpenSource software. This state-of-the-art AI model for #biodesign is capable of generating new proteins that interact with any type of molecule commonly found inside living cells. 🤓 Learn more: https://bit.ly/4iDokVn