T-cell function is tightly linked to metabolism. CARKL regulates cytokine outputs and migration by reprogramming metabolic pathways in T cells. Read here🔗: https://bit.ly/3XDlIh6 ##TCells #Immunology #Metabolism

New study shows abatacept’s effect on T cells is short-lived in vivo. Once treatment stops, immune activity rebounds quickly, important insight for #RA therapy and immune modulation. 🧬 Read more: https://bit.ly/4aDHTrm ##Immunology #TCells #Abatacept

On #WorldAlzheimersDay, we highlight the role of adaptive immune cells & microbial infections in #Alzheimers disease. Could targeting immunity offer new therapies? Read the Open Access review 👉 https://bit.ly/4p7AnNt #Neuroinflammation

New in vitro model links ‘gut-like’ dendritic cells with small intestinal organoids, revealing how epithelial–DC cross-talk shapes intestinal immune responses. Relevant insights for #EMDS2025! Read more🔗 https://bit.ly/45NMAPS

🌿 Calling all researchers! Submit your work to the Ecoimmunology Special Collection exploring how ecological factors shape immune systems in humans & animals. Open to lab & field studies. More info 👉 https://bit.ly/4m0x4EW #Ecoimmunology #Immunology

Heading to #BSIInflammation2025? Check out this new study on how inflammation impacts oligodendrocyte–axon interactions and neurological function. Read the full article by Green et al.🔗 https://bit.ly/45hoSLv

💡 RAM is key for T cell activation! This cofactor of RNA cap methyltransferase RNMT ensures proper RNA processing, protein synthesis & T cell proliferation. Open Access 👉 https://bit.ly/42dSN5l #Immunology #TCells #GeneExpression

New in vitro model links ‘gut-like’ dendritic cells with small intestinal organoids, revealing how epithelial–DC cross-talk shapes intestinal immune responses. Relevant insights for #EMDS2025! Read more🔗 https://bit.ly/45NMAPS

Looking to publish your latest veterinary immunology paper? @discovimmunol.bsky.social is curating a special collection, and your research could be perfect! Submit to join our author community: oxford.ly/4mMMSwg #ImmunoSky

Fever isn’t just a symptom, it's a window into immunity. Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️ https://bit.ly/4cZ8gu7

🐾 Calling veterinary immunologists! Share your research on immune systems across species, vaccines, and One Health in our Advances in Veterinary Immunology collection led by Prof. Jayne Hope. 📅 Submit by March 2026: https://bit.ly/46lLw5W

🧬💉 DNA vaccines for flu? A new study tests a Doggybone™ DNA platform, finding that including neuraminidase (NA) adds extra protection. Another step toward broader, faster, more adaptable vaccines. 🔗 https://bit.ly/4p4bHpk ##VaccinesWork #ImmunisationAwarenessMonth

💉 Alum has powered vaccines for nearly a century, but how it boosts immunity is still being unraveled. From DNA sensing to inflammasomes, new insights into its mechanism could guide the next generation of vaccine adjuvants. 🔬 #NationalImmunisationMonth 🔗 https://bit.ly/3UQM5hB

Cell migration matters: stem-like CD8 T cells travel between tumour and peripheral niches, shaping both local control and systemic memory against cancer. 🔗 https://bit.ly/45SuFq3

🚨 T cells and bacterial microbiota at skin & gut barriers: how epithelial interactions shape immunity, tolerance, and tissue repair. Open Access: https://bit.ly/4mQyQcC #Immunology #Microbiome #TCells

Immunotherapy is emerging as a lifeline for patients with brain metastases. This review explores how the brain’s specialized immune environment, lymphatic drainage & systemic immunity impacts treatment. 🔗 https://bit.ly/4oKb5ET

🐶🐄 Calling veterinary immunology researchers! Share your latest work on immune systems, vaccines, and One Health in our Special Collection: Advances in Veterinary Immunology. Submit by Mar 2026. ##VetImmunology #OneHealth

