CASPASE‑8 plays a crucial role in T cell survival via mechanisms that extend beyond inhibiting RIPK1-dependent necroptosis. Conditional deletion analyses highlight its vital function in the maintenance of CD8⁺ T cells and the development of NKT cells. Read more: vist.ly/59ur8

Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/59qu4

A linear Doggybone™ DNA influenza vaccine induced immune responses to both HA and NA without interference, supporting NA inclusion to broaden protection and improve resilience to HA mismatch. 📖 vist.ly/595zv #Vaccines #Influenza #DNAVaccines

🔬 PD-1 may help prevent autoimmunity triggered by mutation-derived neoantigens. New mouse data sheds light on immune-related adverse events seen with PD-1 blockade. vist.ly/593e2

Obesity disrupts dendritic cell responses to viral infection, reducing cytokine production and altering cellular metabolism in a mouse model. 📖 vist.ly/58wx2 #Immunology #Obesity #ViralInfection #DendriticCells

Discover the benefits available when peer reviewing for the @britsocimm.bsky.social journals, including a chance to work with immunology experts to advance research. 🔗 oxford.ly/4fWq6kZ #ImmunoSky | @ceijournal.bsky.social | @imtadvances.bsky.social | @discovimmunol.bsky.social

🧬 Neutrophils are more adaptable than we thought. This research shows different cytokines trigger distinct gene expression programmes, influencing immune regulation, inflammation and interactions with T cells. 🔗 vist.ly/588kp #Immunology #Neutrophils

PD-1 loss + increased mutagenesis triggers liver granulomatous inflammation in mice, supporting a key role for PD-1 in preventing immune responses to neoantigens, relevant to toxicity seen with checkpoint blockade. 🔬 vist.ly/584be #Immunology

Fluoroquinolones aren’t just antimicrobial, they shape immunity too. Levofloxacin drives mitochondrial hyperpolarization and selectively boosts iNOS in developing macrophages, highlighting stage-specific immune modulation. vist.ly/57yd5

🧬 New insights into Treg biology! This study uncovers how periodic TCR signaling shapes self-reactive T cells and how HTLV-1 hijacks these pathways. A new 2-axis model links activation dynamics to Foxp3 regulation, opening doors for cancer & immunotherapy research. #Immunology #Tcells

CARKL emerges as a key regulator of T-cell function by driving metabolic reprogramming, shaping cytokine output, mitochondrial activity, and migration via CXCR3. A compelling link between immunometabolism and immune regulation. vist.ly/57crf #Immunology #TCells #Immunometabolism

PROS1 released by lung basal cells may help limit severe COVID‑19 inflammation and promote tissue repair, according to a Discovery Immunology study. 🧬 vist.ly/5792z #COVID19 #Immunology

T cell activation depends on rapid gene expression changes. This study shows RAM is upregulated during activation and is essential for RNA cap formation, driving protein synthesis and CD4 T cell proliferation. 🔗 vist.ly/56rbp #Immunology #TCells

γδ T cells in the female reproductive tract, quiet defenders or active players in pregnancy? 🤔 This review unpacks their dynamic, hormone-responsive roles at this unique barrier site ⚖️ Part of our T Cells at Barrier Sites collection🧬 vist.ly/56m3b

Abatacept suppresses T cell activation, but how durable is its effect? Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬 🔗 vist.ly/55mmj #Immunology #Tcells #Autoimmunity

Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/55ib7 #Immunology #Autoimmunity #Tcells

📢 New in Discovery Immunology New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬 🔗 vist.ly/54z8t #Immunology #Vaccines #Bcells #OpenAccess

📢 Call for Papers: Extracellular Vesicles as Regulators of Immune Function Exploring EVs in immune modulation, disease and therapy. Led by Dessi Malinova & Julia Makinde. Submissions open until May 2026. Learn more: vist.ly/54ye2

RNA capping emerges as a key checkpoint in T cell activation: RAM upregulation is essential for RNA cap formation, gene expression, and proliferation, linking transcriptional control to immune function. 🧬 vist.ly/54bsw #Immunology #Tcells #GeneExpression

Basophils may be rare, but their complexity is anything but, this review highlights their developmental pathways, newly identified progenitors, and unexpected heterogeneity revealed by single-cell tools. 🧬 vist.ly/5472c #Immunology #Basophils

Single-cell insights reveal how “periodic” TCR signalling shapes self-reactive T cells, and how HTLV-1 exploits this pathway. A fresh model with implications for cancer and immunotherapy. 🧬 Read here: vist.ly/543sa #Immunology #Tcells #HTLV1

📢 New open‑access study reveals that people with type 2 diabetes accumulate senescent‑like CD4+ EMRA T cells, driven by high glucose and mitochondrial dysfunction, helping explain weaker COVID‑19 vaccine responses in T2D. 🔗 vist.ly/53cv8

🧬 Open‑access study highlights ILC3 as key players in endometrial repair and regeneration, with distinct subsets active during menstruation and tissue rebuilding. Changes in ILC3 positioning in endometriosis may disrupt this process. 👉 vist.ly/537dh #Immunology #ILC3 #EndometrialHealth

🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development. 👉 vist.ly/422ev #Immunology #TCells #CellDeath #OpenAccess

🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation. 👉 vist.ly/42jgf #Immunology #DendriticCells #CellMetabolism #OpenAccess

📢 Call for Papers: Extracellular Vesicles as Regulators of Immune Function Exploring EVs in immune modulation, disease and therapy. Led by Dessi Malinova & Julia Makinde. Submissions open until May 2026. Learn more: vist.ly/42dzq

🔬 Open‑access research shows how different cytokines trigger distinct gene expression programs in human neutrophils, revealing their flexibility in shaping immune and inflammatory responses, far beyond frontline defence. 👉 vist.ly/4248b #Immunology

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: https://bit.ly/45wSe95

Highlighting this open‑access study by Hope et.al on how BCG vaccination in calves increases NK cell frequency, advancing our understanding of immunity to bovine TB 🐄🔬 vist.ly/4zefy #WorldAnimalVaccinationDay #Animalhealth

Measuring immune function in the wild is key to understanding resilience and disease. New open‑access research presents a practical immune toolkit for wild ungulates, revealing variation across individuals, populations and landscapes in bighorn sheep. vist.ly/4z6gk

Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/4wxid

Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research. 🔗 oxford.ly/4sz3vPa #ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social

New study by Priscilla Y. L. Tng et al. shows how virulent ASFV strains disrupt the innate–adaptive immune axis in vivo, key insight for developing safer, more effective ASF vaccines. Read the article here: vist.ly/4w8sr #CelebrateVaccines #Immunology #VaccinesWork

📣 Last chance to submit! The Advances in Veterinary Immunology Special Collection, led by Prof. Jayne Hope, is open for submissions until the end March 2026. Share your work on veterinary immune systems, comparative immunology, vaccines, and One Health research. Submit: vist.ly/4uscp

New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection. 🔗 https://vist.ly/4unhy

🐏 New study on wild bighorn sheep reveals major axes of immune variation across 581 individuals, driven by innate–adaptive trade-offs, inflammatory states, age, and sex. A field‑ready toolkit for understanding wildlife immunity at scale. 🔗 vist.ly/4u8r6 #WildlifeHealth #EcoImmunology

CASPASE‑8 supports T cell survival through mechanisms beyond repressing RIPK1‑dependent necroptosis. Conditional deletion studies reveal its essential role in CD8⁺ T cell maintenance and NKT cell development. Read more: https://bit.ly/4r8Edqc

🧬 New research shows lung basal cell–derived PROS1 reduces COVID‑19‑induced inflammation and enhances antigen presentation in monocytes. Read the study: https://bit.ly/3MBrSMh ##COVID19Research #Immunology

📣 We’re delighted to see our latest African swine fever research featured on the @pirbrightinst.bsky.social blog The study uncovers how ASFV rapidly disrupts the immune system in pigs, shedding new light on why the virus is so hard to control. Read the blog 👉 https://bit.ly/4kn8bnK

📢 Call for papers! Discovery Immunology invites submissions for our Special Collection on Advances in Veterinary Immunology, led by Prof Jayne Hope. We welcome research and reviews across comparative, translational and One Health immunology. Submit by March 2026: https://bit.ly/3WmPhl3

🔬 In Discovery Immunology, Katie J Smith, Giuseppe Sciumè & Shoba Amarnath review the complex world of ILC1s—their roles in anti-tumor immunity, their plasticity, and how PD‑1 shapes their function. Read the open access article: https://bit.ly/4fnU0N0 #Immunology #ILC1 #CancerImmunology

🔬 Discovery Immunology features a review by Sara Alonso & Karen L. Edelblum exploring how intestinal microenvironments and the gut microbiota shape the metabolism and function of γδ intraepithelial lymphocytes. Read the open access article: https://bit.ly/4a6rY6a

🔍 See the research that made the biggest impact this year! Check out our 2025 must‑read articles, featuring the most-read and most‑cited work Read more: https://bit.ly/45ELeXc ##Immunology

Type‑17 immunity shows up in the gut: axSpA stool contains increased IL‑17A, IL‑23 & GM‑CSF, alongside systemic Th17 activation. Metabolomics points to microbial metabolic links. Read here: https://bit.ly/4nkhC7q

How do human ILCs adapt to lung niches? Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells. Read here: https://bit.ly/4qiLJP6

Submissions now open for the Extracellular Vesicles & Immune Function topic—exosomes, microvesicles, immunomodulation, disease mechanisms & therapy. Submit by May 2026: https://bit.ly/3YpmLRI

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: https://bit.ly/45wSe95

Happy holidays from all of us! ❄️✨ Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!

New Open Access study by Povoleri et al. shows anti-TNF therapy boosts IL-10 in CD4+ T cells, with MAF, PRDM1 & EOMES as key TF candidates. 🔗 https://bit.ly/44LZ7TR

🎧 DSI Wrapped! A standout year for Discovery Immunology! Thank you to our authors, reviewers and readers for helping DSI grow its reach in 2025.