Our work using single cell proteomic to define neutrophil functional states in human glioblastoma is out in @natcomms.nature.com Thanks to all authors, collaborators, editors and reviewers. It id exciting to see the potential SCP has to map neutrophil biology.

New study (Walmsley lab) has for the first time, found the set of proteins neutrophils express within a tumour at high detail. This tech has opened the door to understanding neutrophil roles in brain tumours such as glioblastoma but also more generally in health and disease states. edin.ac/48JhnPq

We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.

🎉Thrilled to share that my Wellcome ECA has been funded.🎉 I'll be using ultra-sensitive proteomics—mini-bulk and single-cell—to map neutrophil functional states in COPD. Hugely grateful to @wellcometrust.bsky.social, my host @walmsley-lab.bsky.social and @edinuni-irr.bsky.social colleagues 🙏.

Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage #immunosky

Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors. rdcu.be/eM5MT

Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT

Students celebrate their IRR internship 🧑‍🔬 For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes. Read about the experience on IRR stories: edin.ac/4oPP33G

🚨 New preprint alert! @pranvera.bsky.social uses single-cell proteomics + #Spectronaut® to decode neutrophil roles in glioblastoma. 1,100 proteins from single cells—revealing dynamic states in brain cancer. 🔬 Read more: www.biorxiv.org/content/10.1...

Excellent work!! I just love the term Mini-Bulk so I had chatGPT help me whip something up

In summary, we do single cell proteomics of glioblastoma neutrophils and find exciting functional states invisible to scRNAseq which further define the roles that neutrophils play within glioblastomas, showing some pro-tumorigenic and anti-tumorigenic populations and properties

So excited to see this powerful work out from @ajbrenes.com and team. Neutrophils never cease to amaze. Read on for an awesome science thread. Pushing the limits of single cell proteomics at ~30 picograms per cell 🤯

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

A nice thread explaining our recent work using mass spectrometry-based single cell proteomics to study tumour associated neutrophils in human glioblastoma. Exciting populations with clear functional states that correlate well with neutrophil effector functions. Go take a look

New work from @soehnleinlab.bsky.social

12th Day of Research: IRR in the community🔎 Last but not least in our #12DaysOfResearch we’re spotlighting our partnership with the local community. This year we have been thrilled with the vibrant activity from researchers, local schools and members of the public. #Community

Just less than a month to apply for this exciting PhD project working toward #salivarygland #regeneration after #cancer treatment.

Thinking of starting your own research group? Why not choose the IRR? We spoke to 2019 UKRI Future Leaders Fellow Rod Mitchell about the fellowship and the opportunities it can bring. 🎞️Watch the video and find out more on our website: regeneration-repair.ed.ac.uk/work-with-us...

What a treat to have @ajmhowden.bsky.social visiting @edinuni-irr.bsky.social to talk to us about studying B cell metabolism and protein synthesis capacity using proteomics.

🥳As we approach the end of 2024, we’re celebrating our year of fantastic community and scientific achievement with our #12DaysOfResearch series. Stay tuned for our posts throughout December, reminiscing on the incredible work achieved by our IRR colleagues.

1st Day of Research: Grand Opening of IRR South 🍾 In January we were joined by Chancellor of the University of Edinburgh, Her Royal Highness The Princess Royal, to officially open the state-of-the-art IRR South building. 📰 Read more here: edin.ac/4eoFtym #12DaysOfResearch

Join us!! On here where the sky is blue, & in the Society. A fantastic place to talk #cytokines, #interferons, the coolest #immunology, and a very nice place to meet new people, make new friends, & start new collaborations!

As World AMR Awareness Week comes to a close, we have written a quick digest of some of the activites and events happening in Edinburgh. It is imperative that the work continues all year round if we are ever to beat this crisis. #WAAW24 edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...

📣 Announcing our latest BSI Career Enhancing Grant winners! Congratulations to our 12 members who have been awarded #funding to advance their #CareerDevelopment 🚀 Discover the projects we're supporting to boost #CareersInImmunology here 👉 bit.ly/4fXdtD1 1/2

Dr Neil Ryan, Clinical Lecturer at our Centre for Reproductive Health and the Institute for Genetics and Cancer at UoE, has been awarded an Eve scholarship from The Eve Appeal and North West Cancer Research regeneration-repair.ed.ac.uk/crh-research... Congratulations Neil!

Several Walmsley lab members are already on Bluesky. Please give them a follow if you haven't already: @patriciacoelho.bsky.social @pranvera.bsky.social @mas-g.bsky.social @alejandrobrenes.bsky.social #neutrophil #teamNeutrophil

Hello Bluesky & #immunosky we are a lab researching how oxygen and nutrient availability reprogram #neutrophils We are based in the Centre for Inflammation Research at @edinuni-irr.bsky.social Link up if you're a fan of the most interesting immune cell #teamNeutrophil