loading . . . Decoding the origins of cellular self-organization for engineered biology Zhu, M. & Zernicka-Goetz, M. Principles of self-organization of the mammalian embryo. Cell 183, 1467–1478 (2020. Karsenti, E. Self-organization in cell biology: a brief history. Nat. Rev. Mol. Cell Biol. 9, 255–262 (2008). Chen, Q., Shi, J., Tao, Y. & Zernicka-Goetz, M. Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo. Nat. Commun. 9, 1819 (2018). Squyres, G. R. & Newman, D. K. Biofilms as more than the sum of their parts: lessons from developmental biology. Curr. Opin. Microbiol. 82, 102537 (2024). Brunet, T. & King, N. The origin of animal multicellularity and cell differentiation. Dev. Cell 43, 124–140 (2017). Rados, T. et al. Tissue-like multicellular development triggered by mechanical compression in archaea. Science 388, 109–115 (2025). Rodrigues-Oliveira, T. et al. Actin cytoskeleton and complex cell architecture in an Asgard archaeon. Nature 613, 332–339 (2023). Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253–310 (1995). Fleming, T. P., Papenbrock, T., Fesenko, I., Hausen, P. & Sheth, B. Assembly of tight junctions during early vertebrate development. Semin. Cell Dev. Biol. 11, 291–299 (2000). White, M. D., Zenker, J., Bissiere, S... https://www.nature.com/articles/s41587-026-03161-w