RNA capping emerges as a key checkpoint in T cell activation: RAM upregulation is essential for RNA cap formation, gene expression, and proliferation, linking transcriptional control to immune function. 🧬 vist.ly/54bsw #Immunology #Tcells #GeneExpression

Basophils may be rare, but their complexity is anything but, this review highlights their developmental pathways, newly identified progenitors, and unexpected heterogeneity revealed by single-cell tools. 🧬 vist.ly/5472c #Immunology #Basophils

Single-cell insights reveal how “periodic” TCR signalling shapes self-reactive T cells, and how HTLV-1 exploits this pathway. A fresh model with implications for cancer and immunotherapy. 🧬 Read here: vist.ly/543sa #Immunology #Tcells #HTLV1

📢 New open‑access study reveals that people with type 2 diabetes accumulate senescent‑like CD4+ EMRA T cells, driven by high glucose and mitochondrial dysfunction, helping explain weaker COVID‑19 vaccine responses in T2D. 🔗 vist.ly/53cv8

🧬 Open‑access study highlights ILC3 as key players in endometrial repair and regeneration, with distinct subsets active during menstruation and tissue rebuilding. Changes in ILC3 positioning in endometriosis may disrupt this process. 👉 vist.ly/537dh #Immunology #ILC3 #EndometrialHealth

🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development. 👉 vist.ly/422ev #Immunology #TCells #CellDeath #OpenAccess

🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation. 👉 vist.ly/42jgf #Immunology #DendriticCells #CellMetabolism #OpenAccess

📢 Call for Papers: Extracellular Vesicles as Regulators of Immune Function Exploring EVs in immune modulation, disease and therapy. Led by Dessi Malinova & Julia Makinde. Submissions open until May 2026. Learn more: vist.ly/42dzq

🔬 Open‑access research shows how different cytokines trigger distinct gene expression programs in human neutrophils, revealing their flexibility in shaping immune and inflammatory responses, far beyond frontline defence. 👉 vist.ly/4248b #Immunology

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: https://bit.ly/45wSe95

Highlighting this open‑access study by Hope et.al on how BCG vaccination in calves increases NK cell frequency, advancing our understanding of immunity to bovine TB 🐄🔬 vist.ly/4zefy #WorldAnimalVaccinationDay #Animalhealth

Measuring immune function in the wild is key to understanding resilience and disease. New open‑access research presents a practical immune toolkit for wild ungulates, revealing variation across individuals, populations and landscapes in bighorn sheep. vist.ly/4z6gk

Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/4wxid

Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research. 🔗 oxford.ly/4sz3vPa #ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social

New study by Priscilla Y. L. Tng et al. shows how virulent ASFV strains disrupt the innate–adaptive immune axis in vivo, key insight for developing safer, more effective ASF vaccines. Read the article here: vist.ly/4w8sr #CelebrateVaccines #Immunology #VaccinesWork

📣 Last chance to submit! The Advances in Veterinary Immunology Special Collection, led by Prof. Jayne Hope, is open for submissions until the end March 2026. Share your work on veterinary immune systems, comparative immunology, vaccines, and One Health research. Submit: vist.ly/4uscp

New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection. 🔗 https://vist.ly/4unhy

🐏 New study on wild bighorn sheep reveals major axes of immune variation across 581 individuals, driven by innate–adaptive trade-offs, inflammatory states, age, and sex. A field‑ready toolkit for understanding wildlife immunity at scale. 🔗 vist.ly/4u8r6 #WildlifeHealth #EcoImmunology

CASPASE‑8 supports T cell survival through mechanisms beyond repressing RIPK1‑dependent necroptosis. Conditional deletion studies reveal its essential role in CD8⁺ T cell maintenance and NKT cell development. Read more: https://bit.ly/4r8Edqc

🧬 New research shows lung basal cell–derived PROS1 reduces COVID‑19‑induced inflammation and enhances antigen presentation in monocytes. Read the study: https://bit.ly/3MBrSMh ##COVID19Research #Immunology

📣 We’re delighted to see our latest African swine fever research featured on the @pirbrightinst.bsky.social blog The study uncovers how ASFV rapidly disrupts the immune system in pigs, shedding new light on why the virus is so hard to control. Read the blog 👉 https://bit.ly/4kn8bnK

📢 Call for papers! Discovery Immunology invites submissions for our Special Collection on Advances in Veterinary Immunology, led by Prof Jayne Hope. We welcome research and reviews across comparative, translational and One Health immunology. Submit by March 2026: https://bit.ly/3WmPhl3

🔬 In Discovery Immunology, Katie J Smith, Giuseppe Sciumè & Shoba Amarnath review the complex world of ILC1s—their roles in anti-tumor immunity, their plasticity, and how PD‑1 shapes their function. Read the open access article: https://bit.ly/4fnU0N0 #Immunology #ILC1 #CancerImmunology

🔬 Discovery Immunology features a review by Sara Alonso & Karen L. Edelblum exploring how intestinal microenvironments and the gut microbiota shape the metabolism and function of γδ intraepithelial lymphocytes. Read the open access article: https://bit.ly/4a6rY6a

🔍 See the research that made the biggest impact this year! Check out our 2025 must‑read articles, featuring the most-read and most‑cited work Read more: https://bit.ly/45ELeXc ##Immunology

Type‑17 immunity shows up in the gut: axSpA stool contains increased IL‑17A, IL‑23 & GM‑CSF, alongside systemic Th17 activation. Metabolomics points to microbial metabolic links. Read here: https://bit.ly/4nkhC7q

How do human ILCs adapt to lung niches? Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells. Read here: https://bit.ly/4qiLJP6

Submissions now open for the Extracellular Vesicles & Immune Function topic—exosomes, microvesicles, immunomodulation, disease mechanisms & therapy. Submit by May 2026: https://bit.ly/3YpmLRI

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: https://bit.ly/45wSe95

Happy holidays from all of us! ❄️✨ Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!

