Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage #immunosky

Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors. rdcu.be/eM5MT

How low blood oxygen can affect your body's immune defences 🛡️ A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response. Our article: edin.ac/49nENu4 Nature Immunology paper: www.nature.com/articles/s41...

Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT

#Neutrophils are short lived cells, yet in ARDS display long term changes, with impaired neutrophil functions even after 6 months. How can they undergo long term reprogramming? this is what @mas-g.bsky.social answered, mapping changes to neut. progenitors. @walmsley-lab.bsky.social #immunosky

🚨 Heads-up: a little over a week to apply for this exciting postdoc opportunity in Edinburgh @edinuni-irr.bsky.social! 🚨 I will be in Liverpool for #biologists100. Happy to chat about the position, our research, setting up a lab, spiny mice, axolotls, and whatnot!