Maskell et al. uncover how growth factors & cytokines fuel transmissible Tasmanian devil cancers. PDGFR boosts tumour spread; TGFβ triggers EMT-like shifts. Findings could guide vaccines & therapies to save this endangered species. 🔗 https://bit.ly/47f6uob #IVIS2025

Attending #IVIS2025? 🐷🫁 New research shows airway-resident memory T cells in young pigs aren’t just long-lived, they’re replenished via proliferation, likely in the lung interstitium before migrating to the airways. Dynamic immunity in action! 🔬 https://bit.ly/3RRINsU

From livestock to wildlife, veterinary immunology is key to understanding the immune system. 🐷🐓🐑 Our @discovimmunol.bsky.social highlights for #IVIS2025 showcase research changing how we understand immunity across species. Read here 👉 https://bit.ly/41BQkRO ##VeterinaryImmunology #OpenAccess

How do ILC1s help fight cancer, and what role does PD-1 play? This open access review breaks down the complexity of ILC1 subsets and their checkpoint regulation. 📖 https://bit.ly/4fnU0N0 #ILC1 #CancerImmunology #PD1

Skariah et al. explore the dual nature of IL-15, essential for NK and tissue-resident T cell homeostasis at low levels, but a potent driver of inflammation and autoimmunity when upregulated. 🔗 Open access: https://bit.ly/3JqM8Ow ##Immunology

IL-21 shapes γδ T-cell function in the gut 🧬 New findings show IL-21-conditioned Vγ9/Vδ2 T-cells promote IL-10 expression in CD4+ T-cells, surpassing monocytes/DCs. Implications for mucosal immunity & IBD therapy. 📖 https://bit.ly/4k8cLoX #Immunology

🧬 Spermidine suppresses dendritic cell activation by preserving mitochondrial function through eIF5A hypusination, limiting T cell interactions and shaping immune responses. Could this pathway offer new insights into immune regulation or evasion? 👉 https://bit.ly/4ooi8mE ##Immunology

Studying ecoimmunology? 🌍🧬 Submit your work to Discovery Immunology’s new Ecoimmunology Special Collection, exploring how ecological factors shape immune responses in humans & animals. 📢 Editors: Dr Iris Mair & Prof Kathryn Else 🔗 https://bit.ly/4lZX3NM ##Ecoimmunology #Immunology

Inflammation doesn’t just damage myelin, it disrupts oligodendrocyte-axon interactions, weakening CNS function. New open-access article explores the consequences in MS, leukodystrophies & more. 🧠 📖 https://bit.ly/45hoSLv ##Neuroimmunology #Oligodendrocytes #MS

🧬 New study reveals how two ILC3 subsets guide endometrial repair & regeneration across the menstrual cycle and postpartum. Disrupted ILC3 positioning in #endometriosis may impair healing. 📖 Cuff et al., Discovery Immunology (2025): https://bit.ly/448zYm7 ##WomensHealth

July's featured article from our exchange with @discovimmunol.bsky.social investigates the immunomodulatory capacity of various arginine-related metabolites. academic.oup.com/discovimmuno...

For this month's article exchange with @immunolcellbiol.bsky.social we're highlighting 'Highlights of 2024: γδ T cells and bad blood' by @eberlmat.bsky.social Read here: doi.org/10.1111/imcb...

🐭 How does microbial exposure shape mouse model outcomes? A new Discovery Immunology study compares naturalization methods - co-housing, feralization, or both, and reveals distinct effects on gut immunity and microbiota. 🔗 https://bit.ly/44md5LQ ##Microbiome #Immunology

Writing a paper? Join us tomorrow at 12:00 BST for a free webinar with OUP Publisher Rachel Moriarty & our very own EIC Simon Milling. Essential tips on journal selection, peer review, and maximising impact. Register here: https://bit.ly/44ARC1p

Anti-TNF therapy induces IL-10 in human CD4+ T cells - but how? This study uncovers a transcription factor network (incl. MAF, PRDM1, EOMES) regulating this effect. Open Access 👉 https://bit.ly/44LZ7TR ##Immunology

There's still time to register for our webinar with @oxfordacademic.bsky.social Learn what editors really look for, and how to get your paper noticed. Join for free 🗓️Thursday 17 July 🔗 www.immunology.org/events/bsi-w...