New Open Access study by Povoleri et al. shows anti-TNF therapy boosts IL-10 in CD4+ T cells, with MAF, PRDM1 & EOMES as key TF candidates. 🔗 https://bit.ly/44LZ7TR

🎧 DSI Wrapped! A standout year for Discovery Immunology! Thank you to our authors, reviewers and readers for helping DSI grow its reach in 2025.

Proud to celebrate the BSI journals-sponsored Poster Prize winners! 🌟 Huge congratulations to Flavio Beke, Aisling Newing & Rébecca Barascud for their exceptional work. 🔬 More here: https://bit.ly/3MljD6r

Attending #BSI25?📣 Don’t miss AI in Publishing with Rachel Moriarty from our publisher OUP. Explore how AI is shaping journals, research integrity & ethical practice, plus tips for using AI responsibly as an author. 🗓Today at 13:15–14:10

Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling! Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋

@discovimmunol.bsky.social is inviting submissions to the BSI Congress 2025 Special Collection, highlighting research presented across this year’s meeting. If you're contributing work at #BSI25, we encourage you to learn more and submit: oxford.ly/48M9TLd

This study shows high glucose in T2D drives senescent-like CD4+ EMRA T cells, weakening COVID-19 vaccine responses. Highlights the powerful link between metabolic health, immune ageing & antiviral immunity. 📄 https://bit.ly/48qpAXi #Immunology #COVID19 #ImmuneAging

🛡️ This #PublishingIntegrityWeek, BSI journals are tackling papermills, promoting AI transparency, DEI & accessibility, and supporting ethical research in immunology. Read more 👉 https://bit.ly/4odyvAZ

📢 Presenting your work at #BSI25? Submit your paper to the Discovery Immunology Special Collection and showcase your research from BSI Congress 2025! Peer-reviewed and published together with other highlights. Submit here: https://bit.ly/3WmPhl3 ##Immunology #BSI25

🌿 How does the immune system work in the real world? Join Prof Amy Pedersen & Prof Andrea Graham for Ecoimmunology: the immune system in context. Sponsored by Discovery Immunology. #BSI25 #Ecoimmunology

🌙 New study shows tiny tidal rhythms in the immune system of freshwater three-spined sticklebacks, hinting at a conserved lunar-linked clock beyond circadian cycles. 👉 https://bit.ly/4hMtCMm ##Immunology

Oligodendrocytes do more than make myelin — they actively shape immune responses in the CNS. Pasquini & Correale reveal how OGDs can present antigens, modulate microglia, and balance pro- & anti-inflammatory signals. Read more 👉 https://bit.ly/4mkw9Qe ##Neuroimmunology

📢 This #OneHealthDay, we’re calling for submissions to Advances in Veterinary Immunology, led by Prof. Jayne Hope Share your work on cross-species immune insights & One Health. Submit by March 2026 👉 https://bit.ly/48XEMx2 ##VeterinaryImmunology

Human, animal & environmental health are deeply connected. 🌍 This #OneHealthDay, discover how veterinary immunology research in Discovery Immunology is bridging species & advancing science for all. Read more 👉 https://bit.ly/41BQkRO ##OneHealth #Immunology

EVs aren’t just tiny, they’re powerful! 🦇 These nanoparticles could unlock secrets of immune responses in bats, revealing viral tolerance mechanisms. Read the article: https://bit.ly/4dXLgfE ##WildImmunology

Type-17 immunity in the gut may play a key role in axial spondyloarthritis. Brough et al. report elevated IL-17A/IL-23 in axSpA stool plus increased circulating IL-17+ T cells. 📄 Open access: https://bit.ly/4nkhC7q #Rheumatology #Immunology

Spermidine can suppress dendritic cell activation by regulating metabolism via eIF5A hypusination, reducing T cell interactions. Immune regulation or pathogen exploitation? 🔗 https://bit.ly/4ooi8mE

🌿 Celebrate #BiologyWeek by sharing your ecoimmunology research! Our Special Collection explores how ecological factors shape immunity in humans & animals. Original research & reviews welcome. 📖 Submit here: https://bit.ly/3WmPhl3 #Ecoimmunology #Immunology

Are you looking to publish your #VetImmunology paper? @discovimmunol.bsky.social is building a new special collection, and your research might be a perfect fit! Discover the available author benefits and submit oxford.ly/3L4YM6H#VetImmunology #Immunology

We were so pleased to see researchers working on Regulatory T cells getting the recognition they deserve from the #NobelPrize last week! To celebrate this pioneering field, we created a virtual issue on peripheral immune tolerance: immunology.org/publications...