💙 On #WorldDiabetesDay, explore new insights into immune regulation in childhood #T1D. An Open Access study in Clinical & Experimental Immunology links Galectin-1 with inflammation & Treg cells in children with type 1 diabetes. Read more 👉 https://bit.ly/4r3C2Vw

Tomorrow marks #WorldDiabetesDay, check out this Open Access study: a new LIPS assay detects zinc transporter 8 autoantibodies (ZnT8A) quickly, safely, and with minimal blood, helping identify children at risk for type 1 diabetes. Read more 👉 https://bit.ly/3JBSPhw

🧫 Organoids reveal how gut epithelial diversity shapes host–pathogen interactions, enabling study of viruses, bacteria & parasites previously impossible in vitro. 👉 https://bit.ly/422Z96U ##Organoids #GutImmunology #Immunology

📘 People living with HIV can experience residual immune activation even on ART, raising comorbidity risks. Krystelle Nganou-Makamdop reviews human studies on anti-inflammatory therapies and future strategies. 👉 https://bit.ly/4g5VMm4 ##HIV #Immunology

New study finds IL-17 deficiency may underlie cryptococcosis in HIV-negative “immunocompetent” adults. Could unlock new paths for immunotherapy! 🦠🧬 Open access: https://bit.ly/47rL1Xq ##Immunology #Cryptococcosis #IL17 #InfectiousDiseases

Heading to #BSACI2025? 🫁 We’ve been looking at how allergens ramp up IL-18 & IL-18Rα in Th2/Th17 cells in allergic asthma, and what that means for therapy. 👉 https://bit.ly/4qgknJE ##Allergy #Immunology

Going to #BSACI2025? Let’s talk neutrophils! 🧬 Our new open-access review covers their surprising roles in allergy and potential therapeutic targets. 👉 https://bit.ly/3GReFeX ##Allergy #Immunology

🏆Following last week's #NobelPrize announcement, we've pulled together a new virtual issue. 🔎Check it out for must-read articles on peripheral immune tolerance published in the BSI journals: immunology.org/publications...

HYCO-3, a dual-action CO-releaser/Nrf2 activator, modulates immune cells by reducing pro-inflammatory cytokines & antigen presentation. Promising strategy for autoimmune & chronic inflammatory disorders. Read more 👉 https://bit.ly/3Gf7UDk ##Immunology #Autoimmunity

Neuro-Behçet’s disease is a rare but severe manifestation of Behçet’s. This review highlights advances in diagnosis, biomarkers (IL-6, autoantibodies, BAFF), and immunopathogenesis. 🔗 https://bit.ly/4gZDyU0

🩺 New review highlights immunological insights in liver transplantation from host–graft responses to biomarkers predicting rejection, emphasizing the quest for operational tolerance. 🔗 https://bit.ly/46xnt4l ##LiverTransplant #Immunology

🔬 New study shows 2B4 (CD244) binds Staphylococcus aureus exotoxin SEB, driving allergic inflammation. 2B4 knockout mice had reduced inflammation → a potential therapeutic target. Read here: https://bit.ly/4my2B1e ##Immunology #Staphylococcus #Inflammation

🦴 New study identifies CFI, an NKT cell–related gene, as a promising biomarker in osteoarthritis. Validated in patients & mouse models, CFI knockdown reduced inflammation. 🔗 https://bit.ly/42Lz1OT ##Osteoarthritis #Biomarkers #Immunology

Persistent immune activation remains a challenge for people living with #HIV, even with viral control. On #HIVandAgeing Awareness Day, discover strategies to improve long-term immune health Read the study here👉 https://bit.ly/4g5VMm4

A novel Fc-modified anti-haptoglobin mAb shows non-inferior efficacy to IVIG in an ITP monkey model at much lower doses, potentially reducing treatment burden. Open Access 👉 https://bit.ly/4mN8dWJ #Immunology #ITP #MonoclonalAntibodies

Attending the UK inflammation 2025 meeting? #BSIInflammation2025 If your research explores innate immunity & inflammation, consider submitting to Clinical & Experimental Immunology, showcase your work to a global audience! Learn more🔗 https://bit.ly/443pf8s

Heading to the UK Inflammation 2025 meeting? #BSIInflammation2025 Check out how sulforaphane targets NLRP3 inflammasomes to relieve inflammation in CP/CPPS, preclinical insights that could inform future therapies. Read the full study🔗 https://bit.ly/45QNNpI

HTNV infection impacts CD8+ MAIT cells in HFRS patients, causing both activation and depletion. These cells show antiviral properties, highlighting a key role in disease defence. Open Access 👉 https://bit.ly/4g4SoYA #HFRS #Immunology

CD56 on immune and tumor cells: what is the known and beyond? @ceijournal.bsky.social academic.oup.com/cei/advance-...