New immunological discoveries deserve wide reach. With read & publish deals, eligible authors can publish open access in Discovery Immunology for free! 🚀 Learn more: https://bit.ly/4ksUbHJ

T-helper cell responses in wild Soay sheep are repeatable, positively correlated, and linked to resistance against helminths and coccidia, challenging assumptions about Th1/Th2 trade-offs in natural settings. 📖 Read more: https://bit.ly/3GCm0PN #VeterinaryImmunology

🔬 Targeting T-cell metabolism? This study positions CARKL as a central modulator of T-cell bioenergetics, cytokines, and chemotaxis. Could be a new node for immune modulation in disease. 📖 https://bit.ly/3XDlIh6 ##Immunotherapy #ImmuneRegulation

🧬 CD28 vs. TCR: not a one-size-fits-all signal. New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells. 📖 https://bit.ly/44MG7UD ##Tcells #Immunology

🌿🔬 Call for Papers: Ecoimmunology Special Collection Explore how ecological factors shape immune responses in humans & animals - from wild systems to lab models. 🧪 Submit your work: bridging ecology + immunology! 📖 https://bit.ly/44N141N ##Ecoimmunology #Immunology

🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk. 📖 Read the open-access study: https://bit.ly/40kBiiH By @andrea-woodcock.bsky.social‬ et al. ##Immunology

🧠📣 Final call! Just a few days left to submit to our Update on Neuroinflammation. Don’t miss your chance to share cutting-edge research on immune-CNS interactions. Deadline: June 2025! Submit now 👉 https://bit.ly/4k4HQdv

New immunological discoveries deserve wide reach. With read & publish deals, eligible authors can publish open access in Discovery Immunology for free! 🚀 Find out if you’re eligible here: bit.ly/4no9OTy

Basophils may be rare, but they pack a punch! This new review in Discovery Immunology dives into the ontogenesis & heterogeneity of basophils, revealing their surprising roles beyond allergies - from immune regulation to cancer. 📖 Open Access: https://bit.ly/4kMgDML

⏳ Time is running out to submit to the Update on Neuroinflammation special collection - deadline is the end of June 2025. We’re looking for novel insights into microglia, CNS immunopathogenesis, new models & more. 📩 Submission info: https://bit.ly/4ldvFuN

What can we learn about airway resident memory T cells from pig models? Plenty! Find out more in this month's @discovimmunol.bsky.social Outstanding Article

This month’s article exchange with @immunolcellbiol.bsky.social: New study shows that in Crohn’s disease, aphthous ulcers trigger immune responses via bacterial uptake, not dysbiosis. Peyer’s patches may be the ignition site 🧬 Read here: doi.org/10.1111/imcb... #Crohns #Immunology

Many congratulations to Professor João Marcos Brandet and Professor John Hammond!

🧬 ILC3s show dynamic, stage-specific roles in endometrial repair and regeneration - supporting healthy cycling and potentially disrupted in endometriosis. Explore the findings: https://bit.ly/448zYm7

📢 Final call! Submissions for the Re-discovering Myeloid Cells Special Collection close end of June 2025. Share your latest insights into myeloid cell biology, function, and pathology. Don’t miss out! 🔗 https://bit.ly/43OULe9

Extracellular vesicles: from lab models to the wild 🌿 This review reveals how EVs can expand our understanding of immune responses in diverse species. 🔗 https://bit.ly/4dXLgfE

🌟 Calling all women leaders in immunology! The EJI Ita Askonas Prize 2025 offers €20,000 + ECI 2027 travel to outstanding female group leaders who have run an independent lab. Apply or nominate a colleague via BSI by 20 June! Find out how to apply: https://bit.ly/4kzbwzu