Claudia Mauri
@maurilab.bsky.social
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reposted by
Claudia Mauri
preLights
5 months ago
An immunosuppressive B cell subset has been identified in renal cell carcinoma. Congrats to our new preLighter, Charis Qi, on her first
#preLight
, which talks about the
#preprint
by the
@maurilab.bsky.social
!
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Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal cell carcinoma - preLights
An Immunosuppressive B Cell Subset Is Identified in Renal Cell Carcinoma.
https://prelights.biologists.com/highlights/tumor-infiltrating-cd27-igd-regulatory-b-cells-suppress-cytotoxic-cd8t-cell-responses-in-renal-cell-carcinoma/
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reposted by
Claudia Mauri
Immunity
6 months ago
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More TOR: The expanding role of mTOR in regulating immune responses
The mammalian/mechanistic target of rapamycin (mTOR) signaling pathway integrates critical environmental and metabolic cues to regulate immune cell activation, differentiation, and function. Patel and Powell provide an updated comprehensive review of our current understanding of mTORās evolutionarily conserved role in immune cell biology.
http://dlvr.it/TLqd1n
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reposted by
Claudia Mauri
Immunity
9 months ago
Online now: B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ TĀ cell function
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B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ TĀ cell function
Liver regeneration (LR) is essential for recovery from acute trauma, cancer surgery, or transplantation. Fazel Modares etĀ al. find that mouse LR after injury requires ChAT+ B cells synthesizing acetylcholine (ACh) and Kupffer cells and hepatic CD8+ TĀ cells expressing Ī±7 nicotinic ACh receptor (Chrna7). ChAT+ B cells drive Kupffer cell IL-6 secretion and reduce CD8+ TĀ cell IFNĪ³.
http://dlvr.it/TKNCNV
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