🧠 Altered B-cell subsets and cytokine expression are linked to disease activity in CIDP. Findings suggest immune signatures could help guide diagnosis and prognosis. 🔗 https://bit.ly/3rzemhN ##CIDP #Neuroimmunology

Alzheimer’s disease is one of the greatest health challenges of our time. This #WorldAlzheimersMonth, Clinical & Experimental Immunology calls on immunologists investigating Alzheimer’s & immunity to share their findings with us. Submit here: https://bit.ly/443pf8s @alzheimerssoc.bsky.social‬

💉🌐 Oral vaccines are cheap, easy & life-saving, but why do they underperform in the places they’re needed most? This paper highlights multifactorial causes & urges tailored solutions for equity in immunisation. 👉 https://bit.ly/42aACy3 ##ImmunisationAwarenessMonth

Important insights this #NationalPsoriasisMonth. 🧪 Even with long-term anti-TNF (infliximab) treatment, patients with psoriasis & psoriatic arthritis show immune cell shifts, suggesting ongoing systemic inflammation. 🔗 https://bit.ly/47Ny4sD

IVIG therapy for ITP comes with heavy dose requirements. A novel Fc-engineered anti-haptoglobin mAb matches IVIG efficacy in primates, at a fraction of the dose. 🔗 https://bit.ly/4mN8dWJ

🧬 Mesoporous silica nanocarriers delivering siRNA against G6PI show promise in rheumatoid arthritis treatment, reducing joint inflammation, FLS proliferation, and tissue damage in a rat model. Read here: https://bit.ly/4fHxGxI #Rheumatology #Nanomedicine #Immunology

New study compares mannan vs. imiquimod models of psoriasis in mice. 🧬 Mannan induces more severe, relapsing disease & distinct cytokine profiles, offering a simpler, chronic model for research. Read here: https://bit.ly/4os9ByU ##NationalPsoriasisMonth #PsoriasisResearch

💉 Checkpoint inhibitors help many melanoma patients, but not all respond. A study finds that TGF-β activity isn’t a reliable predictor, highlighting the complexity of immune resistance. 🧬🛡️ Read the full article here 🔗 https://bit.ly/45zZcc5

Swieboda et al. show that at birth, NK cells & ILCs are already capable of cytokine production, while NKT-like cells are less abundant & functionally immature. Read the full article🔗 https://bit.ly/3JfJag1 #Immunology

This #CIDP study links reduced naïve/plasma B cells, increased switched memory B cells, and higher IL-6 to worse outcomes, supporting the role of chronic antigen exposure in disease activity. Read here🔗 https://bit.ly/4lpCE3m

📅 August is National Psoriasis Month 🧬 New research compares mannan vs. imiquimod mouse models, finding mannan triggers stronger, longer-lasting psoriasis-like inflammation and may be a simpler, less harmful way to study chronic disease. 🔗 https://bit.ly/4os9ByU ##immunology

Kromann et al review how intestinal organoids co-cultured with immune cells are advancing our understanding of gut homeostasis, inflammation, infection & cancer. A powerful tool for translational immunology. 📖 https://bit.ly/459Ulzn #Organoids #Immunology #GutHealth

🤰 Exposure to gestational diabetes mellitus (GDM) leads to subclinical inflammation, driven in part by obesity but also evident in non-obese individuals. Immune profiling reveals altered NK, T cell, and monocyte populations across metabolic tissues. 👉 https://bit.ly/4okz8dk ##Immunology

From autoimmunity to infectious diseases, if your research bridges basic and clinical immunology, CEI is your home. With read & publish deals, it's never been easier to go Open Access. 🚀 Learn more: https://bit.ly/4ksUbHJ ##Immunology

🧬 New open access article: A novel TNFAIP3 variant linked to autoimmunity reveals activation of NF-κB, STAT1 & mTOR pathways, highlighting new mechanisms and potential therapeutic targets in HA20. 🔗 https://bit.ly/4moJffE #Autoimmunity #Immunology

