Karen Slattery
@karen--s.bsky.social
š¤ 240
š„ 655
š 7
Cancer immunologist with an interest in metabolism.
Delighted to have our work on ovarian cancer highlighted by Cancer Discovery News this week! š
add a skeleton here at some point
4 months ago
1
4
0
Thrilled to share our new study showing that lipids drive immune dysfunction in ovarian cancer ā and that blocking lipid uptake through SR-B1 can prevent it!
@lydialynch.bsky.social
@tcddublin.bsky.social
add a skeleton here at some point
5 months ago
2
10
1
reposted by
Karen Slattery
Lydia Lynch
5 months ago
Our paper
@sciimmunology.bsky.social
shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy in ovarian cancer. Wonderful to collaborate with Donal Brennan, Marcia Haigis & super postdoc
@karen--s.bsky.social
add a skeleton here at some point
0
14
2
I was honored to recieve the Translational Project of the Year Award at the Irish Cancer Society Awards last week! Thanks so much to the ICS for funding and acknowledging this work, and to
@lydialynch.bsky.social
for all of the support over the years! šš„°
7 months ago
1
16
3
reposted by
Karen Slattery
Delgoffe Lab
8 months ago
I'm delighted to share a new story from our lab published today at
@cp-cellmetabolism.bsky.social
! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/
www.cell.com/cell-metabol...
loading . . .
Redirecting glucose flux during inĀ vitro expansion generates epigenetically and metabolically superior TĀ cells for cancer immunotherapy
T cell therapies for cancer currently rely on extensive inĀ vitro expansion in hypermetabolic conditions. Frisch etĀ al. demonstrate that TĀ cells grown inĀ vitro perform extensive aerobic glycolysis. Rer...
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00489-3
2
44
18
reposted by
Karen Slattery
Isaac Harris
8 months ago
Iām really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
loading . . .
9:30 AM - 3 PM EST, May 5th and 6th, 2025
https://www.cancermetabolismshowcase.org
0
33
19
reposted by
Karen Slattery
Wallace Marshall
9 months ago
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint,
@gavsturm.bsky.social
investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
6
268
101
Check out our new commentary on this interesting study by
@justinaguerrero.bsky.social
and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social
loading . . .
La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
https://journals.lww.com/immunometabolism/fulltext/2025/01000/la_dolce_vita__fueling_chimeric_antigen_receptor.3.aspx#
9 months ago
2
5
5
reposted by
Karen Slattery
Lydia Lynch
9 months ago
Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating
@natureportfolio.bsky.social
Huge effort by whole team and collaborators to work this out.
www.nature.com/articles/s41...
loading . . .
Article Metrics - Rhythmic IL-17 production by γΓ T cells maintains adipose de novo lipogenesis | Nature
https://www.nature.com/articles/s41586-024-08131-3/metrics
2
64
24
reposted by
Karen Slattery
Michael Fischbach
10 months ago
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream.
@djenetbousbaine.bsky.social
led the charge...
@natureportfolio.bsky.social
1/55
24
697
359
reposted by
Karen Slattery
Matthew Sinton š³ļøāš
10 months ago
Working on immunometabolism? Or looking for people who do? Then hereās the starter pack for you! š
#Immunosky
go.bsky.app/MvxkA4Q
add a skeleton here at some point
29
85
32
you reached the end!!
feeds!
log in