🔍 See the research that made the biggest impact this year! Check out our 2025 must‑read articles, featuring the most-read and most‑cited work Read more: https://bit.ly/45ELeXc ##Immunology

Type‑17 immunity shows up in the gut: axSpA stool contains increased IL‑17A, IL‑23 & GM‑CSF, alongside systemic Th17 activation. Metabolomics points to microbial metabolic links. Read here: https://bit.ly/4nkhC7q

How do human ILCs adapt to lung niches? Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells. Read here: https://bit.ly/4qiLJP6

Submissions now open for the Extracellular Vesicles & Immune Function topic—exosomes, microvesicles, immunomodulation, disease mechanisms & therapy. Submit by May 2026: https://bit.ly/3YpmLRI

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: https://bit.ly/45wSe95

Happy holidays from all of us! ❄️✨ Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!

New Open Access study by Povoleri et al. shows anti-TNF therapy boosts IL-10 in CD4+ T cells, with MAF, PRDM1 & EOMES as key TF candidates. 🔗 https://bit.ly/44LZ7TR

🎧 DSI Wrapped! A standout year for Discovery Immunology! Thank you to our authors, reviewers and readers for helping DSI grow its reach in 2025.

Proud to celebrate the BSI journals-sponsored Poster Prize winners! 🌟 Huge congratulations to Flavio Beke, Aisling Newing & Rébecca Barascud for their exceptional work. 🔬 More here: https://bit.ly/3MljD6r

Attending #BSI25?📣 Don’t miss AI in Publishing with Rachel Moriarty from our publisher OUP. Explore how AI is shaping journals, research integrity & ethical practice, plus tips for using AI responsibly as an author. 🗓Today at 13:15–14:10

Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling! Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋

@discovimmunol.bsky.social is inviting submissions to the BSI Congress 2025 Special Collection, highlighting research presented across this year’s meeting. If you're contributing work at #BSI25, we encourage you to learn more and submit: oxford.ly/48M9TLd

This study shows high glucose in T2D drives senescent-like CD4+ EMRA T cells, weakening COVID-19 vaccine responses. Highlights the powerful link between metabolic health, immune ageing & antiviral immunity. 📄 https://bit.ly/48qpAXi #Immunology #COVID19 #ImmuneAging

🛡️ This #PublishingIntegrityWeek, BSI journals are tackling papermills, promoting AI transparency, DEI & accessibility, and supporting ethical research in immunology. Read more 👉 https://bit.ly/4odyvAZ

📢 Presenting your work at #BSI25? Submit your paper to the Discovery Immunology Special Collection and showcase your research from BSI Congress 2025! Peer-reviewed and published together with other highlights. Submit here: https://bit.ly/3WmPhl3 ##Immunology #BSI25

🌿 How does the immune system work in the real world? Join Prof Amy Pedersen & Prof Andrea Graham for Ecoimmunology: the immune system in context. Sponsored by Discovery Immunology. #BSI25 #Ecoimmunology

🌙 New study shows tiny tidal rhythms in the immune system of freshwater three-spined sticklebacks, hinting at a conserved lunar-linked clock beyond circadian cycles. 👉 https://bit.ly/4hMtCMm ##Immunology

Oligodendrocytes do more than make myelin — they actively shape immune responses in the CNS. Pasquini & Correale reveal how OGDs can present antigens, modulate microglia, and balance pro- & anti-inflammatory signals. Read more 👉 https://bit.ly/4mkw9Qe ##Neuroimmunology

📢 This #OneHealthDay, we’re calling for submissions to Advances in Veterinary Immunology, led by Prof. Jayne Hope Share your work on cross-species immune insights & One Health. Submit by March 2026 👉 https://bit.ly/48XEMx2 ##VeterinaryImmunology

Human, animal & environmental health are deeply connected. 🌍 This #OneHealthDay, discover how veterinary immunology research in Discovery Immunology is bridging species & advancing science for all. Read more 👉 https://bit.ly/41BQkRO ##OneHealth #Immunology

EVs aren’t just tiny, they’re powerful! 🦇 These nanoparticles could unlock secrets of immune responses in bats, revealing viral tolerance mechanisms. Read the article: https://bit.ly/4dXLgfE ##WildImmunology

Type-17 immunity in the gut may play a key role in axial spondyloarthritis. Brough et al. report elevated IL-17A/IL-23 in axSpA stool plus increased circulating IL-17+ T cells. 📄 Open access: https://bit.ly/4nkhC7q #Rheumatology #Immunology

Spermidine can suppress dendritic cell activation by regulating metabolism via eIF5A hypusination, reducing T cell interactions. Immune regulation or pathogen exploitation? 🔗 https://bit.ly/4ooi8mE

🌿 Celebrate #BiologyWeek by sharing your ecoimmunology research! Our Special Collection explores how ecological factors shape immunity in humans & animals. Original research & reviews welcome. 📖 Submit here: https://bit.ly/3WmPhl3 #Ecoimmunology #Immunology

Are you looking to publish your #VetImmunology paper? @discovimmunol.bsky.social is building a new special collection, and your research might be a perfect fit! Discover the available author benefits and submit oxford.ly/3L4YM6H#VetImmunology #Immunology

We were so pleased to see researchers working on Regulatory T cells getting the recognition they deserve from the #NobelPrize last week! To celebrate this pioneering field, we created a virtual issue on peripheral immune tolerance: immunology.org/publications...