🧬 New study identifies a truncated CD74 isoform as a key driver of IL-17 overproduction in stromal-immune cell interactions. Blocking it significantly reduces IL-17, pointing to a promising new therapeutic target. 📖 https://bit.ly/3IRIcX0 ##Immunology #IL17 #Inflammation

Karnopp et al. report that vitamin D boosts brain VDR expression and reduces antibody deposits in a neuropsychiatric lupus mouse model, supporting its role in modulating CNS autoimmunity. 🧠 https://bit.ly/467P5gA ##immunology

Can TBK1 inhibition treat IBD? In a DSS colitis model, Hui et al. found that Amlexanox worsens inflammation, despite dampening key pro-inflammatory pathways, underscoring the complexity of immune regulation. 🔗 https://bit.ly/44Bp48h ##IBD #ClinicalImmunology

T cell exhaustion could hold the key to infliximab resistance in pediatric IBD. Schnell et al. show that non-responders have elevated Lag-3+ CD4+ T cells, pointing to a potential biomarker for therapy failure. Read now🔗 https://bit.ly/4nKQCiR

Did you catch our very own Editor-in-Chief, Claudia Mauri, @maurilab.bsky.social speaking at this year’s #LIG2025, @london-immuno.bsky.social ? 🎤✨ Inspiring insights and impactful science from a true leader in the field!

How does epithelial cell diversity shape host–pathogen interactions in the gut? This open-access review explores how organoids are advancing our understanding of GI infections by modelling cellular heterogeneity. 📖 Read: https://bit.ly/422Z96U ##Immunology

This study in shows that targeting FcγRIIB (CD32B) with antibodies boosts immune responses - not by blocking inhibition, but by engaging activating FcγRs. A novel strategy to enhance vaccines & immunotherapies. 🔗 https://bit.ly/4llbQ5n #Immunology #FcReceptors

Rims et al. reveal that the frequency and phenotype of citrulline-specific T cells mirror RA disease activity - offering a potential biomarker for immune monitoring in HLA-DRB1*04:04⁺ patients. 📖 https://bit.ly/4lddfL2 #RAresearch

New evidence connects Nck1 signalling to the generation of human Tregs via AKT-FoxO1 - potential implications for designing immune modulators that tweak Treg levels in disease settings. 📖 https://bit.ly/44dXsWr #ImmuneRegulation

Insightful review on T-cell integrins and their role in autoimmune & inflammatory diseases, covering structure, function, and therapeutic targeting in IBD, MS, and psoriasis. A valuable reference for current and emerging treatments. 📖 https://bit.ly/3F1Dcd5 #Immunology

Did you enjoy @focisimmunology.bsky.social‬'s annual meeting? Want to learn even more? 🔬 Browse the article selection from @ceijournal.bsky.social, curated to complement the scientific programme and plenary sessions. Tag any #Immunosky colleagues who also attended! https://oxford.ly/4ekPYEk

🧴 New research reveals dysregulation in the TGF-β1/SMAD3 pathway in atopic dermatitis - with links to vitamin D deficiency and disease severity. Explore this molecular + immunohistochemical analysis, part of our #FOCIS2025 collection: 🔗 https://bit.ly/4l0RbmX ##Immunology

Today marks the final day of #FOCIS2025! 🧬 Continue the momentum with our special CEI Virtual Issue, packed with cutting-edge research in allergy, immuno-oncology, Tregs & more. 📚 Explore the collection: https://bit.ly/4l2uSgr ##Immunology #OpenAccess

🧬 Can regulatory T cells become dysfunctional like conventional T cells - and what does that mean for cell therapy? This review explores Treg dysfunction and its impact on adoptive immunotherapy Part of our #FOCIS2025 collection 👉 https://bit.ly/3Tb8fdC #Immunology

🧫 Revolutionizing immune research with organoid-based co-culture and chip systems explores how organoids + microfluidics are transforming how we study immune–epithelial interactions. Part of our #FOCIS2025 collection ➡️ https://bit.ly/44nOCV3 #Immunology #Organoids #PrecisionMedicine

Looking to complement the cutting-edge immunology being explored at #FOCIS2025? Check out the @ceijournal.bsky.social Virtual Issue, a special collection of recent CEI papers spanning clinical breakthroughs and foundational mechanisms. 📖 Explore now: bit.ly/4l2uSgr