📢 Call for Papers: Advances in Veterinary Immunology 🐾🧬 Submit original research & reviews on immune function in veterinary species, comparative immunology & One Health. Deadline: March 2026 👉 https://bit.ly/46B1I2a ##Veterinary #Immunology #OneHealth #CFP

T-cell function is tightly linked to metabolism. CARKL regulates cytokine outputs and migration by reprogramming metabolic pathways in T cells. Read here🔗: https://bit.ly/3XDlIh6 ##TCells #Immunology #Metabolism

New study shows abatacept’s effect on T cells is short-lived in vivo. Once treatment stops, immune activity rebounds quickly, important insight for #RA therapy and immune modulation. 🧬 Read more: https://bit.ly/4aDHTrm ##Immunology #TCells #Abatacept

On #WorldAlzheimersDay, we highlight the role of adaptive immune cells & microbial infections in #Alzheimers disease. Could targeting immunity offer new therapies? Read the Open Access review 👉 https://bit.ly/4p7AnNt #Neuroinflammation

New in vitro model links ‘gut-like’ dendritic cells with small intestinal organoids, revealing how epithelial–DC cross-talk shapes intestinal immune responses. Relevant insights for #EMDS2025! Read more🔗 https://bit.ly/45NMAPS

🌿 Calling all researchers! Submit your work to the Ecoimmunology Special Collection exploring how ecological factors shape immune systems in humans & animals. Open to lab & field studies. More info 👉 https://bit.ly/4m0x4EW #Ecoimmunology #Immunology

Heading to #BSIInflammation2025? Check out this new study on how inflammation impacts oligodendrocyte–axon interactions and neurological function. Read the full article by Green et al.🔗 https://bit.ly/45hoSLv

💡 RAM is key for T cell activation! This cofactor of RNA cap methyltransferase RNMT ensures proper RNA processing, protein synthesis & T cell proliferation. Open Access 👉 https://bit.ly/42dSN5l #Immunology #TCells #GeneExpression

New in vitro model links ‘gut-like’ dendritic cells with small intestinal organoids, revealing how epithelial–DC cross-talk shapes intestinal immune responses. Relevant insights for #EMDS2025! Read more🔗 https://bit.ly/45NMAPS

Looking to publish your latest veterinary immunology paper? @discovimmunol.bsky.social is curating a special collection, and your research could be perfect! Submit to join our author community: oxford.ly/4mMMSwg #ImmunoSky

Fever isn’t just a symptom, it's a window into immunity. Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️ https://bit.ly/4cZ8gu7

🐾 Calling veterinary immunologists! Share your research on immune systems across species, vaccines, and One Health in our Advances in Veterinary Immunology collection led by Prof. Jayne Hope. 📅 Submit by March 2026: https://bit.ly/46lLw5W

🧬💉 DNA vaccines for flu? A new study tests a Doggybone™ DNA platform, finding that including neuraminidase (NA) adds extra protection. Another step toward broader, faster, more adaptable vaccines. 🔗 https://bit.ly/4p4bHpk ##VaccinesWork #ImmunisationAwarenessMonth

💉 Alum has powered vaccines for nearly a century, but how it boosts immunity is still being unraveled. From DNA sensing to inflammasomes, new insights into its mechanism could guide the next generation of vaccine adjuvants. 🔬 #NationalImmunisationMonth 🔗 https://bit.ly/3UQM5hB

Cell migration matters: stem-like CD8 T cells travel between tumour and peripheral niches, shaping both local control and systemic memory against cancer. 🔗 https://bit.ly/45SuFq3

🚨 T cells and bacterial microbiota at skin & gut barriers: how epithelial interactions shape immunity, tolerance, and tissue repair. Open Access: https://bit.ly/4mQyQcC #Immunology #Microbiome #TCells

Immunotherapy is emerging as a lifeline for patients with brain metastases. This review explores how the brain’s specialized immune environment, lymphatic drainage & systemic immunity impacts treatment. 🔗 https://bit.ly/4oKb5ET

🐶🐄 Calling veterinary immunology researchers! Share your latest work on immune systems, vaccines, and One Health in our Special Collection: Advances in Veterinary Immunology. Submit by Mar 2026. ##VetImmunology #OneHealth

Maskell et al. uncover how growth factors & cytokines fuel transmissible Tasmanian devil cancers. PDGFR boosts tumour spread; TGFβ triggers EMT-like shifts. Findings could guide vaccines & therapies to save this endangered species. 🔗 https://bit.ly/47f6uob #IVIS2025

Attending #IVIS2025? 🐷🫁 New research shows airway-resident memory T cells in young pigs aren’t just long-lived, they’re replenished via proliferation, likely in the lung interstitium before migrating to the airways. Dynamic immunity in action! 🔬 https://bit.ly/3RRINsU

From livestock to wildlife, veterinary immunology is key to understanding the immune system. 🐷🐓🐑 Our @discovimmunol.bsky.social highlights for #IVIS2025 showcase research changing how we understand immunity across species. Read here 👉 https://bit.ly/41BQkRO ##VeterinaryImmunology #OpenAccess

How do ILC1s help fight cancer, and what role does PD-1 play? This open access review breaks down the complexity of ILC1 subsets and their checkpoint regulation. 📖 https://bit.ly/4fnU0N0 #ILC1 #CancerImmunology #PD1

Skariah et al. explore the dual nature of IL-15, essential for NK and tissue-resident T cell homeostasis at low levels, but a potent driver of inflammation and autoimmunity when upregulated. 🔗 Open access: https://bit.ly/3JqM8Ow ##Immunology

IL-21 shapes γδ T-cell function in the gut 🧬 New findings show IL-21-conditioned Vγ9/Vδ2 T-cells promote IL-10 expression in CD4+ T-cells, surpassing monocytes/DCs. Implications for mucosal immunity & IBD therapy. 📖 https://bit.ly/4k8cLoX #Immunology